Ysine decarboxylase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ysine decarboxylase-like protein

Species:

Leishmania braziliensis

UniProt:

A4H924_LEIBR

TriTrypDb:

LbrM.17.0800 , LBRM2903_170014800

Length:

322

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 6
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 16

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005829	cytosol	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H924

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H924

Function

Biological processes
Term	Name	Level	Count
GO:0006725	cellular aromatic compound metabolic process	3	9
GO:0006807	nitrogen compound metabolic process	2	9
GO:0008152	metabolic process	1	9
GO:0009058	biosynthetic process	2	9
GO:0009308	amine metabolic process	4	9
GO:0009690	cytokinin metabolic process	3	9
GO:0009691	cytokinin biosynthetic process	4	9
GO:0009987	cellular process	1	9
GO:0010817	regulation of hormone levels	3	9
GO:0042445	hormone metabolic process	2	9
GO:0042446	hormone biosynthetic process	3	9
GO:0044237	cellular metabolic process	2	9
GO:0044249	cellular biosynthetic process	3	9
GO:0046483	heterocycle metabolic process	3	9
GO:0065007	biological regulation	1	9
GO:0065008	regulation of biological quality	2	9
GO:0071704	organic substance metabolic process	2	9
GO:1901564	organonitrogen compound metabolic process	3	9

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	9
GO:0016787	hydrolase activity	2	9
GO:0016798	hydrolase activity, acting on glycosyl bonds	3	1
GO:0016799	hydrolase activity, hydrolyzing N-glycosyl compounds	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	109	111	PF00675	0.474
CLV_NRD_NRD_1	216	218	PF00675	0.274
CLV_PCSK_SKI1_1	127	131	PF00082	0.366
CLV_PCSK_SKI1_1	304	308	PF00082	0.341
DOC_CYCLIN_yClb3_PxF_3	308	314	PF00134	0.331
DOC_MAPK_gen_1	254	262	PF00069	0.479
DOC_PP1_RVXF_1	216	223	PF00149	0.474
DOC_PP1_RVXF_1	283	290	PF00149	0.455
DOC_PP4_FxxP_1	306	309	PF00568	0.404
DOC_USP7_MATH_1	212	216	PF00917	0.519
DOC_USP7_MATH_1	302	306	PF00917	0.366
DOC_USP7_UBL2_3	148	152	PF12436	0.441
DOC_WW_Pin1_4	304	309	PF00397	0.447
LIG_14-3-3_CanoR_1	293	303	PF00244	0.422
LIG_14-3-3_CanoR_1	62	67	PF00244	0.561
LIG_AP2alpha_1	20	24	PF02296	0.541
LIG_BRCT_BRCA1_1	218	222	PF00533	0.481
LIG_BRCT_BRCA1_1	310	314	PF00533	0.347
LIG_Clathr_ClatBox_1	259	263	PF01394	0.455
LIG_FHA_1	166	172	PF00498	0.384
LIG_FHA_1	38	44	PF00498	0.515
LIG_FHA_1	6	12	PF00498	0.499
LIG_FHA_2	211	217	PF00498	0.485
LIG_FHA_2	235	241	PF00498	0.474
LIG_FHA_2	293	299	PF00498	0.474
LIG_GSK3_LRP6_1	308	313	PF00069	0.480
LIG_LIR_Apic_2	305	309	PF02991	0.418
LIG_LIR_Gen_1	237	245	PF02991	0.474
LIG_LIR_Gen_1	263	273	PF02991	0.497
LIG_LIR_Gen_1	61	69	PF02991	0.541
LIG_LIR_Nem_3	22	27	PF02991	0.515
LIG_LIR_Nem_3	237	241	PF02991	0.500
LIG_LIR_Nem_3	263	269	PF02991	0.515
LIG_LIR_Nem_3	68	72	PF02991	0.558
LIG_PCNA_yPIPBox_3	177	190	PF02747	0.416
LIG_Pex14_2	20	24	PF04695	0.499
LIG_Pex14_2	265	269	PF04695	0.475
LIG_Pex14_2	314	318	PF04695	0.399
LIG_SH2_STAP1	143	147	PF00017	0.411
LIG_SH2_STAT5	143	146	PF00017	0.419
LIG_SH2_STAT5	153	156	PF00017	0.349
LIG_SH2_STAT5	57	60	PF00017	0.501
LIG_SH3_3	226	232	PF00018	0.498
LIG_SH3_3	288	294	PF00018	0.474
LIG_SH3_3	306	312	PF00018	0.527
LIG_SH3_3	316	322	PF00018	0.604
LIG_SUMO_SIM_anti_2	239	246	PF11976	0.477
LIG_SUMO_SIM_par_1	239	246	PF11976	0.474
LIG_TRAF2_1	90	93	PF00917	0.540
LIG_WRC_WIRS_1	235	240	PF05994	0.499
LIG_WRC_WIRS_1	303	308	PF05994	0.477
MOD_CK1_1	100	106	PF00069	0.541
MOD_CK2_1	192	198	PF00069	0.596
MOD_CK2_1	210	216	PF00069	0.396
MOD_CK2_1	234	240	PF00069	0.474
MOD_CK2_1	292	298	PF00069	0.474
MOD_GlcNHglycan	136	139	PF01048	0.553
MOD_GlcNHglycan	198	202	PF01048	0.312
MOD_GlcNHglycan	75	78	PF01048	0.561
MOD_GSK3_1	208	215	PF00069	0.500
MOD_GSK3_1	304	311	PF00069	0.568
MOD_GSK3_1	97	104	PF00069	0.631
MOD_NEK2_1	210	215	PF00069	0.419
MOD_NEK2_1	314	319	PF00069	0.606
MOD_NEK2_2	5	10	PF00069	0.529
MOD_PIKK_1	101	107	PF00454	0.623
MOD_PIKK_1	141	147	PF00454	0.461
MOD_PK_1	185	191	PF00069	0.541
MOD_PKA_2	216	222	PF00069	0.479
MOD_PKA_2	292	298	PF00069	0.425
MOD_PKA_2	61	67	PF00069	0.501
MOD_Plk_4	199	205	PF00069	0.462
MOD_Plk_4	216	222	PF00069	0.481
MOD_Plk_4	224	230	PF00069	0.474
MOD_ProDKin_1	304	310	PF00069	0.451
MOD_SUMO_rev_2	104	112	PF00179	0.457
MOD_SUMO_rev_2	215	220	PF00179	0.481
MOD_SUMO_rev_2	279	287	PF00179	0.478
MOD_SUMO_rev_2	92	97	PF00179	0.559
TRG_DiLeu_BaLyEn_6	120	125	PF01217	0.548
TRG_ENDOCYTIC_2	57	60	PF00928	0.541
TRG_ENDOCYTIC_2	63	66	PF00928	0.541

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PC81	Leptomonas seymouri	66%	100%
A0A1X0NSV2	Trypanosomatidae	46%	94%
A0A3Q8IDZ9	Leishmania donovani	86%	100%
A0A422MP54	Trypanosoma rangeli	49%	100%
A4HXF6	Leishmania infantum	86%	100%
E9AR51	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
P47044	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	30%	100%
Q4QEB2	Leishmania major	85%	100%