Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein (fragment)

Species:

Leishmania braziliensis

UniProt:

A4H8Z3_LEIBR

TriTrypDb:

LbrM.17.0490 , LBRM2903_170011000

Length:

975

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H8Z3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H8Z3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	548	552	PF00656	0.547
CLV_C14_Caspase3-7	822	826	PF00656	0.740
CLV_NRD_NRD_1	171	173	PF00675	0.532
CLV_NRD_NRD_1	447	449	PF00675	0.696
CLV_NRD_NRD_1	622	624	PF00675	0.718
CLV_NRD_NRD_1	770	772	PF00675	0.626
CLV_NRD_NRD_1	800	802	PF00675	0.682
CLV_PCSK_KEX2_1	170	172	PF00082	0.542
CLV_PCSK_KEX2_1	43	45	PF00082	0.568
CLV_PCSK_KEX2_1	447	449	PF00082	0.696
CLV_PCSK_KEX2_1	622	624	PF00082	0.718
CLV_PCSK_KEX2_1	770	772	PF00082	0.626
CLV_PCSK_KEX2_1	800	802	PF00082	0.682
CLV_PCSK_PC1ET2_1	43	45	PF00082	0.568
CLV_PCSK_SKI1_1	131	135	PF00082	0.619
CLV_PCSK_SKI1_1	4	8	PF00082	0.545
CLV_PCSK_SKI1_1	448	452	PF00082	0.521
CLV_PCSK_SKI1_1	484	488	PF00082	0.505
DEG_SCF_FBW7_1	601	607	PF00400	0.645
DEG_SCF_FBW7_1	898	904	PF00400	0.529
DEG_SPOP_SBC_1	224	228	PF00917	0.550
DOC_ANK_TNKS_1	70	77	PF00023	0.541
DOC_CKS1_1	366	371	PF01111	0.649
DOC_CKS1_1	601	606	PF01111	0.647
DOC_CKS1_1	840	845	PF01111	0.661
DOC_CKS1_1	898	903	PF01111	0.531
DOC_CYCLIN_yClb3_PxF_3	839	845	PF00134	0.515
DOC_CYCLIN_yCln2_LP_2	958	964	PF00134	0.504
DOC_MAPK_gen_1	11	20	PF00069	0.545
DOC_MAPK_MEF2A_6	14	22	PF00069	0.551
DOC_MAPK_MEF2A_6	459	466	PF00069	0.530
DOC_PP2B_LxvP_1	20	23	PF13499	0.552
DOC_PP2B_LxvP_1	559	562	PF13499	0.654
DOC_PP2B_LxvP_1	606	609	PF13499	0.475
DOC_PP2B_LxvP_1	958	961	PF13499	0.671
DOC_PP4_FxxP_1	343	346	PF00568	0.521
DOC_PP4_FxxP_1	714	717	PF00568	0.520
DOC_USP7_MATH_1	124	128	PF00917	0.526
DOC_USP7_MATH_1	268	272	PF00917	0.553
DOC_USP7_MATH_1	377	381	PF00917	0.608
DOC_USP7_MATH_1	391	395	PF00917	0.586
DOC_USP7_MATH_1	413	417	PF00917	0.471
DOC_USP7_MATH_1	42	46	PF00917	0.628
DOC_USP7_MATH_1	435	439	PF00917	0.653
DOC_USP7_MATH_1	504	508	PF00917	0.722
DOC_USP7_MATH_1	525	529	PF00917	0.751
DOC_USP7_MATH_1	539	543	PF00917	0.523
DOC_USP7_MATH_1	575	579	PF00917	0.623
DOC_USP7_MATH_1	581	585	PF00917	0.505
DOC_USP7_MATH_1	609	613	PF00917	0.640
