Kinesin-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

OSM3-like kinesin, putative

Species:

Leishmania braziliensis

UniProt:

A4H925_LEIBR

TriTrypDb:

LbrM.17.0810 , LBRM2903_170016500

Length:

928

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 16

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005874	microtubule	6	8
GO:0099080	supramolecular complex	2	8
GO:0099081	supramolecular polymer	3	8
GO:0099512	supramolecular fiber	4	8
GO:0099513	polymeric cytoskeletal fiber	5	8
GO:0110165	cellular anatomical entity	1	8
GO:0005737	cytoplasm	2	1
GO:0005871	kinesin complex	3	1
GO:0005875	microtubule associated complex	2	1
GO:0005929	cilium	4	1
GO:0032991	protein-containing complex	1	1
GO:0042995	cell projection	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0120025	plasma membrane bounded cell projection	3	1

Expansion

Sequence features

A4H925

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H925

Function

Biological processes
Term	Name	Level	Count
GO:0007017	microtubule-based process	2	8
GO:0007018	microtubule-based movement	3	8
GO:0009987	cellular process	1	8

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	8
GO:0003774	cytoskeletal motor activity	1	8
GO:0003777	microtubule motor activity	2	8
GO:0005488	binding	1	8
GO:0005515	protein binding	2	8
GO:0005524	ATP binding	5	8
GO:0008017	microtubule binding	5	8
GO:0008092	cytoskeletal protein binding	3	8
GO:0015631	tubulin binding	4	8
GO:0017076	purine nucleotide binding	4	8
GO:0030554	adenyl nucleotide binding	5	8
GO:0032553	ribonucleotide binding	3	8
GO:0032555	purine ribonucleotide binding	4	8
GO:0032559	adenyl ribonucleotide binding	5	8
GO:0035639	purine ribonucleoside triphosphate binding	4	8
GO:0036094	small molecule binding	2	8
GO:0043167	ion binding	2	8
GO:0043168	anion binding	3	8
GO:0097159	organic cyclic compound binding	2	8
GO:0097367	carbohydrate derivative binding	2	8
GO:0140657	ATP-dependent activity	1	8
GO:1901265	nucleoside phosphate binding	3	8
GO:1901363	heterocyclic compound binding	2	8
GO:0003824	catalytic activity	1	1
GO:0016462	pyrophosphatase activity	5	1
GO:0016787	hydrolase activity	2	1
GO:0016817	hydrolase activity, acting on acid anhydrides	3	1
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	1
GO:0016887	ATP hydrolysis activity	7	1
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	788	792	PF00656	0.602
CLV_NRD_NRD_1	203	205	PF00675	0.404
CLV_NRD_NRD_1	867	869	PF00675	0.537
CLV_NRD_NRD_1	897	899	PF00675	0.612
