Endo/exonuclease/phosphatase domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H912_LEIBR

TriTrypDb:

LbrM.17.0680 , LBRM2903_170013100

Length:

464

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H912

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H912

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	249	253	PF00656	0.770
CLV_C14_Caspase3-7	289	293	PF00656	0.731
CLV_NRD_NRD_1	165	167	PF00675	0.770
CLV_NRD_NRD_1	17	19	PF00675	0.443
CLV_NRD_NRD_1	304	306	PF00675	0.736
CLV_PCSK_KEX2_1	433	435	PF00082	0.619
CLV_PCSK_PC1ET2_1	433	435	PF00082	0.619
CLV_PCSK_SKI1_1	170	174	PF00082	0.749
CLV_PCSK_SKI1_1	245	249	PF00082	0.745
CLV_PCSK_SKI1_1	321	325	PF00082	0.551
DEG_SCF_FBW7_2	71	78	PF00400	0.558
DOC_CKS1_1	110	115	PF01111	0.547
DOC_CKS1_1	162	167	PF01111	0.765
DOC_CKS1_1	415	420	PF01111	0.642
DOC_CKS1_1	72	77	PF01111	0.562
DOC_MAPK_gen_1	321	330	PF00069	0.500
DOC_MAPK_gen_1	377	385	PF00069	0.607
DOC_MAPK_MEF2A_6	321	330	PF00069	0.500
DOC_PP4_FxxP_1	257	260	PF00568	0.578
DOC_PP4_FxxP_1	317	320	PF00568	0.370
DOC_USP7_MATH_1	120	124	PF00917	0.712
DOC_USP7_MATH_1	400	404	PF00917	0.351
DOC_USP7_MATH_1	448	452	PF00917	0.548
DOC_USP7_MATH_1	98	102	PF00917	0.698
DOC_WW_Pin1_4	109	114	PF00397	0.721
DOC_WW_Pin1_4	123	128	PF00397	0.585
DOC_WW_Pin1_4	151	156	PF00397	0.773
DOC_WW_Pin1_4	158	163	PF00397	0.682
DOC_WW_Pin1_4	178	183	PF00397	0.666
DOC_WW_Pin1_4	206	211	PF00397	0.685
DOC_WW_Pin1_4	217	222	PF00397	0.635
DOC_WW_Pin1_4	259	264	PF00397	0.607
DOC_WW_Pin1_4	267	272	PF00397	0.602
DOC_WW_Pin1_4	297	302	PF00397	0.621
DOC_WW_Pin1_4	414	419	PF00397	0.630
DOC_WW_Pin1_4	71	76	PF00397	0.668
LIG_14-3-3_CanoR_1	305	312	PF00244	0.712
LIG_14-3-3_CanoR_1	337	341	PF00244	0.643
LIG_14-3-3_CanoR_1	346	352	PF00244	0.468
LIG_14-3-3_CanoR_1	357	362	PF00244	0.514
LIG_14-3-3_CanoR_1	434	440	PF00244	0.388
LIG_BIR_III_2	176	180	PF00653	0.725
LIG_CSL_BTD_1	260	263	PF09270	0.616
LIG_CtBP_PxDLS_1	182	186	PF00389	0.771
LIG_FHA_1	110	116	PF00498	0.615
LIG_FHA_1	196	202	PF00498	0.544
LIG_FHA_1	268	274	PF00498	0.778
LIG_FHA_1	323	329	PF00498	0.457
LIG_FHA_1	402	408	PF00498	0.608
LIG_FHA_1	454	460	PF00498	0.532
LIG_FHA_1	5	11	PF00498	0.485
LIG_FHA_1	65	71	PF00498	0.636
LIG_FHA_1	72	78	PF00498	0.733
LIG_FHA_2	21	27	PF00498	0.453
