Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4H8Z5_LEIBR

TriTrypDb:

LbrM.17.0510 , LBRM2903_170011200

Length:

908

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H8Z5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H8Z5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	330	334	PF00656	0.537
CLV_C14_Caspase3-7	369	373	PF00656	0.717
CLV_C14_Caspase3-7	723	727	PF00656	0.686
CLV_C14_Caspase3-7	735	739	PF00656	0.592
CLV_NRD_NRD_1	103	105	PF00675	0.613
CLV_NRD_NRD_1	226	228	PF00675	0.656
CLV_NRD_NRD_1	32	34	PF00675	0.551
CLV_NRD_NRD_1	409	411	PF00675	0.570
CLV_NRD_NRD_1	63	65	PF00675	0.540
CLV_NRD_NRD_1	634	636	PF00675	0.703
CLV_NRD_NRD_1	828	830	PF00675	0.553
CLV_PCSK_FUR_1	29	33	PF00082	0.553
CLV_PCSK_KEX2_1	226	228	PF00082	0.656
CLV_PCSK_KEX2_1	31	33	PF00082	0.550
CLV_PCSK_KEX2_1	409	411	PF00082	0.570
CLV_PCSK_KEX2_1	8	10	PF00082	0.539
CLV_PCSK_KEX2_1	902	904	PF00082	0.706
CLV_PCSK_PC1ET2_1	8	10	PF00082	0.539
CLV_PCSK_PC1ET2_1	902	904	PF00082	0.659
CLV_PCSK_SKI1_1	631	635	PF00082	0.702
CLV_PCSK_SKI1_1	787	791	PF00082	0.684
CLV_PCSK_SKI1_1	8	12	PF00082	0.546
CLV_PCSK_SKI1_1	83	87	PF00082	0.532
DEG_SCF_FBW7_1	608	615	PF00400	0.531
DEG_SCF_SKP2-CKS1_1	98	105	PF00560	0.562
DEG_SPOP_SBC_1	498	502	PF00917	0.556
DOC_CKS1_1	446	451	PF01111	0.848
DOC_CKS1_1	461	466	PF01111	0.568
DOC_CKS1_1	517	522	PF01111	0.654
DOC_CKS1_1	609	614	PF01111	0.535
DOC_CKS1_1	702	707	PF01111	0.582
DOC_CKS1_1	825	830	PF01111	0.728
DOC_CKS1_1	874	879	PF01111	0.539
DOC_CYCLIN_RxL_1	316	325	PF00134	0.594
DOC_CYCLIN_yCln2_LP_2	273	279	PF00134	0.531
DOC_CYCLIN_yCln2_LP_2	323	329	PF00134	0.537
DOC_MAPK_gen_1	223	233	PF00069	0.546
DOC_MAPK_gen_1	31	40	PF00069	0.533
DOC_MAPK_gen_1	423	431	PF00069	0.536
DOC_MAPK_gen_1	902	908	PF00069	0.670
DOC_MAPK_MEF2A_6	423	431	PF00069	0.693
DOC_PP1_SILK_1	631	636	PF00149	0.702
DOC_PP2B_LxvP_1	273	276	PF13499	0.527
DOC_PP4_FxxP_1	170	173	PF00568	0.524
DOC_PP4_FxxP_1	435	438	PF00568	0.667
DOC_USP7_MATH_1	117	121	PF00917	0.676
DOC_USP7_MATH_1	197	201	PF00917	0.629
DOC_USP7_MATH_1	265	269	PF00917	0.778
DOC_USP7_MATH_1	317	321	PF00917	0.645
DOC_USP7_MATH_1	364	368	PF00917	0.689
DOC_USP7_MATH_1	373	377	PF00917	0.663
DOC_USP7_MATH_1	413	417	PF00917	0.677
DOC_USP7_MATH_1	43	47	PF00917	0.519
DOC_USP7_MATH_1	430	434	PF00917	0.581
DOC_USP7_MATH_1	438	442	PF00917	0.689
DOC_USP7_MATH_1	456	460	PF00917	0.529
DOC_USP7_MATH_1	471	475	PF00917	0.582
DOC_USP7_MATH_1	499	503	PF00917	0.633
DOC_USP7_MATH_1	544	548	PF00917	0.771
DOC_USP7_MATH_1	560	564	PF00917	0.594
DOC_USP7_MATH_1	614	618	PF00917	0.617