DOC_USP7_MATH_1	628	632	PF00917	0.630
DOC_USP7_MATH_1	635	639	PF00917	0.686
DOC_USP7_MATH_1	901	905	PF00917	0.558
DOC_USP7_MATH_1	946	950	PF00917	0.690
DOC_USP7_MATH_1	966	970	PF00917	0.469
DOC_WW_Pin1_4	165	170	PF00397	0.617
DOC_WW_Pin1_4	263	268	PF00397	0.714
DOC_WW_Pin1_4	281	286	PF00397	0.537
DOC_WW_Pin1_4	293	298	PF00397	0.621
DOC_WW_Pin1_4	33	38	PF00397	0.630
DOC_WW_Pin1_4	334	339	PF00397	0.578
DOC_WW_Pin1_4	345	350	PF00397	0.672
DOC_WW_Pin1_4	365	370	PF00397	0.484
DOC_WW_Pin1_4	383	388	PF00397	0.606
DOC_WW_Pin1_4	4	9	PF00397	0.598
DOC_WW_Pin1_4	452	457	PF00397	0.573
DOC_WW_Pin1_4	496	501	PF00397	0.666
DOC_WW_Pin1_4	511	516	PF00397	0.535
DOC_WW_Pin1_4	595	600	PF00397	0.665
DOC_WW_Pin1_4	642	647	PF00397	0.572
DOC_WW_Pin1_4	734	739	PF00397	0.716
DOC_WW_Pin1_4	782	787	PF00397	0.773
DOC_WW_Pin1_4	839	844	PF00397	0.653
DOC_WW_Pin1_4	871	876	PF00397	0.710
DOC_WW_Pin1_4	879	884	PF00397	0.648
DOC_WW_Pin1_4	888	893	PF00397	0.553
DOC_WW_Pin1_4	897	902	PF00397	0.552
LIG_14-3-3_CanoR_1	213	217	PF00244	0.567
LIG_14-3-3_CanoR_1	44	52	PF00244	0.561
LIG_14-3-3_CanoR_1	543	553	PF00244	0.570
LIG_14-3-3_CanoR_1	583	593	PF00244	0.770
LIG_14-3-3_CanoR_1	629	635	PF00244	0.539
LIG_14-3-3_CanoR_1	669	679	PF00244	0.665
LIG_14-3-3_CanoR_1	751	759	PF00244	0.567
LIG_14-3-3_CanoR_1	800	805	PF00244	0.685
LIG_14-3-3_CanoR_1	808	816	PF00244	0.695
LIG_14-3-3_CanoR_1	894	901	PF00244	0.658
LIG_14-3-3_CanoR_1	940	945	PF00244	0.681
LIG_Actin_WH2_2	957	973	PF00022	0.503
LIG_AP2alpha_1	549	553	PF02296	0.616
LIG_BIR_II_1	1	5	PF00653	0.556
LIG_BRCT_BRCA1_1	339	343	PF00533	0.585
LIG_BRCT_BRCA1_1	397	401	PF00533	0.651
LIG_BRCT_BRCA1_1	545	549	PF00533	0.704
LIG_BRCT_BRCA1_1	551	555	PF00533	0.650
LIG_BRCT_BRCA1_1	710	714	PF00533	0.517
LIG_Clathr_ClatBox_1	560	564	PF01394	0.596
LIG_FHA_1	123	129	PF00498	0.583
LIG_FHA_1	134	140	PF00498	0.582
LIG_FHA_1	144	150	PF00498	0.570
LIG_FHA_1	155	161	PF00498	0.597
LIG_FHA_1	194	200	PF00498	0.519
LIG_FHA_1	247	253	PF00498	0.517
LIG_FHA_1	342	348	PF00498	0.688
LIG_FHA_1	407	413	PF00498	0.627
LIG_FHA_1	426	432	PF00498	0.619
LIG_FHA_1	461	467	PF00498	0.527
LIG_FHA_1	556	562	PF00498	0.652
LIG_FHA_1	601	607	PF00498	0.749
LIG_FHA_2	124	130	PF00498	0.665
LIG_FHA_2	133	139	PF00498	0.579
