Myb-like DNA-binding domain containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Myb-like DNA-binding domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4H921_LEIBR

TriTrypDb:

LbrM.17.0770 , LBRM2903_170014500

Length:

807

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0000974	Prp19 complex	2	1
GO:0005654	nucleoplasm	2	1
GO:0005681	spliceosomal complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0110165	cellular anatomical entity	1	1
GO:0140513	nuclear protein-containing complex	2	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

A4H921

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H921

Function

Biological processes
Term	Name	Level	Count
GO:0000375	RNA splicing, via transesterification reactions	8	1
GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	9	1
GO:0000398	mRNA splicing, via spliceosome	8	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006396	RNA processing	6	1
GO:0006397	mRNA processing	7	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0008380	RNA splicing	7	1
GO:0009987	cellular process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0016071	mRNA metabolic process	6	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	1
GO:0003677	DNA binding	4	1
GO:0005488	binding	1	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	260	264	PF00656	0.712
CLV_C14_Caspase3-7	313	317	PF00656	0.587
CLV_C14_Caspase3-7	450	454	PF00656	0.720
CLV_C14_Caspase3-7	535	539	PF00656	0.626
CLV_C14_Caspase3-7	545	549	PF00656	0.612
CLV_C14_Caspase3-7	723	727	PF00656	0.644
CLV_NRD_NRD_1	151	153	PF00675	0.462
CLV_NRD_NRD_1	154	156	PF00675	0.487
CLV_NRD_NRD_1	194	196	PF00675	0.492
CLV_NRD_NRD_1	228	230	PF00675	0.532
CLV_NRD_NRD_1	500	502	PF00675	0.578
CLV_NRD_NRD_1	522	524	PF00675	0.555
CLV_NRD_NRD_1	568	570	PF00675	0.693
CLV_NRD_NRD_1	775	777	PF00675	0.504
CLV_NRD_NRD_1	92	94	PF00675	0.277
CLV_PCSK_FUR_1	148	152	PF00082	0.448
CLV_PCSK_KEX2_1	148	150	PF00082	0.444
CLV_PCSK_KEX2_1	151	153	PF00082	0.462
CLV_PCSK_KEX2_1	435	437	PF00082	0.631
CLV_PCSK_KEX2_1	481	483	PF00082	0.634
CLV_PCSK_KEX2_1	522	524	PF00082	0.555
CLV_PCSK_KEX2_1	568	570	PF00082	0.584
CLV_PCSK_KEX2_1	629	631	PF00082	0.560
CLV_PCSK_KEX2_1	775	777	PF00082	0.504
CLV_PCSK_KEX2_1	92	94	PF00082	0.277
CLV_PCSK_PC1ET2_1	435	437	PF00082	0.628
CLV_PCSK_PC1ET2_1	481	483	PF00082	0.559
CLV_PCSK_PC1ET2_1	629	631	PF00082	0.560
CLV_PCSK_SKI1_1	20	24	PF00082	0.277
CLV_PCSK_SKI1_1	229	233	PF00082	0.528
CLV_PCSK_SKI1_1	297	301	PF00082	0.475
CLV_PCSK_SKI1_1	334	338	PF00082	0.625
CLV_PCSK_SKI1_1	346	350	PF00082	0.504
