DUF2062 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H918_LEIBR

TriTrypDb:

LbrM.17.0740 , LBRM2903_170014200

Length:

443

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

A4H918

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H918

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	205	209	PF00656	0.574
CLV_MEL_PAP_1	197	203	PF00089	0.391
CLV_NRD_NRD_1	357	359	PF00675	0.405
CLV_NRD_NRD_1	366	368	PF00675	0.360
CLV_NRD_NRD_1	386	388	PF00675	0.465
CLV_PCSK_FUR_1	364	368	PF00082	0.388
CLV_PCSK_KEX2_1	322	324	PF00082	0.412
CLV_PCSK_KEX2_1	357	359	PF00082	0.387
CLV_PCSK_KEX2_1	366	368	PF00082	0.367
CLV_PCSK_KEX2_1	385	387	PF00082	0.494
CLV_PCSK_KEX2_1	90	92	PF00082	0.435
CLV_PCSK_PC1ET2_1	322	324	PF00082	0.441
CLV_PCSK_PC1ET2_1	357	359	PF00082	0.399
CLV_PCSK_PC1ET2_1	90	92	PF00082	0.412
CLV_PCSK_SKI1_1	265	269	PF00082	0.325
CLV_PCSK_SKI1_1	303	307	PF00082	0.425
CLV_PCSK_SKI1_1	322	326	PF00082	0.387
CLV_PCSK_SKI1_1	335	339	PF00082	0.387
CLV_PCSK_SKI1_1	45	49	PF00082	0.239
DEG_Nend_Nbox_1	1	3	PF02207	0.625
DOC_CKS1_1	30	35	PF01111	0.392
DOC_CYCLIN_RxL_1	332	345	PF00134	0.494
DOC_CYCLIN_RxL_1	42	52	PF00134	0.239
DOC_CYCLIN_yCln2_LP_2	130	136	PF00134	0.331
DOC_CYCLIN_yCln2_LP_2	231	237	PF00134	0.410
DOC_CYCLIN_yCln2_LP_2	47	53	PF00134	0.401
DOC_MAPK_gen_1	212	222	PF00069	0.536
DOC_MAPK_gen_1	332	342	PF00069	0.595
DOC_MAPK_MEF2A_6	212	220	PF00069	0.546
DOC_PP1_RVXF_1	198	204	PF00149	0.595
DOC_PP1_RVXF_1	301	307	PF00149	0.606
DOC_PP1_RVXF_1	82	89	PF00149	0.544
DOC_PP2B_LxvP_1	130	133	PF13499	0.341
DOC_PP2B_LxvP_1	239	242	PF13499	0.425
DOC_PP2B_LxvP_1	47	50	PF13499	0.357
DOC_PP4_FxxP_1	246	249	PF00568	0.354
DOC_PP4_FxxP_1	279	282	PF00568	0.623
DOC_USP7_MATH_1	120	124	PF00917	0.417
DOC_USP7_MATH_1	226	230	PF00917	0.428
DOC_USP7_MATH_1	407	411	PF00917	0.640
DOC_USP7_UBL2_3	355	359	PF12436	0.654
DOC_WW_Pin1_4	147	152	PF00397	0.412
DOC_WW_Pin1_4	29	34	PF00397	0.401
LIG_14-3-3_CanoR_1	103	109	PF00244	0.562
LIG_14-3-3_CanoR_1	367	373	PF00244	0.694
LIG_14-3-3_CanoR_1	45	50	PF00244	0.221
LIG_Actin_WH2_2	251	267	PF00022	0.402
LIG_APCC_ABBA_1	340	345	PF00400	0.628
LIG_APCC_ABBA_1	51	56	PF00400	0.399
LIG_APCC_ABBAyCdc20_2	339	345	PF00400	0.575
LIG_Clathr_ClatBox_1	175	179	PF01394	0.410
LIG_EVH1_2	242	246	PF00568	0.285
LIG_FHA_1	108	114	PF00498	0.548
LIG_FHA_1	179	185	PF00498	0.352
LIG_FHA_1	259	265	PF00498	0.355
LIG_FHA_1	312	318	PF00498	0.660
LIG_FHA_2	305	311	PF00498	0.607
LIG_FHA_2	369	375	PF00498	0.651
LIG_FHA_2	395	401	PF00498	0.643
LIG_GBD_Chelix_1	216	224	PF00786	0.184
LIG_IRF3_LxIS_1	148	155	PF10401	0.257
LIG_LIR_Gen_1	189	197	PF02991	0.412
LIG_LIR_Nem_3	102	108	PF02991	0.611
LIG_LIR_Nem_3	189	194	PF02991	0.503
LIG_LIR_Nem_3	42	47	PF02991	0.283
LIG_LIR_Nem_3	48	54	PF02991	0.352
LIG_NRBOX	332	338	PF00104	0.548
LIG_PCNA_yPIPBox_3	200	211	PF02747	0.543
LIG_RPA_C_Insects	86	101	PF08784	0.439
