ACB domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Acyl CoA binding protein, putative

Species:

Leishmania braziliensis

UniProt:

A4H904_LEIBR

TriTrypDb:

LbrM.17.0600 , LBRM2903_170012200

Length:

491

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H904

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H904

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	1
GO:0006629	lipid metabolic process	3	1
GO:0006631	fatty acid metabolic process	4	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0019752	carboxylic acid metabolic process	5	1
GO:0032787	monocarboxylic acid metabolic process	6	1
GO:0043436	oxoacid metabolic process	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044255	cellular lipid metabolic process	3	1
GO:0044281	small molecule metabolic process	2	1
GO:0071704	organic substance metabolic process	2	1

Molecular functions
Term	Name	Level	Count
GO:0000062	fatty-acyl-CoA binding	4	7
GO:0000166	nucleotide binding	3	7
GO:0005488	binding	1	7
GO:0008289	lipid binding	2	7
GO:0017076	purine nucleotide binding	4	7
GO:0030554	adenyl nucleotide binding	5	7
GO:0032553	ribonucleotide binding	3	7
GO:0032555	purine ribonucleotide binding	4	7
GO:0032559	adenyl ribonucleotide binding	5	7
GO:0033218	amide binding	2	7
GO:0036094	small molecule binding	2	7
GO:0097159	organic cyclic compound binding	2	7
GO:0097367	carbohydrate derivative binding	2	7
GO:0120227	acyl-CoA binding	3	7
GO:1901265	nucleoside phosphate binding	3	7
GO:1901363	heterocyclic compound binding	2	7
GO:1901567	fatty acid derivative binding	3	7
GO:1901681	sulfur compound binding	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	101	103	PF00675	0.411
CLV_NRD_NRD_1	124	126	PF00675	0.543
CLV_NRD_NRD_1	327	329	PF00675	0.732
CLV_NRD_NRD_1	335	337	PF00675	0.527
CLV_NRD_NRD_1	47	49	PF00675	0.513
CLV_NRD_NRD_1	8	10	PF00675	0.573
CLV_PCSK_FUR_1	327	331	PF00082	0.744
CLV_PCSK_FUR_1	480	484	PF00082	0.586
CLV_PCSK_KEX2_1	227	229	PF00082	0.411
CLV_PCSK_KEX2_1	268	270	PF00082	0.755
CLV_PCSK_KEX2_1	327	329	PF00082	0.640
CLV_PCSK_KEX2_1	482	484	PF00082	0.714
CLV_PCSK_KEX2_1	8	10	PF00082	0.578
CLV_PCSK_PC1ET2_1	227	229	PF00082	0.411
CLV_PCSK_PC1ET2_1	268	270	PF00082	0.755
CLV_PCSK_PC1ET2_1	329	331	PF00082	0.652
CLV_PCSK_PC1ET2_1	482	484	PF00082	0.706
CLV_PCSK_PC7_1	4	10	PF00082	0.478
CLV_PCSK_SKI1_1	105	109	PF00082	0.513
CLV_PCSK_SKI1_1	201	205	PF00082	0.298
CLV_PCSK_SKI1_1	232	236	PF00082	0.518
CLV_PCSK_SKI1_1	264	268	PF00082	0.667