CLV_PCSK_SKI1_1	41	45	PF00082	0.281
CLV_PCSK_SKI1_1	438	442	PF00082	0.647
CLV_PCSK_SKI1_1	761	765	PF00082	0.491
CLV_PCSK_SKI1_1	769	773	PF00082	0.542
DEG_APCC_DBOX_1	333	341	PF00400	0.538
DEG_APCC_DBOX_1	437	445	PF00400	0.640
DEG_APCC_DBOX_1	774	782	PF00400	0.507
DEG_SCF_TRCP1_1	484	489	PF00400	0.538
DEG_SPOP_SBC_1	473	477	PF00917	0.682
DEG_SPOP_SBC_1	540	544	PF00917	0.778
DEG_SPOP_SBC_1	582	586	PF00917	0.567
DOC_CKS1_1	353	358	PF01111	0.548
DOC_CKS1_1	495	500	PF01111	0.527
DOC_MAPK_DCC_7	436	446	PF00069	0.720
DOC_MAPK_gen_1	501	508	PF00069	0.547
DOC_PP1_RVXF_1	1	7	PF00149	0.545
DOC_PP1_RVXF_1	69	76	PF00149	0.418
DOC_PP2B_LxvP_1	736	739	PF13499	0.647
DOC_USP7_MATH_1	261	265	PF00917	0.725
DOC_USP7_MATH_1	325	329	PF00917	0.661
DOC_USP7_MATH_1	373	377	PF00917	0.543
DOC_USP7_MATH_1	378	382	PF00917	0.505
DOC_USP7_MATH_1	473	477	PF00917	0.658
DOC_USP7_MATH_1	480	484	PF00917	0.711
DOC_USP7_MATH_1	514	518	PF00917	0.707
DOC_USP7_MATH_1	534	538	PF00917	0.596
DOC_USP7_MATH_1	549	553	PF00917	0.533
DOC_USP7_MATH_1	582	586	PF00917	0.704
DOC_USP7_MATH_1	616	620	PF00917	0.562
DOC_USP7_MATH_1	724	728	PF00917	0.587
DOC_USP7_MATH_1	737	741	PF00917	0.544
DOC_USP7_UBL2_3	192	196	PF12436	0.494
DOC_USP7_UBL2_3	392	396	PF12436	0.630
DOC_WW_Pin1_4	352	357	PF00397	0.699
DOC_WW_Pin1_4	417	422	PF00397	0.632
DOC_WW_Pin1_4	494	499	PF00397	0.604
DOC_WW_Pin1_4	584	589	PF00397	0.692
DOC_WW_Pin1_4	591	596	PF00397	0.633
DOC_WW_Pin1_4	634	639	PF00397	0.541
DOC_WW_Pin1_4	698	703	PF00397	0.611
DOC_WW_Pin1_4	718	723	PF00397	0.677
DOC_WW_Pin1_4	91	96	PF00397	0.477
LIG_14-3-3_CanoR_1	33	38	PF00244	0.477
LIG_14-3-3_CanoR_1	645	653	PF00244	0.655
LIG_Actin_WH2_2	705	721	PF00022	0.458
LIG_APCC_ABBA_1	277	282	PF00400	0.541
LIG_BIR_II_1	1	5	PF00653	0.554
LIG_BIR_III_4	256	260	PF00653	0.541
LIG_BIR_III_4	316	320	PF00653	0.615
LIG_BRCT_BRCA1_1	551	555	PF00533	0.537
LIG_FHA_1	180	186	PF00498	0.453
LIG_FHA_1	220	226	PF00498	0.529
LIG_FHA_1	239	245	PF00498	0.562
LIG_FHA_1	353	359	PF00498	0.597
LIG_FHA_1	695	701	PF00498	0.587
LIG_FHA_2	10	16	PF00498	0.477
LIG_FHA_2	155	161	PF00498	0.465
LIG_FHA_2	313	319	PF00498	0.510
LIG_FHA_2	396	402	PF00498	0.467
LIG_FHA_2	445	451	PF00498	0.751
LIG_FHA_2	552	558	PF00498	0.616
LIG_FHA_2	584	590	PF00498	0.698
LIG_FHA_2	592	598	PF00498	0.669
LIG_FHA_2	646	652	PF00498	0.487
LIG_FHA_2	721	727	PF00498	0.638
LIG_LIR_Apic_2	51	56	PF02991	0.477
LIG_LIR_Gen_1	106	115	PF02991	0.382
LIG_LIR_Gen_1	271	280	PF02991	0.584
LIG_LIR_Gen_1	30	38	PF02991	0.477
LIG_LIR_Gen_1	401	410	PF02991	0.554
LIG_LIR_Gen_1	552	562	PF02991	0.590
