Methyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Methyltransferase

Gene product:

Putative methyltransferase, putative

Species:

Leishmania braziliensis

UniProt:

A4H920_LEIBR

TriTrypDb:

LbrM.17.0760 , LBRM2903_170014400

Length:

474

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H920

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H920

Function

Biological processes
Term	Name	Level	Count
GO:0008152	metabolic process	1	1
GO:0032259	methylation	2	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0008168	methyltransferase activity	4	1
GO:0016740	transferase activity	2	1
GO:0016741	transferase activity, transferring one-carbon groups	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	445	449	PF00656	0.659
CLV_NRD_NRD_1	361	363	PF00675	0.435
CLV_NRD_NRD_1	431	433	PF00675	0.760
CLV_PCSK_FUR_1	429	433	PF00082	0.661
CLV_PCSK_KEX2_1	133	135	PF00082	0.369
CLV_PCSK_KEX2_1	361	363	PF00082	0.435
CLV_PCSK_KEX2_1	429	431	PF00082	0.697
CLV_PCSK_PC1ET2_1	133	135	PF00082	0.288
CLV_PCSK_PC7_1	129	135	PF00082	0.288
CLV_PCSK_SKI1_1	118	122	PF00082	0.400
CLV_PCSK_SKI1_1	355	359	PF00082	0.246
CLV_PCSK_SKI1_1	65	69	PF00082	0.370
DEG_Nend_Nbox_1	1	3	PF02207	0.388
DEG_SCF_FBW7_1	187	193	PF00400	0.728
DEG_SPOP_SBC_1	190	194	PF00917	0.433
DEG_SPOP_SBC_1	230	234	PF00917	0.693
DEG_SPOP_SBC_1	334	338	PF00917	0.557
DEG_SPOP_SBC_1	70	74	PF00917	0.375
DOC_ANK_TNKS_1	431	438	PF00023	0.632
DOC_CKS1_1	187	192	PF01111	0.544
DOC_CKS1_1	240	245	PF01111	0.450
DOC_CYCLIN_yCln2_LP_2	240	246	PF00134	0.443
DOC_MAPK_gen_1	166	173	PF00069	0.343
DOC_MAPK_MEF2A_6	166	173	PF00069	0.343
DOC_PP1_RVXF_1	387	393	PF00149	0.410
DOC_PP4_FxxP_1	67	70	PF00568	0.313
DOC_USP7_MATH_1	154	158	PF00917	0.466
DOC_USP7_MATH_1	191	195	PF00917	0.461
DOC_USP7_MATH_1	214	218	PF00917	0.436
DOC_USP7_MATH_1	224	228	PF00917	0.282
DOC_USP7_MATH_1	229	233	PF00917	0.643
DOC_USP7_MATH_1	30	34	PF00917	0.466
DOC_USP7_MATH_1	324	328	PF00917	0.470
DOC_USP7_MATH_1	349	353	PF00917	0.520
DOC_USP7_MATH_1	415	419	PF00917	0.753
DOC_USP7_MATH_1	71	75	PF00917	0.450
DOC_USP7_UBL2_3	162	166	PF12436	0.426
DOC_USP7_UBL2_3	168	172	PF12436	0.426
DOC_WW_Pin1_4	180	185	PF00397	0.735
DOC_WW_Pin1_4	186	191	PF00397	0.623
DOC_WW_Pin1_4	210	215	PF00397	0.374
DOC_WW_Pin1_4	239	244	PF00397	0.519
DOC_WW_Pin1_4	448	453	PF00397	0.500
DOC_WW_Pin1_4	8	13	PF00397	0.406
LIG_14-3-3_CanoR_1	111	121	PF00244	0.284
LIG_14-3-3_CanoR_1	202	208	PF00244	0.380
LIG_14-3-3_CanoR_1	333	341	PF00244	0.543
LIG_14-3-3_CanoR_1	366	374	PF00244	0.368
LIG_BRCT_BRCA1_1	418	422	PF00533	0.657
LIG_CaM_NSCaTE_8	321	328	PF13499	0.261
LIG_eIF4E_1	265	271	PF01652	0.433
LIG_FHA_1	191	197	PF00498	0.567
LIG_FHA_1	266	272	PF00498	0.259
LIG_FHA_1	320	326	PF00498	0.486
LIG_FHA_1	368	374	PF00498	0.403
LIG_FHA_1	406	412	PF00498	0.520
LIG_FHA_1	54	60	PF00498	0.236
LIG_FHA_2	111	117	PF00498	0.211
LIG_FHA_2	264	270	PF00498	0.319
LIG_FHA_2	271	277	PF00498	0.347
LIG_FHA_2	443	449	PF00498	0.649
LIG_Integrin_RGD_1	434	436	PF01839	0.514
LIG_IRF3_LxIS_1	456	461	PF10401	0.523
LIG_LIR_Apic_2	18	24	PF02991	0.451
LIG_LIR_Apic_2	251	257	PF02991	0.383
LIG_LIR_Gen_1	242	252	PF02991	0.387
