Isomerase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Isomerase

Gene product:

Phenazine biosynthesis-like protein, putative

Species:

Leishmania braziliensis

UniProt:

A4H8Z1_LEIBR

TriTrypDb:

LbrM.17.0460 , LBRM2903_170010800

Length:

532

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H8Z1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H8Z1

Function

Biological processes
Term	Name	Level	Count
GO:0008152	metabolic process	1	7
GO:0009058	biosynthetic process	2	7

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0016853	isomerase activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	119	121	PF00675	0.450
CLV_NRD_NRD_1	141	143	PF00675	0.615
CLV_NRD_NRD_1	226	228	PF00675	0.601
CLV_NRD_NRD_1	229	231	PF00675	0.506
CLV_NRD_NRD_1	399	401	PF00675	0.395
CLV_NRD_NRD_1	504	506	PF00675	0.315
CLV_PCSK_FUR_1	227	231	PF00082	0.545
CLV_PCSK_KEX2_1	140	142	PF00082	0.575
CLV_PCSK_KEX2_1	181	183	PF00082	0.566
CLV_PCSK_KEX2_1	226	228	PF00082	0.601
CLV_PCSK_KEX2_1	229	231	PF00082	0.506
CLV_PCSK_KEX2_1	399	401	PF00082	0.395
CLV_PCSK_KEX2_1	493	495	PF00082	0.315
CLV_PCSK_PC1ET2_1	181	183	PF00082	0.566
CLV_PCSK_PC1ET2_1	493	495	PF00082	0.315
CLV_PCSK_SKI1_1	239	243	PF00082	0.315
CLV_PCSK_SKI1_1	399	403	PF00082	0.319
CLV_PCSK_SKI1_1	509	513	PF00082	0.315
CLV_PCSK_SKI1_1	80	84	PF00082	0.454
DEG_Kelch_actinfilin_1	153	157	PF01344	0.524
DEG_Nend_UBRbox_2	1	3	PF02207	0.542
DOC_CKS1_1	240	245	PF01111	0.315
DOC_CKS1_1	8	13	PF01111	0.467
DOC_MAPK_gen_1	505	512	PF00069	0.315
DOC_MAPK_JIP1_4	313	319	PF00069	0.233
DOC_PP1_RVXF_1	483	489	PF00149	0.233
DOC_PP2B_LxvP_1	186	189	PF13499	0.639
DOC_PP2B_PxIxI_1	153	159	PF00149	0.525
DOC_PP4_FxxP_1	284	287	PF00568	0.315
DOC_PP4_FxxP_1	402	405	PF00568	0.233
DOC_PP4_FxxP_1	447	450	PF00568	0.351
DOC_USP7_MATH_1	169	173	PF00917	0.639
DOC_USP7_MATH_1	196	200	PF00917	0.607
DOC_USP7_MATH_1	214	218	PF00917	0.583
DOC_USP7_MATH_1	437	441	PF00917	0.300
DOC_USP7_MATH_1	44	48	PF00917	0.523
DOC_USP7_UBL2_3	477	481	PF12436	0.268
DOC_USP7_UBL2_3	63	67	PF12436	0.618
DOC_WW_Pin1_4	172	177	PF00397	0.576
DOC_WW_Pin1_4	188	193	PF00397	0.703
DOC_WW_Pin1_4	239	244	PF00397	0.315
DOC_WW_Pin1_4	401	406	PF00397	0.256
DOC_WW_Pin1_4	7	12	PF00397	0.404
LIG_14-3-3_CanoR_1	182	187	PF00244	0.554
LIG_14-3-3_CanoR_1	266	276	PF00244	0.315
