VASt domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

GRAM domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4H911_LEIBR

TriTrypDb:

LbrM.17.0670 , LBRM2903_170013000

Length:

714

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9
GO:0005789	endoplasmic reticulum membrane	4	1
GO:0005886	plasma membrane	3	1
GO:0031090	organelle membrane	3	1
GO:0044232	organelle membrane contact site	2	1
GO:0140268	endoplasmic reticulum-plasma membrane contact site	3	1

Expansion

Sequence features

A4H911

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H911

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0006869	lipid transport	5	1
GO:0009987	cellular process	1	1
GO:0015850	organic hydroxy compound transport	5	1
GO:0015918	sterol transport	6	1
GO:0032365	intracellular lipid transport	4	1
GO:0032366	intracellular sterol transport	5	1
GO:0046907	intracellular transport	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0071702	organic substance transport	4	1

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	1
GO:0005319	lipid transporter activity	2	1
GO:0005488	binding	1	1
GO:0005496	steroid binding	3	1
GO:0008289	lipid binding	2	1
GO:0015248	sterol transporter activity	3	1
GO:0032934	sterol binding	4	1
GO:0097159	organic cyclic compound binding	2	1
GO:0120013	lipid transfer activity	3	1
GO:0120015	sterol transfer activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	144	148	PF00656	0.433
CLV_C14_Caspase3-7	173	177	PF00656	0.528
CLV_C14_Caspase3-7	272	276	PF00656	0.309
CLV_C14_Caspase3-7	347	351	PF00656	0.264
CLV_C14_Caspase3-7	5	9	PF00656	0.399
CLV_NRD_NRD_1	240	242	PF00675	0.738
CLV_NRD_NRD_1	261	263	PF00675	0.510
CLV_NRD_NRD_1	32	34	PF00675	0.397
CLV_NRD_NRD_1	457	459	PF00675	0.481
CLV_NRD_NRD_1	47	49	PF00675	0.380
CLV_NRD_NRD_1	615	617	PF00675	0.738
CLV_NRD_NRD_1	85	87	PF00675	0.510
CLV_PCSK_KEX2_1	261	263	PF00082	0.510
CLV_PCSK_KEX2_1	32	34	PF00082	0.399
CLV_PCSK_KEX2_1	47	49	PF00082	0.382
CLV_PCSK_SKI1_1	261	265	PF00082	0.544
CLV_PCSK_SKI1_1	324	328	PF00082	0.557
CLV_PCSK_SKI1_1	434	438	PF00082	0.509
CLV_PCSK_SKI1_1	481	485	PF00082	0.516
CLV_PCSK_SKI1_1	504	508	PF00082	0.481
CLV_PCSK_SKI1_1	681	685	PF00082	0.456
DEG_APCC_DBOX_1	46	54	PF00400	0.207
DEG_APCC_DBOX_1	503	511	PF00400	0.389
DEG_APCC_DBOX_1	680	688	PF00400	0.618
DEG_SPOP_SBC_1	13	17	PF00917	0.370
DOC_CDC14_PxL_1	631	639	PF14671	0.361
DOC_CKS1_1	424	429	PF01111	0.436
DOC_CKS1_1	57	62	PF01111	0.309
