Bis(5'-nucleosyl)-tetraphosphatase,symmetrical-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

bis(5'-nucleosyl)-tetraphosphatase, symmetrical-like protein

Species:

Leishmania braziliensis

UniProt:

A4H901_LEIBR

TriTrypDb:

LbrM.17.0570 , LBRM2903_170011800

Length:

312

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H901

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H901

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	1
GO:0006793	phosphorus metabolic process	3	1
GO:0006797	polyphosphate metabolic process	4	1
GO:0006798	polyphosphate catabolic process	4	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009987	cellular process	1	1
GO:0043436	oxoacid metabolic process	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044248	cellular catabolic process	3	1
GO:0044281	small molecule metabolic process	2	1
GO:0071704	organic substance metabolic process	2	1

Molecular functions
Term	Name	Level	Count
GO:0000298	endopolyphosphatase activity	6	1
GO:0003824	catalytic activity	1	4
GO:0016462	pyrophosphatase activity	5	1
GO:0016787	hydrolase activity	2	4
GO:0016788	hydrolase activity, acting on ester bonds	3	1
GO:0016791	phosphatase activity	5	1
GO:0016817	hydrolase activity, acting on acid anhydrides	3	1
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	1
GO:0042578	phosphoric ester hydrolase activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	203	207	PF00656	0.592
CLV_NRD_NRD_1	244	246	PF00675	0.513
CLV_NRD_NRD_1	265	267	PF00675	0.302
CLV_PCSK_KEX2_1	246	248	PF00082	0.639
CLV_PCSK_KEX2_1	264	266	PF00082	0.279
CLV_PCSK_PC1ET2_1	246	248	PF00082	0.562
CLV_PCSK_PC1ET2_1	264	266	PF00082	0.370
CLV_PCSK_SKI1_1	197	201	PF00082	0.542
DEG_Nend_UBRbox_4	1	3	PF02207	0.440
DEG_SCF_TRCP1_1	206	212	PF00400	0.524
DOC_MAPK_gen_1	47	57	PF00069	0.328
DOC_MAPK_gen_1	71	80	PF00069	0.453
DOC_MAPK_HePTP_8	68	80	PF00069	0.288
DOC_MAPK_MEF2A_6	161	168	PF00069	0.341
DOC_MAPK_MEF2A_6	71	80	PF00069	0.299
DOC_USP7_UBL2_3	190	194	PF12436	0.512
DOC_USP7_UBL2_3	232	236	PF12436	0.632
DOC_WW_Pin1_4	15	20	PF00397	0.594
DOC_WW_Pin1_4	302	307	PF00397	0.575
LIG_Actin_WH2_2	51	69	PF00022	0.239
LIG_APCC_ABBAyCdc20_2	245	251	PF00400	0.514
LIG_BRCT_BRCA1_1	168	172	PF00533	0.465
LIG_FHA_1	285	291	PF00498	0.352
LIG_FHA_2	16	22	PF00498	0.470
LIG_FHA_2	198	204	PF00498	0.479
LIG_FHA_2	77	83	PF00498	0.376
LIG_LIR_Gen_1	169	180	PF02991	0.464
LIG_LIR_Gen_1	185	195	PF02991	0.429
LIG_LIR_Gen_1	96	106	PF02991	0.336
LIG_LIR_Nem_3	185	191	PF02991	0.489
LIG_LIR_Nem_3	251	255	PF02991	0.403
LIG_LIR_Nem_3	41	46	PF02991	0.328
LIG_PDZ_Class_1	307	312	PF00595	0.508
LIG_Pex14_2	180	184	PF04695	0.388
LIG_SH2_CRK	114	118	PF00017	0.439
LIG_SH2_CRK	43	47	PF00017	0.332
LIG_SH2_SRC	272	275	PF00017	0.354
LIG_SH3_3	228	234	PF00018	0.519
LIG_SH3_3	293	299	PF00018	0.462
LIG_SUMO_SIM_par_1	75	86	PF11976	0.301
LIG_TRAF2_1	79	82	PF00917	0.326
LIG_UBA3_1	65	71	PF00899	0.328
LIG_WRC_WIRS_1	98	103	PF05994	0.253
MOD_CDK_SPxxK_3	302	309	PF00069	0.512
MOD_CK1_1	15	21	PF00069	0.481
MOD_CK1_1	214	220	PF00069	0.667
MOD_CK2_1	15	21	PF00069	0.464
MOD_CK2_1	150	156	PF00069	0.472
MOD_CK2_1	197	203	PF00069	0.473
MOD_CK2_1	76	82	PF00069	0.419
MOD_GlcNHglycan	14	17	PF01048	0.684
MOD_GlcNHglycan	168	171	PF01048	0.667
MOD_GlcNHglycan	184	187	PF01048	0.383
MOD_GlcNHglycan	206	209	PF01048	0.628
MOD_GlcNHglycan	211	214	PF01048	0.692
MOD_GlcNHglycan	221	224	PF01048	0.694
MOD_GlcNHglycan	277	280	PF01048	0.531
MOD_GSK3_1	10	17	PF00069	0.559
MOD_GSK3_1	180	187	PF00069	0.414
MOD_GSK3_1	193	200	PF00069	0.449
MOD_GSK3_1	211	218	PF00069	0.588
MOD_GSK3_1	290	297	PF00069	0.550
MOD_GSK3_1	76	83	PF00069	0.360
MOD_GSK3_1	97	104	PF00069	0.260
MOD_N-GLC_1	219	224	PF02516	0.519
MOD_NEK2_1	101	106	PF00069	0.424
MOD_NEK2_1	12	17	PF00069	0.540
MOD_NEK2_1	166	171	PF00069	0.616
MOD_NEK2_1	180	185	PF00069	0.411
MOD_PKA_2	150	156	PF00069	0.561
MOD_PKA_2	215	221	PF00069	0.711
MOD_PKA_2	66	72	PF00069	0.279
MOD_Plk_4	291	297	PF00069	0.392
MOD_Plk_4	83	89	PF00069	0.411
MOD_ProDKin_1	15	21	PF00069	0.594
MOD_ProDKin_1	302	308	PF00069	0.575
TRG_DiLeu_BaEn_1	285	290	PF01217	0.339
TRG_ENDOCYTIC_2	114	117	PF00928	0.446
TRG_ENDOCYTIC_2	252	255	PF00928	0.403
TRG_ENDOCYTIC_2	43	46	PF00928	0.326
TRG_ER_diArg_1	244	247	PF00400	0.567
TRG_ER_diArg_1	265	267	PF00400	0.379
TRG_NLS_Bipartite_1	232	249	PF00514	0.496
TRG_NLS_MonoCore_2	231	236	PF00514	0.610
TRG_NLS_MonoExtC_3	231	236	PF00514	0.604
TRG_NLS_MonoExtN_4	243	249	PF00514	0.442

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD44	Leptomonas seymouri	56%	72%
A0A3S7WUL2	Leishmania donovani	71%	98%
A4HXD2	Leishmania infantum	71%	98%
E9AR27	Leishmania mexicana (strain MHOM/GT/2001/U1103)	72%	100%
Q3JBF6	Nitrosococcus oceani (strain ATCC 19707 / BCRC 17464 / JCM 30415 / NCIMB 11848 / C-107)	27%	100%
Q4QED6	Leishmania major	73%	100%