LIG_14-3-3_CanoR_1	381	389	PF00244	0.315
LIG_14-3-3_CanoR_1	399	405	PF00244	0.315
LIG_14-3-3_CanoR_1	521	527	PF00244	0.480
LIG_BRCT_BRCA1_1	196	200	PF00533	0.607
LIG_BRCT_BRCA1_1	403	407	PF00533	0.315
LIG_BRCT_BRCA1_1	444	448	PF00533	0.315
LIG_EH1_1	261	269	PF00400	0.395
LIG_FHA_1	106	112	PF00498	0.456
LIG_FHA_1	242	248	PF00498	0.257
LIG_FHA_1	271	277	PF00498	0.306
LIG_FHA_1	288	294	PF00498	0.426
LIG_FHA_1	458	464	PF00498	0.331
LIG_FHA_1	497	503	PF00498	0.347
LIG_FHA_1	523	529	PF00498	0.581
LIG_FHA_1	98	104	PF00498	0.385
LIG_FHA_2	111	117	PF00498	0.545
LIG_FHA_2	146	152	PF00498	0.568
LIG_FHA_2	63	69	PF00498	0.531
LIG_LIR_Apic_2	283	287	PF02991	0.315
LIG_LIR_Apic_2	321	325	PF02991	0.334
LIG_LIR_Apic_2	445	450	PF02991	0.315
LIG_LIR_Gen_1	348	357	PF02991	0.227
LIG_LIR_Gen_1	41	50	PF02991	0.522
LIG_LIR_Gen_1	462	472	PF02991	0.227
LIG_LIR_Nem_3	348	353	PF02991	0.288
LIG_LIR_Nem_3	41	45	PF02991	0.501
LIG_LIR_Nem_3	462	467	PF02991	0.257
LIG_MLH1_MIPbox_1	444	448	PF16413	0.315
LIG_MYND_1	192	196	PF01753	0.613
LIG_Pex14_2	236	240	PF04695	0.315
LIG_Pex14_2	447	451	PF04695	0.321
LIG_SH2_CRK	104	108	PF00017	0.429
LIG_SH2_CRK	322	326	PF00017	0.345
LIG_SH2_NCK_1	211	215	PF00017	0.668
LIG_SH2_NCK_1	322	326	PF00017	0.270
LIG_SH2_NCK_1	350	354	PF00017	0.233
LIG_SH2_STAP1	129	133	PF00017	0.517
LIG_SH2_STAP1	329	333	PF00017	0.315
LIG_SH2_STAP1	350	354	PF00017	0.233
LIG_SH2_STAT5	211	214	PF00017	0.660
LIG_SH2_STAT5	322	325	PF00017	0.508
LIG_SH2_STAT5	378	381	PF00017	0.351
LIG_SH2_STAT5	38	41	PF00017	0.447
LIG_SH2_STAT5	464	467	PF00017	0.254
LIG_SH3_3	186	192	PF00018	0.631
LIG_SH3_3	328	334	PF00018	0.325
LIG_SH3_3	5	11	PF00018	0.613
LIG_SUMO_SIM_anti_2	440	445	PF11976	0.233
LIG_SUMO_SIM_anti_2	508	514	PF11976	0.315
LIG_SUMO_SIM_par_1	154	160	PF11976	0.528
LIG_WRC_WIRS_1	516	521	PF05994	0.305
MOD_CDK_SPK_2	401	406	PF00069	0.233
MOD_CDK_SPxK_1	239	245	PF00069	0.315
MOD_CK1_1	162	168	PF00069	0.550
MOD_CK1_1	172	178	PF00069	0.579
MOD_CK1_1	198	204	PF00069	0.596
MOD_CK1_1	205	211	PF00069	0.590
MOD_CK1_1	270	276	PF00069	0.315
MOD_CK1_1	372	378	PF00069	0.395
MOD_CK1_1	43	49	PF00069	0.529
MOD_CK2_1	110	116	PF00069	0.613
MOD_CK2_1	165	171	PF00069	0.542
MOD_CK2_1	337	343	PF00069	0.288
MOD_CK2_1	43	49	PF00069	0.529
MOD_Cter_Amidation	503	506	PF01082	0.315
MOD_GlcNHglycan	167	170	PF01048	0.608
