AB hydrolase-1 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Alpha/beta hydrolase family, putative

Species:

Leishmania braziliensis

UniProt:

A4H908_LEIBR

TriTrypDb:

LbrM.17.0640 , LBRM2903_170012700

Length:

344

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H908

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H908

PDB structure(s): 7aih_Ak , 7ane_Ak

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0016787	hydrolase activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	261	263	PF00675	0.419
CLV_NRD_NRD_1	303	305	PF00675	0.484
CLV_PCSK_KEX2_1	261	263	PF00082	0.419
CLV_PCSK_KEX2_1	302	304	PF00082	0.416
CLV_PCSK_PC1ET2_1	302	304	PF00082	0.425
CLV_PCSK_SKI1_1	255	259	PF00082	0.386
CLV_PCSK_SKI1_1	307	311	PF00082	0.479
CLV_PCSK_SKI1_1	329	333	PF00082	0.499
DEG_Nend_Nbox_1	1	3	PF02207	0.302
DEG_SCF_FBW7_1	142	149	PF00400	0.331
DOC_CKS1_1	143	148	PF01111	0.324
DOC_CYCLIN_yCln2_LP_2	191	197	PF00134	0.466
DOC_MAPK_gen_1	164	171	PF00069	0.564
DOC_MAPK_MEF2A_6	294	301	PF00069	0.453
DOC_PP2B_LxvP_1	240	243	PF13499	0.322
DOC_USP7_MATH_1	197	201	PF00917	0.407
DOC_USP7_MATH_1	331	335	PF00917	0.627
DOC_USP7_UBL2_3	332	336	PF12436	0.577
DOC_USP7_UBL2_3	337	341	PF12436	0.568
DOC_WW_Pin1_4	142	147	PF00397	0.322
LIG_14-3-3_CanoR_1	126	134	PF00244	0.463
LIG_14-3-3_CanoR_1	18	22	PF00244	0.435
LIG_14-3-3_CanoR_1	46	55	PF00244	0.341
LIG_APCC_ABBA_1	251	256	PF00400	0.453
LIG_BIR_III_4	14	18	PF00653	0.335
LIG_Clathr_ClatBox_1	140	144	PF01394	0.365
LIG_Clathr_ClatBox_1	37	41	PF01394	0.320
LIG_DLG_GKlike_1	136	143	PF00625	0.453
LIG_EH1_1	134	142	PF00400	0.417
LIG_FHA_1	143	149	PF00498	0.317
LIG_FHA_1	21	27	PF00498	0.454
LIG_FHA_1	50	56	PF00498	0.486
LIG_FHA_2	247	253	PF00498	0.356
LIG_HCF-1_HBM_1	222	225	PF13415	0.515
LIG_HP1_1	36	40	PF01393	0.389
LIG_Integrin_isoDGR_2	327	329	PF01839	0.493
LIG_LIR_Gen_1	108	119	PF02991	0.351
LIG_LIR_Gen_1	62	73	PF02991	0.393
LIG_LIR_Nem_3	108	114	PF02991	0.354
LIG_LIR_Nem_3	118	122	PF02991	0.300
LIG_LIR_Nem_3	222	228	PF02991	0.365
LIG_LIR_Nem_3	256	260	PF02991	0.379
LIG_LIR_Nem_3	75	79	PF02991	0.260
LIG_Pex14_1	291	295	PF04695	0.344
LIG_REV1ctd_RIR_1	255	266	PF16727	0.389
LIG_SH2_CRK	119	123	PF00017	0.313
LIG_SH2_CRK	76	80	PF00017	0.235
LIG_SH2_PTP2	225	228	PF00017	0.367
LIG_SH2_PTP2	80	83	PF00017	0.297
LIG_SH2_SRC	202	205	PF00017	0.440
LIG_SH2_SRC	225	228	PF00017	0.386
LIG_SH2_STAP1	202	206	PF00017	0.408
LIG_SH2_STAP1	65	69	PF00017	0.391
LIG_SH2_STAT3	28	31	PF00017	0.327
LIG_SH2_STAT5	225	228	PF00017	0.351