CLV_NRD_NRD_1	916	918	PF00675	0.529
CLV_PCSK_KEX2_1	202	204	PF00082	0.399
CLV_PCSK_KEX2_1	800	802	PF00082	0.601
CLV_PCSK_KEX2_1	867	869	PF00082	0.617
CLV_PCSK_KEX2_1	896	898	PF00082	0.612
CLV_PCSK_KEX2_1	916	918	PF00082	0.519
CLV_PCSK_PC1ET2_1	800	802	PF00082	0.601
CLV_PCSK_SKI1_1	120	124	PF00082	0.376
CLV_PCSK_SKI1_1	130	134	PF00082	0.307
CLV_PCSK_SKI1_1	156	160	PF00082	0.413
CLV_PCSK_SKI1_1	169	173	PF00082	0.449
CLV_PCSK_SKI1_1	339	343	PF00082	0.429
CLV_PCSK_SKI1_1	369	373	PF00082	0.545
CLV_PCSK_SKI1_1	476	480	PF00082	0.525
CLV_PCSK_SKI1_1	532	536	PF00082	0.701
CLV_PCSK_SKI1_1	590	594	PF00082	0.491
CLV_PCSK_SKI1_1	665	669	PF00082	0.552
CLV_PCSK_SKI1_1	678	682	PF00082	0.497
CLV_PCSK_SKI1_1	745	749	PF00082	0.597
CLV_PCSK_SKI1_1	821	825	PF00082	0.609
CLV_PCSK_SKI1_1	852	856	PF00082	0.577
CLV_Separin_Metazoa	492	496	PF03568	0.641
DEG_APCC_DBOX_1	688	696	PF00400	0.558
DOC_CKS1_1	470	475	PF01111	0.636
DOC_CYCLIN_RxL_1	742	749	PF00134	0.601
DOC_MAPK_gen_1	665	674	PF00069	0.460
DOC_MAPK_gen_1	770	779	PF00069	0.596
DOC_MAPK_MEF2A_6	161	168	PF00069	0.413
DOC_MAPK_MEF2A_6	265	274	PF00069	0.353
DOC_MAPK_MEF2A_6	32	39	PF00069	0.413
DOC_MAPK_MEF2A_6	342	349	PF00069	0.532
DOC_MAPK_MEF2A_6	391	399	PF00069	0.665
DOC_PP1_RVXF_1	309	316	PF00149	0.413
DOC_PP4_FxxP_1	470	473	PF00568	0.630
DOC_PP4_FxxP_1	75	78	PF00568	0.413
DOC_USP7_MATH_1	238	242	PF00917	0.418
DOC_USP7_MATH_1	292	296	PF00917	0.444
DOC_USP7_MATH_1	402	406	PF00917	0.558
DOC_USP7_MATH_1	486	490	PF00917	0.581
DOC_USP7_MATH_1	611	615	PF00917	0.698
DOC_USP7_MATH_1	720	724	PF00917	0.666
DOC_USP7_MATH_1	915	919	PF00917	0.563
DOC_USP7_MATH_1	920	924	PF00917	0.530
DOC_USP7_UBL2_3	528	532	PF12436	0.642
DOC_USP7_UBL2_3	586	590	PF12436	0.550
DOC_USP7_UBL2_3	757	761	PF12436	0.586
DOC_USP7_UBL2_3	821	825	PF12436	0.609
DOC_WW_Pin1_4	293	298	PF00397	0.440
DOC_WW_Pin1_4	469	474	PF00397	0.639
LIG_14-3-3_CanoR_1	20	29	PF00244	0.413
LIG_14-3-3_CanoR_1	216	221	PF00244	0.430
LIG_14-3-3_CanoR_1	237	246	PF00244	0.369
LIG_14-3-3_CanoR_1	323	332	PF00244	0.436
LIG_14-3-3_CanoR_1	424	428	PF00244	0.584
LIG_14-3-3_CanoR_1	430	435	PF00244	0.522
LIG_14-3-3_CanoR_1	55	59	PF00244	0.362
LIG_14-3-3_CanoR_1	916	922	PF00244	0.663
LIG_Actin_WH2_2	838	854	PF00022	0.570
LIG_APCC_ABBAyCdc20_2	678	684	PF00400	0.614
LIG_CaM_IQ_9	657	672	PF13499	0.469
LIG_Clathr_ClatBox_1	431	435	PF01394	0.621
LIG_deltaCOP1_diTrp_1	461	470	PF00928	0.616
LIG_deltaCOP1_diTrp_1	54	58	PF00928	0.433
LIG_FHA_1	173	179	PF00498	0.433
