VID27 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

VID27 cytoplasmic protein, putative

Species:

Leishmania braziliensis

UniProt:

A4H914_LEIBR

TriTrypDb:

LbrM.17.0700 , LBRM2903_170013700

Length:

556

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H914

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H914

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	248	252	PF00656	0.197
CLV_NRD_NRD_1	259	261	PF00675	0.277
CLV_NRD_NRD_1	339	341	PF00675	0.355
CLV_NRD_NRD_1	372	374	PF00675	0.282
CLV_PCSK_SKI1_1	341	345	PF00082	0.311
CLV_PCSK_SKI1_1	382	386	PF00082	0.297
DEG_SPOP_SBC_1	407	411	PF00917	0.355
DEG_SPOP_SBC_1	517	521	PF00917	0.491
DOC_CYCLIN_RxL_1	382	390	PF00134	0.327
DOC_MAPK_JIP1_4	279	285	PF00069	0.355
DOC_MAPK_MEF2A_6	391	399	PF00069	0.279
DOC_PP1_RVXF_1	305	312	PF00149	0.357
DOC_PP4_FxxP_1	108	111	PF00568	0.480
DOC_PP4_FxxP_1	72	75	PF00568	0.454
DOC_USP7_MATH_1	192	196	PF00917	0.439
DOC_USP7_MATH_1	284	288	PF00917	0.355
DOC_USP7_MATH_1	295	299	PF00917	0.242
DOC_USP7_MATH_1	495	499	PF00917	0.355
DOC_USP7_MATH_1	87	91	PF00917	0.490
DOC_WW_Pin1_4	446	451	PF00397	0.387
LIG_14-3-3_CanoR_1	133	139	PF00244	0.334
LIG_14-3-3_CanoR_1	463	472	PF00244	0.476
LIG_14-3-3_CanoR_1	524	531	PF00244	0.544
LIG_14-3-3_CanoR_1	549	554	PF00244	0.504
LIG_APCC_ABBA_1	413	418	PF00400	0.355
LIG_BIR_II_1	1	5	PF00653	0.655
LIG_BRCT_BRCA1_1	194	198	PF00533	0.378
LIG_BRCT_BRCA1_1	409	413	PF00533	0.355
LIG_BRCT_BRCA1_1	428	432	PF00533	0.160
LIG_BRCT_BRCA1_1	465	469	PF00533	0.287
LIG_CaM_NSCaTE_8	151	158	PF13499	0.498
LIG_Clathr_ClatBox_1	414	418	PF01394	0.355
LIG_FHA_1	133	139	PF00498	0.288
LIG_FHA_1	158	164	PF00498	0.490
LIG_FHA_1	167	173	PF00498	0.469
LIG_FHA_1	241	247	PF00498	0.472
LIG_FHA_1	251	257	PF00498	0.410
LIG_FHA_1	3	9	PF00498	0.543
LIG_FHA_1	36	42	PF00498	0.349
LIG_FHA_1	409	415	PF00498	0.437
LIG_FHA_1	417	423	PF00498	0.342
LIG_FHA_1	473	479	PF00498	0.392
LIG_FHA_1	488	494	PF00498	0.281
LIG_FHA_2	138	144	PF00498	0.387
LIG_FHA_2	157	163	PF00498	0.543
LIG_FHA_2	243	249	PF00498	0.432
LIG_FHA_2	384	390	PF00498	0.279
LIG_GBD_Chelix_1	309	317	PF00786	0.410
LIG_HCF-1_HBM_1	24	27	PF13415	0.472
LIG_LIR_Apic_2	24	30	PF02991	0.458
LIG_LIR_Apic_2	69	75	PF02991	0.462
LIG_LIR_Apic_2	83	87	PF02991	0.279
LIG_LIR_Gen_1	126	131	PF02991	0.307
LIG_LIR_Gen_1	135	142	PF02991	0.386
LIG_LIR_Gen_1	149	158	PF02991	0.369
LIG_LIR_Gen_1	195	204	PF02991	0.469
