J domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DnaJ domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4H8Y9_LEIBR

TriTrypDb:

LbrM.17.0440 , LBRM2903_170010600

Length:

325

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11
GO:0005783	endoplasmic reticulum	5	1
GO:0031207	Sec62/Sec63 complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0098796	membrane protein complex	2	1
GO:0140534	endoplasmic reticulum protein-containing complex	2	1

Expansion

Sequence features

A4H8Y9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H8Y9

Function

Biological processes
Term	Name	Level	Count
GO:0006605	protein targeting	5	1
GO:0006612	protein targeting to membrane	5	1
GO:0006613	cotranslational protein targeting to membrane	6	1
GO:0006614	SRP-dependent cotranslational protein targeting to membrane	7	1
GO:0006620	post-translational protein targeting to endoplasmic reticulum membrane	6	1
GO:0006810	transport	3	1
GO:0006886	intracellular protein transport	4	1
GO:0008104	protein localization	4	1
GO:0009987	cellular process	1	1
GO:0015031	protein transport	4	1
GO:0033036	macromolecule localization	2	1
GO:0033365	protein localization to organelle	5	1
GO:0045047	protein targeting to ER	6	1
GO:0045184	establishment of protein localization	3	1
GO:0046907	intracellular transport	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0051668	localization within membrane	3	1
GO:0070727	cellular macromolecule localization	3	1
GO:0070972	protein localization to endoplasmic reticulum	6	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1
GO:0072594	establishment of protein localization to organelle	4	1
GO:0072599	establishment of protein localization to endoplasmic reticulum	5	1
GO:0072657	protein localization to membrane	4	1
GO:0090150	establishment of protein localization to membrane	4	1