DOC_USP7_MATH_1	724	728	PF00917	0.556
DOC_USP7_MATH_1	743	747	PF00917	0.599
DOC_USP7_MATH_1	764	768	PF00917	0.560
DOC_USP7_MATH_1	771	775	PF00917	0.545
DOC_WW_Pin1_4	108	113	PF00397	0.638
DOC_WW_Pin1_4	115	120	PF00397	0.614
DOC_WW_Pin1_4	157	162	PF00397	0.522
DOC_WW_Pin1_4	183	188	PF00397	0.520
DOC_WW_Pin1_4	191	196	PF00397	0.522
DOC_WW_Pin1_4	210	215	PF00397	0.586
DOC_WW_Pin1_4	280	285	PF00397	0.691
DOC_WW_Pin1_4	307	312	PF00397	0.611
DOC_WW_Pin1_4	322	327	PF00397	0.563
DOC_WW_Pin1_4	331	336	PF00397	0.539
DOC_WW_Pin1_4	409	414	PF00397	0.610
DOC_WW_Pin1_4	445	450	PF00397	0.746
DOC_WW_Pin1_4	452	457	PF00397	0.628
DOC_WW_Pin1_4	460	465	PF00397	0.595
DOC_WW_Pin1_4	516	521	PF00397	0.685
DOC_WW_Pin1_4	608	613	PF00397	0.699
DOC_WW_Pin1_4	681	686	PF00397	0.767
DOC_WW_Pin1_4	701	706	PF00397	0.538
DOC_WW_Pin1_4	739	744	PF00397	0.776
DOC_WW_Pin1_4	760	765	PF00397	0.575
DOC_WW_Pin1_4	803	808	PF00397	0.726
DOC_WW_Pin1_4	814	819	PF00397	0.594
DOC_WW_Pin1_4	824	829	PF00397	0.714
DOC_WW_Pin1_4	84	89	PF00397	0.597
DOC_WW_Pin1_4	873	878	PF00397	0.541
DOC_WW_Pin1_4	883	888	PF00397	0.678
DOC_WW_Pin1_4	895	900	PF00397	0.713
DOC_WW_Pin1_4	99	104	PF00397	0.625
LIG_14-3-3_CanoR_1	156	160	PF00244	0.570
LIG_14-3-3_CanoR_1	267	272	PF00244	0.544
LIG_14-3-3_CanoR_1	426	430	PF00244	0.542
LIG_14-3-3_CanoR_1	531	535	PF00244	0.662
LIG_14-3-3_CanoR_1	721	730	PF00244	0.736
LIG_14-3-3_CanoR_1	820	826	PF00244	0.596
LIG_BRCT_BRCA1_1	416	420	PF00533	0.557
LIG_BRCT_BRCA1_1	871	875	PF00533	0.558
LIG_FHA_1	217	223	PF00498	0.571
LIG_FHA_1	248	254	PF00498	0.617
LIG_FHA_1	299	305	PF00498	0.546
LIG_FHA_1	352	358	PF00498	0.528
LIG_FHA_1	426	432	PF00498	0.645
LIG_FHA_1	461	467	PF00498	0.749
LIG_FHA_1	499	505	PF00498	0.613
LIG_FHA_1	550	556	PF00498	0.696
LIG_FHA_1	625	631	PF00498	0.590
LIG_FHA_1	645	651	PF00498	0.509
LIG_FHA_1	713	719	PF00498	0.567
LIG_FHA_2	161	167	PF00498	0.523
LIG_FHA_2	588	594	PF00498	0.534
LIG_FHA_2	613	619	PF00498	0.674
LIG_FHA_2	721	727	PF00498	0.688
LIG_FHA_2	733	739	PF00498	0.592
LIG_FHA_2	779	785	PF00498	0.702
LIG_FHA_2	865	871	PF00498	0.736
LIG_FHA_2	884	890	PF00498	0.681
LIG_LIR_Apic_2	167	173	PF02991	0.520
LIG_LIR_Apic_2	433	438	PF02991	0.666
LIG_LIR_Gen_1	268	279	PF02991	0.536
LIG_LIR_Gen_1	715	724	PF02991	0.536
LIG_LIR_Nem_3	268	274	PF02991	0.535
LIG_LIR_Nem_3	488	493	PF02991	0.678
LIG_LIR_Nem_3	715	720	PF02991	0.687
LIG_PCNA_yPIPBox_3	772	780	PF02747	0.564
LIG_PDZ_Class_2	903	908	PF00595	0.672
LIG_PTAP_UEV_1	286	291	PF05743	0.551
LIG_SH2_CRK	271	275	PF00017	0.532
LIG_SH2_CRK	812	816	PF00017	0.534
