N6-adenine methyltransferase family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Probable N6-adenine methyltransferase, putative

Species:

Leishmania braziliensis

UniProt:

A4H8Y5_LEIBR

TriTrypDb:

LbrM.17.0400 , LBRM2903_170010000

Length:

547

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	12
GO:0110165	cellular anatomical entity	1	12
GO:0016020	membrane	2	1

Expansion

Sequence features

A4H8Y5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H8Y5

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	9
GO:0003824	catalytic activity	1	12
GO:0005488	binding	1	9
GO:0008168	methyltransferase activity	4	12
GO:0008170	N-methyltransferase activity	5	12
GO:0008276	protein methyltransferase activity	3	12
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	5	12
GO:0016278	lysine N-methyltransferase activity	6	12
GO:0016279	protein-lysine N-methyltransferase activity	4	12
GO:0016740	transferase activity	2	12
GO:0016741	transferase activity, transferring one-carbon groups	3	12
GO:0097159	organic cyclic compound binding	2	9
GO:0140096	catalytic activity, acting on a protein	2	12
GO:1901363	heterocyclic compound binding	2	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	351	355	PF00656	0.508
CLV_NRD_NRD_1	240	242	PF00675	0.556
CLV_NRD_NRD_1	523	525	PF00675	0.430
CLV_NRD_NRD_1	71	73	PF00675	0.342
CLV_PCSK_KEX2_1	242	244	PF00082	0.606
CLV_PCSK_KEX2_1	510	512	PF00082	0.527
CLV_PCSK_KEX2_1	523	525	PF00082	0.546
CLV_PCSK_KEX2_1	71	73	PF00082	0.342
CLV_PCSK_PC1ET2_1	242	244	PF00082	0.652
CLV_PCSK_PC1ET2_1	510	512	PF00082	0.419
CLV_PCSK_SKI1_1	147	151	PF00082	0.252
CLV_PCSK_SKI1_1	155	159	PF00082	0.227
CLV_PCSK_SKI1_1	174	178	PF00082	0.241
CLV_PCSK_SKI1_1	20	24	PF00082	0.357
CLV_PCSK_SKI1_1	375	379	PF00082	0.583
CLV_PCSK_SKI1_1	523	527	PF00082	0.454
CLV_PCSK_SKI1_1	534	538	PF00082	0.348
CLV_PCSK_SKI1_1	541	545	PF00082	0.328
DEG_APCC_DBOX_1	510	518	PF00400	0.363
DEG_SPOP_SBC_1	325	329	PF00917	0.486
DOC_AGCK_PIF_2	105	110	PF00069	0.377
DOC_CKS1_1	59	64	PF01111	0.452
DOC_CYCLIN_RxL_1	144	152	PF00134	0.544
DOC_CYCLIN_yCln2_LP_2	172	178	PF00134	0.466
DOC_MAPK_FxFP_2	525	528	PF00069	0.454
DOC_MAPK_gen_1	365	373	PF00069	0.552
DOC_MAPK_gen_1	428	437	PF00069	0.473
DOC_MAPK_RevD_3	57	72	PF00069	0.542
DOC_PIKK_1	163	171	PF02985	0.542
DOC_PP1_RVXF_1	153	159	PF00149	0.452
DOC_PP1_RVXF_1	27	33	PF00149	0.262
DOC_PP4_FxxP_1	110	113	PF00568	0.452
DOC_PP4_FxxP_1	525	528	PF00568	0.510
DOC_USP7_MATH_1	315	319	PF00917	0.686
DOC_USP7_MATH_1	323	327	PF00917	0.667
DOC_USP7_MATH_1	402	406	PF00917	0.541
DOC_USP7_MATH_1	456	460	PF00917	0.524
DOC_USP7_MATH_1	492	496	PF00917	0.434
DOC_USP7_UBL2_3	147	151	PF12436	0.488
DOC_USP7_UBL2_3	381	385	PF12436	0.661
DOC_WW_Pin1_4	58	63	PF00397	0.452
LIG_14-3-3_CanoR_1	228	236	PF00244	0.573
LIG_14-3-3_CanoR_1	87	95	PF00244	0.530
LIG_Actin_WH2_2	214	230	PF00022	0.463
LIG_APCC_ABBA_1	296	301	PF00400	0.661
LIG_BRCT_BRCA1_1	328	332	PF00533	0.561
LIG_BRCT_BRCA1_1	62	66	PF00533	0.458
LIG_BRCT_BRCA1_1	89	93	PF00533	0.441
LIG_deltaCOP1_diTrp_1	96	105	PF00928	0.377
LIG_FHA_1	133	139	PF00498	0.450
LIG_FHA_1	143	149	PF00498	0.441
LIG_FHA_1	279	285	PF00498	0.590
LIG_FHA_1	416	422	PF00498	0.444
LIG_FHA_1	496	502	PF00498	0.495
LIG_FHA_1	59	65	PF00498	0.471
LIG_FHA_2	158	164	PF00498	0.452
LIG_FHA_2	26	32	PF00498	0.494
LIG_FHA_2	342	348	PF00498	0.456
LIG_FHA_2	74	80	PF00498	0.539
LIG_Integrin_RGD_1	72	74	PF01839	0.327
LIG_LIR_Apic_2	109	113	PF02991	0.441
LIG_LIR_Apic_2	522	528	PF02991	0.394
LIG_LIR_Gen_1	189	200	PF02991	0.441
