Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H8Z6_LEIBR

TriTrypDb:

LbrM.17.0520 , LBRM2903_170011300

Length:

935

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H8Z6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H8Z6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	312	314	PF00675	0.810
CLV_NRD_NRD_1	447	449	PF00675	0.649
CLV_NRD_NRD_1	54	56	PF00675	0.372
CLV_NRD_NRD_1	829	831	PF00675	0.337
CLV_NRD_NRD_1	868	870	PF00675	0.637
CLV_PCSK_FUR_1	52	56	PF00082	0.371
CLV_PCSK_KEX2_1	312	314	PF00082	0.810
CLV_PCSK_KEX2_1	447	449	PF00082	0.649
CLV_PCSK_KEX2_1	54	56	PF00082	0.372
CLV_PCSK_KEX2_1	544	546	PF00082	0.470
CLV_PCSK_KEX2_1	600	602	PF00082	0.641
CLV_PCSK_KEX2_1	829	831	PF00082	0.438
CLV_PCSK_KEX2_1	868	870	PF00082	0.639
CLV_PCSK_PC1ET2_1	544	546	PF00082	0.346
CLV_PCSK_PC1ET2_1	600	602	PF00082	0.641
CLV_PCSK_PC7_1	308	314	PF00082	0.768
CLV_PCSK_SKI1_1	233	237	PF00082	0.569
CLV_PCSK_SKI1_1	400	404	PF00082	0.654
CLV_PCSK_SKI1_1	422	426	PF00082	0.749
CLV_PCSK_SKI1_1	513	517	PF00082	0.371
CLV_PCSK_SKI1_1	55	59	PF00082	0.360
CLV_PCSK_SKI1_1	618	622	PF00082	0.482
CLV_PCSK_SKI1_1	636	640	PF00082	0.483
CLV_PCSK_SKI1_1	719	723	PF00082	0.467
CLV_PCSK_SKI1_1	765	769	PF00082	0.468
CLV_PCSK_SKI1_1	85	89	PF00082	0.613
DEG_APCC_DBOX_1	679	687	PF00400	0.632
DEG_Nend_UBRbox_1	1	4	PF02207	0.531
DEG_SCF_FBW7_1	330	336	PF00400	0.659
DEG_SPOP_SBC_1	142	146	PF00917	0.593
DEG_SPOP_SBC_1	163	167	PF00917	0.576
DEG_SPOP_SBC_1	486	490	PF00917	0.514
DOC_CKS1_1	236	241	PF01111	0.560
DOC_CKS1_1	330	335	PF01111	0.660
DOC_CKS1_1	501	506	PF01111	0.535
DOC_MAPK_gen_1	369	378	PF00069	0.798
DOC_MAPK_gen_1	52	60	PF00069	0.568
DOC_MAPK_gen_1	745	752	PF00069	0.350
DOC_MAPK_gen_1	829	836	PF00069	0.449
DOC_MAPK_MEF2A_6	85	92	PF00069	0.618
DOC_MAPK_RevD_3	530	545	PF00069	0.349
DOC_PP4_FxxP_1	236	239	PF00568	0.566
DOC_USP7_MATH_1	10	14	PF00917	0.515
DOC_USP7_MATH_1	123	127	PF00917	0.606
DOC_USP7_MATH_1	136	140	PF00917	0.633
DOC_USP7_MATH_1	142	146	PF00917	0.771
DOC_USP7_MATH_1	149	153	PF00917	0.599
DOC_USP7_MATH_1	325	329	PF00917	0.706
DOC_USP7_MATH_1	340	344	PF00917	0.583
DOC_USP7_MATH_1	364	368	PF00917	0.609
DOC_USP7_MATH_1	486	490	PF00917	0.611
DOC_USP7_MATH_1	642	646	PF00917	0.553
DOC_USP7_MATH_1	647	651	PF00917	0.539
DOC_USP7_MATH_1	688	692	PF00917	0.401
DOC_USP7_MATH_1	847	851	PF00917	0.640
DOC_USP7_MATH_1	906	910	PF00917	0.567
DOC_WW_Pin1_4	145	150	PF00397	0.648
DOC_WW_Pin1_4	172	177	PF00397	0.681
DOC_WW_Pin1_4	205	210	PF00397	0.649
DOC_WW_Pin1_4	216	221	PF00397	0.650
DOC_WW_Pin1_4	235	240	PF00397	0.772
DOC_WW_Pin1_4	241	246	PF00397	0.779
DOC_WW_Pin1_4	271	276	PF00397	0.720
DOC_WW_Pin1_4	329	334	PF00397	0.663