LIG_FHA_1	226	232	PF00498	0.443
LIG_FHA_1	234	240	PF00498	0.275
LIG_FHA_1	297	303	PF00498	0.356
LIG_FHA_1	358	364	PF00498	0.530
LIG_FHA_1	376	382	PF00498	0.550
LIG_FHA_1	41	47	PF00498	0.462
LIG_FHA_1	427	433	PF00498	0.603
LIG_FHA_1	485	491	PF00498	0.737
LIG_FHA_1	515	521	PF00498	0.619
LIG_FHA_1	611	617	PF00498	0.673
LIG_FHA_1	71	77	PF00498	0.386
LIG_FHA_1	78	84	PF00498	0.413
LIG_FHA_2	228	234	PF00498	0.355
LIG_FHA_2	261	267	PF00498	0.413
LIG_FHA_2	277	283	PF00498	0.413
LIG_FHA_2	31	37	PF00498	0.407
LIG_FHA_2	353	359	PF00498	0.408
LIG_FHA_2	470	476	PF00498	0.614
LIG_FHA_2	486	492	PF00498	0.630
LIG_FHA_2	528	534	PF00498	0.651
LIG_FHA_2	537	543	PF00498	0.736
LIG_FHA_2	636	642	PF00498	0.684
LIG_FHA_2	719	725	PF00498	0.657
LIG_FHA_2	726	732	PF00498	0.690
LIG_FHA_2	744	750	PF00498	0.491
LIG_IRF3_LxIS_1	441	448	PF10401	0.624
LIG_LIR_Apic_2	73	78	PF02991	0.413
LIG_LIR_Gen_1	146	155	PF02991	0.366
LIG_LIR_Gen_1	219	225	PF02991	0.413
LIG_LIR_Gen_1	312	320	PF02991	0.386
LIG_LIR_Gen_1	464	473	PF02991	0.621
LIG_LIR_Gen_1	57	66	PF02991	0.409
LIG_LIR_Gen_1	679	687	PF02991	0.594
LIG_LIR_Gen_1	70	79	PF02991	0.257
LIG_LIR_Gen_1	773	783	PF02991	0.479
LIG_LIR_Nem_3	146	150	PF02991	0.353
LIG_LIR_Nem_3	219	224	PF02991	0.413
LIG_LIR_Nem_3	312	318	PF02991	0.413
LIG_LIR_Nem_3	464	470	PF02991	0.655
LIG_LIR_Nem_3	554	558	PF02991	0.547
LIG_LIR_Nem_3	57	61	PF02991	0.407
LIG_LIR_Nem_3	679	685	PF02991	0.615
LIG_LIR_Nem_3	70	75	PF02991	0.364
LIG_LIR_Nem_3	763	767	PF02991	0.623
LIG_LIR_Nem_3	773	779	PF02991	0.533
LIG_NRBOX	743	749	PF00104	0.487
LIG_PCNA_yPIPBox_3	152	161	PF02747	0.413
LIG_PDZ_Class_1	923	928	PF00595	0.551
LIG_Pex14_1	463	467	PF04695	0.607
LIG_Pex14_1	837	841	PF04695	0.568
LIG_PTB_Apo_2	60	67	PF02174	0.413
LIG_Rb_LxCxE_1	222	240	PF01857	0.413
LIG_SH2_GRB2like	373	376	PF00017	0.525
LIG_SH2_STAP1	713	717	PF00017	0.609
LIG_SH2_STAT5	144	147	PF00017	0.413
LIG_SH2_STAT5	469	472	PF00017	0.609
LIG_SH2_STAT5	764	767	PF00017	0.592
LIG_SH3_3	183	189	PF00018	0.446
LIG_SH3_3	568	574	PF00018	0.601
LIG_SH3_3	620	626	PF00018	0.810
LIG_SUMO_SIM_par_1	42	48	PF11976	0.433
LIG_TRAF2_1	472	475	PF00917	0.492
LIG_TRAF2_1	489	492	PF00917	0.639
LIG_TRAF2_1	854	857	PF00917	0.579
LIG_TRAF2_1	892	895	PF00917	0.617
LIG_TRFH_1	469	473	PF08558	0.635
LIG_UBA3_1	581	590	PF00899	0.696
LIG_WRC_WIRS_1	144	149	PF05994	0.413
MOD_CDK_SPxxK_3	469	476	PF00069	0.637
MOD_CK1_1	214	220	PF00069	0.353
MOD_CK1_1	260	266	PF00069	0.383
MOD_CK1_1	296	302	PF00069	0.373