LIG_FHA_2	174	180	PF00498	0.536
LIG_FHA_2	226	232	PF00498	0.555
LIG_FHA_2	301	307	PF00498	0.719
LIG_FHA_2	449	455	PF00498	0.523
LIG_FHA_2	589	595	PF00498	0.511
LIG_FHA_2	751	757	PF00498	0.538
LIG_FHA_2	945	951	PF00498	0.521
LIG_LIR_Apic_2	340	346	PF02991	0.513
LIG_LIR_Apic_2	676	682	PF02991	0.618
LIG_LIR_Apic_2	711	717	PF02991	0.515
LIG_LIR_Gen_1	105	114	PF02991	0.517
LIG_LIR_Gen_1	860	869	PF02991	0.616
LIG_LIR_Gen_1	928	936	PF02991	0.674
LIG_LIR_Gen_1	937	946	PF02991	0.594
LIG_LIR_Nem_3	105	111	PF02991	0.524
LIG_LIR_Nem_3	398	403	PF02991	0.635
LIG_LIR_Nem_3	612	616	PF02991	0.665
LIG_LIR_Nem_3	860	864	PF02991	0.698
LIG_LIR_Nem_3	928	932	PF02991	0.683
LIG_LIR_Nem_3	935	941	PF02991	0.603
LIG_MLH1_MIPbox_1	397	401	PF16413	0.651
LIG_Pex14_2	549	553	PF04695	0.642
LIG_PTB_Apo_2	251	258	PF02174	0.624
LIG_SH2_CRK	938	942	PF00017	0.677
LIG_SH2_GRB2like	952	955	PF00017	0.507
LIG_SH2_NCK_1	108	112	PF00017	0.513
LIG_SH2_SRC	108	111	PF00017	0.516
LIG_SH2_SRC	679	682	PF00017	0.639
LIG_SH2_STAT5	332	335	PF00017	0.509
LIG_SH2_STAT5	400	403	PF00017	0.628
LIG_SH2_STAT5	411	414	PF00017	0.506
LIG_SH2_STAT5	679	682	PF00017	0.639
LIG_SH3_2	38	43	PF14604	0.699
LIG_SH3_2	72	77	PF14604	0.743
LIG_SH3_2	883	888	PF14604	0.552
LIG_SH3_3	22	28	PF00018	0.723
LIG_SH3_3	284	290	PF00018	0.567
LIG_SH3_3	335	341	PF00018	0.501
LIG_SH3_3	343	349	PF00018	0.566
LIG_SH3_3	35	41	PF00018	0.619
LIG_SH3_3	356	362	PF00018	0.643
LIG_SH3_3	454	460	PF00018	0.526
LIG_SH3_3	471	477	PF00018	0.504
LIG_SH3_3	491	497	PF00018	0.743
LIG_SH3_3	509	515	PF00018	0.516
LIG_SH3_3	532	538	PF00018	0.618
LIG_SH3_3	598	604	PF00018	0.625
LIG_SH3_3	624	630	PF00018	0.675
LIG_SH3_3	645	651	PF00018	0.561
LIG_SH3_3	69	75	PF00018	0.746
LIG_SH3_3	737	743	PF00018	0.710
LIG_SH3_3	834	840	PF00018	0.590
LIG_SH3_3	873	879	PF00018	0.715
LIG_SH3_3	880	886	PF00018	0.657
LIG_SH3_3	895	901	PF00018	0.676
LIG_SUMO_SIM_anti_2	248	254	PF11976	0.517
LIG_SUMO_SIM_par_1	135	141	PF11976	0.511
LIG_SUMO_SIM_par_1	145	150	PF11976	0.505
LIG_SUMO_SIM_par_1	959	965	PF11976	0.496
LIG_TRAF2_1	229	232	PF00917	0.558
LIG_TRAF2_1	274	277	PF00917	0.702
LIG_TRAF2_1	849	852	PF00917	0.538
LIG_TRAF2_2	702	707	PF00917	0.565
LIG_UBA3_1	160	167	PF00899	0.539
LIG_WRC_WIRS_1	103	108	PF05994	0.706
