Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H919_LEIBR

TriTrypDb:

LbrM.17.0750 , LBRM2903_170014300

Length:

524

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H919

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H919

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	470	474	PF00656	0.395
CLV_NRD_NRD_1	112	114	PF00675	0.467
CLV_NRD_NRD_1	174	176	PF00675	0.393
CLV_NRD_NRD_1	308	310	PF00675	0.572
CLV_NRD_NRD_1	457	459	PF00675	0.559
CLV_NRD_NRD_1	70	72	PF00675	0.465
CLV_PCSK_KEX2_1	174	176	PF00082	0.377
CLV_PCSK_KEX2_1	308	310	PF00082	0.572
CLV_PCSK_KEX2_1	457	459	PF00082	0.559
CLV_PCSK_KEX2_1	69	71	PF00082	0.517
CLV_PCSK_SKI1_1	120	124	PF00082	0.481
CLV_PCSK_SKI1_1	174	178	PF00082	0.337
DEG_APCC_DBOX_1	69	77	PF00400	0.476
DEG_Nend_UBRbox_1	1	4	PF02207	0.419
DEG_SPOP_SBC_1	277	281	PF00917	0.544
DOC_CDC14_PxL_1	371	379	PF14671	0.671
DOC_CKS1_1	236	241	PF01111	0.604
DOC_CKS1_1	247	252	PF01111	0.681
DOC_CKS1_1	290	295	PF01111	0.707
DOC_CYCLIN_yCln2_LP_2	26	32	PF00134	0.366
DOC_MAPK_gen_1	174	181	PF00069	0.446
DOC_MAPK_gen_1	457	466	PF00069	0.417
DOC_MAPK_MEF2A_6	174	181	PF00069	0.476
DOC_MAPK_MEF2A_6	2	10	PF00069	0.475
DOC_PP2B_LxvP_1	26	29	PF13499	0.404
DOC_PP4_FxxP_1	47	50	PF00568	0.424
DOC_USP7_MATH_1	131	135	PF00917	0.552
DOC_USP7_MATH_1	155	159	PF00917	0.558
DOC_USP7_MATH_1	237	241	PF00917	0.812
DOC_USP7_MATH_1	272	276	PF00917	0.627
DOC_USP7_MATH_1	277	281	PF00917	0.536
DOC_USP7_MATH_1	311	315	PF00917	0.644
DOC_USP7_MATH_1	340	344	PF00917	0.685
DOC_USP7_MATH_1	505	509	PF00917	0.739
DOC_WW_Pin1_4	132	137	PF00397	0.517
DOC_WW_Pin1_4	235	240	PF00397	0.797
DOC_WW_Pin1_4	246	251	PF00397	0.629
DOC_WW_Pin1_4	278	283	PF00397	0.608
DOC_WW_Pin1_4	289	294	PF00397	0.678
DOC_WW_Pin1_4	295	300	PF00397	0.615
DOC_WW_Pin1_4	307	312	PF00397	0.516
DOC_WW_Pin1_4	348	353	PF00397	0.716
DOC_WW_Pin1_4	378	383	PF00397	0.619
DOC_WW_Pin1_4	390	395	PF00397	0.514
DOC_WW_Pin1_4	485	490	PF00397	0.615
LIG_14-3-3_CanoR_1	120	129	PF00244	0.588
LIG_14-3-3_CanoR_1	2	10	PF00244	0.400
LIG_14-3-3_CanoR_1	384	394	PF00244	0.551
LIG_14-3-3_CanoR_1	461	465	PF00244	0.415
LIG_14-3-3_CanoR_1	504	514	PF00244	0.518
LIG_Actin_WH2_2	18	36	PF00022	0.391
LIG_BIR_III_2	379	383	PF00653	0.542
LIG_BRCT_BRCA1_1	211	215	PF00533	0.646
LIG_eIF4E_1	27	33	PF01652	0.348
LIG_EVH1_1	374	378	PF00568	0.604