DOC_CYCLIN_yCln2_LP_2	687	693	PF00134	0.510
DOC_MAPK_DCC_7	422	430	PF00069	0.329
DOC_MAPK_DCC_7	55	63	PF00069	0.207
DOC_MAPK_gen_1	318	328	PF00069	0.309
DOC_MAPK_gen_1	47	58	PF00069	0.207
DOC_MAPK_MEF2A_6	509	518	PF00069	0.319
DOC_PP1_RVXF_1	60	66	PF00149	0.279
DOC_PP4_FxxP_1	300	303	PF00568	0.309
DOC_USP7_MATH_1	151	155	PF00917	0.492
DOC_USP7_MATH_1	167	171	PF00917	0.488
DOC_USP7_MATH_1	174	178	PF00917	0.590
DOC_USP7_MATH_1	208	212	PF00917	0.448
DOC_USP7_MATH_1	245	249	PF00917	0.581
DOC_USP7_MATH_1	396	400	PF00917	0.381
DOC_USP7_MATH_1	710	714	PF00917	0.480
DOC_USP7_UBL2_3	586	590	PF12436	0.242
DOC_WW_Pin1_4	299	304	PF00397	0.309
DOC_WW_Pin1_4	3	8	PF00397	0.440
DOC_WW_Pin1_4	423	428	PF00397	0.431
DOC_WW_Pin1_4	510	515	PF00397	0.196
DOC_WW_Pin1_4	56	61	PF00397	0.349
DOC_WW_Pin1_4	670	675	PF00397	0.548
DOC_WW_Pin1_4	686	691	PF00397	0.632
LIG_14-3-3_CanoR_1	136	141	PF00244	0.444
LIG_14-3-3_CanoR_1	207	213	PF00244	0.509
LIG_14-3-3_CanoR_1	235	239	PF00244	0.518
LIG_14-3-3_CanoR_1	481	489	PF00244	0.306
LIG_14-3-3_CanoR_1	571	581	PF00244	0.340
LIG_14-3-3_CanoR_1	62	70	PF00244	0.322
LIG_14-3-3_CanoR_1	86	91	PF00244	0.287
LIG_Actin_WH2_2	321	338	PF00022	0.309
LIG_Actin_WH2_2	549	566	PF00022	0.222
LIG_AP2alpha_1	529	533	PF02296	0.306
LIG_BIR_II_1	1	5	PF00653	0.433
LIG_BRCT_BRCA1_1	339	343	PF00533	0.309
LIG_Clathr_ClatBox_1	325	329	PF01394	0.309
LIG_EH1_1	532	540	PF00400	0.287
LIG_eIF4E_1	502	508	PF01652	0.389
LIG_FHA_1	106	112	PF00498	0.201
LIG_FHA_1	150	156	PF00498	0.409
LIG_FHA_1	180	186	PF00498	0.494
LIG_FHA_1	226	232	PF00498	0.414
LIG_FHA_1	268	274	PF00498	0.309
LIG_FHA_1	446	452	PF00498	0.389
LIG_FHA_1	484	490	PF00498	0.281
LIG_FHA_1	511	517	PF00498	0.283
LIG_FHA_1	551	557	PF00498	0.330
LIG_FHA_1	645	651	PF00498	0.256
LIG_FHA_1	686	692	PF00498	0.654
LIG_FHA_1	694	700	PF00498	0.302
LIG_FHA_1	707	713	PF00498	0.269
LIG_FHA_1	92	98	PF00498	0.285
LIG_FHA_2	201	207	PF00498	0.497
LIG_FHA_2	254	260	PF00498	0.494
LIG_FHA_2	270	276	PF00498	0.381
LIG_FHA_2	345	351	PF00498	0.264
LIG_FHA_2	368	374	PF00498	0.518
LIG_FHA_2	383	389	PF00498	0.445
LIG_FHA_2	573	579	PF00498	0.235
LIG_FHA_2	99	105	PF00498	0.237
LIG_Integrin_isoDGR_2	194	196	PF01839	0.606
LIG_LIR_Gen_1	104	115	PF02991	0.381
LIG_LIR_Gen_1	116	125	PF02991	0.221
LIG_LIR_Gen_1	21	31	PF02991	0.215
LIG_LIR_Gen_1	294	305	PF02991	0.255
LIG_LIR_Gen_1	310	319	PF02991	0.255
LIG_LIR_Gen_1	340	351	PF02991	0.235
LIG_LIR_Gen_1	401	410	PF02991	0.345
LIG_LIR_Gen_1	415	425	PF02991	0.319