LIG_WRC_WIRS_1	610	615	PF05994	0.635
LIG_WW_3	37	41	PF00397	0.702
LIG_WW_3	476	480	PF00397	0.520
MOD_CDC14_SPxK_1	168	171	PF00782	0.537
MOD_CDC14_SPxK_1	891	894	PF00782	0.717
MOD_CDK_SPK_2	165	170	PF00069	0.681
MOD_CDK_SPK_2	4	9	PF00069	0.546
MOD_CDK_SPxK_1	165	171	PF00069	0.540
MOD_CDK_SPxK_1	263	269	PF00069	0.717
MOD_CDK_SPxK_1	888	894	PF00069	0.670
MOD_CDK_SPxxK_3	165	172	PF00069	0.681
MOD_CDK_SPxxK_3	293	300	PF00069	0.646
MOD_CDK_SPxxK_3	33	40	PF00069	0.709
MOD_CDK_SPxxK_3	4	11	PF00069	0.546
MOD_CDK_SPxxK_3	452	459	PF00069	0.693
MOD_CK1_1	2	8	PF00069	0.547
MOD_CK1_1	215	221	PF00069	0.513
MOD_CK1_1	259	265	PF00069	0.702
MOD_CK1_1	275	281	PF00069	0.571
MOD_CK1_1	348	354	PF00069	0.691
MOD_CK1_1	364	370	PF00069	0.525
MOD_CK1_1	395	401	PF00069	0.496
MOD_CK1_1	434	440	PF00069	0.679
MOD_CK1_1	441	447	PF00069	0.629
MOD_CK1_1	45	51	PF00069	0.694
MOD_CK1_1	547	553	PF00069	0.595
MOD_CK1_1	584	590	PF00069	0.777
MOD_CK1_1	600	606	PF00069	0.483
MOD_CK1_1	633	639	PF00069	0.684
MOD_CK1_1	642	648	PF00069	0.710
MOD_CK1_1	769	775	PF00069	0.741
MOD_CK1_1	785	791	PF00069	0.556
MOD_CK1_1	862	868	PF00069	0.553
MOD_CK1_1	893	899	PF00069	0.665
MOD_CK1_1	931	937	PF00069	0.667
MOD_CK2_1	132	138	PF00069	0.515
MOD_CK2_1	225	231	PF00069	0.646
MOD_CK2_1	234	240	PF00069	0.704
MOD_CK2_1	300	306	PF00069	0.721
MOD_CK2_1	448	454	PF00069	0.524
MOD_CK2_1	759	765	PF00069	0.532
MOD_CK2_1	790	796	PF00069	0.632
MOD_CK2_1	944	950	PF00069	0.570
MOD_Cter_Amidation	620	623	PF01082	0.499
MOD_GlcNHglycan	281	284	PF01048	0.716
MOD_GlcNHglycan	394	397	PF01048	0.514
MOD_GlcNHglycan	433	436	PF01048	0.667
MOD_GlcNHglycan	443	446	PF01048	0.609
MOD_GlcNHglycan	489	492	PF01048	0.746
MOD_GlcNHglycan	506	509	PF01048	0.547
MOD_GlcNHglycan	523	526	PF01048	0.574
MOD_GlcNHglycan	530	534	PF01048	0.663
MOD_GlcNHglycan	569	573	PF01048	0.643
MOD_GlcNHglycan	710	713	PF01048	0.651
MOD_GlcNHglycan	746	749	PF01048	0.516
MOD_GlcNHglycan	790	793	PF01048	0.621
MOD_GlcNHglycan	821	824	PF01048	0.733
MOD_GlcNHglycan	861	864	PF01048	0.679
MOD_GlcNHglycan	90	93	PF01048	0.615
MOD_GlcNHglycan	964	967	PF01048	0.653
MOD_GSK3_1	143	150	PF00069	0.579
MOD_GSK3_1	193	200	PF00069	0.635
MOD_GSK3_1	212	219	PF00069	0.521
MOD_GSK3_1	256	263	PF00069	0.670