LIG_FHA_2	247	253	PF00498	0.728
LIG_FHA_2	287	293	PF00498	0.611
LIG_FHA_2	97	103	PF00498	0.662
LIG_GBD_Chelix_1	406	414	PF00786	0.591
LIG_LIR_Apic_2	255	260	PF02991	0.695
LIG_LIR_Apic_2	315	320	PF02991	0.359
LIG_LIR_Nem_3	342	347	PF02991	0.637
LIG_PAM2_1	171	183	PF00658	0.673
LIG_PAM2_1	252	264	PF00658	0.639
LIG_Pex14_2	257	261	PF04695	0.576
LIG_Pex14_2	312	316	PF04695	0.629
LIG_SH2_CRK	232	236	PF00017	0.595
LIG_SH2_CRK	344	348	PF00017	0.642
LIG_SH2_NCK_1	232	236	PF00017	0.595
LIG_SH2_STAP1	393	397	PF00017	0.451
LIG_SH2_STAP1	454	458	PF00017	0.663
LIG_SH2_STAT5	22	25	PF00017	0.473
LIG_SH2_STAT5	435	438	PF00017	0.489
LIG_SH2_STAT5	439	442	PF00017	0.480
LIG_SH3_2	162	167	PF14604	0.836
LIG_SH3_3	129	135	PF00018	0.674
LIG_SH3_3	159	165	PF00018	0.737
LIG_SH3_3	176	182	PF00018	0.665
LIG_SH3_3	209	215	PF00018	0.657
LIG_SH3_3	218	224	PF00018	0.611
LIG_SH3_3	257	263	PF00018	0.598
LIG_SH3_3	293	299	PF00018	0.662
LIG_SH3_3	358	364	PF00018	0.634
LIG_SH3_3	69	75	PF00018	0.666
LIG_SUMO_SIM_par_1	181	187	PF11976	0.769
LIG_SUMO_SIM_par_1	270	278	PF11976	0.504
LIG_SUMO_SIM_par_1	324	329	PF11976	0.487
LIG_SUMO_SIM_par_1	403	411	PF11976	0.377
LIG_SUMO_SIM_par_1	455	463	PF11976	0.705
LIG_TRAF2_1	140	143	PF00917	0.742
LIG_UBA3_1	371	379	PF00899	0.517
MOD_CDK_SPK_2	109	114	PF00069	0.587
MOD_CDK_SPK_2	161	166	PF00069	0.711
MOD_CDK_SPxK_1	161	167	PF00069	0.837
MOD_CK1_1	123	129	PF00069	0.629
MOD_CK1_1	154	160	PF00069	0.745
MOD_CK1_1	161	167	PF00069	0.715
MOD_CK1_1	181	187	PF00069	0.650
MOD_CK1_1	217	223	PF00069	0.640
MOD_CK1_1	89	95	PF00069	0.686
MOD_CK2_1	136	142	PF00069	0.762
MOD_CK2_1	20	26	PF00069	0.451
MOD_CK2_1	435	441	PF00069	0.423
MOD_CK2_1	96	102	PF00069	0.674
MOD_Cter_Amidation	431	434	PF01082	0.548
MOD_Cter_Amidation	80	83	PF01082	0.559
MOD_GlcNHglycan	127	130	PF01048	0.673
MOD_GlcNHglycan	137	141	PF01048	0.607
MOD_GlcNHglycan	145	148	PF01048	0.745
MOD_GlcNHglycan	254	257	PF01048	0.738
MOD_GlcNHglycan	286	289	PF01048	0.698
MOD_GlcNHglycan	410	413	PF01048	0.515
MOD_GlcNHglycan	43	46	PF01048	0.754
MOD_GlcNHglycan	78	81	PF01048	0.616
MOD_GSK3_1	105	112	PF00069	0.508
MOD_GSK3_1	121	128	PF00069	0.595
MOD_GSK3_1	154	161	PF00069	0.758
MOD_GSK3_1	186	193	PF00069	0.592
MOD_GSK3_1	195	202	PF00069	0.507
MOD_GSK3_1	246	253	PF00069	0.725