LIG_LIR_Gen_1	663	672	PF02991	0.316
LIG_LIR_Gen_1	709	714	PF02991	0.508
LIG_LIR_Gen_1	72	82	PF02991	0.345
LIG_LIR_Nem_3	104	110	PF02991	0.272
LIG_LIR_Nem_3	116	122	PF02991	0.255
LIG_LIR_Nem_3	21	27	PF02991	0.215
LIG_LIR_Nem_3	259	263	PF02991	0.289
LIG_LIR_Nem_3	294	300	PF02991	0.255
LIG_LIR_Nem_3	310	316	PF02991	0.255
LIG_LIR_Nem_3	329	335	PF02991	0.188
LIG_LIR_Nem_3	340	346	PF02991	0.214
LIG_LIR_Nem_3	401	406	PF02991	0.364
LIG_LIR_Nem_3	415	420	PF02991	0.319
LIG_LIR_Nem_3	501	505	PF02991	0.285
LIG_LIR_Nem_3	583	588	PF02991	0.350
LIG_LIR_Nem_3	663	668	PF02991	0.389
LIG_LIR_Nem_3	671	675	PF02991	0.621
LIG_LIR_Nem_3	709	714	PF02991	0.553
LIG_LIR_Nem_3	72	78	PF02991	0.345
LIG_PDZ_Class_2	709	714	PF00595	0.618
LIG_Pex14_2	24	28	PF04695	0.215
LIG_Pex14_2	260	264	PF04695	0.309
LIG_Pex14_2	440	444	PF04695	0.281
LIG_Pex14_2	529	533	PF04695	0.306
LIG_Pex14_2	65	69	PF04695	0.279
LIG_Pex14_2	661	665	PF04695	0.364
LIG_PTB_Apo_2	254	261	PF02174	0.352
LIG_SH2_CRK	119	123	PF00017	0.309
LIG_SH2_CRK	585	589	PF00017	0.299
LIG_SH2_PTP2	332	335	PF00017	0.309
LIG_SH2_PTP2	57	60	PF00017	0.309
LIG_SH2_PTP2	633	636	PF00017	0.473
LIG_SH2_SRC	497	500	PF00017	0.298
LIG_SH2_STAT5	132	135	PF00017	0.320
LIG_SH2_STAT5	332	335	PF00017	0.309
LIG_SH2_STAT5	499	502	PF00017	0.380
LIG_SH2_STAT5	559	562	PF00017	0.345
LIG_SH2_STAT5	57	60	PF00017	0.309
LIG_SH2_STAT5	633	636	PF00017	0.568
LIG_SH3_1	262	268	PF00018	0.309
LIG_SH3_3	214	220	PF00018	0.508
LIG_SH3_3	262	268	PF00018	0.269
LIG_SH3_3	373	379	PF00018	0.499
LIG_SH3_3	421	427	PF00018	0.299
LIG_SH3_3	629	635	PF00018	0.513
LIG_SUMO_SIM_anti_2	93	99	PF11976	0.309
LIG_SUMO_SIM_par_1	324	329	PF11976	0.279
LIG_SUMO_SIM_par_1	651	656	PF11976	0.369
LIG_SUMO_SIM_par_1	79	85	PF11976	0.300
LIG_SUMO_SIM_par_1	93	99	PF11976	0.328
LIG_UBA3_1	27	36	PF00899	0.250
LIG_WRC_WIRS_1	669	674	PF05994	0.409
LIG_WRC_WIRS_1	701	706	PF05994	0.369
MOD_CDC14_SPxK_1	673	676	PF00782	0.538
MOD_CDK_SPxK_1	423	429	PF00069	0.435
MOD_CDK_SPxK_1	56	62	PF00069	0.309
MOD_CDK_SPxK_1	670	676	PF00069	0.529
MOD_CDK_SPxxK_3	3	10	PF00069	0.402
MOD_CK1_1	146	152	PF00069	0.498
MOD_CK1_1	153	159	PF00069	0.468
MOD_CK1_1	179	185	PF00069	0.509
MOD_CK1_1	2	8	PF00069	0.413
MOD_CK1_1	337	343	PF00069	0.268
MOD_CK1_1	344	350	PF00069	0.240
MOD_CK1_1	412	418	PF00069	0.343
MOD_CK1_1	546	552	PF00069	0.389
MOD_CK1_1	598	604	PF00069	0.449
MOD_CK1_1	625	631	PF00069	0.411
MOD_CK1_1	686	692	PF00069	0.629
MOD_CK2_1	124	130	PF00069	0.371