DOC_WW_Pin1_4	411	416	PF00397	0.816
DOC_WW_Pin1_4	474	479	PF00397	0.809
DOC_WW_Pin1_4	500	505	PF00397	0.529
DOC_WW_Pin1_4	652	657	PF00397	0.739
DOC_WW_Pin1_4	8	13	PF00397	0.541
DOC_WW_Pin1_4	883	888	PF00397	0.753
LIG_14-3-3_CanoR_1	255	259	PF00244	0.545
LIG_14-3-3_CanoR_1	765	773	PF00244	0.371
LIG_14-3-3_CanoR_1	871	881	PF00244	0.786
LIG_14-3-3_CanoR_1	929	935	PF00244	0.668
LIG_Actin_WH2_2	672	689	PF00022	0.540
LIG_Actin_WH2_2	732	749	PF00022	0.457
LIG_BRCT_BRCA1_1	247	251	PF00533	0.567
LIG_Clathr_ClatBox_1	610	614	PF01394	0.604
LIG_CSL_BTD_1	154	157	PF09270	0.550
LIG_EVH1_1	155	159	PF00568	0.796
LIG_FHA_1	142	148	PF00498	0.545
LIG_FHA_1	168	174	PF00498	0.797
LIG_FHA_1	183	189	PF00498	0.600
LIG_FHA_1	330	336	PF00498	0.707
LIG_FHA_1	346	352	PF00498	0.558
LIG_FHA_1	468	474	PF00498	0.591
LIG_FHA_1	475	481	PF00498	0.662
LIG_FHA_1	536	542	PF00498	0.602
LIG_FHA_1	766	772	PF00498	0.477
LIG_FHA_1	918	924	PF00498	0.673
LIG_FHA_2	197	203	PF00498	0.561
LIG_FHA_2	282	288	PF00498	0.705
LIG_FHA_2	501	507	PF00498	0.520
LIG_FHA_2	622	628	PF00498	0.466
LIG_FHA_2	707	713	PF00498	0.572
LIG_LIR_Apic_2	7	12	PF02991	0.548
LIG_LIR_Gen_1	20	30	PF02991	0.595
LIG_LIR_Gen_1	207	216	PF02991	0.618
LIG_LIR_Gen_1	533	541	PF02991	0.589
LIG_LIR_Gen_1	547	556	PF02991	0.574
LIG_LIR_Nem_3	152	158	PF02991	0.795
LIG_LIR_Nem_3	185	190	PF02991	0.682
LIG_LIR_Nem_3	20	25	PF02991	0.602
LIG_LIR_Nem_3	207	213	PF02991	0.618
LIG_LIR_Nem_3	533	537	PF02991	0.500
LIG_LIR_Nem_3	547	553	PF02991	0.347
LIG_MYND_1	156	160	PF01753	0.794
LIG_PCNA_yPIPBox_3	584	596	PF02747	0.601
LIG_PDZ_Class_1	930	935	PF00595	0.455
LIG_Pex14_1	492	496	PF04695	0.448
LIG_PTAP_UEV_1	150	155	PF05743	0.552
LIG_PTB_Apo_2	392	399	PF02174	0.788
LIG_PTB_Phospho_1	392	398	PF10480	0.790
LIG_SH2_CRK	210	214	PF00017	0.651
LIG_SH2_CRK	225	229	PF00017	0.658
LIG_SH2_CRK	498	502	PF00017	0.561
LIG_SH2_CRK	907	911	PF00017	0.647
LIG_SH2_PTP2	534	537	PF00017	0.392
LIG_SH2_SRC	22	25	PF00017	0.360
LIG_SH2_SRC	534	537	PF00017	0.355
LIG_SH2_SRC	64	67	PF00017	0.599
LIG_SH2_STAP1	802	806	PF00017	0.450
LIG_SH2_STAT3	496	499	PF00017	0.695
LIG_SH2_STAT5	105	108	PF00017	0.641
LIG_SH2_STAT5	172	175	PF00017	0.795
LIG_SH2_STAT5	210	213	PF00017	0.653
LIG_SH2_STAT5	496	499	PF00017	0.560
LIG_SH2_STAT5	534	537	PF00017	0.392
LIG_SH2_STAT5	550	553	PF00017	0.324
LIG_SH3_1	498	504	PF00018	0.549
LIG_SH3_2	370	375	PF14604	0.554
LIG_SH3_3	148	154	PF00018	0.682
LIG_SH3_3	176	182	PF00018	0.594
LIG_SH3_3	183	189	PF00018	0.539
LIG_SH3_3	240	246	PF00018	0.752
LIG_SH3_3	367	373	PF00018	0.588
LIG_SH3_3	498	504	PF00018	0.558
LIG_SH3_3	884	890	PF00018	0.546
LIG_SUMO_SIM_par_1	609	616	PF11976	0.604
LIG_SUMO_SIM_par_1	889	896	PF11976	0.521