LIG_SH2_STAT3	834	837	PF00017	0.554
LIG_SH2_STAT5	574	577	PF00017	0.537
LIG_SH2_STAT5	729	732	PF00017	0.553
LIG_SH3_1	281	287	PF00018	0.534
LIG_SH3_1	458	464	PF00018	0.557
LIG_SH3_3	100	106	PF00018	0.562
LIG_SH3_3	276	282	PF00018	0.726
LIG_SH3_3	284	290	PF00018	0.672
LIG_SH3_3	31	37	PF00018	0.538
LIG_SH3_3	402	408	PF00018	0.588
LIG_SH3_3	458	464	PF00018	0.626
LIG_SH3_3	478	484	PF00018	0.708
LIG_SH3_3	791	797	PF00018	0.558
LIG_SH3_3	85	91	PF00018	0.700
LIG_SH3_3	884	890	PF00018	0.638
LIG_SH3_CIN85_PxpxPR_1	119	124	PF14604	0.562
LIG_SUMO_SIM_anti_2	428	434	PF11976	0.651
LIG_SUMO_SIM_par_1	353	359	PF11976	0.528
LIG_SUMO_SIM_par_1	36	42	PF11976	0.517
LIG_SUMO_SIM_par_1	427	434	PF11976	0.551
LIG_SUMO_SIM_par_1	500	508	PF11976	0.557
LIG_SUMO_SIM_par_1	551	558	PF11976	0.562
LIG_SUMO_SIM_par_1	75	80	PF11976	0.549
LIG_TYR_ITIM	810	815	PF00017	0.538
LIG_WRC_WIRS_1	432	437	PF05994	0.678
MOD_CDC14_SPxK_1	455	458	PF00782	0.590
MOD_CDC14_SPxK_1	817	820	PF00782	0.594
MOD_CDK_SPK_2	516	521	PF00069	0.564
MOD_CDK_SPK_2	681	686	PF00069	0.738
MOD_CDK_SPK_2	824	829	PF00069	0.538
MOD_CDK_SPK_2	99	104	PF00069	0.558
MOD_CDK_SPxK_1	452	458	PF00069	0.570
MOD_CDK_SPxK_1	814	820	PF00069	0.597
MOD_CDK_SPxK_1	824	830	PF00069	0.700
MOD_CDK_SPxK_1	99	105	PF00069	0.561
MOD_CDK_SPxxK_3	445	452	PF00069	0.803
MOD_CDK_SPxxK_3	895	902	PF00069	0.658
MOD_CK1_1	115	121	PF00069	0.550
MOD_CK1_1	130	136	PF00069	0.530
MOD_CK1_1	157	163	PF00069	0.528
MOD_CK1_1	207	213	PF00069	0.612
MOD_CK1_1	39	45	PF00069	0.519
MOD_CK1_1	414	420	PF00069	0.669
MOD_CK1_1	445	451	PF00069	0.728
MOD_CK1_1	459	465	PF00069	0.616
MOD_CK1_1	497	503	PF00069	0.666
MOD_CK1_1	522	528	PF00069	0.634
MOD_CK1_1	546	552	PF00069	0.721
MOD_CK1_1	586	592	PF00069	0.568
MOD_CK1_1	706	712	PF00069	0.698
MOD_CK1_1	731	737	PF00069	0.556
MOD_CK1_1	763	769	PF00069	0.629
MOD_CK1_1	814	820	PF00069	0.624
MOD_CK1_1	824	830	PF00069	0.740
MOD_CK1_1	843	849	PF00069	0.577
MOD_CK1_1	857	863	PF00069	0.653
MOD_CK1_1	866	872	PF00069	0.708
MOD_CK1_1	98	104	PF00069	0.644
MOD_CK2_1	368	374	PF00069	0.544
MOD_CK2_1	430	436	PF00069	0.572
MOD_CK2_1	566	572	PF00069	0.640
MOD_CK2_1	612	618	PF00069	0.680
MOD_CK2_1	688	694	PF00069	0.689
MOD_CK2_1	778	784	PF00069	0.682
MOD_CK2_1	864	870	PF00069	0.639
MOD_CK2_1	883	889	PF00069	0.687
MOD_GlcNHglycan	119	122	PF01048	0.616
MOD_GlcNHglycan	144	147	PF01048	0.640
MOD_GlcNHglycan	206	209	PF01048	0.719
MOD_GlcNHglycan	25	28	PF01048	0.583
MOD_GlcNHglycan	257	260	PF01048	0.596
MOD_GlcNHglycan	287	290	PF01048	0.595
MOD_GlcNHglycan	304	307	PF01048	0.507
MOD_GlcNHglycan	368	371	PF01048	0.675