LIG_SH2_NCK_1	370	374	PF00017	0.396
LIG_SH2_NCK_1	404	408	PF00017	0.455
LIG_SH2_PTP2	250	253	PF00017	0.197
LIG_SH2_STAP1	23	27	PF00017	0.284
LIG_SH2_STAP1	327	331	PF00017	0.491
LIG_SH2_STAT3	54	57	PF00017	0.449
LIG_SH2_STAT5	128	131	PF00017	0.359
LIG_SH2_STAT5	237	240	PF00017	0.454
LIG_SH2_STAT5	250	253	PF00017	0.315
LIG_SH2_STAT5	370	373	PF00017	0.391
LIG_SH2_STAT5	76	79	PF00017	0.535
LIG_SH3_3	279	285	PF00018	0.546
LIG_SH3_3	77	83	PF00018	0.435
LIG_SUMO_SIM_par_1	150	155	PF11976	0.474
LIG_TRAF2_1	397	400	PF00917	0.652
LIG_WRC_WIRS_1	105	110	PF05994	0.398
LIG_WRC_WIRS_1	13	18	PF05994	0.197
LIG_WRC_WIRS_1	137	142	PF05994	0.464
MOD_CK1_1	107	113	PF00069	0.497
MOD_CK1_1	123	129	PF00069	0.336
MOD_CK1_1	163	169	PF00069	0.627
MOD_CK1_1	259	265	PF00069	0.332
MOD_CK1_1	29	35	PF00069	0.551
MOD_CK1_1	378	384	PF00069	0.630
MOD_CK1_1	394	400	PF00069	0.755
MOD_CK1_1	405	411	PF00069	0.637
MOD_CK2_1	394	400	PF00069	0.749
MOD_GlcNHglycan	122	125	PF01048	0.383
MOD_GlcNHglycan	258	261	PF01048	0.427
MOD_GlcNHglycan	39	42	PF01048	0.407
MOD_GlcNHglycan	393	396	PF01048	0.726
MOD_GlcNHglycan	405	408	PF01048	0.508
MOD_GSK3_1	174	181	PF00069	0.369
MOD_GSK3_1	186	193	PF00069	0.322
MOD_GSK3_1	25	32	PF00069	0.405
MOD_GSK3_1	259	266	PF00069	0.344
MOD_GSK3_1	313	320	PF00069	0.622
MOD_GSK3_1	391	398	PF00069	0.645
MOD_GSK3_1	402	409	PF00069	0.553
MOD_GSK3_1	45	52	PF00069	0.269
MOD_N-GLC_1	269	274	PF02516	0.420
MOD_NEK2_1	12	17	PF00069	0.421
MOD_NEK2_1	136	141	PF00069	0.493
MOD_NEK2_1	152	157	PF00069	0.512
MOD_NEK2_1	256	261	PF00069	0.309
MOD_NEK2_1	304	309	PF00069	0.490
MOD_NEK2_1	368	373	PF00069	0.518
MOD_NEK2_1	37	42	PF00069	0.360
MOD_NEK2_2	186	191	PF00069	0.357
MOD_NEK2_2	263	268	PF00069	0.197
MOD_PIKK_1	317	323	PF00454	0.484
MOD_PIKK_1	378	384	PF00454	0.613
MOD_PIKK_1	395	401	PF00454	0.587
MOD_Plk_1	375	381	PF00069	0.405
MOD_Plk_4	12	18	PF00069	0.357
MOD_Plk_4	123	129	PF00069	0.302
MOD_Plk_4	136	142	PF00069	0.405
MOD_Plk_4	226	232	PF00069	0.309
MOD_Plk_4	263	269	PF00069	0.417
MOD_Plk_4	39	45	PF00069	0.225
MOD_ProDKin_1	147	153	PF00069	0.516
MOD_ProDKin_1	29	35	PF00069	0.495
TRG_DiLeu_BaLyEn_6	332	337	PF01217	0.425
TRG_ENDOCYTIC_2	76	79	PF00928	0.415
TRG_ER_diArg_1	364	367	PF00400	0.499
TRG_ER_diArg_1	385	387	PF00400	0.653
TRG_NLS_MonoCore_2	356	361	PF00514	0.519
TRG_NLS_MonoExtN_4	355	362	PF00514	0.518
TRG_Pf-PMV_PEXEL_1	315	319	PF00026	0.588
TRG_Pf-PMV_PEXEL_1	323	328	PF00026	0.526

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3N4	Leptomonas seymouri	61%	94%
A0A0S4KHH7	Bodo saltans	37%	90%
A0A1X0NTB3	Trypanosomatidae	44%	100%
A0A3S7WUI4	Leishmania donovani	84%	100%
A4HXF0	Leishmania infantum	84%	100%
C9ZP21	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	100%
E9AR45	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
Q4QEB8	Leishmania major	83%	100%
V5BFE7	Trypanosoma cruzi	47%	100%