RING-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Ring finger domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4H8Y3_LEIBR

TriTrypDb:

LbrM.17.0380 , LBRM2903_170009700

Length:

1058

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H8Y3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H8Y3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	612	616	PF00656	0.653
CLV_C14_Caspase3-7	71	75	PF00656	0.619
CLV_C14_Caspase3-7	942	946	PF00656	0.231
CLV_NRD_NRD_1	195	197	PF00675	0.724
CLV_NRD_NRD_1	293	295	PF00675	0.569
CLV_NRD_NRD_1	456	458	PF00675	0.402
CLV_NRD_NRD_1	492	494	PF00675	0.703
CLV_NRD_NRD_1	53	55	PF00675	0.586
CLV_NRD_NRD_1	610	612	PF00675	0.647
CLV_NRD_NRD_1	625	627	PF00675	0.434
CLV_NRD_NRD_1	717	719	PF00675	0.552
CLV_NRD_NRD_1	858	860	PF00675	0.355
CLV_PCSK_FUR_1	293	297	PF00082	0.611
CLV_PCSK_KEX2_1	195	197	PF00082	0.727
CLV_PCSK_KEX2_1	205	207	PF00082	0.617
CLV_PCSK_KEX2_1	243	245	PF00082	0.743
CLV_PCSK_KEX2_1	293	295	PF00082	0.546
CLV_PCSK_KEX2_1	385	387	PF00082	0.554
CLV_PCSK_KEX2_1	492	494	PF00082	0.702
CLV_PCSK_KEX2_1	52	54	PF00082	0.557
CLV_PCSK_KEX2_1	610	612	PF00082	0.647
CLV_PCSK_KEX2_1	717	719	PF00082	0.552
CLV_PCSK_KEX2_1	857	859	PF00082	0.409
CLV_PCSK_PC1ET2_1	205	207	PF00082	0.560
CLV_PCSK_PC1ET2_1	243	245	PF00082	0.653
CLV_PCSK_PC1ET2_1	295	297	PF00082	0.602
CLV_PCSK_PC1ET2_1	385	387	PF00082	0.630
CLV_PCSK_PC1ET2_1	857	859	PF00082	0.409
CLV_PCSK_PC7_1	49	55	PF00082	0.474
CLV_PCSK_SKI1_1	1041	1045	PF00082	0.540
CLV_PCSK_SKI1_1	29	33	PF00082	0.647
CLV_PCSK_SKI1_1	382	386	PF00082	0.620
CLV_PCSK_SKI1_1	555	559	PF00082	0.672
CLV_PCSK_SKI1_1	979	983	PF00082	0.430
CLV_Separin_Metazoa	431	435	PF03568	0.588
DEG_APCC_DBOX_1	28	36	PF00400	0.622
DEG_APCC_DBOX_1	51	59	PF00400	0.504
DEG_APCC_DBOX_1	625	633	PF00400	0.423
DEG_Nend_UBRbox_3	1	3	PF02207	0.646
DEG_ODPH_VHL_1	620	631	PF01847	0.587
DEG_SCF_TRCP1_1	726	731	PF00400	0.593
DOC_ANK_TNKS_1	309	316	PF00023	0.459
DOC_CYCLIN_RxL_1	243	256	PF00134	0.653
DOC_CYCLIN_yCln2_LP_2	696	702	PF00134	0.575
DOC_CYCLIN_yCln2_LP_2	913	919	PF00134	0.285
DOC_MAPK_gen_1	243	252	PF00069	0.746
DOC_MAPK_gen_1	382	392	PF00069	0.635
DOC_MAPK_gen_1	52	61	PF00069	0.491
DOC_MAPK_MEF2A_6	133	142	PF00069	0.560
DOC_MAPK_MEF2A_6	385	392	PF00069	0.568
DOC_MAPK_MEF2A_6	54	63	PF00069	0.502
DOC_MAPK_MEF2A_6	678	686	PF00069	0.479
DOC_MAPK_RevD_3	702	718	PF00069	0.566
DOC_PP1_RVXF_1	715	722	PF00149	0.476
DOC_PP2B_LxvP_1	140	143	PF13499	0.553
DOC_PP2B_LxvP_1	849	852	PF13499	0.417
DOC_PP2B_LxvP_1	982	985	PF13499	0.459
DOC_PP4_FxxP_1	163	166	PF00568	0.628
DOC_PP4_FxxP_1	557	560	PF00568	0.676
DOC_USP7_MATH_1	117	121	PF00917	0.665
DOC_USP7_MATH_1	134	138	PF00917	0.577
DOC_USP7_MATH_1	340	344	PF00917	0.710
DOC_USP7_MATH_1	36	40	PF00917	0.497
DOC_USP7_MATH_1	384	388	PF00917	0.495
DOC_USP7_MATH_1	522	526	PF00917	0.528
DOC_USP7_MATH_1	560	564	PF00917	0.520
DOC_USP7_MATH_1	883	887	PF00917	0.552
DOC_USP7_UBL2_3	664	668	PF12436	0.599
DOC_WW_Pin1_4	1051	1056	PF00397	0.647
DOC_WW_Pin1_4	162	167	PF00397	0.627
DOC_WW_Pin1_4	185	190	PF00397	0.572
DOC_WW_Pin1_4	348	353	PF00397	0.601
DOC_WW_Pin1_4	507	512	PF00397	0.670
DOC_WW_Pin1_4	669	674	PF00397	0.550
DOC_WW_Pin1_4	806	811	PF00397	0.391
DOC_WW_Pin1_4	912	917	PF00397	0.285
LIG_14-3-3_CanoR_1	133	140	PF00244	0.560
LIG_14-3-3_CanoR_1	326	333	PF00244	0.559
LIG_14-3-3_CanoR_1	492	502	PF00244	0.581
LIG_14-3-3_CanoR_1	610	614	PF00244	0.649
LIG_14-3-3_CanoR_1	717	722	PF00244	0.467
LIG_14-3-3_CanoR_1	770	776	PF00244	0.422
LIG_14-3-3_CanoR_1	784	789	PF00244	0.339
LIG_14-3-3_CanoR_1	858	863	PF00244	0.367
LIG_14-3-3_CanoR_1	958	966	PF00244	0.461
LIG_Actin_WH2_2	385	402	PF00022	0.626
LIG_Actin_WH2_2	758	774	PF00022	0.339
LIG_AP2alpha_1	3	7	PF02296	0.460
LIG_AP2alpha_1	613	617	PF02296	0.653
LIG_BIR_III_4	9	13	PF00653	0.556
LIG_BRCT_BRCA1_1	110	114	PF00533	0.625
LIG_BRCT_BRCA1_1	324	328	PF00533	0.447
LIG_BRCT_BRCA1_1	773	777	PF00533	0.374
LIG_BRCT_BRCA1_1	865	869	PF00533	0.364
LIG_CSL_BTD_1	33	36	PF09270	0.474
LIG_CtBP_PxDLS_1	446	450	PF00389	0.636
LIG_EH1_1	280	288	PF00400	0.457
LIG_eIF4E_1	16	22	PF01652	0.614
LIG_EVH1_1	849	853	PF00568	0.496
LIG_EVH1_2	109	113	PF00568	0.607
LIG_FHA_1	1051	1057	PF00498	0.514
LIG_FHA_1	133	139	PF00498	0.557
LIG_FHA_1	227	233	PF00498	0.555
LIG_FHA_1	486	492	PF00498	0.544
LIG_FHA_1	512	518	PF00498	0.545
LIG_FHA_1	570	576	PF00498	0.438
LIG_FHA_1	681	687	PF00498	0.571
LIG_FHA_1	799	805	PF00498	0.446
LIG_FHA_1	840	846	PF00498	0.573
LIG_FHA_1	95	101	PF00498	0.556
LIG_FHA_2	15	21	PF00498	0.590
LIG_FHA_2	235	241	PF00498	0.511
LIG_FHA_2	494	500	PF00498	0.543
LIG_FHA_2	540	546	PF00498	0.567
LIG_FHA_2	560	566	PF00498	0.579
LIG_FHA_2	610	616	PF00498	0.629
LIG_FHA_2	792	798	PF00498	0.370
LIG_FHA_2	940	946	PF00498	0.231
LIG_FHA_2	965	971	PF00498	0.544
LIG_LIR_Apic_2	161	166	PF02991	0.630
LIG_LIR_Apic_2	960	965	PF02991	0.532
LIG_LIR_Gen_1	277	288	PF02991	0.460
LIG_LIR_Gen_1	409	416	PF02991	0.531
LIG_LIR_Gen_1	615	624	PF02991	0.539
LIG_LIR_Gen_1	720	729	PF02991	0.497
LIG_LIR_Gen_1	809	819	PF02991	0.304
LIG_LIR_Nem_3	1028	1034	PF02991	0.370
LIG_LIR_Nem_3	277	283	PF02991	0.615
LIG_LIR_Nem_3	409	414	PF02991	0.522
LIG_LIR_Nem_3	441	445	PF02991	0.634
LIG_LIR_Nem_3	615	620	PF02991	0.559
LIG_LIR_Nem_3	720	724	PF02991	0.473
LIG_LIR_Nem_3	750	754	PF02991	0.430
LIG_LIR_Nem_3	774	780	PF02991	0.378
LIG_LIR_Nem_3	975	981	PF02991	0.324
LIG_MLH1_MIPbox_1	110	114	PF16413	0.545
LIG_PCNA_TLS_4	458	465	PF02747	0.411
LIG_PDZ_Class_2	1053	1058	PF00595	0.545
LIG_Pex14_2	3	7	PF04695	0.618
LIG_Pex14_2	464	468	PF04695	0.482
LIG_Pex14_2	613	617	PF04695	0.653
LIG_PTB_Apo_2	402	409	PF02174	0.511
LIG_Rb_LxCxE_1	599	615	PF01857	0.591
LIG_SH2_CRK	1031	1035	PF00017	0.293
LIG_SH2_CRK	289	293	PF00017	0.608
LIG_SH2_CRK	411	415	PF00017	0.574
LIG_SH2_CRK	962	966	PF00017	0.525
LIG_SH2_CRK	978	982	PF00017	0.278
LIG_SH2_GRB2like	1018	1021	PF00017	0.424
LIG_SH2_STAP1	411	415	PF00017	0.574
LIG_SH2_STAP1	657	661	PF00017	0.465
LIG_SH2_STAP1	743	747	PF00017	0.522
LIG_SH2_STAT5	16	19	PF00017	0.584
LIG_SH2_STAT5	279	282	PF00017	0.540
LIG_SH2_STAT5	303	306	PF00017	0.648
LIG_SH2_STAT5	379	382	PF00017	0.600
LIG_SH2_STAT5	623	626	PF00017	0.425
LIG_SH3_3	103	109	PF00018	0.666
LIG_SH3_3	140	146	PF00018	0.606
LIG_SH3_3	387	393	PF00018	0.648
LIG_SH3_3	440	446	PF00018	0.558
LIG_SH3_3	481	487	PF00018	0.667
LIG_SH3_3	847	853	PF00018	0.514
LIG_SUMO_SIM_anti_2	628	634	PF11976	0.581
LIG_SUMO_SIM_anti_2	681	686	PF11976	0.498
LIG_SUMO_SIM_anti_2	801	806	PF11976	0.445
LIG_SUMO_SIM_par_1	165	171	PF11976	0.542
LIG_SUMO_SIM_par_1	475	481	PF11976	0.473
LIG_TRAF2_1	17	20	PF00917	0.452
LIG_TRAF2_1	563	566	PF00917	0.474
LIG_TYR_ITIM	287	292	PF00017	0.612
LIG_UBA3_1	264	270	PF00899	0.459
LIG_UBA3_1	286	295	PF00899	0.616
MOD_CDC14_SPxK_1	188	191	PF00782	0.556
MOD_CDK_SPxK_1	185	191	PF00069	0.553
MOD_CK1_1	165	171	PF00069	0.649
MOD_CK1_1	223	229	PF00069	0.707
MOD_CK1_1	231	237	PF00069	0.618
MOD_CK1_1	329	335	PF00069	0.552
MOD_CK1_1	510	516	PF00069	0.643
MOD_CK1_1	66	72	PF00069	0.660
MOD_CK1_1	809	815	PF00069	0.323
MOD_CK1_1	84	90	PF00069	0.710
MOD_CK2_1	14	20	PF00069	0.593
MOD_CK2_1	233	239	PF00069	0.530
MOD_CK2_1	348	354	PF00069	0.704
MOD_CK2_1	36	42	PF00069	0.525
MOD_CK2_1	493	499	PF00069	0.545
MOD_CK2_1	559	565	PF00069	0.580
MOD_CK2_1	61	67	PF00069	0.694
MOD_CK2_1	622	628	PF00069	0.502
MOD_CK2_1	791	797	PF00069	0.479
MOD_GlcNHglycan	100	103	PF01048	0.739
MOD_GlcNHglycan	120	123	PF01048	0.495
MOD_GlcNHglycan	150	153	PF01048	0.640
MOD_GlcNHglycan	160	163	PF01048	0.680
MOD_GlcNHglycan	170	173	PF01048	0.552
MOD_GlcNHglycan	223	226	PF01048	0.708
MOD_GlcNHglycan	420	423	PF01048	0.421
MOD_GlcNHglycan	547	550	PF01048	0.671
MOD_GlcNHglycan	726	729	PF01048	0.612
MOD_GlcNHglycan	827	831	PF01048	0.497
MOD_GlcNHglycan	869	872	PF01048	0.440
MOD_GSK3_1	1019	1026	PF00069	0.469
MOD_GSK3_1	1037	1044	PF00069	0.371
MOD_GSK3_1	108	115	PF00069	0.645
MOD_GSK3_1	158	165	PF00069	0.661
MOD_GSK3_1	175	182	PF00069	0.522
MOD_GSK3_1	221	228	PF00069	0.693
MOD_GSK3_1	230	237	PF00069	0.592
MOD_GSK3_1	322	329	PF00069	0.536
MOD_GSK3_1	406	413	PF00069	0.515
MOD_GSK3_1	503	510	PF00069	0.675
MOD_GSK3_1	61	68	PF00069	0.635
MOD_GSK3_1	724	731	PF00069	0.583
MOD_GSK3_1	836	843	PF00069	0.459
MOD_GSK3_1	863	870	PF00069	0.452
MOD_GSK3_1	90	97	PF00069	0.632
MOD_N-GLC_1	1019	1024	PF02516	0.415
MOD_N-GLC_1	158	163	PF02516	0.546
MOD_N-GLC_1	220	225	PF02516	0.549
MOD_N-GLC_1	503	508	PF02516	0.829
MOD_N-GLC_1	863	868	PF02516	0.424
MOD_N-GLC_2	952	954	PF02516	0.312
MOD_NEK2_1	1050	1055	PF00069	0.560
MOD_NEK2_1	150	155	PF00069	0.689
MOD_NEK2_1	232	237	PF00069	0.539
MOD_NEK2_1	399	404	PF00069	0.590
MOD_NEK2_1	406	411	PF00069	0.508
MOD_NEK2_1	505	510	PF00069	0.557
MOD_NEK2_1	574	579	PF00069	0.421
MOD_NEK2_1	694	699	PF00069	0.482
MOD_NEK2_1	771	776	PF00069	0.396
MOD_NEK2_1	869	874	PF00069	0.446
MOD_NEK2_1	972	977	PF00069	0.481
MOD_NEK2_2	924	929	PF00069	0.231
MOD_OFUCOSY	330	336	PF10250	0.479