MOD_GSK3_1	268	275	PF00069	0.624
MOD_GSK3_1	279	286	PF00069	0.535
MOD_GSK3_1	289	296	PF00069	0.586
MOD_GSK3_1	324	331	PF00069	0.611
MOD_GSK3_1	337	344	PF00069	0.632
MOD_GSK3_1	345	352	PF00069	0.582
MOD_GSK3_1	361	368	PF00069	0.515
MOD_GSK3_1	383	390	PF00069	0.656
MOD_GSK3_1	391	398	PF00069	0.583
MOD_GSK3_1	431	438	PF00069	0.677
MOD_GSK3_1	448	455	PF00069	0.539
MOD_GSK3_1	521	528	PF00069	0.547
MOD_GSK3_1	539	546	PF00069	0.579
MOD_GSK3_1	564	571	PF00069	0.498
MOD_GSK3_1	581	588	PF00069	0.681
MOD_GSK3_1	600	607	PF00069	0.704
MOD_GSK3_1	633	640	PF00069	0.757
MOD_GSK3_1	734	741	PF00069	0.546
MOD_GSK3_1	782	789	PF00069	0.673
MOD_GSK3_1	800	807	PF00069	0.466
MOD_GSK3_1	867	874	PF00069	0.626
MOD_GSK3_1	893	900	PF00069	0.547
MOD_GSK3_1	928	935	PF00069	0.667
MOD_GSK3_1	940	947	PF00069	0.558
MOD_GSK3_1	956	963	PF00069	0.653
MOD_N-GLC_1	186	191	PF02516	0.515
MOD_N-GLC_1	2	7	PF02516	0.549
MOD_N-GLC_1	448	453	PF02516	0.523
MOD_N-GLC_1	65	70	PF02516	0.553
MOD_N-GLC_1	827	832	PF02516	0.529
MOD_NEK2_1	140	145	PF00069	0.556
MOD_NEK2_1	163	168	PF00069	0.542
MOD_NEK2_1	18	23	PF00069	0.560
MOD_NEK2_1	246	251	PF00069	0.685
MOD_NEK2_1	260	265	PF00069	0.569
MOD_NEK2_1	279	284	PF00069	0.529
MOD_NEK2_1	326	331	PF00069	0.523
MOD_NEK2_1	382	387	PF00069	0.535
MOD_NEK2_1	419	424	PF00069	0.738
MOD_NEK2_1	425	430	PF00069	0.743
MOD_NEK2_1	431	436	PF00069	0.650
MOD_NEK2_1	544	549	PF00069	0.667
MOD_NEK2_1	555	560	PF00069	0.618
MOD_NEK2_1	563	568	PF00069	0.507
MOD_NEK2_1	639	644	PF00069	0.716
MOD_NEK2_1	790	795	PF00069	0.632
MOD_NEK2_1	802	807	PF00069	0.544
MOD_NEK2_1	816	821	PF00069	0.636
MOD_NEK2_1	832	837	PF00069	0.602
MOD_NEK2_1	932	937	PF00069	0.666
MOD_NEK2_1	962	967	PF00069	0.728
MOD_NEK2_2	377	382	PF00069	0.525
MOD_NEK2_2	609	614	PF00069	0.788
MOD_NEK2_2	686	691	PF00069	0.469
MOD_NEK2_2	966	971	PF00069	0.499
MOD_PIKK_1	201	207	PF00454	0.602
MOD_PIKK_1	352	358	PF00454	0.538
MOD_PIKK_1	751	757	PF00454	0.707
MOD_PIKK_1	847	853	PF00454	0.537
MOD_PKA_1	800	806	PF00069	0.640
MOD_PKA_2	209	215	PF00069	0.511
MOD_PKA_2	585	591	PF00069	0.676
MOD_PKA_2	628	634	PF00069	0.547
MOD_PKA_2	750	756	PF00069	0.679
MOD_PKA_2	769	775	PF00069	0.549
MOD_PKA_2	800	806	PF00069	0.679
MOD_PKA_2	893	899	PF00069	0.665
