LeishMANIAdb
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Serine/threonine-protein kinase PLK

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Serine/threonine-protein kinase PLK
Gene product:
polo-like protein kinase, putative
Species:
Leishmania braziliensis
UniProt:
A4H913_LEIBR
TriTrypDb:
LbrM.17.0690 , LBRM2903_170013600
Length:
698

Annotations

LeishMANIAdb annotations

A large and apprently artificial collection of diverse kinetoplastid protein kinases. None of them appear to be TM.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0000922 spindle pole 2 1
GO:0005634 nucleus 5 1
GO:0005737 cytoplasm 2 1
GO:0005813 centrosome 3 1
GO:0005815 microtubule organizing center 2 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A4H913
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H913

Function

Biological processes
Term Name Level Count
GO:0006468 protein phosphorylation 5 11
GO:0006793 phosphorus metabolic process 3 11
GO:0006796 phosphate-containing compound metabolic process 4 11
GO:0006807 nitrogen compound metabolic process 2 11
GO:0008152 metabolic process 1 11
GO:0009987 cellular process 1 11
GO:0016310 phosphorylation 5 11
GO:0019538 protein metabolic process 3 11
GO:0036211 protein modification process 4 11
GO:0043170 macromolecule metabolic process 3 11
GO:0043412 macromolecule modification 4 11
GO:0044237 cellular metabolic process 2 11
GO:0044238 primary metabolic process 2 11
GO:0071704 organic substance metabolic process 2 11
GO:1901564 organonitrogen compound metabolic process 3 11
GO:0000278 mitotic cell cycle 3 1
GO:0007049 cell cycle 2 1
GO:0010564 regulation of cell cycle process 5 1
GO:0032465 regulation of cytokinesis 5 1
GO:0050789 regulation of biological process 2 1
GO:0050794 regulation of cellular process 3 1
GO:0051302 regulation of cell division 4 1
GO:0051726 regulation of cell cycle 4 1
GO:0065007 biological regulation 1 1
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 11
GO:0003824 catalytic activity 1 11
GO:0004672 protein kinase activity 3 11
GO:0004674 protein serine/threonine kinase activity 4 10
GO:0005488 binding 1 11
GO:0005524 ATP binding 5 11
GO:0016301 kinase activity 4 11
GO:0016740 transferase activity 2 11
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 11
GO:0016773 phosphotransferase activity, alcohol group as acceptor 4 11
GO:0017076 purine nucleotide binding 4 11
GO:0030554 adenyl nucleotide binding 5 11
GO:0032553 ribonucleotide binding 3 11
GO:0032555 purine ribonucleotide binding 4 11
GO:0032559 adenyl ribonucleotide binding 5 11
GO:0035639 purine ribonucleoside triphosphate binding 4 11
GO:0036094 small molecule binding 2 11