MOD_CK2_1	14	20	PF00069	0.371
MOD_CK2_1	167	173	PF00069	0.465
MOD_CK2_1	253	259	PF00069	0.512
MOD_CK2_1	304	310	PF00069	0.357
MOD_CK2_1	311	317	PF00069	0.306
MOD_CK2_1	382	388	PF00069	0.420
MOD_CK2_1	401	407	PF00069	0.241
MOD_CK2_1	415	421	PF00069	0.425
MOD_CK2_1	623	629	PF00069	0.574
MOD_CK2_1	65	71	PF00069	0.309
MOD_CK2_1	98	104	PF00069	0.208
MOD_CMANNOS	465	468	PF00535	0.481
MOD_GlcNHglycan	149	152	PF01048	0.699
MOD_GlcNHglycan	155	158	PF01048	0.710
MOD_GlcNHglycan	164	167	PF01048	0.670
MOD_GlcNHglycan	169	172	PF01048	0.754
MOD_GlcNHglycan	17	20	PF01048	0.569
MOD_GlcNHglycan	185	188	PF01048	0.590
MOD_GlcNHglycan	228	231	PF01048	0.631
MOD_GlcNHglycan	242	245	PF01048	0.636
MOD_GlcNHglycan	253	256	PF01048	0.588
MOD_GlcNHglycan	336	339	PF01048	0.525
MOD_GlcNHglycan	376	379	PF01048	0.706
MOD_GlcNHglycan	411	414	PF01048	0.648
MOD_GlcNHglycan	510	513	PF01048	0.529
MOD_GlcNHglycan	545	548	PF01048	0.545
MOD_GlcNHglycan	600	603	PF01048	0.728
MOD_GlcNHglycan	606	610	PF01048	0.771
MOD_GlcNHglycan	655	658	PF01048	0.369
MOD_GSK3_1	105	112	PF00069	0.279
MOD_GSK3_1	113	120	PF00069	0.279
MOD_GSK3_1	143	150	PF00069	0.489
MOD_GSK3_1	153	160	PF00069	0.457
MOD_GSK3_1	179	186	PF00069	0.532
MOD_GSK3_1	208	215	PF00069	0.476
MOD_GSK3_1	263	270	PF00069	0.357
MOD_GSK3_1	337	344	PF00069	0.259
MOD_GSK3_1	356	363	PF00069	0.212
MOD_GSK3_1	367	374	PF00069	0.454
MOD_GSK3_1	401	408	PF00069	0.356
MOD_GSK3_1	464	471	PF00069	0.208
MOD_GSK3_1	508	515	PF00069	0.391
MOD_GSK3_1	539	546	PF00069	0.344
MOD_GSK3_1	572	579	PF00069	0.387
MOD_GSK3_1	598	605	PF00069	0.434
MOD_GSK3_1	618	625	PF00069	0.450
MOD_GSK3_1	644	651	PF00069	0.196
MOD_GSK3_1	685	692	PF00069	0.695
MOD_GSK3_1	706	713	PF00069	0.400
MOD_N-GLC_1	2	7	PF02516	0.601
MOD_N-GLC_1	344	349	PF02516	0.477
MOD_N-GLC_1	367	372	PF02516	0.590
MOD_N-GLC_1	648	653	PF02516	0.502
MOD_NEK2_1	1	6	PF00069	0.411
MOD_NEK2_1	110	115	PF00069	0.278
MOD_NEK2_1	121	126	PF00069	0.243
MOD_NEK2_1	185	190	PF00069	0.485
MOD_NEK2_1	212	217	PF00069	0.598
MOD_NEK2_1	233	238	PF00069	0.424
MOD_NEK2_1	283	288	PF00069	0.283
MOD_NEK2_1	291	296	PF00069	0.313
MOD_NEK2_1	304	309	PF00069	0.237
MOD_NEK2_1	341	346	PF00069	0.398
MOD_NEK2_1	360	365	PF00069	0.259
MOD_NEK2_1	37	42	PF00069	0.215
MOD_NEK2_1	382	387	PF00069	0.458
MOD_NEK2_1	483	488	PF00069	0.298
MOD_NEK2_1	508	513	PF00069	0.389
MOD_NEK2_1	65	70	PF00069	0.316
MOD_NEK2_1	653	658	PF00069	0.413
MOD_NEK2_1	660	665	PF00069	0.336
MOD_NEK2_1	668	673	PF00069	0.449