MOD_PKA_2	939	945	PF00069	0.682
MOD_Plk_1	140	146	PF00069	0.561
MOD_Plk_1	2	8	PF00069	0.547
MOD_Plk_1	275	281	PF00069	0.558
MOD_Plk_1	413	419	PF00069	0.628
MOD_Plk_1	438	444	PF00069	0.524
MOD_Plk_1	555	561	PF00069	0.662
MOD_Plk_1	563	569	PF00069	0.600
MOD_Plk_1	575	581	PF00069	0.706
MOD_Plk_1	99	105	PF00069	0.538
MOD_Plk_2-3	234	240	PF00069	0.715
MOD_Plk_2-3	55	61	PF00069	0.549
MOD_Plk_2-3	564	570	PF00069	0.497
MOD_Plk_4	102	108	PF00069	0.537
MOD_Plk_4	246	252	PF00069	0.684
MOD_Plk_4	275	281	PF00069	0.716
MOD_Plk_4	328	334	PF00069	0.513
MOD_Plk_4	361	367	PF00069	0.521
MOD_Plk_4	377	383	PF00069	0.504
MOD_Plk_4	425	431	PF00069	0.622
MOD_Plk_4	555	561	PF00069	0.747
MOD_Plk_4	575	581	PF00069	0.593
MOD_Plk_4	597	603	PF00069	0.643
MOD_Plk_4	832	838	PF00069	0.532
MOD_Plk_4	928	934	PF00069	0.679
MOD_ProDKin_1	165	171	PF00069	0.617
MOD_ProDKin_1	263	269	PF00069	0.717
MOD_ProDKin_1	281	287	PF00069	0.532
MOD_ProDKin_1	293	299	PF00069	0.622
MOD_ProDKin_1	33	39	PF00069	0.629
MOD_ProDKin_1	334	340	PF00069	0.580
MOD_ProDKin_1	345	351	PF00069	0.672
MOD_ProDKin_1	365	371	PF00069	0.483
MOD_ProDKin_1	383	389	PF00069	0.606
MOD_ProDKin_1	4	10	PF00069	0.597
MOD_ProDKin_1	452	458	PF00069	0.574
MOD_ProDKin_1	496	502	PF00069	0.665
MOD_ProDKin_1	511	517	PF00069	0.532
MOD_ProDKin_1	595	601	PF00069	0.664
MOD_ProDKin_1	642	648	PF00069	0.566
MOD_ProDKin_1	734	740	PF00069	0.712
MOD_ProDKin_1	782	788	PF00069	0.772
MOD_ProDKin_1	839	845	PF00069	0.657
MOD_ProDKin_1	871	877	PF00069	0.711
MOD_ProDKin_1	879	885	PF00069	0.647
MOD_ProDKin_1	888	894	PF00069	0.555
MOD_ProDKin_1	897	903	PF00069	0.550
MOD_SUMO_rev_2	127	133	PF00179	0.519
MOD_SUMO_rev_2	327	331	PF00179	0.545
TRG_DiLeu_BaEn_1	248	253	PF01217	0.518
TRG_DiLeu_BaLyEn_6	540	545	PF01217	0.631
TRG_ENDOCYTIC_2	108	111	PF00928	0.516
TRG_ENDOCYTIC_2	400	403	PF00928	0.628
TRG_ENDOCYTIC_2	938	941	PF00928	0.510
TRG_ER_diArg_1	169	172	PF00400	0.678
TRG_ER_diArg_1	446	448	PF00400	0.526
TRG_ER_diArg_1	800	802	PF00400	0.689
TRG_ER_diArg_1	813	816	PF00400	0.688

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WUF2	Leishmania donovani	64%	68%
A4HXC4	Leishmania infantum	64%	68%
E9AR19	Leishmania mexicana (strain MHOM/GT/2001/U1103)	61%	73%
Q4QEE4	Leishmania major	62%	100%