GO:0043167 ion binding 2 11
GO:0043168 anion binding 3 11
GO:0097159 organic cyclic compound binding 2 11
GO:0097367 carbohydrate derivative binding 2 11
GO:0140096 catalytic activity, acting on a protein 2 11
GO:1901265 nucleoside phosphate binding 3 11
GO:1901363 heterocyclic compound binding 2 11

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 268 272 PF00656 0.346
CLV_C14_Caspase3-7 471 475 PF00656 0.455
CLV_NRD_NRD_1 100 102 PF00675 0.323
CLV_NRD_NRD_1 139 141 PF00675 0.336
CLV_NRD_NRD_1 199 201 PF00675 0.244
CLV_NRD_NRD_1 343 345 PF00675 0.651
CLV_NRD_NRD_1 441 443 PF00675 0.513
CLV_NRD_NRD_1 663 665 PF00675 0.265
CLV_PCSK_KEX2_1 100 102 PF00082 0.262
CLV_PCSK_KEX2_1 139 141 PF00082 0.339
CLV_PCSK_KEX2_1 201 203 PF00082 0.244
CLV_PCSK_KEX2_1 256 258 PF00082 0.262
CLV_PCSK_KEX2_1 343 345 PF00082 0.651
CLV_PCSK_KEX2_1 441 443 PF00082 0.484
CLV_PCSK_KEX2_1 617 619 PF00082 0.311
CLV_PCSK_KEX2_1 662 664 PF00082 0.266
CLV_PCSK_PC1ET2_1 201 203 PF00082 0.244
CLV_PCSK_PC1ET2_1 256 258 PF00082 0.377
CLV_PCSK_PC1ET2_1 617 619 PF00082 0.311
CLV_PCSK_SKI1_1 100 104 PF00082 0.287
CLV_PCSK_SKI1_1 139 143 PF00082 0.377
CLV_PCSK_SKI1_1 168 172 PF00082 0.287
CLV_PCSK_SKI1_1 360 364 PF00082 0.632
CLV_PCSK_SKI1_1 369 373 PF00082 0.543
CLV_PCSK_SKI1_1 566 570 PF00082 0.179
CLV_PCSK_SKI1_1 572 576 PF00082 0.261
CLV_PCSK_SKI1_1 652 656 PF00082 0.209
CLV_PCSK_SKI1_1 686 690 PF00082 0.371
CLV_Separin_Metazoa 370 374 PF03568 0.616
CLV_Separin_Metazoa 416 420 PF03568 0.496
DEG_APCC_DBOX_1 287 295 PF00400 0.262
DEG_APCC_DBOX_1 368 376 PF00400 0.592
DEG_Nend_UBRbox_2 1 3 PF02207 0.701
DEG_SCF_FBW7_1 306 313 PF00400 0.474
DEG_SCF_FBW7_1 400 405 PF00400 0.552
DEG_SPOP_SBC_1 19 23 PF00917 0.642
DEG_SPOP_SBC_1 329 333 PF00917 0.702
DEG_SPOP_SBC_1 335 339 PF00917 0.606
DEG_SPOP_SBC_1 607 611 PF00917 0.532
DOC_CKS1_1 307 312 PF01111 0.527
DOC_CKS1_1 399 404 PF01111 0.551
DOC_CKS1_1 656 661 PF01111 0.440
DOC_CYCLIN_RxL_1 661 669 PF00134 0.426
DOC_CYCLIN_yCln2_LP_2 308 314 PF00134 0.528
DOC_MAPK_gen_1 100 110 PF00069 0.262
DOC_MAPK_gen_1 115 124 PF00069 0.262
DOC_MAPK_gen_1 168 177 PF00069 0.364
DOC_MAPK_gen_1 617 628 PF00069 0.446
DOC_MAPK_gen_1 662 670 PF00069 0.503
DOC_MAPK_MEF2A_6 343 350 PF00069 0.563
DOC_MAPK_MEF2A_6 662 670 PF00069 0.356
DOC_MAPK_NFAT4_5 663 671 PF00069 0.356
DOC_PP1_RVXF_1 515 521 PF00149 0.503
DOC_PP2B_LxvP_1 308 311 PF13499 0.465
DOC_PP2B_LxvP_1 319 322 PF13499 0.524
DOC_PP2B_LxvP_1 354 357 PF13499 0.487
DOC_PP2B_LxvP_1 363 366 PF13499 0.574
DOC_PP4_FxxP_1 317 320 PF00568 0.620
DOC_SPAK_OSR1_1 140 144 PF12202 0.262
DOC_USP7_MATH_1 324 328 PF00917 0.560
DOC_USP7_MATH_1 33 37 PF00917 0.441
DOC_USP7_MATH_1 475 479 PF00917 0.514