MOD_GlcNHglycan	204	207	PF01048	0.657
MOD_GlcNHglycan	298	301	PF01048	0.313
MOD_GlcNHglycan	41	45	PF01048	0.499
MOD_GlcNHglycan	413	417	PF01048	0.395
MOD_GSK3_1	106	113	PF00069	0.473
MOD_GSK3_1	141	148	PF00069	0.540
MOD_GSK3_1	165	172	PF00069	0.650
MOD_GSK3_1	177	184	PF00069	0.568
MOD_GSK3_1	194	201	PF00069	0.588
MOD_GSK3_1	205	212	PF00069	0.590
MOD_GSK3_1	296	303	PF00069	0.294
MOD_GSK3_1	333	340	PF00069	0.483
MOD_GSK3_1	40	47	PF00069	0.517
MOD_N-GLC_1	522	527	PF02516	0.421
MOD_N-GLC_1	95	100	PF02516	0.420
MOD_NEK2_1	202	207	PF00069	0.602
MOD_NEK2_1	209	214	PF00069	0.574
MOD_NEK2_1	262	267	PF00069	0.395
MOD_NEK2_1	357	362	PF00069	0.233
MOD_NEK2_1	382	387	PF00069	0.233
MOD_NEK2_1	40	45	PF00069	0.510
MOD_NEK2_1	424	429	PF00069	0.321
MOD_NEK2_1	48	53	PF00069	0.600
MOD_NEK2_1	97	102	PF00069	0.390
MOD_NEK2_2	300	305	PF00069	0.315
MOD_PIKK_1	382	388	PF00454	0.233
MOD_PKA_1	141	147	PF00069	0.538
MOD_PKA_1	181	187	PF00069	0.556
MOD_PKA_2	141	147	PF00069	0.545
MOD_PKA_2	181	187	PF00069	0.556
MOD_PKA_2	212	218	PF00069	0.586
MOD_PKA_2	380	386	PF00069	0.315
MOD_PKB_1	140	148	PF00069	0.452
MOD_Plk_1	262	268	PF00069	0.315
MOD_Plk_1	40	46	PF00069	0.501
MOD_Plk_1	48	54	PF00069	0.564
MOD_Plk_1	522	528	PF00069	0.510
MOD_Plk_2-3	337	343	PF00069	0.288
MOD_Plk_4	162	168	PF00069	0.525
MOD_Plk_4	205	211	PF00069	0.585
MOD_Plk_4	214	220	PF00069	0.594
MOD_Plk_4	33	39	PF00069	0.411
MOD_Plk_4	459	465	PF00069	0.290
MOD_Plk_4	515	521	PF00069	0.315
MOD_ProDKin_1	172	178	PF00069	0.576
MOD_ProDKin_1	188	194	PF00069	0.707
MOD_ProDKin_1	239	245	PF00069	0.315
MOD_ProDKin_1	401	407	PF00069	0.256
MOD_ProDKin_1	7	13	PF00069	0.398
MOD_SUMO_for_1	133	136	PF00179	0.425
MOD_SUMO_rev_2	56	65	PF00179	0.667
TRG_DiLeu_BaEn_1	263	268	PF01217	0.395
TRG_DiLeu_BaEn_1	508	513	PF01217	0.315
TRG_ENDOCYTIC_2	350	353	PF00928	0.233
TRG_ENDOCYTIC_2	464	467	PF00928	0.254
TRG_ER_diArg_1	140	142	PF00400	0.578
TRG_ER_diArg_1	226	229	PF00400	0.581
TRG_ER_diArg_1	398	400	PF00400	0.395
TRG_ER_diArg_1	472	475	PF00400	0.227
TRG_Pf-PMV_PEXEL_1	112	116	PF00026	0.504

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCR2	Leptomonas seymouri	70%	100%
A0A3Q8IJD5	Leishmania donovani	79%	100%
A4HXC2	Leishmania infantum	78%	100%
E9AR17	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	100%
Q4QEE6	Leishmania major	78%	100%