TENA_THI-4 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H8Z9_LEIBR

TriTrypDb:

LbrM.17.0550 , LBRM2903_170011600

Length:

221

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H8Z9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H8Z9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	167	171	PF00656	0.668
CLV_NRD_NRD_1	10	12	PF00675	0.681
CLV_NRD_NRD_1	58	60	PF00675	0.788
CLV_NRD_NRD_1	85	87	PF00675	0.557
CLV_PCSK_KEX2_1	10	12	PF00082	0.681
CLV_PCSK_KEX2_1	58	60	PF00082	0.725
CLV_PCSK_KEX2_1	85	87	PF00082	0.591
CLV_PCSK_SKI1_1	132	136	PF00082	0.661
CLV_PCSK_SKI1_1	215	219	PF00082	0.529
DOC_MAPK_gen_1	58	64	PF00069	0.717
DOC_PP2B_LxvP_1	6	9	PF13499	0.796
DOC_PP2B_LxvP_1	76	79	PF13499	0.537
DOC_USP7_MATH_1	12	16	PF00917	0.659
DOC_USP7_MATH_1	47	51	PF00917	0.768
DOC_USP7_MATH_1	87	91	PF00917	0.701
DOC_WW_Pin1_4	77	82	PF00397	0.695
LIG_14-3-3_CanoR_1	10	20	PF00244	0.767
LIG_14-3-3_CanoR_1	139	148	PF00244	0.639
LIG_14-3-3_CanoR_1	156	164	PF00244	0.716
LIG_14-3-3_CanoR_1	215	220	PF00244	0.528
LIG_14-3-3_CanoR_1	85	95	PF00244	0.705
LIG_Actin_WH2_2	24	40	PF00022	0.747
LIG_Actin_WH2_2	45	60	PF00022	0.599
LIG_BRCT_BRCA1_1	141	145	PF00533	0.638
LIG_deltaCOP1_diTrp_1	190	197	PF00928	0.648
LIG_FHA_1	64	70	PF00498	0.562
LIG_GBD_Chelix_1	140	148	PF00786	0.734
LIG_LIR_Gen_1	122	128	PF02991	0.496
LIG_LIR_Nem_3	122	127	PF02991	0.496
LIG_LIR_Nem_3	142	148	PF02991	0.612
LIG_LIR_Nem_3	170	176	PF02991	0.647
LIG_MYND_3	198	202	PF01753	0.731
LIG_NRBOX	15	21	PF00104	0.661
LIG_PCNA_PIPBox_1	137	146	PF02747	0.749
LIG_PCNA_yPIPBox_3	10	20	PF02747	0.667
LIG_Pex14_1	193	197	PF04695	0.640
LIG_Rb_pABgroove_1	139	147	PF01858	0.641
LIG_SH2_CRK	176	180	PF00017	0.472
LIG_SH2_SRC	183	186	PF00017	0.512
LIG_SH2_STAT5	27	30	PF00017	0.651
LIG_SH3_3	20	26	PF00018	0.650
LIG_TRAF2_1	128	131	PF00917	0.744
LIG_TRAF2_1	165	168	PF00917	0.700
MOD_CK2_1	104	110	PF00069	0.527
MOD_CK2_1	162	168	PF00069	0.706
MOD_CK2_1	86	92	PF00069	0.710
MOD_GlcNHglycan	151	154	PF01048	0.654
MOD_GlcNHglycan	180	183	PF01048	0.746
MOD_GlcNHglycan	2	5	PF01048	0.630
MOD_GlcNHglycan	49	52	PF01048	0.771
MOD_GlcNHglycan	89	92	PF01048	0.722
MOD_NEK2_2	171	176	PF00069	0.739
MOD_PIKK_1	80	86	PF00454	0.814
MOD_ProDKin_1	77	83	PF00069	0.697
MOD_SUMO_rev_2	110	120	PF00179	0.752
MOD_SUMO_rev_2	125	134	PF00179	0.570
TRG_DiLeu_BaEn_4	130	136	PF01217	0.661
TRG_DiLeu_BaLyEn_6	15	20	PF01217	0.532
TRG_ENDOCYTIC_2	124	127	PF00928	0.658
TRG_ENDOCYTIC_2	176	179	PF00928	0.732
TRG_ER_diArg_1	57	59	PF00400	0.779
TRG_ER_diArg_1	9	11	PF00400	0.784
TRG_NES_CRM1_1	146	161	PF08389	0.770
TRG_NES_CRM1_1	196	209	PF08389	0.613
TRG_Pf-PMV_PEXEL_1	18	22	PF00026	0.526

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I6A6	Leptomonas seymouri	64%	79%
A0A3S5H706	Leishmania donovani	82%	100%
A4HXD0	Leishmania infantum	81%	100%
E9AR25	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
Q4QED8	Leishmania major	81%	100%