DOC_USP7_MATH_1 607 611 PF00917 0.589
DOC_USP7_UBL2_3 87 91 PF12436 0.287
DOC_WW_Pin1_4 204 209 PF00397 0.244
DOC_WW_Pin1_4 281 286 PF00397 0.365
DOC_WW_Pin1_4 300 305 PF00397 0.299
DOC_WW_Pin1_4 306 311 PF00397 0.401
DOC_WW_Pin1_4 385 390 PF00397 0.660
DOC_WW_Pin1_4 398 403 PF00397 0.615
DOC_WW_Pin1_4 433 438 PF00397 0.620
DOC_WW_Pin1_4 581 586 PF00397 0.527
DOC_WW_Pin1_4 591 596 PF00397 0.288
DOC_WW_Pin1_4 655 660 PF00397 0.440
LIG_14-3-3_CanoR_1 139 144 PF00244 0.287
LIG_14-3-3_CanoR_1 295 300 PF00244 0.323
LIG_14-3-3_CanoR_1 580 585 PF00244 0.506
LIG_14-3-3_CanoR_1 603 607 PF00244 0.592
LIG_14-3-3_CanoR_1 652 657 PF00244 0.409
LIG_14-3-3_CanoR_1 662 667 PF00244 0.409
LIG_14-3-3_CanoR_1 681 690 PF00244 0.305
LIG_14-3-3_CanoR_1 80 84 PF00244 0.323
LIG_BRCT_BRCA1_1 609 613 PF00533 0.624
LIG_eIF4E_1 118 124 PF01652 0.377
LIG_FHA_1 144 150 PF00498 0.262
LIG_FHA_1 21 27 PF00498 0.582
LIG_FHA_1 227 233 PF00498 0.301
LIG_FHA_1 236 242 PF00498 0.257
LIG_FHA_1 276 282 PF00498 0.377
LIG_FHA_1 331 337 PF00498 0.723
LIG_FHA_1 401 407 PF00498 0.675
LIG_FHA_1 422 428 PF00498 0.750
LIG_FHA_1 514 520 PF00498 0.409
LIG_FHA_1 522 528 PF00498 0.409
LIG_FHA_1 632 638 PF00498 0.422
LIG_FHA_1 663 669 PF00498 0.413
LIG_FHA_1 683 689 PF00498 0.225
LIG_FHA_1 70 76 PF00498 0.346
LIG_FHA_2 111 117 PF00498 0.262
LIG_FHA_2 129 135 PF00498 0.262
LIG_FHA_2 140 146 PF00498 0.262
LIG_FHA_2 288 294 PF00498 0.244
LIG_FHA_2 469 475 PF00498 0.482
LIG_FHA_2 607 613 PF00498 0.569
LIG_FHA_2 671 677 PF00498 0.541
LIG_LIR_Apic_2 207 213 PF02991 0.287
LIG_LIR_Apic_2 316 320 PF02991 0.669
LIG_LIR_Apic_2 655 659 PF02991 0.431
LIG_LIR_Gen_1 116 124 PF02991 0.323
LIG_LIR_Gen_1 145 156 PF02991 0.287
LIG_LIR_Gen_1 528 538 PF02991 0.387
LIG_LIR_Gen_1 610 620 PF02991 0.477
LIG_LIR_Gen_1 687 698 PF02991 0.444
LIG_LIR_Nem_3 116 121 PF02991 0.262
LIG_LIR_Nem_3 145 151 PF02991 0.287
LIG_LIR_Nem_3 252 258 PF02991 0.250
LIG_LIR_Nem_3 528 533 PF02991 0.387
LIG_LIR_Nem_3 571 577 PF02991 0.452
LIG_LIR_Nem_3 594 599 PF02991 0.556
LIG_LIR_Nem_3 610 616 PF02991 0.478
LIG_LIR_Nem_3 648 654 PF02991 0.503
LIG_LIR_Nem_3 687 693 PF02991 0.420
LIG_MYND_1 13 17 PF01753 0.484
LIG_MYND_1 306 310 PF01753 0.454
LIG_NRBOX 131 137 PF00104 0.377
LIG_NRBOX 235 241 PF00104 0.244
LIG_PAM2_1 666 678 PF00658 0.437
LIG_Pex14_2 110 114 PF04695 0.262
LIG_SH2_CRK 237 241 PF00017 0.260
LIG_SH2_CRK 255 259 PF00017 0.177
LIG_SH2_CRK 263 267 PF00017 0.377
LIG_SH2_CRK 530 534 PF00017 0.387
LIG_SH2_CRK 656 660 PF00017 0.440
LIG_SH2_CRK 690 694 PF00017 0.488
LIG_SH2_NCK_1 656 660 PF00017 0.431
LIG_SH2_PTP2 148 151 PF00017 0.323
LIG_SH2_PTP2 210 213 PF00017 0.244
LIG_SH2_STAP1 237 241 PF00017 0.300
LIG_SH2_STAP1 73 77 PF00017 0.289