CLV_PCSK_SKI1_1	465	469	PF00082	0.672
CLV_PCSK_SKI1_1	71	75	PF00082	0.387
CLV_PCSK_SKI1_1	8	12	PF00082	0.486
CLV_PCSK_SKI1_1	81	85	PF00082	0.327
DEG_APCC_KENBOX_2	486	490	PF00400	0.584
DEG_Nend_Nbox_1	1	3	PF02207	0.735
DEG_SPOP_SBC_1	361	365	PF00917	0.591
DOC_CKS1_1	185	190	PF01111	0.513
DOC_CYCLIN_yCln2_LP_2	441	447	PF00134	0.588
DOC_MAPK_gen_1	111	119	PF00069	0.377
DOC_MAPK_gen_1	8	16	PF00069	0.492
DOC_MAPK_MEF2A_6	115	124	PF00069	0.385
DOC_MAPK_MEF2A_6	8	16	PF00069	0.492
DOC_PP1_RVXF_1	61	67	PF00149	0.411
DOC_PP2B_LxvP_1	441	444	PF13499	0.583
DOC_PP4_FxxP_1	29	32	PF00568	0.604
DOC_USP7_MATH_1	321	325	PF00917	0.588
DOC_USP7_MATH_1	341	345	PF00917	0.705
DOC_USP7_MATH_1	359	363	PF00917	0.693
DOC_USP7_MATH_1	424	428	PF00917	0.598
DOC_USP7_MATH_1	471	475	PF00917	0.668
DOC_USP7_UBL2_3	11	15	PF12436	0.498
DOC_USP7_UBL2_3	232	236	PF12436	0.620
DOC_USP7_UBL2_3	264	268	PF12436	0.769
DOC_USP7_UBL2_3	448	452	PF12436	0.595
DOC_USP7_UBL2_3	478	482	PF12436	0.690
DOC_WW_Pin1_4	184	189	PF00397	0.513
DOC_WW_Pin1_4	219	224	PF00397	0.261
DOC_WW_Pin1_4	417	422	PF00397	0.594
LIG_14-3-3_CanoR_1	125	131	PF00244	0.685
LIG_14-3-3_CanoR_1	303	307	PF00244	0.644
LIG_CtBP_PxDLS_1	162	166	PF00389	0.261
LIG_deltaCOP1_diTrp_1	138	144	PF00928	0.537
LIG_deltaCOP1_diTrp_1	91	96	PF00928	0.411
LIG_FHA_1	418	424	PF00498	0.593
LIG_FHA_2	368	374	PF00498	0.854
LIG_FHA_2	385	391	PF00498	0.703
LIG_FHA_2	459	465	PF00498	0.625
LIG_FHA_2	72	78	PF00498	0.411
LIG_LIR_Apic_2	129	135	PF02991	0.690
LIG_LIR_Apic_2	28	32	PF02991	0.605
LIG_LIR_Gen_1	114	124	PF02991	0.411
LIG_LIR_Gen_1	138	148	PF02991	0.411
LIG_LIR_Gen_1	213	223	PF02991	0.411
LIG_LIR_Gen_1	389	397	PF02991	0.757
LIG_LIR_Nem_3	114	119	PF02991	0.411
LIG_LIR_Nem_3	138	144	PF02991	0.537
LIG_LIR_Nem_3	192	198	PF02991	0.418
LIG_LIR_Nem_3	213	218	PF02991	0.411
LIG_LIR_Nem_3	389	394	PF02991	0.754
LIG_LIR_Nem_3	91	95	PF02991	0.411
LIG_PCNA_yPIPBox_3	232	244	PF02747	0.558
LIG_Pex14_2	2	6	PF04695	0.539
LIG_Pex14_2	66	70	PF04695	0.513
LIG_REV1ctd_RIR_1	3	11	PF16727	0.632
LIG_SH2_NCK_1	36	40	PF00017	0.513
LIG_SH2_PTP2	116	119	PF00017	0.383
LIG_SH2_STAP1	212	216	PF00017	0.411
LIG_SH2_STAP1	36	40	PF00017	0.513
LIG_SH2_STAT5	116	119	PF00017	0.411
LIG_SH2_STAT5	230	233	PF00017	0.411
LIG_SH2_STAT5	243	246	PF00017	0.581
LIG_SH2_STAT5	46	49	PF00017	0.411
LIG_SH3_1	448	454	PF00018	0.591
LIG_SH3_3	241	247	PF00018	0.567
LIG_SH3_3	29	35	PF00018	0.520
LIG_SH3_3	448	454	PF00018	0.591