LIG_SH2_STAT5	80	83	PF00017	0.297
LIG_SH3_3	166	172	PF00018	0.432
LIG_SH3_3	231	237	PF00018	0.412
LIG_SH3_3	76	82	PF00018	0.321
LIG_SUMO_SIM_anti_2	139	145	PF11976	0.399
LIG_SUMO_SIM_par_1	139	145	PF11976	0.401
LIG_SUMO_SIM_par_1	35	41	PF11976	0.312
LIG_SUMO_SIM_par_1	81	86	PF11976	0.415
LIG_TRAF2_1	57	60	PF00917	0.459
LIG_UBA3_1	240	245	PF00899	0.277
LIG_WRC_WIRS_1	1	6	PF05994	0.297
LIG_WRPW_2	4	7	PF00400	0.300
MOD_CK1_1	20	26	PF00069	0.299
MOD_CK1_1	208	214	PF00069	0.564
MOD_CK2_1	197	203	PF00069	0.469
MOD_CK2_1	246	252	PF00069	0.294
MOD_CK2_1	318	324	PF00069	0.614
MOD_CK2_1	83	89	PF00069	0.503
MOD_GlcNHglycan	208	211	PF01048	0.431
MOD_GlcNHglycan	276	279	PF01048	0.445
MOD_GlcNHglycan	49	52	PF01048	0.534
MOD_GSK3_1	142	149	PF00069	0.322
MOD_GSK3_1	16	23	PF00069	0.435
MOD_NEK2_1	115	120	PF00069	0.297
MOD_NEK2_1	127	132	PF00069	0.345
MOD_NEK2_1	187	192	PF00069	0.477
MOD_NEK2_1	206	211	PF00069	0.495
MOD_NEK2_1	40	45	PF00069	0.342
MOD_NEK2_1	47	52	PF00069	0.449
MOD_NEK2_1	68	73	PF00069	0.466
MOD_NEK2_1	83	88	PF00069	0.445
MOD_NEK2_1	93	98	PF00069	0.336
MOD_NEK2_2	179	184	PF00069	0.507
MOD_NEK2_2	197	202	PF00069	0.217
MOD_PKA_2	153	159	PF00069	0.520
MOD_PKA_2	17	23	PF00069	0.438
MOD_Plk_1	174	180	PF00069	0.443
MOD_Plk_1	187	193	PF00069	0.409
MOD_Plk_1	197	203	PF00069	0.371
MOD_Plk_1	40	46	PF00069	0.484
MOD_Plk_2-3	318	324	PF00069	0.426
MOD_Plk_4	136	142	PF00069	0.328
MOD_Plk_4	197	203	PF00069	0.449
MOD_Plk_4	208	214	PF00069	0.390
MOD_Plk_4	21	27	PF00069	0.405
MOD_ProDKin_1	142	148	PF00069	0.323
MOD_SUMO_rev_2	334	342	PF00179	0.642
TRG_DiLeu_BaEn_1	311	316	PF01217	0.432
TRG_DiLeu_BaLyEn_6	79	84	PF01217	0.455
TRG_ENDOCYTIC_2	119	122	PF00928	0.313
TRG_ENDOCYTIC_2	225	228	PF00928	0.351
TRG_ENDOCYTIC_2	65	68	PF00928	0.371
TRG_ENDOCYTIC_2	76	79	PF00928	0.362
TRG_ENDOCYTIC_2	80	83	PF00928	0.381
TRG_ER_diArg_1	260	262	PF00400	0.413
TRG_ER_diArg_1	303	305	PF00400	0.486
TRG_ER_diLys_1	339	344	PF00400	0.609
TRG_NLS_MonoExtN_4	337	344	PF00514	0.731
TRG_Pf-PMV_PEXEL_1	199	203	PF00026	0.446
TRG_Pf-PMV_PEXEL_1	229	233	PF00026	0.477

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBS7	Leptomonas seymouri	74%	83%
A0A0S4J8H7	Bodo saltans	39%	82%
A0A1X0NUK7	Trypanosomatidae	52%	86%
A0A3S7WUH0	Leishmania donovani	87%	100%
A0A422N4J3	Trypanosoma rangeli	50%	91%
A4HXE0	Leishmania infantum	87%	100%
C9ZU35	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	91%
E9AR35	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4QEC8	Leishmania major	87%	100%
V5API2	Trypanosoma cruzi	50%	91%