LIG_SH2_STAT5 119 122 PF00017 0.316
LIG_SH2_STAT5 148 151 PF00017 0.344
LIG_SH2_STAT5 210 213 PF00017 0.244
LIG_SH2_STAT5 237 240 PF00017 0.262
LIG_SH2_STAT5 573 576 PF00017 0.330
LIG_SH2_STAT5 577 580 PF00017 0.340
LIG_SH2_STAT5 615 618 PF00017 0.340
LIG_SH2_STAT5 656 659 PF00017 0.409
LIG_SH3_2 598 603 PF14604 0.570
LIG_SH3_3 14 20 PF00018 0.639
LIG_SH3_3 238 244 PF00018 0.244
LIG_SH3_3 301 307 PF00018 0.409
LIG_SH3_3 368 374 PF00018 0.603
LIG_SH3_3 376 382 PF00018 0.581
LIG_SH3_3 383 389 PF00018 0.527
LIG_SH3_3 401 407 PF00018 0.709
LIG_SH3_3 431 437 PF00018 0.552
LIG_SH3_3 478 484 PF00018 0.523
LIG_SH3_3 516 522 PF00018 0.422
LIG_SH3_3 592 598 PF00018 0.510
LIG_SH3_4 28 35 PF00018 0.511
LIG_SH3_CIN85_PxpxPR_1 598 603 PF14604 0.507
LIG_SUMO_SIM_anti_2 586 592 PF11976 0.317
LIG_TRAF2_1 447 450 PF00917 0.514
LIG_TRAF2_2 245 250 PF00917 0.244
LIG_TYR_ITIM 235 240 PF00017 0.262
LIG_TYR_ITIM 688 693 PF00017 0.475
LIG_UBA3_1 132 137 PF00899 0.287
LIG_WRC_WIRS_1 111 116 PF05994 0.262
LIG_WRC_WIRS_1 314 319 PF05994 0.567
LIG_WW_3 600 604 PF00397 0.513
MOD_CDC14_SPxK_1 584 587 PF00782 0.496
MOD_CDK_SPK_2 385 390 PF00069 0.698
MOD_CDK_SPxK_1 581 587 PF00069 0.563
MOD_CDK_SPxxK_3 281 288 PF00069 0.377
MOD_CDK_SPxxK_3 655 662 PF00069 0.440
MOD_CK1_1 298 304 PF00069 0.584
MOD_CK1_1 313 319 PF00069 0.562
MOD_CK1_1 556 562 PF00069 0.545
MOD_CK1_1 631 637 PF00069 0.419
MOD_CK1_1 67 73 PF00069 0.377
MOD_CK1_1 684 690 PF00069 0.466
MOD_CK1_1 94 100 PF00069 0.323
MOD_CK2_1 139 145 PF00069 0.309
MOD_CK2_1 19 25 PF00069 0.550
MOD_CK2_1 33 39 PF00069 0.399
MOD_CK2_1 670 676 PF00069 0.579
MOD_Cter_Amidation 660 663 PF01082 0.303
MOD_GlcNHglycan 154 157 PF01048 0.443
MOD_GlcNHglycan 326 329 PF01048 0.692
MOD_GlcNHglycan 41 45 PF01048 0.534
MOD_GlcNHglycan 419 422 PF01048 0.692
MOD_GlcNHglycan 429 432 PF01048 0.583
MOD_GlcNHglycan 623 626 PF01048 0.447
MOD_GlcNHglycan 659 662 PF01048 0.265
MOD_GSK3_1 139 146 PF00069 0.272
MOD_GSK3_1 200 207 PF00069 0.247
MOD_GSK3_1 217 224 PF00069 0.358
MOD_GSK3_1 295 302 PF00069 0.325
MOD_GSK3_1 306 313 PF00069 0.373
MOD_GSK3_1 324 331 PF00069 0.621
MOD_GSK3_1 398 405 PF00069 0.567
MOD_GSK3_1 417 424 PF00069 0.685
MOD_GSK3_1 501 508 PF00069 0.503
MOD_GSK3_1 576 583 PF00069 0.353
MOD_GSK3_1 602 609 PF00069 0.572
MOD_GSK3_1 662 669 PF00069 0.393
MOD_N-GLC_1 512 517 PF02516 0.214
MOD_N-GLC_1 631 636 PF02516 0.222
MOD_NEK2_1 110 115 PF00069 0.296
MOD_NEK2_1 299 304 PF00069 0.554
MOD_NEK2_1 330 335 PF00069 0.682
MOD_NEK2_1 40 45 PF00069 0.589
MOD_NEK2_1 462 467 PF00069 0.393
MOD_NEK2_1 512 517 PF00069 0.414
MOD_NEK2_1 628 633 PF00069 0.409
MOD_NEK2_1 682 687 PF00069 0.457
MOD_NEK2_2 33 38 PF00069 0.504