MOD_GlcNHglycan	389	392	PF01048	0.849
MOD_GlcNHglycan	397	400	PF01048	0.720
MOD_GlcNHglycan	41	44	PF01048	0.487
MOD_GlcNHglycan	413	416	PF01048	0.640
MOD_GlcNHglycan	471	474	PF01048	0.635
MOD_GlcNHglycan	496	499	PF01048	0.633
MOD_GlcNHglycan	526	529	PF01048	0.765
MOD_GlcNHglycan	576	579	PF01048	0.582
MOD_GlcNHglycan	689	693	PF01048	0.782
MOD_GlcNHglycan	694	698	PF01048	0.773
MOD_GlcNHglycan	706	709	PF01048	0.637
MOD_GlcNHglycan	768	771	PF01048	0.608
MOD_GlcNHglycan	775	778	PF01048	0.628
MOD_GlcNHglycan	78	82	PF01048	0.628
MOD_GlcNHglycan	790	793	PF01048	0.556
MOD_GlcNHglycan	807	810	PF01048	0.561
MOD_GlcNHglycan	845	848	PF01048	0.740
MOD_GlcNHglycan	856	859	PF01048	0.688
MOD_GlcNHglycan	97	100	PF01048	0.562
MOD_GSK3_1	108	115	PF00069	0.558
MOD_GSK3_1	126	133	PF00069	0.613
MOD_GSK3_1	160	167	PF00069	0.665
MOD_GSK3_1	210	217	PF00069	0.652
MOD_GSK3_1	23	30	PF00069	0.555
MOD_GSK3_1	248	255	PF00069	0.663
MOD_GSK3_1	298	305	PF00069	0.566
MOD_GSK3_1	307	314	PF00069	0.539
MOD_GSK3_1	327	334	PF00069	0.674
MOD_GSK3_1	351	358	PF00069	0.556
MOD_GSK3_1	364	371	PF00069	0.579
MOD_GSK3_1	387	394	PF00069	0.787
MOD_GSK3_1	39	46	PF00069	0.492
MOD_GSK3_1	409	416	PF00069	0.700
MOD_GSK3_1	438	445	PF00069	0.801
MOD_GSK3_1	452	459	PF00069	0.582
MOD_GSK3_1	467	474	PF00069	0.589
MOD_GSK3_1	489	496	PF00069	0.738
MOD_GSK3_1	499	506	PF00069	0.571
MOD_GSK3_1	530	537	PF00069	0.714
MOD_GSK3_1	544	551	PF00069	0.678
MOD_GSK3_1	555	562	PF00069	0.656
MOD_GSK3_1	583	590	PF00069	0.599
MOD_GSK3_1	608	615	PF00069	0.772
MOD_GSK3_1	720	727	PF00069	0.588
MOD_GSK3_1	728	735	PF00069	0.568
MOD_GSK3_1	739	746	PF00069	0.659
MOD_GSK3_1	751	758	PF00069	0.590
MOD_GSK3_1	760	767	PF00069	0.636
MOD_GSK3_1	799	806	PF00069	0.636
MOD_GSK3_1	853	860	PF00069	0.754
MOD_GSK3_1	866	873	PF00069	0.611
MOD_GSK3_1	95	102	PF00069	0.732
MOD_N-GLC_1	392	397	PF02516	0.577
MOD_N-GLC_1	467	472	PF02516	0.809
MOD_N-GLC_1	681	686	PF02516	0.581
MOD_N-GLC_1	771	776	PF02516	0.684
MOD_N-GLC_1	853	858	PF02516	0.707
MOD_NEK2_1	107	112	PF00069	0.636
MOD_NEK2_1	126	131	PF00069	0.602
MOD_NEK2_1	181	186	PF00069	0.551
MOD_NEK2_1	242	247	PF00069	0.670
MOD_NEK2_1	248	253	PF00069	0.657
MOD_NEK2_1	293	298	PF00069	0.571
MOD_NEK2_1	489	494	PF00069	0.543
MOD_NEK2_1	583	588	PF00069	0.639
MOD_NEK2_1	664	669	PF00069	0.557
MOD_NEK2_1	688	693	PF00069	0.604
MOD_NEK2_1	720	725	PF00069	0.790
MOD_NEK2_1	77	82	PF00069	0.536
MOD_NEK2_1	811	816	PF00069	0.654
MOD_NMyristoyl	1	7	PF02799	0.557
MOD_PIKK_1	112	118	PF00454	0.628
MOD_PIKK_1	20	26	PF00454	0.546
MOD_PIKK_1	304	310	PF00454	0.605