LIG_LIR_Gen_1	292	301	PF02991	0.368
LIG_LIR_Nem_3	10	16	PF02991	0.348
LIG_LIR_Nem_3	242	247	PF02991	0.377
LIG_LIR_Nem_3	259	263	PF02991	0.249
LIG_LIR_Nem_3	292	298	PF02991	0.367
LIG_LIR_Nem_3	419	425	PF02991	0.502
LIG_NRBOX	266	272	PF00104	0.315
LIG_SH2_CRK	254	258	PF00017	0.434
LIG_SH2_PTP2	246	249	PF00017	0.423
LIG_SH2_PTP2	356	359	PF00017	0.429
LIG_SH2_STAP1	369	373	PF00017	0.385
LIG_SH2_STAT5	246	249	PF00017	0.366
LIG_SH2_STAT5	265	268	PF00017	0.191
LIG_SH2_STAT5	356	359	PF00017	0.394
LIG_SH2_STAT5	369	372	PF00017	0.404
LIG_SH3_3	184	190	PF00018	0.480
LIG_SH3_3	421	427	PF00018	0.797
LIG_SH3_3	6	12	PF00018	0.351
LIG_SH3_3	79	85	PF00018	0.312
LIG_TRFH_1	67	71	PF08558	0.300
LIG_TYR_ITIM	354	359	PF00017	0.446
MOD_CDK_SPK_2	180	185	PF00069	0.588
MOD_CK1_1	194	200	PF00069	0.459
MOD_CK1_1	206	212	PF00069	0.386
MOD_CK1_1	232	238	PF00069	0.715
MOD_CK1_1	239	245	PF00069	0.377
MOD_CK1_1	72	78	PF00069	0.414
MOD_CK2_1	214	220	PF00069	0.401
MOD_CK2_1	263	269	PF00069	0.319
MOD_CK2_1	448	454	PF00069	0.503
MOD_GlcNHglycan	193	196	PF01048	0.517
MOD_GlcNHglycan	214	217	PF01048	0.518
MOD_GlcNHglycan	226	229	PF01048	0.429
MOD_GlcNHglycan	326	329	PF01048	0.364
MOD_GlcNHglycan	337	340	PF01048	0.590
MOD_GlcNHglycan	41	44	PF01048	0.400
MOD_GlcNHglycan	75	78	PF01048	0.262
MOD_GSK3_1	186	193	PF00069	0.646
MOD_GSK3_1	202	209	PF00069	0.470
MOD_GSK3_1	210	217	PF00069	0.536
MOD_GSK3_1	229	236	PF00069	0.666
MOD_GSK3_1	405	412	PF00069	0.644
MOD_GSK3_1	413	420	PF00069	0.664
MOD_GSK3_1	444	451	PF00069	0.657
MOD_GSK3_1	69	76	PF00069	0.437
MOD_N-GLC_1	31	36	PF02516	0.360
MOD_N-GLC_2	282	284	PF02516	0.326
MOD_NEK2_1	207	212	PF00069	0.324
MOD_NEK2_1	263	268	PF00069	0.322
MOD_NEK2_1	270	275	PF00069	0.333
MOD_NEK2_1	31	36	PF00069	0.426
MOD_NEK2_1	335	340	PF00069	0.369
MOD_NEK2_1	458	463	PF00069	0.523
MOD_NEK2_1	51	56	PF00069	0.284
MOD_NEK2_2	417	422	PF00069	0.500
MOD_PIKK_1	319	325	PF00454	0.477
MOD_PKA_2	110	116	PF00069	0.274
MOD_PKA_2	365	371	PF00069	0.314
MOD_PKA_2	385	391	PF00069	0.346
MOD_Plk_1	303	309	PF00069	0.293
MOD_Plk_1	31	37	PF00069	0.404
MOD_Plk_4	155	161	PF00069	0.461
MOD_Plk_4	203	209	PF00069	0.473
MOD_Plk_4	214	220	PF00069	0.353
MOD_Plk_4	303	309	PF00069	0.293
MOD_Plk_4	349	355	PF00069	0.426
MOD_Plk_4	417	423	PF00069	0.500
MOD_ProDKin_1	180	186	PF00069	0.737
MOD_ProDKin_1	210	216	PF00069	0.379
MOD_ProDKin_1	239	245	PF00069	0.507
MOD_ProDKin_1	448	454	PF00069	0.503
MOD_ProDKin_1	8	14	PF00069	0.405
TRG_ENDOCYTIC_2	13	16	PF00928	0.369
TRG_ENDOCYTIC_2	246	249	PF00928	0.371
TRG_ENDOCYTIC_2	356	359	PF00928	0.429
TRG_ER_diArg_1	389	392	PF00400	0.447
TRG_ER_diArg_1	429	432	PF00400	0.783
TRG_NES_CRM1_1	119	132	PF08389	0.422
TRG_NLS_MonoExtC_3	462	467	PF00514	0.725
TRG_NLS_MonoExtN_4	463	468	PF00514	0.675

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HWR5	Leptomonas seymouri	59%	100%
A0A1X0NSU1	Trypanosomatidae	39%	100%
A0A3S7WUF8	Leishmania donovani	80%	100%
A0A422N4P6	Trypanosoma rangeli	40%	100%
A4HXF2	Leishmania infantum	80%	100%
C9ZP24	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
E9AR47	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	99%
Q4QEB6	Leishmania major	77%	100%