MOD_PIKK_1 143 149 PF00454 0.262
MOD_PIKK_1 275 281 PF00454 0.394
MOD_PIKK_1 485 491 PF00454 0.457
MOD_PKA_1 139 145 PF00069 0.377
MOD_PKA_1 200 206 PF00069 0.244
MOD_PKA_1 566 572 PF00069 0.457
MOD_PKA_1 662 668 PF00069 0.503
MOD_PKA_2 139 145 PF00069 0.298
MOD_PKA_2 287 293 PF00069 0.287
MOD_PKA_2 501 507 PF00069 0.422
MOD_PKA_2 602 608 PF00069 0.587
MOD_PKA_2 628 634 PF00069 0.409
MOD_PKA_2 662 668 PF00069 0.409
MOD_PKA_2 682 688 PF00069 0.223
MOD_PKA_2 79 85 PF00069 0.323
MOD_Plk_1 251 257 PF00069 0.383
MOD_Plk_1 631 637 PF00069 0.422
MOD_Plk_1 94 100 PF00069 0.364
MOD_Plk_2-3 128 134 PF00069 0.377
MOD_Plk_4 128 134 PF00069 0.272
MOD_Plk_4 235 241 PF00069 0.302
MOD_Plk_4 287 293 PF00069 0.254
MOD_Plk_4 295 301 PF00069 0.261
MOD_Plk_4 33 39 PF00069 0.401
MOD_Plk_4 573 579 PF00069 0.355
MOD_Plk_4 666 672 PF00069 0.366
MOD_Plk_4 684 690 PF00069 0.374
MOD_ProDKin_1 204 210 PF00069 0.244
MOD_ProDKin_1 281 287 PF00069 0.365
MOD_ProDKin_1 300 306 PF00069 0.290
MOD_ProDKin_1 385 391 PF00069 0.659
MOD_ProDKin_1 398 404 PF00069 0.616
MOD_ProDKin_1 433 439 PF00069 0.619
MOD_ProDKin_1 581 587 PF00069 0.520
MOD_ProDKin_1 591 597 PF00069 0.298
MOD_ProDKin_1 655 661 PF00069 0.440
MOD_SUMO_for_1 533 536 PF00179 0.503
MOD_SUMO_for_1 548 551 PF00179 0.503
MOD_SUMO_rev_2 163 172 PF00179 0.380
MOD_SUMO_rev_2 193 203 PF00179 0.244
MOD_SUMO_rev_2 214 220 PF00179 0.377
MOD_SUMO_rev_2 559 569 PF00179 0.500
TRG_DiLeu_BaEn_4 450 456 PF01217 0.360
TRG_ENDOCYTIC_2 119 122 PF00928 0.269
TRG_ENDOCYTIC_2 148 151 PF00928 0.323
TRG_ENDOCYTIC_2 237 240 PF00928 0.260
TRG_ENDOCYTIC_2 255 258 PF00928 0.177
TRG_ENDOCYTIC_2 530 533 PF00928 0.387
TRG_ENDOCYTIC_2 690 693 PF00928 0.483
TRG_ER_diArg_1 100 102 PF00400 0.323
TRG_ER_diArg_1 138 140 PF00400 0.277
TRG_ER_diArg_1 662 664 PF00400 0.496
TRG_NES_CRM1_1 134 145 PF08389 0.377
TRG_NES_CRM1_1 180 193 PF08389 0.289
TRG_Pf-PMV_PEXEL_1 274 279 PF00026 0.377
TRG_Pf-PMV_PEXEL_1 618 623 PF00026 0.463

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I191 Leptomonas seymouri 73% 94%
A0A0S4JMY6 Bodo saltans 47% 91%
A0A1X0NTN5 Trypanosomatidae 50% 92%
A0A3Q8IAR8 Leishmania donovani 92% 100%
A0A422N3U8 Trypanosoma rangeli 48% 97%
A4HXE5 Leishmania infantum 92% 100%
C9ZTW0 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 46% 100%
E9AR40 Leishmania mexicana (strain MHOM/GT/2001/U1103) 90% 99%
P0C8M8 Zea mays 39% 100%
P34331 Caenorhabditis elegans 30% 100%
P50528 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 33% 100%
P53351 Mus musculus 30% 100%
Q4QEC3 Leishmania major 91% 100%
Q5R4L1 Pongo abelii 30% 100%
Q9NYY3 Homo sapiens 30% 100%
Q9R011 Rattus norvegicus 31% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS