Str_synth domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4H906_LEIBR

TriTrypDb:

LbrM.17.0620 , LBRM2903_170012400

Length:

418

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H906

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H906

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0016491	oxidoreductase activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	11	15	PF00656	0.292
CLV_C14_Caspase3-7	72	76	PF00656	0.470
CLV_NRD_NRD_1	234	236	PF00675	0.554
CLV_PCSK_KEX2_1	233	235	PF00082	0.520
CLV_PCSK_PC1ET2_1	233	235	PF00082	0.407
CLV_PCSK_SKI1_1	28	32	PF00082	0.428
CLV_PCSK_SKI1_1	377	381	PF00082	0.392
DEG_APCC_DBOX_1	233	241	PF00400	0.559
DEG_APCC_KENBOX_2	274	278	PF00400	0.311
DOC_CYCLIN_yCln2_LP_2	226	232	PF00134	0.412
DOC_CYCLIN_yCln2_LP_2	264	270	PF00134	0.380
DOC_MAPK_DCC_7	156	166	PF00069	0.293
DOC_MAPK_gen_1	156	163	PF00069	0.299
DOC_MAPK_gen_1	194	203	PF00069	0.386
DOC_MAPK_MEF2A_6	158	166	PF00069	0.282
DOC_MAPK_MEF2A_6	194	203	PF00069	0.386
DOC_PP2B_LxvP_1	226	229	PF13499	0.396
DOC_PP4_FxxP_1	116	119	PF00568	0.556
DOC_PP4_FxxP_1	320	323	PF00568	0.272
DOC_SPAK_OSR1_1	196	200	PF12202	0.382
DOC_USP7_MATH_1	132	136	PF00917	0.279
DOC_USP7_MATH_1	243	247	PF00917	0.584
DOC_USP7_UBL2_3	152	156	PF12436	0.294
DOC_USP7_UBL2_3	215	219	PF12436	0.432
DOC_USP7_UBL2_3	394	398	PF12436	0.504
DOC_WW_Pin1_4	181	186	PF00397	0.412
DOC_WW_Pin1_4	409	414	PF00397	0.472
LIG_14-3-3_CanoR_1	111	117	PF00244	0.436
LIG_14-3-3_CanoR_1	296	302	PF00244	0.436
LIG_APCC_ABBA_1	6	11	PF00400	0.363
LIG_BIR_II_1	1	5	PF00653	0.444
LIG_BIR_III_4	81	85	PF00653	0.432
LIG_BRCT_BRCA1_1	138	142	PF00533	0.262
LIG_Clathr_ClatBox_1	163	167	PF01394	0.283
LIG_deltaCOP1_diTrp_1	78	85	PF00928	0.452
LIG_FHA_1	155	161	PF00498	0.416
LIG_FHA_1	253	259	PF00498	0.333
LIG_FHA_1	263	269	PF00498	0.266
LIG_FHA_1	31	37	PF00498	0.383
LIG_FHA_1	365	371	PF00498	0.429
LIG_FHA_2	257	263	PF00498	0.427
LIG_Integrin_RGD_1	21	23	PF01839	0.440
LIG_Integrin_RGD_1	284	286	PF01839	0.436
LIG_LIR_Apic_2	115	119	PF02991	0.545
LIG_LIR_Apic_2	179	185	PF02991	0.420
LIG_MLH1_MIPbox_1	138	142	PF16413	0.262
LIG_Pex14_2	316	320	PF04695	0.283
LIG_PTB_Apo_2	205	212	PF02174	0.275
LIG_REV1ctd_RIR_1	139	149	PF16727	0.374
LIG_REV1ctd_RIR_1	209	216	PF16727	0.382
LIG_SH2_CRK	182	186	PF00017	0.422
LIG_SH2_CRK	349	353	PF00017	0.357
LIG_SH2_STAT5	278	281	PF00017	0.406
LIG_SH2_STAT5	351	354	PF00017	0.461