LIG_SH3_3	80	86	PF00018	0.408
LIG_SH3_4	11	18	PF00018	0.495
LIG_SUMO_SIM_anti_2	250	259	PF11976	0.505
LIG_TRAF2_1	286	289	PF00917	0.714
LIG_TRAF2_1	364	367	PF00917	0.597
LIG_UBA3_1	119	126	PF00899	0.506
LIG_UBA3_1	150	156	PF00899	0.472
LIG_WRC_WIRS_1	306	311	PF05994	0.712
MOD_CDC14_SPxK_1	222	225	PF00782	0.261
MOD_CDK_SPxK_1	219	225	PF00069	0.261
MOD_CDK_SPxxK_3	184	191	PF00069	0.261
MOD_CK1_1	262	268	PF00069	0.746
MOD_CK1_1	362	368	PF00069	0.709
MOD_CK1_1	384	390	PF00069	0.618
MOD_CK1_1	393	399	PF00069	0.569
MOD_CK2_1	283	289	PF00069	0.719
MOD_CK2_1	296	302	PF00069	0.489
MOD_CK2_1	360	366	PF00069	0.809
MOD_CK2_1	458	464	PF00069	0.754
MOD_Cter_Amidation	6	9	PF01082	0.727
MOD_GlcNHglycan	191	194	PF01048	0.261
MOD_GlcNHglycan	261	264	PF01048	0.658
MOD_GlcNHglycan	323	326	PF01048	0.503
MOD_GlcNHglycan	353	356	PF01048	0.595
MOD_GlcNHglycan	417	420	PF01048	0.759
MOD_GlcNHglycan	426	429	PF01048	0.700
MOD_GSK3_1	258	265	PF00069	0.671
MOD_GSK3_1	283	290	PF00069	0.594
MOD_GSK3_1	347	354	PF00069	0.705
MOD_GSK3_1	386	393	PF00069	0.556
MOD_GSK3_1	422	429	PF00069	0.592
MOD_N-GLC_1	291	296	PF02516	0.480
MOD_PIKK_1	381	387	PF00454	0.580
MOD_PKA_2	302	308	PF00069	0.594
MOD_Plk_1	287	293	PF00069	0.520
MOD_Plk_1	378	384	PF00069	0.630
MOD_Plk_2-3	367	373	PF00069	0.606
MOD_Plk_4	126	132	PF00069	0.588
MOD_Plk_4	19	25	PF00069	0.601
MOD_Plk_4	296	302	PF00069	0.724
MOD_Plk_4	305	311	PF00069	0.623
MOD_Plk_4	65	71	PF00069	0.390
MOD_Plk_4	84	90	PF00069	0.411
MOD_ProDKin_1	184	190	PF00069	0.513
MOD_ProDKin_1	219	225	PF00069	0.261
MOD_ProDKin_1	417	423	PF00069	0.595
MOD_SUMO_for_1	10	13	PF00179	0.492
MOD_SUMO_for_1	310	313	PF00179	0.467
MOD_SUMO_for_1	374	377	PF00179	0.609
MOD_SUMO_for_1	439	442	PF00179	0.706
MOD_SUMO_rev_2	308	316	PF00179	0.467
MOD_SUMO_rev_2	367	376	PF00179	0.603
MOD_SUMO_rev_2	442	450	PF00179	0.663
MOD_SUMO_rev_2	77	86	PF00179	0.406
TRG_DiLeu_BaLyEn_6	451	456	PF01217	0.592
TRG_ENDOCYTIC_2	116	119	PF00928	0.411
TRG_ENDOCYTIC_2	195	198	PF00928	0.411
TRG_ENDOCYTIC_2	67	70	PF00928	0.472
TRG_ENDOCYTIC_2	95	98	PF00928	0.513
TRG_ER_diArg_1	198	201	PF00400	0.393
TRG_ER_diArg_1	327	330	PF00400	0.493
TRG_NLS_MonoExtN_4	264	271	PF00514	0.491
TRG_Pf-PMV_PEXEL_1	48	53	PF00026	0.290

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5F7	Leptomonas seymouri	47%	100%
A0A3Q8IDY9	Leishmania donovani	69%	98%
A4HXD5	Leishmania infantum	69%	98%
E9AR30	Leishmania mexicana (strain MHOM/GT/2001/U1103)	67%	99%
Q4QED3	Leishmania major	70%	100%