LIG_TRAF2_1	43	46	PF00917	0.469
LIG_TRAF2_1	507	510	PF00917	0.496
LIG_TRAF2_1	759	762	PF00917	0.468
LIG_TRAF2_1	791	794	PF00917	0.609
LIG_TYR_ITIM	532	537	PF00017	0.499
LIG_TYR_ITIM	905	910	PF00017	0.411
LIG_WRC_WIRS_1	635	640	PF05994	0.379
LIG_WW_2	156	159	PF00397	0.794
MOD_CDK_SPK_2	883	888	PF00069	0.544
MOD_CDK_SPxxK_3	271	278	PF00069	0.774
MOD_CK1_1	145	151	PF00069	0.700
MOD_CK1_1	175	181	PF00069	0.567
MOD_CK1_1	208	214	PF00069	0.602
MOD_CK1_1	215	221	PF00069	0.650
MOD_CK1_1	244	250	PF00069	0.797
MOD_CK1_1	345	351	PF00069	0.739
MOD_CK1_1	406	412	PF00069	0.668
MOD_CK1_1	413	419	PF00069	0.648
MOD_CK1_1	479	485	PF00069	0.815
MOD_CK1_1	490	496	PF00069	0.677
MOD_CK1_1	645	651	PF00069	0.658
MOD_CK1_1	652	658	PF00069	0.672
MOD_CK1_1	678	684	PF00069	0.390
MOD_CK1_1	797	803	PF00069	0.519
MOD_CK1_1	870	876	PF00069	0.583
MOD_CK1_1	883	889	PF00069	0.639
MOD_CK2_1	196	202	PF00069	0.590
MOD_CK2_1	215	221	PF00069	0.716
MOD_CK2_1	333	339	PF00069	0.652
MOD_CK2_1	352	358	PF00069	0.556
MOD_CK2_1	500	506	PF00069	0.531
MOD_CK2_1	613	619	PF00069	0.482
MOD_CK2_1	621	627	PF00069	0.464
MOD_CK2_1	706	712	PF00069	0.625
MOD_CK2_1	714	720	PF00069	0.464
MOD_CK2_1	797	803	PF00069	0.603
MOD_CK2_1	8	14	PF00069	0.534
MOD_CK2_1	870	876	PF00069	0.574
MOD_GlcNHglycan	138	141	PF01048	0.567
MOD_GlcNHglycan	151	154	PF01048	0.669
MOD_GlcNHglycan	190	193	PF01048	0.667
MOD_GlcNHglycan	260	263	PF01048	0.685
MOD_GlcNHglycan	354	357	PF01048	0.575
MOD_GlcNHglycan	366	369	PF01048	0.557
MOD_GlcNHglycan	408	411	PF01048	0.714
MOD_GlcNHglycan	649	652	PF01048	0.671
MOD_GlcNHglycan	779	784	PF01048	0.495
MOD_GlcNHglycan	851	854	PF01048	0.674
MOD_GlcNHglycan	915	918	PF01048	0.600
MOD_GSK3_1	141	148	PF00069	0.731
MOD_GSK3_1	158	165	PF00069	0.600
MOD_GSK3_1	204	211	PF00069	0.637
MOD_GSK3_1	212	219	PF00069	0.636
MOD_GSK3_1	241	248	PF00069	0.671
MOD_GSK3_1	253	260	PF00069	0.636
MOD_GSK3_1	281	288	PF00069	0.574
MOD_GSK3_1	325	332	PF00069	0.656
MOD_GSK3_1	342	349	PF00069	0.679
MOD_GSK3_1	382	389	PF00069	0.588
MOD_GSK3_1	4	11	PF00069	0.532
MOD_GSK3_1	400	407	PF00069	0.640
MOD_GSK3_1	409	416	PF00069	0.674
MOD_GSK3_1	465	472	PF00069	0.664
MOD_GSK3_1	476	483	PF00069	0.742
MOD_GSK3_1	484	491	PF00069	0.580
MOD_GSK3_1	642	649	PF00069	0.565
MOD_GSK3_1	706	713	PF00069	0.402
MOD_GSK3_1	765	772	PF00069	0.370
MOD_GSK3_1	793	800	PF00069	0.574
MOD_GSK3_1	849	856	PF00069	0.439
MOD_GSK3_1	891	898	PF00069	0.523
MOD_GSK3_1	913	920	PF00069	0.510
MOD_GSK3_1	923	930	PF00069	0.528
MOD_N-GLC_1	382	387	PF02516	0.665
MOD_N-GLC_1	927	932	PF02516	0.435
MOD_N-GLC_2	442	444	PF02516	0.542
MOD_NEK2_1	253	258	PF00069	0.686
MOD_NEK2_1	276	281	PF00069	0.727
MOD_NEK2_1	342	347	PF00069	0.561