MOD_GSK3_1	282	289	PF00069	0.696
MOD_GSK3_1	94	101	PF00069	0.639
MOD_N-GLC_1	331	336	PF02516	0.378
MOD_N-GLC_1	357	362	PF02516	0.640
MOD_N-GLC_1	385	390	PF02516	0.636
MOD_N-GLC_1	400	405	PF02516	0.359
MOD_N-GLC_1	54	59	PF02516	0.683
MOD_NEK2_1	141	146	PF00069	0.646
MOD_NEK2_1	190	195	PF00069	0.778
MOD_NEK2_1	304	309	PF00069	0.585
MOD_NEK2_1	312	317	PF00069	0.518
MOD_NEK2_1	331	336	PF00069	0.506
MOD_NEK2_1	443	448	PF00069	0.593
MOD_NEK2_1	76	81	PF00069	0.557
MOD_NEK2_2	336	341	PF00069	0.613
MOD_NEK2_2	352	357	PF00069	0.288
MOD_PIKK_1	401	407	PF00454	0.602
MOD_PK_1	357	363	PF00069	0.633
MOD_PKA_1	305	311	PF00069	0.716
MOD_PKA_2	304	310	PF00069	0.717
MOD_PKA_2	336	342	PF00069	0.652
MOD_PKA_2	345	351	PF00069	0.479
MOD_PKA_2	443	449	PF00069	0.728
MOD_PKA_2	86	92	PF00069	0.550
MOD_Plk_1	105	111	PF00069	0.571
MOD_Plk_1	136	142	PF00069	0.686
MOD_Plk_1	265	271	PF00069	0.704
MOD_Plk_1	352	358	PF00069	0.555
MOD_Plk_1	54	60	PF00069	0.739
MOD_Plk_2-3	54	60	PF00069	0.763
MOD_Plk_4	105	111	PF00069	0.615
MOD_Plk_4	190	196	PF00069	0.707
MOD_Plk_4	286	292	PF00069	0.507
MOD_Plk_4	312	318	PF00069	0.401
MOD_Plk_4	339	345	PF00069	0.497
MOD_Plk_4	86	92	PF00069	0.571
MOD_ProDKin_1	109	115	PF00069	0.721
MOD_ProDKin_1	123	129	PF00069	0.586
MOD_ProDKin_1	151	157	PF00069	0.773
MOD_ProDKin_1	158	164	PF00069	0.682
MOD_ProDKin_1	178	184	PF00069	0.665
MOD_ProDKin_1	206	212	PF00069	0.684
MOD_ProDKin_1	217	223	PF00069	0.634
MOD_ProDKin_1	259	265	PF00069	0.607
MOD_ProDKin_1	267	273	PF00069	0.602
MOD_ProDKin_1	297	303	PF00069	0.625
MOD_ProDKin_1	414	420	PF00069	0.640
MOD_ProDKin_1	71	77	PF00069	0.669
MOD_SUMO_for_1	103	106	PF00179	0.794
MOD_SUMO_for_1	243	246	PF00179	0.804
MOD_SUMO_rev_2	287	296	PF00179	0.681
MOD_SUMO_rev_2	441	449	PF00179	0.714
TRG_DiLeu_BaEn_1	106	111	PF01217	0.611
TRG_DiLeu_BaEn_2	104	110	PF01217	0.541
TRG_DiLeu_BaLyEn_6	72	77	PF01217	0.562
TRG_ENDOCYTIC_2	344	347	PF00928	0.601
TRG_ENDOCYTIC_2	423	426	PF00928	0.523

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3C3	Leptomonas seymouri	66%	100%
A0A3S7WUF4	Leishmania donovani	73%	100%
A4HXE4	Leishmania infantum	73%	100%
C9ZU38	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
E9AR39	Leishmania mexicana (strain MHOM/GT/2001/U1103)	73%	100%
Q4QEC4	Leishmania major	71%	100%