Putative RNA-binding protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA-binding protein, putative

Species:

Leishmania braziliensis

UniProt:

A4H8Z8_LEIBR

TriTrypDb:

LbrM.17.0540 , LBRM2903_170011500

Length:

303

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H8Z8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H8Z8

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	11
GO:0003723	RNA binding	4	11
GO:0005488	binding	1	11
GO:0097159	organic cyclic compound binding	2	11
GO:1901363	heterocyclic compound binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	147	149	PF00675	0.724
CLV_NRD_NRD_1	97	99	PF00675	0.685
CLV_PCSK_KEX2_1	107	109	PF00082	0.649
CLV_PCSK_KEX2_1	125	127	PF00082	0.592
CLV_PCSK_KEX2_1	132	134	PF00082	0.629
CLV_PCSK_KEX2_1	147	149	PF00082	0.759
CLV_PCSK_KEX2_1	41	43	PF00082	0.521
CLV_PCSK_KEX2_1	97	99	PF00082	0.761
CLV_PCSK_PC1ET2_1	107	109	PF00082	0.635
CLV_PCSK_PC1ET2_1	125	127	PF00082	0.561
CLV_PCSK_PC1ET2_1	132	134	PF00082	0.582
CLV_PCSK_PC1ET2_1	41	43	PF00082	0.521
CLV_PCSK_SKI1_1	42	46	PF00082	0.493
CLV_PCSK_SKI1_1	58	62	PF00082	0.464
DEG_APCC_DBOX_1	251	259	PF00400	0.473
DEG_Nend_UBRbox_2	1	3	PF02207	0.507
DOC_CYCLIN_yClb3_PxF_3	212	218	PF00134	0.589
DOC_MAPK_gen_1	41	49	PF00069	0.432
DOC_MAPK_MEF2A_6	252	261	PF00069	0.536
DOC_MAPK_MEF2A_6	292	301	PF00069	0.469
DOC_MAPK_MEF2A_6	42	51	PF00069	0.416
DOC_PP4_FxxP_1	187	190	PF00568	0.652
DOC_PP4_FxxP_1	261	264	PF00568	0.536
DOC_USP7_MATH_1	30	34	PF00917	0.456
DOC_USP7_MATH_1	86	90	PF00917	0.693
DOC_USP7_UBL2_3	37	41	PF12436	0.515
DOC_WW_Pin1_4	180	185	PF00397	0.544
DOC_WW_Pin1_4	77	82	PF00397	0.656
LIG_14-3-3_CanoR_1	11	18	PF00244	0.512
LIG_FHA_1	288	294	PF00498	0.483
LIG_FHA_1	44	50	PF00498	0.452
LIG_FHA_1	72	78	PF00498	0.727
LIG_FHA_2	19	25	PF00498	0.548
LIG_FHA_2	48	54	PF00498	0.540
LIG_LIR_Apic_2	186	190	PF02991	0.517
LIG_LIR_Gen_1	113	120	PF02991	0.651
LIG_LIR_Gen_1	12	22	PF02991	0.443
LIG_LIR_Gen_1	45	56	PF02991	0.404
LIG_LIR_Nem_3	113	117	PF02991	0.648
LIG_LIR_Nem_3	12	18	PF02991	0.455
LIG_LIR_Nem_3	24	28	PF02991	0.493
LIG_LIR_Nem_3	242	247	PF02991	0.442
LIG_LIR_Nem_3	45	51	PF02991	0.387
LIG_MYND_1	213	217	PF01753	0.676
LIG_PROFILIN_1	205	211	PF00235	0.489
LIG_PTB_Apo_2	224	231	PF02174	0.455
LIG_SH2_CRK	203	207	PF00017	0.460
LIG_SH2_SRC	193	196	PF00017	0.496