MOD_PIKK_1	44	50	PF00454	0.518
MOD_PIKK_1	555	561	PF00454	0.647
MOD_PIKK_1	706	712	PF00454	0.554
MOD_PIKK_1	751	757	PF00454	0.557
MOD_PIKK_1	857	863	PF00454	0.704
MOD_PK_1	227	233	PF00069	0.535
MOD_PK_1	629	635	PF00069	0.615
MOD_PKA_2	155	161	PF00069	0.668
MOD_PKA_2	266	272	PF00069	0.555
MOD_PKA_2	387	393	PF00069	0.710
MOD_PKA_2	425	431	PF00069	0.539
MOD_PKA_2	530	536	PF00069	0.686
MOD_PKA_2	587	593	PF00069	0.534
MOD_PKA_2	720	726	PF00069	0.747
MOD_PKA_2	779	785	PF00069	0.569
MOD_PKA_2	838	844	PF00069	0.708
MOD_Plk_1	154	160	PF00069	0.533
MOD_Plk_1	164	170	PF00069	0.516
MOD_Plk_1	233	239	PF00069	0.520
MOD_Plk_1	373	379	PF00069	0.561
MOD_Plk_1	439	445	PF00069	0.551
MOD_Plk_1	77	83	PF00069	0.521
MOD_Plk_1	771	777	PF00069	0.628
MOD_Plk_1	869	875	PF00069	0.553
MOD_Plk_2-3	374	380	PF00069	0.567
MOD_Plk_4	233	239	PF00069	0.677
MOD_Plk_4	248	254	PF00069	0.554
MOD_Plk_4	358	364	PF00069	0.534
MOD_Plk_4	629	635	PF00069	0.695
MOD_Plk_4	645	651	PF00069	0.545
MOD_Plk_4	870	876	PF00069	0.566
MOD_ProDKin_1	108	114	PF00069	0.639
MOD_ProDKin_1	115	121	PF00069	0.616
MOD_ProDKin_1	157	163	PF00069	0.522
MOD_ProDKin_1	183	189	PF00069	0.516
MOD_ProDKin_1	191	197	PF00069	0.523
MOD_ProDKin_1	210	216	PF00069	0.587
MOD_ProDKin_1	280	286	PF00069	0.690
MOD_ProDKin_1	307	313	PF00069	0.611
MOD_ProDKin_1	322	328	PF00069	0.565
MOD_ProDKin_1	331	337	PF00069	0.540
MOD_ProDKin_1	409	415	PF00069	0.609
MOD_ProDKin_1	445	451	PF00069	0.746
MOD_ProDKin_1	452	458	PF00069	0.631
MOD_ProDKin_1	460	466	PF00069	0.598
MOD_ProDKin_1	516	522	PF00069	0.682
MOD_ProDKin_1	608	614	PF00069	0.694
MOD_ProDKin_1	681	687	PF00069	0.768
MOD_ProDKin_1	701	707	PF00069	0.534
MOD_ProDKin_1	739	745	PF00069	0.776
MOD_ProDKin_1	760	766	PF00069	0.576
MOD_ProDKin_1	803	809	PF00069	0.725
MOD_ProDKin_1	814	820	PF00069	0.597
MOD_ProDKin_1	824	830	PF00069	0.716
MOD_ProDKin_1	84	90	PF00069	0.597
MOD_ProDKin_1	873	879	PF00069	0.539
MOD_ProDKin_1	883	889	PF00069	0.674
MOD_ProDKin_1	895	901	PF00069	0.710
MOD_ProDKin_1	99	105	PF00069	0.628
MOD_SPalmitoyl_4	1	7	PF01529	0.557
MOD_SUMO_rev_2	52	62	PF00179	0.541
TRG_ENDOCYTIC_2	271	274	PF00928	0.535
TRG_ENDOCYTIC_2	812	815	PF00928	0.537
TRG_ER_diArg_1	11	14	PF00400	0.544
TRG_ER_diArg_1	225	227	PF00400	0.659
TRG_ER_diArg_1	28	31	PF00400	0.524
TRG_ER_diArg_1	32	34	PF00400	0.544
TRG_ER_diArg_1	408	410	PF00400	0.560

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WUD2	Leishmania donovani	51%	100%
A4HXC6	Leishmania infantum	51%	100%
E9AR21	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	100%
Q4QEE2	Leishmania major	49%	100%