MOD_NEK2_1	351	356	PF00069	0.576
MOD_NEK2_1	405	410	PF00069	0.799
MOD_NEK2_1	480	485	PF00069	0.632
MOD_NEK2_1	580	585	PF00069	0.473
MOD_NEK2_1	613	618	PF00069	0.606
MOD_NEK2_1	646	651	PF00069	0.654
MOD_NEK2_1	706	711	PF00069	0.599
MOD_NEK2_1	913	918	PF00069	0.508
MOD_NEK2_1	923	928	PF00069	0.523
MOD_NEK2_2	182	187	PF00069	0.541
MOD_NEK2_2	853	858	PF00069	0.471
MOD_PIKK_1	557	563	PF00454	0.363
MOD_PIKK_1	568	574	PF00454	0.333
MOD_PIKK_1	603	609	PF00454	0.607
MOD_PIKK_1	794	800	PF00454	0.472
MOD_PKA_2	194	200	PF00069	0.551
MOD_PKA_2	254	260	PF00069	0.549
MOD_PKA_2	436	442	PF00069	0.549
MOD_PKA_2	578	584	PF00069	0.548
MOD_PKA_2	867	873	PF00069	0.774
MOD_PKA_2	913	919	PF00069	0.509
MOD_PKA_2	928	934	PF00069	0.547
MOD_PKB_1	708	716	PF00069	0.364
MOD_PKB_1	763	771	PF00069	0.475
MOD_Plk_1	769	775	PF00069	0.499
MOD_Plk_1	779	785	PF00069	0.473
MOD_Plk_1	895	901	PF00069	0.478
MOD_Plk_4	182	188	PF00069	0.540
MOD_Plk_4	208	214	PF00069	0.615
MOD_Plk_4	325	331	PF00069	0.648
MOD_Plk_4	346	352	PF00069	0.589
MOD_Plk_4	853	859	PF00069	0.473
MOD_ProDKin_1	145	151	PF00069	0.650
MOD_ProDKin_1	172	178	PF00069	0.677
MOD_ProDKin_1	205	211	PF00069	0.646
MOD_ProDKin_1	216	222	PF00069	0.651
MOD_ProDKin_1	235	241	PF00069	0.768
MOD_ProDKin_1	271	277	PF00069	0.722
MOD_ProDKin_1	329	335	PF00069	0.663
MOD_ProDKin_1	411	417	PF00069	0.810
MOD_ProDKin_1	474	480	PF00069	0.810
MOD_ProDKin_1	500	506	PF00069	0.524
MOD_ProDKin_1	652	658	PF00069	0.734
MOD_ProDKin_1	8	14	PF00069	0.534
MOD_ProDKin_1	883	889	PF00069	0.749
MOD_SUMO_rev_2	576	586	PF00179	0.597
TRG_DiLeu_BaEn_1	823	828	PF01217	0.580
TRG_DiLeu_BaEn_1	83	88	PF01217	0.614
TRG_DiLeu_BaEn_4	510	516	PF01217	0.628
TRG_DiLeu_BaEn_4	83	89	PF01217	0.615
TRG_DiLeu_BaLyEn_6	330	335	PF01217	0.555
TRG_ENDOCYTIC_2	210	213	PF00928	0.621
TRG_ENDOCYTIC_2	22	25	PF00928	0.360
TRG_ENDOCYTIC_2	534	537	PF00928	0.594
TRG_ENDOCYTIC_2	550	553	PF00928	0.344
TRG_ENDOCYTIC_2	907	910	PF00928	0.648
TRG_ER_diArg_1	447	449	PF00400	0.537
TRG_ER_diArg_1	708	711	PF00400	0.610
TRG_ER_diArg_1	763	766	PF00400	0.471
TRG_ER_diArg_1	828	830	PF00400	0.347
TRG_ER_diArg_1	868	871	PF00400	0.591
TRG_NES_CRM1_1	526	540	PF08389	0.555
TRG_Pf-PMV_PEXEL_1	19	23	PF00026	0.613
TRG_Pf-PMV_PEXEL_1	369	374	PF00026	0.584
TRG_Pf-PMV_PEXEL_1	447	451	PF00026	0.542
TRG_Pf-PMV_PEXEL_1	513	517	PF00026	0.490
TRG_Pf-PMV_PEXEL_1	55	59	PF00026	0.360
TRG_Pf-PMV_PEXEL_1	787	792	PF00026	0.611

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5F8	Leptomonas seymouri	40%	70%
A0A3S7WUD7	Leishmania donovani	71%	88%
A4HXC7	Leishmania infantum	71%	88%
E9AR22	Leishmania mexicana (strain MHOM/GT/2001/U1103)	69%	87%
Q4QEE1	Leishmania major	69%	100%