LIG_LIR_Gen_1	690	699	PF02991	0.520
LIG_LIR_Gen_1	74	80	PF02991	0.418
LIG_LIR_Nem_3	106	112	PF02991	0.378
LIG_LIR_Nem_3	271	277	PF02991	0.595
LIG_LIR_Nem_3	30	34	PF02991	0.477
LIG_LIR_Nem_3	401	406	PF02991	0.541
LIG_LIR_Nem_3	48	53	PF02991	0.477
LIG_LIR_Nem_3	489	495	PF02991	0.583
LIG_LIR_Nem_3	552	558	PF02991	0.609
LIG_LIR_Nem_3	690	694	PF02991	0.511
LIG_LIR_Nem_3	74	78	PF02991	0.418
LIG_MYND_1	429	433	PF01753	0.545
LIG_Pex14_2	75	79	PF04695	0.481
LIG_PROFILIN_1	426	432	PF00235	0.539
LIG_Rb_pABgroove_1	486	494	PF01858	0.534
LIG_SH2_PTP2	98	101	PF00017	0.413
LIG_SH2_SRC	472	475	PF00017	0.552
LIG_SH2_SRC	53	56	PF00017	0.539
LIG_SH2_STAP1	656	660	PF00017	0.451
LIG_SH2_STAT3	280	283	PF00017	0.521
LIG_SH2_STAT3	656	659	PF00017	0.463
LIG_SH2_STAT5	109	112	PF00017	0.370
LIG_SH2_STAT5	119	122	PF00017	0.449
LIG_SH2_STAT5	53	56	PF00017	0.539
LIG_SH2_STAT5	711	714	PF00017	0.539
LIG_SH2_STAT5	744	747	PF00017	0.571
LIG_SH2_STAT5	98	101	PF00017	0.413
LIG_SH3_2	430	435	PF14604	0.651
LIG_SH3_2	466	471	PF14604	0.648
LIG_SH3_3	353	359	PF00018	0.605
LIG_SH3_3	409	415	PF00018	0.533
LIG_SH3_3	422	428	PF00018	0.597
LIG_SH3_3	463	469	PF00018	0.749
LIG_SUMO_SIM_par_1	442	447	PF11976	0.720
LIG_TRAF2_1	157	160	PF00917	0.458
LIG_TRAF2_1	234	237	PF00917	0.509
LIG_TRAF2_1	391	394	PF00917	0.629
LIG_TRAF2_1	447	450	PF00917	0.718
LIG_TRAF2_1	65	68	PF00917	0.477
LIG_WRC_WIRS_1	141	146	PF05994	0.513
LIG_WW_2	356	359	PF00397	0.543
LIG_WW_2	429	432	PF00397	0.697
MOD_CDK_SPK_2	698	703	PF00069	0.448
MOD_CDK_SPxxK_3	494	501	PF00069	0.524
MOD_CK1_1	140	146	PF00069	0.519
MOD_CK1_1	327	333	PF00069	0.604
MOD_CK1_1	36	42	PF00069	0.315
MOD_CK1_1	420	426	PF00069	0.609
MOD_CK1_1	455	461	PF00069	0.597
MOD_CK2_1	154	160	PF00069	0.470
MOD_CK2_1	210	216	PF00069	0.473
MOD_CK2_1	379	385	PF00069	0.513
MOD_CK2_1	444	450	PF00069	0.720
MOD_CK2_1	551	557	PF00069	0.621
MOD_CK2_1	583	589	PF00069	0.717
MOD_CK2_1	591	597	PF00069	0.660
MOD_CK2_1	62	68	PF00069	0.315
MOD_CK2_1	645	651	PF00069	0.502
MOD_CK2_1	9	15	PF00069	0.315
MOD_GlcNHglycan	168	171	PF01048	0.518
MOD_GlcNHglycan	219	222	PF01048	0.518
MOD_GlcNHglycan	241	244	PF01048	0.504
MOD_GlcNHglycan	254	260	PF01048	0.604
MOD_GlcNHglycan	263	266	PF01048	0.589
MOD_GlcNHglycan	312	315	PF01048	0.723
MOD_GlcNHglycan	327	330	PF01048	0.517
MOD_GlcNHglycan	364	367	PF01048	0.670
MOD_GlcNHglycan	407	410	PF01048	0.772
MOD_GlcNHglycan	484	487	PF01048	0.639
MOD_GlcNHglycan	544	547	PF01048	0.672
MOD_GlcNHglycan	618	621	PF01048	0.653
MOD_GlcNHglycan	648	651	PF01048	0.477
MOD_GlcNHglycan	656	659	PF01048	0.443
MOD_GlcNHglycan	726	729	PF01048	0.688
MOD_GSK3_1	160	167	PF00069	0.553
MOD_GSK3_1	217	224	PF00069	0.503
MOD_GSK3_1	321	328	PF00069	0.631
MOD_GSK3_1	347	354	PF00069	0.622
MOD_GSK3_1	413	420	PF00069	0.655
MOD_GSK3_1	482	489	PF00069	0.616
MOD_GSK3_1	514	521	PF00069	0.626
MOD_GSK3_1	549	556	PF00069	0.635
MOD_GSK3_1	694	701	PF00069	0.582
MOD_GSK3_1	720	727	PF00069	0.638
MOD_N-GLC_1	362	367	PF02516	0.535
MOD_NEK2_1	180	185	PF00069	0.447
MOD_NEK2_1	225	230	PF00069	0.532
MOD_NEK2_1	395	400	PF00069	0.530
MOD_NEK2_1	402	407	PF00069	0.595
MOD_NEK2_2	221	226	PF00069	0.535
MOD_PIKK_1	41	47	PF00454	0.320
MOD_PIKK_1	629	635	PF00454	0.717
MOD_PIKK_1	667	673	PF00454	0.578
MOD_PK_1	442	448	PF00069	0.693
MOD_PKA_1	629	635	PF00069	0.555
MOD_PKA_2	154	160	PF00069	0.470
MOD_PKA_2	225	231	PF00069	0.530
MOD_PKA_2	261	267	PF00069	0.705
MOD_PKA_2	576	582	PF00069	0.604
MOD_PKA_2	629	635	PF00069	0.555
MOD_PKA_2	799	805	PF00069	0.430
MOD_PKB_1	755	763	PF00069	0.505
MOD_Plk_1	321	327	PF00069	0.534
MOD_Plk_1	473	479	PF00069	0.570
MOD_Plk_1	791	797	PF00069	0.501
MOD_Plk_2-3	137	143	PF00069	0.566
MOD_Plk_2-3	312	318	PF00069	0.500
MOD_Plk_2-3	608	614	PF00069	0.489
MOD_Plk_2-3	62	68	PF00069	0.315
MOD_Plk_4	140	146	PF00069	0.519
MOD_Plk_4	33	39	PF00069	0.315
MOD_ProDKin_1	352	358	PF00069	0.700
MOD_ProDKin_1	417	423	PF00069	0.634
MOD_ProDKin_1	494	500	PF00069	0.598
MOD_ProDKin_1	584	590	PF00069	0.693
MOD_ProDKin_1	591	597	PF00069	0.630
MOD_ProDKin_1	634	640	PF00069	0.541
MOD_ProDKin_1	698	704	PF00069	0.611
MOD_ProDKin_1	718	724	PF00069	0.684
MOD_ProDKin_1	91	97	PF00069	0.315
MOD_SUMO_for_1	112	115	PF00179	0.385
MOD_SUMO_for_1	209	212	PF00179	0.476
MOD_SUMO_for_1	391	394	PF00179	0.629
MOD_SUMO_rev_2	390	398	PF00179	0.548
MOD_SUMO_rev_2	65	73	PF00179	0.315
TRG_DiLeu_BaEn_1	301	306	PF01217	0.436
TRG_DiLeu_BaEn_1	68	73	PF01217	0.315
TRG_DiLeu_BaLyEn_6	81	86	PF01217	0.315
TRG_DiLeu_LyEn_5	301	306	PF01217	0.436
TRG_ENDOCYTIC_2	109	112	PF00928	0.370
TRG_ER_diArg_1	148	151	PF00400	0.452
TRG_ER_diArg_1	568	570	PF00400	0.584
TRG_ER_diArg_1	755	758	PF00400	0.670
TRG_ER_diArg_1	774	776	PF00400	0.387
TRG_NLS_MonoExtC_3	228	233	PF00514	0.515
TRG_NLS_MonoExtN_4	226	233	PF00514	0.522
TRG_Pf-PMV_PEXEL_1	233	237	PF00026	0.508
TRG_Pf-PMV_PEXEL_1	293	298	PF00026	0.482
TRG_Pf-PMV_PEXEL_1	304	308	PF00026	0.508
TRG_Pf-PMV_PEXEL_1	84	88	PF00026	0.315

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKC2	Leptomonas seymouri	54%	100%
A0A3S7WUG8	Leishmania donovani	82%	100%
A4HXF3	Leishmania infantum	82%	100%
E9AR48	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
Q4QEB5	Leishmania major	81%	100%