LIG_FHA_1	160	166	PF00498	0.627
LIG_FHA_1	227	233	PF00498	0.618
LIG_FHA_1	290	296	PF00498	0.681
LIG_FHA_1	34	40	PF00498	0.401
LIG_FHA_1	423	429	PF00498	0.616
LIG_FHA_1	433	439	PF00498	0.530
LIG_FHA_1	94	100	PF00498	0.367
LIG_FHA_2	12	18	PF00498	0.447
LIG_FHA_2	164	170	PF00498	0.397
LIG_FHA_2	220	226	PF00498	0.683
LIG_FHA_2	437	443	PF00498	0.490
LIG_LIR_Apic_2	45	50	PF02991	0.429
LIG_LIR_Gen_1	196	206	PF02991	0.480
LIG_LIR_Nem_3	127	132	PF02991	0.392
LIG_LIR_Nem_3	17	21	PF02991	0.424
LIG_LIR_Nem_3	196	201	PF02991	0.465
LIG_NRBOX	474	480	PF00104	0.565
LIG_NRBOX	61	67	PF00104	0.422
LIG_Pex14_2	47	51	PF04695	0.425
LIG_PTB_Apo_2	100	107	PF02174	0.428
LIG_PTB_Phospho_1	100	106	PF10480	0.427
LIG_SH2_NCK_1	189	193	PF00017	0.368
LIG_SH2_STAT3	413	416	PF00017	0.674
LIG_SH2_STAT5	18	21	PF00017	0.457
LIG_SH2_STAT5	413	416	PF00017	0.531
LIG_SH3_3	252	258	PF00018	0.653
LIG_SH3_3	279	285	PF00018	0.553
LIG_SH3_3	290	296	PF00018	0.535
LIG_SH3_3	372	378	PF00018	0.667
LIG_SH3_3	388	394	PF00018	0.565
LIG_SH3_3	397	403	PF00018	0.585
LIG_SH3_3	411	417	PF00018	0.486
LIG_SH3_CIN85_PxpxPR_1	254	259	PF14604	0.559
LIG_SUMO_SIM_anti_2	317	322	PF11976	0.524
LIG_SUMO_SIM_anti_2	4	10	PF11976	0.408
LIG_SUMO_SIM_par_1	435	442	PF11976	0.497
LIG_SxIP_EBH_1	507	519	PF03271	0.518
LIG_TRAF2_1	439	442	PF00917	0.538
LIG_TRAF2_1	451	454	PF00917	0.540
LIG_UBA3_1	65	72	PF00899	0.405
LIG_UBA3_1	90	97	PF00899	0.384
LIG_WW_2	375	378	PF00397	0.603
MOD_CDC14_SPxK_1	488	491	PF00782	0.531
MOD_CDK_SPxK_1	378	384	PF00069	0.621
MOD_CDK_SPxK_1	485	491	PF00069	0.521
MOD_CK1_1	134	140	PF00069	0.645
MOD_CK1_1	235	241	PF00069	0.541
MOD_CK1_1	294	300	PF00069	0.610
MOD_CK1_1	343	349	PF00069	0.587
MOD_CK1_1	351	357	PF00069	0.611
MOD_CK1_1	386	392	PF00069	0.634
MOD_CK1_1	4	10	PF00069	0.384
MOD_CK1_1	487	493	PF00069	0.559
MOD_CK1_1	495	501	PF00069	0.702
MOD_CK1_1	513	519	PF00069	0.492
MOD_CK2_1	163	169	PF00069	0.485
MOD_CK2_1	219	225	PF00069	0.657
MOD_CK2_1	294	300	PF00069	0.708
MOD_CK2_1	311	317	PF00069	0.537
MOD_CK2_1	436	442	PF00069	0.494
MOD_GlcNHglycan	138	142	PF01048	0.687
MOD_GlcNHglycan	157	160	PF01048	0.485
MOD_GlcNHglycan	190	193	PF01048	0.506
MOD_GlcNHglycan	209	212	PF01048	0.452
MOD_GlcNHglycan	239	242	PF01048	0.647
MOD_GlcNHglycan	274	277	PF01048	0.533
MOD_GlcNHglycan	371	374	PF01048	0.667
MOD_GlcNHglycan	507	510	PF01048	0.590