MOD_CK1_1	536	542	PF00069	0.526
MOD_CK1_1	614	620	PF00069	0.620
MOD_CK1_1	653	659	PF00069	0.669
MOD_CK1_1	814	820	PF00069	0.465
MOD_CK1_1	82	88	PF00069	0.486
MOD_CK1_1	910	916	PF00069	0.687
MOD_CK1_1	99	105	PF00069	0.325
MOD_CK2_1	143	149	PF00069	0.413
MOD_CK2_1	20	26	PF00069	0.353
MOD_CK2_1	260	266	PF00069	0.375
MOD_CK2_1	352	358	PF00069	0.572
MOD_CK2_1	469	475	PF00069	0.599
MOD_CK2_1	485	491	PF00069	0.667
MOD_CK2_1	520	526	PF00069	0.587
MOD_CK2_1	527	533	PF00069	0.611
MOD_CK2_1	536	542	PF00069	0.544
MOD_CK2_1	718	724	PF00069	0.732
MOD_CK2_1	725	731	PF00069	0.441
MOD_CK2_1	743	749	PF00069	0.493
MOD_CK2_1	869	875	PF00069	0.638
MOD_Cter_Amidation	1	4	PF01082	0.711
MOD_GlcNHglycan	259	262	PF01048	0.391
MOD_GlcNHglycan	274	277	PF01048	0.411
MOD_GlcNHglycan	565	568	PF01048	0.617
MOD_GlcNHglycan	618	621	PF01048	0.680
MOD_GlcNHglycan	629	632	PF01048	0.738
MOD_GlcNHglycan	640	644	PF01048	0.816
MOD_GlcNHglycan	652	655	PF01048	0.678
MOD_GlcNHglycan	696	699	PF01048	0.528
MOD_GlcNHglycan	84	87	PF01048	0.401
MOD_GlcNHglycan	909	912	PF01048	0.667
MOD_GlcNHglycan	917	920	PF01048	0.643
MOD_GlcNHglycan	96	99	PF01048	0.338
MOD_GSK3_1	205	212	PF00069	0.490
MOD_GSK3_1	233	240	PF00069	0.371
MOD_GSK3_1	272	279	PF00069	0.439
MOD_GSK3_1	292	299	PF00069	0.441
MOD_GSK3_1	323	330	PF00069	0.400
MOD_GSK3_1	348	355	PF00069	0.522
MOD_GSK3_1	412	419	PF00069	0.587
MOD_GSK3_1	426	433	PF00069	0.662
MOD_GSK3_1	447	454	PF00069	0.699
MOD_GSK3_1	610	617	PF00069	0.614
MOD_GSK3_1	635	642	PF00069	0.704
MOD_GSK3_1	649	656	PF00069	0.758
MOD_GSK3_1	725	732	PF00069	0.640
MOD_GSK3_1	99	106	PF00069	0.413
MOD_N-GLC_1	270	275	PF02516	0.353
MOD_N-GLC_1	323	328	PF02516	0.413
MOD_N-GLC_1	400	405	PF02516	0.539
MOD_N-GLC_1	520	525	PF02516	0.532
MOD_N-GLC_1	536	541	PF02516	0.746
MOD_N-GLC_1	636	641	PF02516	0.662
MOD_N-GLC_1	64	69	PF02516	0.415
MOD_N-GLC_1	87	92	PF02516	0.413
MOD_NEK2_1	143	148	PF00069	0.372
MOD_NEK2_1	272	277	PF00069	0.374
MOD_NEK2_1	302	307	PF00069	0.353
MOD_NEK2_1	325	330	PF00069	0.365
MOD_NEK2_1	484	489	PF00069	0.698
MOD_NEK2_1	494	499	PF00069	0.658
MOD_NEK2_1	520	525	PF00069	0.637
MOD_NEK2_1	562	567	PF00069	0.640
MOD_NEK2_1	610	615	PF00069	0.588
MOD_NEK2_1	648	653	PF00069	0.679
MOD_NEK2_1	765	770	PF00069	0.549
MOD_NEK2_1	79	84	PF00069	0.436
MOD_NEK2_1	87	92	PF00069	0.427
MOD_PIKK_1	383	389	PF00454	0.441
MOD_PIKK_1	454	460	PF00454	0.517
MOD_PIKK_1	461	467	PF00454	0.598
MOD_PIKK_1	520	526	PF00454	0.642
MOD_PIKK_1	536	542	PF00454	0.496
MOD_PIKK_1	64	70	PF00454	0.413