LIG_SH2_SRC	203	206	PF00017	0.661
LIG_SH2_STAT3	120	123	PF00017	0.597
LIG_SH3_1	203	209	PF00018	0.484
LIG_SH3_2	209	214	PF14604	0.557
LIG_SH3_3	199	205	PF00018	0.647
LIG_SH3_3	206	212	PF00018	0.537
LIG_SH3_3	288	294	PF00018	0.427
LIG_SH3_CIN85_PxpxPR_1	209	214	PF14604	0.557
LIG_SUMO_SIM_anti_2	254	259	PF11976	0.536
LIG_SUMO_SIM_par_1	281	288	PF11976	0.529
LIG_SUMO_SIM_par_1	74	80	PF11976	0.490
LIG_WRC_WIRS_1	114	119	PF05994	0.534
LIG_WRC_WIRS_1	31	36	PF05994	0.603
LIG_WRC_WIRS_1	48	53	PF05994	0.554
LIG_WW_3	211	215	PF00397	0.578
MOD_CK1_1	116	122	PF00069	0.511
MOD_CK1_1	183	189	PF00069	0.497
MOD_CK1_1	287	293	PF00069	0.425
MOD_CK1_1	9	15	PF00069	0.564
MOD_CK1_1	93	99	PF00069	0.668
MOD_CK2_1	13	19	PF00069	0.570
MOD_CK2_1	30	36	PF00069	0.586
MOD_GlcNHglycan	15	18	PF01048	0.599
MOD_GlcNHglycan	170	173	PF01048	0.612
MOD_GlcNHglycan	176	179	PF01048	0.572
MOD_GlcNHglycan	241	244	PF01048	0.279
MOD_GlcNHglycan	287	290	PF01048	0.418
MOD_GlcNHglycan	88	91	PF01048	0.618
MOD_GSK3_1	102	109	PF00069	0.483
MOD_GSK3_1	127	134	PF00069	0.622
MOD_GSK3_1	43	50	PF00069	0.525
MOD_GSK3_1	5	12	PF00069	0.559
MOD_GSK3_1	71	78	PF00069	0.661
MOD_GSK3_1	86	93	PF00069	0.745
MOD_LATS_1	166	172	PF00433	0.523
MOD_N-GLC_1	274	279	PF02516	0.296
MOD_NEK2_1	230	235	PF00069	0.536
MOD_NEK2_1	274	279	PF00069	0.518
MOD_NEK2_1	5	10	PF00069	0.548
MOD_NEK2_2	30	35	PF00069	0.461
MOD_PKA_1	131	137	PF00069	0.691
MOD_PKA_2	10	16	PF00069	0.510
MOD_PKA_2	167	173	PF00069	0.622
MOD_PKA_2	96	102	PF00069	0.632
MOD_Plk_1	18	24	PF00069	0.496
MOD_Plk_1	42	48	PF00069	0.463
MOD_Plk_1	71	77	PF00069	0.468
MOD_Plk_2-3	113	119	PF00069	0.434
MOD_Plk_4	43	49	PF00069	0.460
MOD_Plk_4	72	78	PF00069	0.482
MOD_ProDKin_1	180	186	PF00069	0.541
MOD_ProDKin_1	77	83	PF00069	0.654
MOD_SUMO_for_1	62	65	PF00179	0.368
TRG_ER_diArg_1	173	176	PF00400	0.731
TRG_ER_diArg_1	97	100	PF00400	0.520
TRG_Pf-PMV_PEXEL_1	108	113	PF00026	0.420

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZY5	Leptomonas seymouri	50%	100%
A0A1X0P0T6	Trypanosomatidae	34%	100%
A0A3Q8IAN2	Leishmania donovani	79%	100%
A0A3R7MFN4	Trypanosoma rangeli	34%	100%
A4HXC9	Leishmania infantum	76%	100%
D0A4S0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
E9AR24	Leishmania mexicana (strain MHOM/GT/2001/U1103)	74%	99%
Q4QED9	Leishmania major	77%	97%
V5AZY6	Trypanosoma cruzi	35%	100%