LIG_SH2_STAT5	408	411	PF00017	0.485
LIG_SH3_1	182	188	PF00018	0.414
LIG_SH3_3	100	106	PF00018	0.320
LIG_SH3_3	182	188	PF00018	0.414
LIG_SH3_3	248	254	PF00018	0.483
LIG_SH3_3	84	90	PF00018	0.394
LIG_SUMO_SIM_anti_2	255	262	PF11976	0.430
LIG_SUMO_SIM_anti_2	265	274	PF11976	0.313
LIG_SUMO_SIM_anti_2	96	102	PF11976	0.317
LIG_SUMO_SIM_par_1	162	168	PF11976	0.291
LIG_SUMO_SIM_par_1	255	262	PF11976	0.430
LIG_TRAF2_1	177	180	PF00917	0.513
LIG_TRAF2_1	390	393	PF00917	0.444
LIG_UBA3_1	124	129	PF00899	0.330
LIG_WRC_WIRS_1	113	118	PF05994	0.433
MOD_CDK_SPxK_1	411	417	PF00069	0.465
MOD_CK1_1	112	118	PF00069	0.431
MOD_CK1_1	165	171	PF00069	0.295
MOD_CK1_1	218	224	PF00069	0.325
MOD_CK2_1	174	180	PF00069	0.499
MOD_CK2_1	181	187	PF00069	0.478
MOD_CK2_1	243	249	PF00069	0.568
MOD_CK2_1	93	99	PF00069	0.313
MOD_Cter_Amidation	25	28	PF01082	0.337
MOD_GlcNHglycan	23	27	PF01048	0.440
MOD_GlcNHglycan	245	248	PF01048	0.580
MOD_GlcNHglycan	44	48	PF01048	0.412
MOD_GlcNHglycan	95	98	PF01048	0.309
MOD_GSK3_1	132	139	PF00069	0.279
MOD_GSK3_1	22	29	PF00069	0.447
MOD_GSK3_1	252	259	PF00069	0.365
MOD_GSK3_1	392	399	PF00069	0.495
MOD_GSK3_1	43	50	PF00069	0.305
MOD_N-GLC_1	48	53	PF02516	0.318
MOD_N-GLC_1	93	98	PF02516	0.311
MOD_NEK2_1	109	114	PF00069	0.475
MOD_NEK2_1	124	129	PF00069	0.349
MOD_NEK2_1	279	284	PF00069	0.284
MOD_NEK2_1	30	35	PF00069	0.314
MOD_NEK2_1	342	347	PF00069	0.345
MOD_NEK2_1	43	48	PF00069	0.314
MOD_NEK2_2	26	31	PF00069	0.419
MOD_Plk_1	13	19	PF00069	0.404
MOD_Plk_1	43	49	PF00069	0.415
MOD_Plk_1	93	99	PF00069	0.313
MOD_Plk_2-3	187	193	PF00069	0.386
MOD_Plk_2-3	392	398	PF00069	0.495
MOD_Plk_4	136	142	PF00069	0.269
MOD_Plk_4	236	242	PF00069	0.474
MOD_Plk_4	253	259	PF00069	0.427
MOD_Plk_4	26	32	PF00069	0.436
MOD_ProDKin_1	181	187	PF00069	0.411
MOD_ProDKin_1	409	415	PF00069	0.468
MOD_SUMO_rev_2	391	399	PF00179	0.489
MOD_SUMO_rev_2	96	106	PF00179	0.318
TRG_DiLeu_BaEn_1	205	210	PF01217	0.282
TRG_DiLeu_BaEn_1	266	271	PF01217	0.377
TRG_DiLeu_BaEn_2	311	317	PF01217	0.310
TRG_DiLeu_BaLyEn_6	120	125	PF01217	0.413
TRG_DiLeu_LyEn_5	159	164	PF01217	0.400
TRG_ENDOCYTIC_2	349	352	PF00928	0.379
TRG_ER_diArg_1	386	389	PF00400	0.320

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8ICT3	Leishmania donovani	76%	100%
A0A3Q8IJF2	Leishmania donovani	76%	100%
A4HXD7	Leishmania infantum	76%	100%
E9AR32	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	100%
Q4QED1	Leishmania major	75%	100%