LIG_LIR_Gen_1	300	310	PF02991	0.349
LIG_LIR_Gen_1	332	339	PF02991	0.197
LIG_LIR_Gen_1	410	421	PF02991	0.327
LIG_LIR_Gen_1	466	473	PF02991	0.357
LIG_LIR_LC3C_4	231	235	PF02991	0.463
LIG_LIR_Nem_3	126	130	PF02991	0.319
LIG_LIR_Nem_3	135	139	PF02991	0.349
LIG_LIR_Nem_3	140	145	PF02991	0.418
LIG_LIR_Nem_3	149	155	PF02991	0.327
LIG_LIR_Nem_3	195	201	PF02991	0.409
LIG_LIR_Nem_3	300	305	PF02991	0.349
LIG_LIR_Nem_3	332	337	PF02991	0.197
LIG_LIR_Nem_3	410	416	PF02991	0.327
LIG_LIR_Nem_3	466	472	PF02991	0.297
LIG_LIR_Nem_3	90	96	PF02991	0.355
LIG_PCNA_yPIPBox_3	114	128	PF02747	0.394
LIG_SH2_CRK	136	140	PF00017	0.356
LIG_SH2_CRK	152	156	PF00017	0.383
LIG_SH2_CRK	28	32	PF00017	0.484
LIG_SH2_CRK	302	306	PF00017	0.297
LIG_SH2_CRK	334	338	PF00017	0.355
LIG_SH2_CRK	366	370	PF00017	0.279
LIG_SH2_CRK	84	88	PF00017	0.478
LIG_SH2_GRB2like	290	293	PF00017	0.410
LIG_SH2_NCK_1	142	146	PF00017	0.469
LIG_SH2_NCK_1	84	88	PF00017	0.425
LIG_SH2_SRC	142	145	PF00017	0.539
LIG_SH2_SRC	16	19	PF00017	0.556
LIG_SH2_SRC	290	293	PF00017	0.410
LIG_SH2_SRC	421	424	PF00017	0.355
LIG_SH2_SRC	60	63	PF00017	0.468
LIG_SH2_STAT5	154	157	PF00017	0.378
LIG_SH2_STAT5	302	305	PF00017	0.279
LIG_SH2_STAT5	353	356	PF00017	0.331
LIG_SH2_STAT5	366	369	PF00017	0.246
LIG_SH2_STAT5	379	382	PF00017	0.297
LIG_SH2_STAT5	405	408	PF00017	0.279
LIG_SH2_STAT5	421	424	PF00017	0.279
LIG_SH2_STAT5	487	490	PF00017	0.322
LIG_SH2_STAT5	60	63	PF00017	0.452
LIG_SH3_3	435	441	PF00018	0.277
LIG_SH3_3	88	94	PF00018	0.415
LIG_SUMO_SIM_anti_2	38	43	PF11976	0.406
LIG_SUMO_SIM_par_1	393	398	PF11976	0.316
LIG_SUMO_SIM_par_1	59	67	PF11976	0.494
LIG_TRAF2_1	19	22	PF00917	0.542
LIG_TYR_ITSM	138	145	PF00017	0.452
LIG_UBA3_1	336	341	PF00899	0.197
LIG_UBA3_1	414	420	PF00899	0.355
MOD_CK1_1	137	143	PF00069	0.418
MOD_CK1_1	184	190	PF00069	0.397
MOD_CK1_1	2	8	PF00069	0.484
MOD_CK1_1	242	248	PF00069	0.428
MOD_CK1_1	297	303	PF00069	0.397
MOD_CK1_1	499	505	PF00069	0.364
MOD_CK1_1	53	59	PF00069	0.610
MOD_CK2_1	1	7	PF00069	0.567
MOD_CK2_1	156	162	PF00069	0.545
MOD_CK2_1	242	248	PF00069	0.355
MOD_CK2_1	53	59	PF00069	0.552
MOD_Cter_Amidation	258	261	PF01082	0.197
MOD_GlcNHglycan	1	4	PF01048	0.603
MOD_GlcNHglycan	186	189	PF01048	0.453
MOD_GlcNHglycan	297	300	PF01048	0.351
MOD_GlcNHglycan	465	468	PF01048	0.292
MOD_GlcNHglycan	501	504	PF01048	0.593
MOD_GlcNHglycan	508	511	PF01048	0.400
MOD_GlcNHglycan	520	523	PF01048	0.369
MOD_GlcNHglycan	84	87	PF01048	0.438