MOD_PIKK_1	718	724	PF00454	0.492
MOD_PK_1	216	222	PF00069	0.413
MOD_PKA_2	423	429	PF00069	0.610
MOD_PKA_2	494	500	PF00069	0.588
MOD_PKA_2	54	60	PF00069	0.366
MOD_PKA_2	915	921	PF00069	0.723
MOD_PKB_1	18	26	PF00069	0.353
MOD_PKB_1	202	210	PF00069	0.413
MOD_PKB_1	235	243	PF00069	0.271
MOD_PKB_1	733	741	PF00069	0.600
MOD_Plk_1	172	178	PF00069	0.433
MOD_Plk_1	270	276	PF00069	0.353
MOD_Plk_1	352	358	PF00069	0.486
MOD_Plk_1	383	389	PF00069	0.708
MOD_Plk_1	536	542	PF00069	0.496
MOD_Plk_1	639	645	PF00069	0.571
MOD_Plk_1	725	731	PF00069	0.673
MOD_Plk_1	87	93	PF00069	0.413
MOD_Plk_2-3	54	60	PF00069	0.413
MOD_Plk_2-3	870	876	PF00069	0.468
MOD_Plk_4	143	149	PF00069	0.435
MOD_Plk_4	172	178	PF00069	0.413
MOD_Plk_4	216	222	PF00069	0.413
MOD_Plk_4	276	282	PF00069	0.413
MOD_Plk_4	296	302	PF00069	0.358
MOD_Plk_4	309	315	PF00069	0.395
MOD_Plk_4	45	51	PF00069	0.433
MOD_Plk_4	611	617	PF00069	0.514
MOD_Plk_4	79	85	PF00069	0.436
MOD_Plk_4	87	93	PF00069	0.391
MOD_ProDKin_1	293	299	PF00069	0.440
MOD_ProDKin_1	469	475	PF00069	0.638
MOD_SUMO_for_1	132	135	PF00179	0.326
MOD_SUMO_for_1	693	696	PF00179	0.651
MOD_SUMO_for_1	892	895	PF00179	0.617
MOD_SUMO_rev_2	523	530	PF00179	0.593
MOD_SUMO_rev_2	531	536	PF00179	0.522
MOD_SUMO_rev_2	550	558	PF00179	0.651
MOD_SUMO_rev_2	600	605	PF00179	0.521
MOD_SUMO_rev_2	658	667	PF00179	0.638
MOD_SUMO_rev_2	785	792	PF00179	0.601
MOD_SUMO_rev_2	838	845	PF00179	0.596
MOD_SUMO_rev_2	850	860	PF00179	0.678
TRG_DiLeu_BaEn_4	600	606	PF01217	0.628
TRG_DiLeu_BaLyEn_6	427	432	PF01217	0.627
TRG_ENDOCYTIC_2	144	147	PF00928	0.360
TRG_ENDOCYTIC_2	467	470	PF00928	0.636
TRG_ENDOCYTIC_2	682	685	PF00928	0.599
TRG_ENDOCYTIC_2	764	767	PF00928	0.613
TRG_ER_diArg_1	17	20	PF00400	0.388
TRG_ER_diArg_1	202	204	PF00400	0.404
TRG_ER_diArg_1	866	868	PF00400	0.612
TRG_ER_diArg_1	896	898	PF00400	0.628
TRG_NES_CRM1_1	387	400	PF08389	0.563
TRG_NLS_MonoExtC_3	820	825	PF00514	0.611
TRG_NLS_MonoExtN_4	819	825	PF00514	0.616
TRG_Pf-PMV_PEXEL_1	194	198	PF00026	0.433
TRG_Pf-PMV_PEXEL_1	354	358	PF00026	0.620
TRG_Pf-PMV_PEXEL_1	430	435	PF00026	0.622
TRG_Pf-PMV_PEXEL_1	543	547	PF00026	0.640
TRG_Pf-PMV_PEXEL_1	596	600	PF00026	0.664
TRG_Pf-PMV_PEXEL_1	745	749	PF00026	0.561

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5L3	Leptomonas seymouri	67%	99%
A0A3Q8I9R7	Leishmania donovani	84%	99%
A4HXF7	Leishmania infantum	83%	99%
E9AR52	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	99%
Q4QEB1	Leishmania major	84%	100%
V5B325	Trypanosoma cruzi	31%	100%