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	1
GO:0008320	protein transmembrane transporter activity	3	1
GO:0022857	transmembrane transporter activity	2	1
GO:0022884	macromolecule transmembrane transporter activity	3	1
GO:0140318	protein transporter activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	120	122	PF00675	0.503
CLV_NRD_NRD_1	205	207	PF00675	0.430
CLV_NRD_NRD_1	320	322	PF00675	0.363
CLV_NRD_NRD_1	83	85	PF00675	0.463
CLV_PCSK_KEX2_1	119	121	PF00082	0.483
CLV_PCSK_KEX2_1	205	207	PF00082	0.398
CLV_PCSK_KEX2_1	320	322	PF00082	0.350
CLV_PCSK_KEX2_1	83	85	PF00082	0.462
CLV_PCSK_PC7_1	116	122	PF00082	0.468
CLV_PCSK_SKI1_1	104	108	PF00082	0.381
CLV_PCSK_SKI1_1	316	320	PF00082	0.339
CLV_Separin_Metazoa	232	236	PF03568	0.565
DEG_Nend_Nbox_1	1	3	PF02207	0.693
DEG_SPOP_SBC_1	46	50	PF00917	0.663
DOC_CKS1_1	242	247	PF01111	0.562
DOC_USP7_MATH_1	154	158	PF00917	0.456
DOC_USP7_MATH_1	22	26	PF00917	0.622
DOC_USP7_MATH_1	303	307	PF00917	0.613
DOC_USP7_MATH_1	46	50	PF00917	0.768
DOC_WW_Pin1_4	197	202	PF00397	0.559
DOC_WW_Pin1_4	241	246	PF00397	0.559
DOC_WW_Pin1_4	311	316	PF00397	0.570
DOC_WW_Pin1_4	38	43	PF00397	0.708
DOC_WW_Pin1_4	87	92	PF00397	0.713
DOC_WW_Pin1_4	99	104	PF00397	0.637
LIG_14-3-3_CanoR_1	208	218	PF00244	0.594
LIG_14-3-3_CanoR_1	235	240	PF00244	0.565
LIG_14-3-3_CanoR_1	83	93	PF00244	0.713
LIG_BRCT_BRCA1_1	271	275	PF00533	0.427
LIG_deltaCOP1_diTrp_1	308	318	PF00928	0.558
LIG_eIF4E_1	264	270	PF01652	0.339
LIG_FHA_1	10	16	PF00498	0.585
LIG_FHA_1	156	162	PF00498	0.482
LIG_FHA_1	52	58	PF00498	0.745
LIG_FHA_2	108	114	PF00498	0.768
LIG_FHA_2	126	132	PF00498	0.654
LIG_LIR_Gen_1	246	254	PF02991	0.349
LIG_LIR_Gen_1	272	283	PF02991	0.437
LIG_LIR_Nem_3	204	210	PF02991	0.574
LIG_LIR_Nem_3	213	219	PF02991	0.585
LIG_LIR_Nem_3	246	251	PF02991	0.399
LIG_LIR_Nem_3	272	278	PF02991	0.431
LIG_LIR_Nem_3	90	96	PF02991	0.585
LIG_MLH1_MIPbox_1	271	275	PF16413	0.344
LIG_NRBOX	279	285	PF00104	0.334
LIG_Pex14_2	217	221	PF04695	0.553
LIG_Pex14_2	263	267	PF04695	0.295
LIG_SH2_CRK	207	211	PF00017	0.565
LIG_SH2_CRK	219	223	PF00017	0.540
LIG_SH2_CRK	93	97	PF00017	0.637
LIG_SH2_NCK_1	194	198	PF00017	0.440
LIG_SH2_STAP1	299	303	PF00017	0.341
LIG_SH2_STAP1	307	311	PF00017	0.526
LIG_SH2_STAT5	216	219	PF00017	0.551
LIG_SH2_STAT5	258	261	PF00017	0.355
LIG_TRAF2_1	109	112	PF00917	0.615
LIG_TRAF2_1	128	131	PF00917	0.608
LIG_TYR_ITAM	191	210	PF00017	0.549
LIG_TYR_ITIM	163	168	PF00017	0.440
LIG_Vh1_VBS_1	269	287	PF01044	0.313
MOD_CDK_SPK_2	311	316	PF00069	0.554
MOD_CDK_SPK_2	99	104	PF00069	0.664
MOD_CK1_1	157	163	PF00069	0.473
MOD_CK1_1	50	56	PF00069	0.675
MOD_CK1_1	87	93	PF00069	0.631
MOD_CK1_1	9	15	PF00069	0.617
MOD_CK2_1	107	113	PF00069	0.771
MOD_CK2_1	125	131	PF00069	0.568
MOD_CMANNOS	239	242	PF00535	0.370
MOD_GlcNHglycan	12	15	PF01048	0.548
MOD_GlcNHglycan	141	144	PF01048	0.494
MOD_GlcNHglycan	245	248	PF01048	0.287
MOD_GlcNHglycan	76	79	PF01048	0.448
MOD_GSK3_1	195	202	PF00069	0.467
MOD_GSK3_1	3	10	PF00069	0.717
MOD_GSK3_1	34	41	PF00069	0.634
MOD_GSK3_1	46	53	PF00069	0.739
MOD_GSK3_1	68	75	PF00069	0.658
MOD_GSK3_1	85	92	PF00069	0.666
MOD_NEK2_1	269	274	PF00069	0.377
MOD_NEK2_1	283	288	PF00069	0.326
MOD_NEK2_1	297	302	PF00069	0.309
MOD_NEK2_1	3	8	PF00069	0.717
MOD_NEK2_1	34	39	PF00069	0.596
MOD_NEK2_1	47	52	PF00069	0.701
MOD_NEK2_1	68	73	PF00069	0.597
MOD_OFUCOSY	69	74	PF10250	0.352
MOD_PIKK_1	155	161	PF00454	0.532
MOD_PIKK_1	211	217	PF00454	0.564
MOD_PKA_1	119	125	PF00069	0.674
MOD_PKA_2	119	125	PF00069	0.675
MOD_PKA_2	3	9	PF00069	0.683
MOD_Plk_4	269	275	PF00069	0.382
MOD_Plk_4	283	289	PF00069	0.305
MOD_Plk_4	297	303	PF00069	0.242
MOD_ProDKin_1	197	203	PF00069	0.567
MOD_ProDKin_1	241	247	PF00069	0.553
MOD_ProDKin_1	311	317	PF00069	0.565
MOD_ProDKin_1	38	44	PF00069	0.709
MOD_ProDKin_1	87	93	PF00069	0.715
MOD_ProDKin_1	99	105	PF00069	0.637
TRG_DiLeu_BaLyEn_6	265	270	PF01217	0.338
TRG_ENDOCYTIC_2	165	168	PF00928	0.440
TRG_ENDOCYTIC_2	194	197	PF00928	0.440
TRG_ENDOCYTIC_2	207	210	PF00928	0.569
TRG_ENDOCYTIC_2	218	221	PF00928	0.551
TRG_ENDOCYTIC_2	264	267	PF00928	0.298
TRG_ENDOCYTIC_2	299	302	PF00928	0.295
TRG_ENDOCYTIC_2	93	96	PF00928	0.642
TRG_ER_diArg_1	119	121	PF00400	0.689
TRG_ER_diArg_1	161	164	PF00400	0.440
TRG_ER_diArg_1	205	207	PF00400	0.614
TRG_ER_diArg_1	319	321	PF00400	0.561
TRG_ER_diArg_1	83	85	PF00400	0.664
TRG_Pf-PMV_PEXEL_1	208	213	PF00026	0.398
TRG_Pf-PMV_PEXEL_1	220	224	PF00026	0.384

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IK95	Leptomonas seymouri	83%	100%
A0A0S4J1V7	Bodo saltans	51%	100%
A0A1X0NSX2	Trypanosomatidae	63%	100%
A0A3Q8ICS4	Leishmania donovani	88%	91%
A0A3R7MRU2	Trypanosoma rangeli	63%	100%
A4HXB9	Leishmania infantum	88%	100%
C9ZU12	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	64%	100%
E9AR15	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4QEE8	Leishmania major	95%	100%