LIG_LIR_Nem_3	102	108	PF02991	0.441
LIG_LIR_Nem_3	137	142	PF02991	0.455
LIG_LIR_Nem_3	180	185	PF02991	0.465
LIG_LIR_Nem_3	189	195	PF02991	0.424
LIG_LIR_Nem_3	288	292	PF02991	0.661
LIG_LIR_Nem_3	31	35	PF02991	0.476
LIG_LIR_Nem_3	63	68	PF02991	0.465
LIG_LYPXL_S_1	181	185	PF13949	0.342
LIG_LYPXL_yS_3	182	185	PF13949	0.542
LIG_MLH1_MIPbox_1	62	66	PF16413	0.441
LIG_NRBOX	167	173	PF00104	0.466
LIG_NRP_CendR_1	544	547	PF00754	0.557
LIG_Pex14_2	177	181	PF04695	0.452
LIG_Pex14_2	32	36	PF04695	0.452
LIG_SH2_CRK	190	194	PF00017	0.452
LIG_SH2_SRC	190	193	PF00017	0.441
LIG_SH2_STAP1	142	146	PF00017	0.526
LIG_SH2_STAP1	493	497	PF00017	0.493
LIG_SH2_STAP1	95	99	PF00017	0.542
LIG_SH2_STAT3	95	98	PF00017	0.508
LIG_SH2_STAT5	126	129	PF00017	0.489
LIG_SH2_STAT5	192	195	PF00017	0.467
LIG_SH2_STAT5	291	294	PF00017	0.477
LIG_SH3_3	125	131	PF00018	0.484
LIG_Sin3_3	8	15	PF02671	0.477
LIG_TRAF2_1	513	516	PF00917	0.558
LIG_TYR_ITIM	188	193	PF00017	0.452
LIG_UBA3_1	529	534	PF00899	0.377
LIG_UBA3_1	536	544	PF00899	0.402
LIG_WRC_WIRS_1	346	351	PF05994	0.326
MOD_CK1_1	16	22	PF00069	0.588
MOD_CK1_1	326	332	PF00069	0.499
MOD_CK1_1	38	44	PF00069	0.441
MOD_CK1_1	396	402	PF00069	0.655
MOD_CK1_1	405	411	PF00069	0.541
MOD_CK1_1	459	465	PF00069	0.716
MOD_CK1_1	478	484	PF00069	0.628
MOD_CK1_1	495	501	PF00069	0.341
MOD_CK1_1	60	66	PF00069	0.455
MOD_CK2_1	157	163	PF00069	0.441
MOD_CK2_1	227	233	PF00069	0.447
MOD_CK2_1	25	31	PF00069	0.387
MOD_CK2_1	324	330	PF00069	0.555
MOD_CK2_1	405	411	PF00069	0.533
MOD_GlcNHglycan	15	18	PF01048	0.540
MOD_GlcNHglycan	404	407	PF01048	0.501
MOD_GlcNHglycan	477	480	PF01048	0.740
MOD_GlcNHglycan	483	486	PF01048	0.638
MOD_GlcNHglycan	494	497	PF01048	0.280
MOD_GlcNHglycan	6	9	PF01048	0.680
MOD_GSK3_1	194	201	PF00069	0.523
MOD_GSK3_1	321	328	PF00069	0.699
MOD_GSK3_1	341	348	PF00069	0.453
MOD_GSK3_1	371	378	PF00069	0.522
MOD_GSK3_1	402	409	PF00069	0.547
MOD_GSK3_1	455	462	PF00069	0.577
MOD_GSK3_1	475	482	PF00069	0.714
MOD_N-GLC_1	163	168	PF02516	0.252
MOD_N-GLC_2	337	339	PF02516	0.451
MOD_NEK2_1	156	161	PF00069	0.442
MOD_NEK2_1	321	326	PF00069	0.499
MOD_NEK2_1	86	91	PF00069	0.496
MOD_NEK2_2	18	23	PF00069	0.643
MOD_PIKK_1	1	7	PF00454	0.734
MOD_PIKK_1	137	143	PF00454	0.462
MOD_PKA_2	227	233	PF00069	0.442
MOD_PKA_2	38	44	PF00069	0.502
MOD_PKA_2	86	92	PF00069	0.528
MOD_Plk_1	163	169	PF00069	0.452
MOD_Plk_1	375	381	PF00069	0.514
MOD_Plk_1	479	485	PF00069	0.500
MOD_Plk_1	78	84	PF00069	0.382
MOD_Plk_2-3	163	169	PF00069	0.470
MOD_Plk_4	163	169	PF00069	0.447
MOD_Plk_4	294	300	PF00069	0.577
MOD_Plk_4	375	381	PF00069	0.449
MOD_Plk_4	393	399	PF00069	0.408
MOD_Plk_4	60	66	PF00069	0.465
MOD_ProDKin_1	58	64	PF00069	0.452
MOD_SUMO_for_1	270	273	PF00179	0.384
MOD_SUMO_rev_2	209	218	PF00179	0.417
TRG_DiLeu_BaEn_1	152	157	PF01217	0.542
TRG_DiLeu_BaEn_1	163	168	PF01217	0.542
TRG_ENDOCYTIC_2	182	185	PF00928	0.464
TRG_ENDOCYTIC_2	190	193	PF00928	0.423
TRG_ENDOCYTIC_2	504	507	PF00928	0.383
TRG_ER_diArg_1	340	343	PF00400	0.470
TRG_ER_diArg_1	523	525	PF00400	0.480
TRG_NES_CRM1_1	354	369	PF08389	0.522

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDR6	Leptomonas seymouri	62%	100%
A0A0S4KEA9	Bodo saltans	38%	100%
A0A1X0NT88	Trypanosomatidae	42%	100%
A0A3Q8IDX6	Leishmania donovani	79%	100%
A0A422NXL8	Trypanosoma rangeli	42%	100%
A4HXB5	Leishmania infantum	79%	100%
C9ZU02	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	100%
E9AR11	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	98%
Q4QEF2	Leishmania major	81%	100%
V5BAJ7	Trypanosoma cruzi	42%	87%