MOD_NEK2_2	208	213	PF00069	0.395
MOD_NEK2_2	550	555	PF00069	0.319
MOD_PIKK_1	113	119	PF00454	0.310
MOD_PIKK_1	174	180	PF00454	0.509
MOD_PIKK_1	291	297	PF00454	0.309
MOD_PIKK_1	401	407	PF00454	0.453
MOD_PIKK_1	519	525	PF00454	0.389
MOD_PIKK_1	539	545	PF00454	0.162
MOD_PIKK_1	618	624	PF00454	0.412
MOD_PIKK_1	98	104	PF00454	0.350
MOD_PK_1	213	219	PF00069	0.397
MOD_PKA_1	371	377	PF00069	0.394
MOD_PKA_1	458	464	PF00069	0.281
MOD_PKA_1	86	92	PF00069	0.315
MOD_PKA_2	157	163	PF00069	0.551
MOD_PKA_2	174	180	PF00069	0.531
MOD_PKA_2	212	218	PF00069	0.580
MOD_PKA_2	234	240	PF00069	0.541
MOD_Plk_1	105	111	PF00069	0.309
MOD_Plk_1	233	239	PF00069	0.542
MOD_Plk_1	356	362	PF00069	0.264
MOD_Plk_1	415	421	PF00069	0.357
MOD_Plk_1	445	451	PF00069	0.193
MOD_Plk_1	550	556	PF00069	0.389
MOD_Plk_1	648	654	PF00069	0.502
MOD_Plk_2-3	200	206	PF00069	0.515
MOD_Plk_4	117	123	PF00069	0.283
MOD_Plk_4	484	490	PF00069	0.306
MOD_Plk_4	648	654	PF00069	0.503
MOD_Plk_4	65	71	PF00069	0.341
MOD_Plk_4	660	666	PF00069	0.431
MOD_Plk_4	86	92	PF00069	0.289
MOD_ProDKin_1	299	305	PF00069	0.309
MOD_ProDKin_1	3	9	PF00069	0.439
MOD_ProDKin_1	423	429	PF00069	0.435
MOD_ProDKin_1	510	516	PF00069	0.196
MOD_ProDKin_1	56	62	PF00069	0.349
MOD_ProDKin_1	670	676	PF00069	0.552
MOD_ProDKin_1	686	692	PF00069	0.629
MOD_SUMO_rev_2	139	146	PF00179	0.384
MOD_SUMO_rev_2	2	11	PF00179	0.413
MOD_SUMO_rev_2	306	314	PF00179	0.285
MOD_SUMO_rev_2	317	326	PF00179	0.253
MOD_SUMO_rev_2	387	395	PF00179	0.473
MOD_SUMO_rev_2	452	461	PF00179	0.306
MOD_SUMO_rev_2	79	89	PF00179	0.309
TRG_DiLeu_BaEn_2	70	76	PF01217	0.196
TRG_DiLeu_BaEn_3	71	77	PF01217	0.309
TRG_DiLeu_BaLyEn_6	632	637	PF01217	0.392
TRG_ENDOCYTIC_2	119	122	PF00928	0.309
TRG_ENDOCYTIC_2	332	335	PF00928	0.309
TRG_ENDOCYTIC_2	497	500	PF00928	0.312
TRG_ENDOCYTIC_2	505	508	PF00928	0.250
TRG_ENDOCYTIC_2	559	562	PF00928	0.345
TRG_ENDOCYTIC_2	585	588	PF00928	0.302
TRG_ENDOCYTIC_2	633	636	PF00928	0.473
TRG_ER_diArg_1	260	262	PF00400	0.309
TRG_ER_diArg_1	31	33	PF00400	0.199
TRG_ER_diArg_1	46	48	PF00400	0.182
TRG_NES_CRM1_1	72	85	PF08389	0.196
TRG_Pf-PMV_PEXEL_1	138	143	PF00026	0.546

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0NSV7	Trypanosomatidae	40%	100%
A0A3R7LZ26	Trypanosoma rangeli	38%	100%
A0A3S7WUF7	Leishmania donovani	81%	100%
A4HXE3	Leishmania infantum	81%	100%
E9AR38	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
Q4QEC5	Leishmania major	79%	100%
V5B9G2	Trypanosoma cruzi	39%	99%