MOD_GSK3_1	178	185	PF00069	0.531
MOD_GSK3_1	238	245	PF00069	0.417
MOD_GSK3_1	291	298	PF00069	0.373
MOD_GSK3_1	3	10	PF00069	0.419
MOD_GSK3_1	341	348	PF00069	0.282
MOD_GSK3_1	383	390	PF00069	0.297
MOD_GSK3_1	427	434	PF00069	0.372
MOD_GSK3_1	446	453	PF00069	0.336
MOD_GSK3_1	495	502	PF00069	0.361
MOD_GSK3_1	50	57	PF00069	0.635
MOD_GSK3_1	513	520	PF00069	0.523
MOD_GSK3_1	545	552	PF00069	0.473
MOD_N-GLC_1	291	296	PF02516	0.410
MOD_N-GLC_2	132	134	PF02516	0.321
MOD_N-GLC_2	189	191	PF02516	0.364
MOD_NEK2_1	1	6	PF00069	0.525
MOD_NEK2_1	267	272	PF00069	0.210
MOD_NEK2_1	37	42	PF00069	0.441
MOD_NEK2_1	387	392	PF00069	0.297
MOD_NEK2_1	416	421	PF00069	0.329
MOD_NEK2_1	478	483	PF00069	0.392
MOD_NEK2_1	489	494	PF00069	0.410
MOD_NEK2_1	518	523	PF00069	0.438
MOD_NEK2_1	80	85	PF00069	0.374
MOD_NEK2_2	335	340	PF00069	0.243
MOD_NEK2_2	450	455	PF00069	0.355
MOD_NEK2_2	87	92	PF00069	0.412
MOD_OFUCOSY	479	484	PF10250	0.355
MOD_PIKK_1	346	352	PF00454	0.355
MOD_PIKK_1	496	502	PF00454	0.488
MOD_PKA_2	132	138	PF00069	0.341
MOD_PKA_2	270	276	PF00069	0.474
MOD_PKA_2	523	529	PF00069	0.555
MOD_Plk_1	209	215	PF00069	0.439
MOD_Plk_1	250	256	PF00069	0.395
MOD_Plk_1	450	456	PF00069	0.355
MOD_Plk_1	53	59	PF00069	0.649
MOD_Plk_2-3	209	215	PF00069	0.453
MOD_Plk_2-3	54	60	PF00069	0.351
MOD_Plk_4	11	17	PF00069	0.391
MOD_Plk_4	134	140	PF00069	0.426
MOD_Plk_4	242	248	PF00069	0.410
MOD_Plk_4	250	256	PF00069	0.410
MOD_Plk_4	270	276	PF00069	0.150
MOD_Plk_4	297	303	PF00069	0.402
MOD_Plk_4	383	389	PF00069	0.279
MOD_Plk_4	409	415	PF00069	0.449
MOD_Plk_4	457	463	PF00069	0.294
MOD_Plk_4	513	519	PF00069	0.446
MOD_ProDKin_1	446	452	PF00069	0.387
MOD_SUMO_rev_2	326	331	PF00179	0.399
MOD_SUMO_rev_2	412	422	PF00179	0.477
TRG_ENDOCYTIC_2	136	139	PF00928	0.332
TRG_ENDOCYTIC_2	142	145	PF00928	0.394
TRG_ENDOCYTIC_2	152	155	PF00928	0.367
TRG_ENDOCYTIC_2	28	31	PF00928	0.410
TRG_ENDOCYTIC_2	302	305	PF00928	0.279
TRG_ENDOCYTIC_2	334	337	PF00928	0.461
TRG_ENDOCYTIC_2	353	356	PF00928	0.336

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HUK8	Leptomonas seymouri	62%	100%
A0A1X0NPH3	Trypanosomatidae	41%	100%
A0A3R7NJV3	Trypanosoma rangeli	42%	100%
A0A3S7WUG9	Leishmania donovani	89%	100%
A4HXE6	Leishmania infantum	89%	100%
C9ZUK3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
E9AR41	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4QEC2	Leishmania major	89%	100%
V5BNW8	Trypanosoma cruzi	43%	100%