MOD_GSK3_1	120	127	PF00069	0.415
MOD_GSK3_1	151	158	PF00069	0.616
MOD_GSK3_1	159	166	PF00069	0.480
MOD_GSK3_1	209	216	PF00069	0.641
MOD_GSK3_1	272	279	PF00069	0.650
MOD_GSK3_1	291	298	PF00069	0.745
MOD_GSK3_1	303	310	PF00069	0.575
MOD_GSK3_1	340	347	PF00069	0.566
MOD_GSK3_1	348	355	PF00069	0.603
MOD_GSK3_1	386	393	PF00069	0.635
MOD_GSK3_1	398	405	PF00069	0.503
MOD_GSK3_1	432	439	PF00069	0.505
MOD_GSK3_1	479	486	PF00069	0.551
MOD_GSK3_1	505	512	PF00069	0.744
MOD_GSK3_1	513	520	PF00069	0.582
MOD_N-GLC_1	369	374	PF02516	0.518
MOD_NEK2_1	344	349	PF00069	0.591
MOD_NEK2_1	383	388	PF00069	0.562
MOD_NEK2_1	471	476	PF00069	0.511
MOD_NEK2_1	479	484	PF00069	0.508
MOD_NEK2_1	510	515	PF00069	0.518
MOD_NEK2_2	124	129	PF00069	0.435
MOD_PIKK_1	146	152	PF00454	0.618
MOD_PIKK_1	159	165	PF00454	0.471
MOD_PIKK_1	226	232	PF00454	0.672
MOD_PIKK_1	346	352	PF00454	0.584
MOD_PKA_2	1	7	PF00069	0.428
MOD_PKA_2	232	238	PF00069	0.688
MOD_PKA_2	33	39	PF00069	0.324
MOD_PKA_2	383	389	PF00069	0.547
MOD_PKA_2	460	466	PF00069	0.417
MOD_PKA_2	492	498	PF00069	0.692
MOD_Plk_1	4	10	PF00069	0.389
MOD_Plk_1	423	429	PF00069	0.606
MOD_Plk_1	432	438	PF00069	0.636
MOD_Plk_1	58	64	PF00069	0.483
MOD_Plk_4	4	10	PF00069	0.446
MOD_Plk_4	423	429	PF00069	0.564
MOD_Plk_4	58	64	PF00069	0.427
MOD_ProDKin_1	132	138	PF00069	0.521
MOD_ProDKin_1	235	241	PF00069	0.798
MOD_ProDKin_1	246	252	PF00069	0.631
MOD_ProDKin_1	278	284	PF00069	0.610
MOD_ProDKin_1	289	295	PF00069	0.679
MOD_ProDKin_1	307	313	PF00069	0.508
MOD_ProDKin_1	348	354	PF00069	0.717
MOD_ProDKin_1	378	384	PF00069	0.621
MOD_ProDKin_1	390	396	PF00069	0.508
MOD_ProDKin_1	485	491	PF00069	0.619
MOD_SUMO_rev_2	185	190	PF00179	0.370
MOD_SUMO_rev_2	468	474	PF00179	0.393
TRG_DiLeu_BaLyEn_6	332	337	PF01217	0.511
TRG_ENDOCYTIC_2	18	21	PF00928	0.419
TRG_ER_diArg_1	173	175	PF00400	0.418
TRG_ER_diArg_1	332	335	PF00400	0.504
TRG_ER_diArg_1	457	459	PF00400	0.498
TRG_ER_diArg_1	68	71	PF00400	0.471
TRG_NES_CRM1_1	169	183	PF08389	0.465
TRG_Pf-PMV_PEXEL_1	174	178	PF00026	0.349
TRG_Pf-PMV_PEXEL_1	519	524	PF00026	0.514

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBW8	Leptomonas seymouri	41%	99%
A0A3S5H709	Leishmania donovani	70%	100%
A4HXF1	Leishmania infantum	70%	100%
E9AR46	Leishmania mexicana (strain MHOM/GT/2001/U1103)	68%	100%
Q4QEB7	Leishmania major	70%	98%