MOD_PIKK_1	108	114	PF00454	0.669
MOD_PIKK_1	132	138	PF00454	0.550
MOD_PIKK_1	298	304	PF00454	0.475
MOD_PIKK_1	493	499	PF00454	0.572
MOD_PK_1	784	790	PF00069	0.378
MOD_PKA_1	717	723	PF00069	0.549
MOD_PKA_1	858	864	PF00069	0.338
MOD_PKA_2	132	138	PF00069	0.550
MOD_PKA_2	309	315	PF00069	0.493
MOD_PKA_2	399	405	PF00069	0.650
MOD_PKA_2	48	54	PF00069	0.582
MOD_PKA_2	609	615	PF00069	0.645
MOD_PKA_2	717	723	PF00069	0.549
MOD_PKA_2	771	777	PF00069	0.455
MOD_PKA_2	778	784	PF00069	0.423
MOD_PKA_2	78	84	PF00069	0.677
MOD_PKA_2	858	864	PF00069	0.434
MOD_PKA_2	957	963	PF00069	0.457
MOD_Plk_1	1041	1047	PF00069	0.460
MOD_Plk_1	12	18	PF00069	0.497
MOD_Plk_1	36	42	PF00069	0.475
MOD_Plk_1	522	528	PF00069	0.526
MOD_Plk_1	680	686	PF00069	0.497
MOD_Plk_1	798	804	PF00069	0.456
MOD_Plk_2-3	609	615	PF00069	0.645
MOD_Plk_2-3	70	76	PF00069	0.564
MOD_Plk_4	1007	1013	PF00069	0.378
MOD_Plk_4	282	288	PF00069	0.613
MOD_Plk_4	410	416	PF00069	0.538
MOD_Plk_4	475	481	PF00069	0.672
MOD_Plk_4	485	491	PF00069	0.592
MOD_Plk_4	516	522	PF00069	0.622
MOD_Plk_4	523	529	PF00069	0.611
MOD_Plk_4	680	686	PF00069	0.497
MOD_Plk_4	747	753	PF00069	0.440
MOD_Plk_4	809	815	PF00069	0.323
MOD_Plk_4	939	945	PF00069	0.439
MOD_ProDKin_1	1051	1057	PF00069	0.647
MOD_ProDKin_1	162	168	PF00069	0.626
MOD_ProDKin_1	185	191	PF00069	0.576
MOD_ProDKin_1	348	354	PF00069	0.605
MOD_ProDKin_1	507	513	PF00069	0.669
MOD_ProDKin_1	669	675	PF00069	0.544
MOD_ProDKin_1	806	812	PF00069	0.398
MOD_ProDKin_1	912	918	PF00069	0.285
MOD_SUMO_rev_2	381	387	PF00179	0.613
TRG_DiLeu_BaEn_1	681	686	PF01217	0.498
TRG_DiLeu_BaLyEn_6	171	176	PF01217	0.667
TRG_DiLeu_BaLyEn_6	757	762	PF01217	0.403
TRG_DiLeu_BaLyEn_6	830	835	PF01217	0.388
TRG_DiLeu_BaLyEn_6	976	981	PF01217	0.289
TRG_ENDOCYTIC_2	1031	1034	PF00928	0.372
TRG_ENDOCYTIC_2	289	292	PF00928	0.606
TRG_ENDOCYTIC_2	411	414	PF00928	0.492
TRG_ENDOCYTIC_2	811	814	PF00928	0.490
TRG_ENDOCYTIC_2	978	981	PF00928	0.422
TRG_ER_diArg_1	292	294	PF00400	0.531
TRG_ER_diArg_1	304	307	PF00400	0.568
TRG_ER_diArg_1	397	400	PF00400	0.713
TRG_ER_diArg_1	491	493	PF00400	0.632
TRG_ER_diArg_1	52	54	PF00400	0.632
TRG_ER_diArg_1	717	719	PF00400	0.552
TRG_ER_diArg_1	769	772	PF00400	0.367
TRG_NES_CRM1_1	628	642	PF08389	0.609
TRG_NES_CRM1_1	840	855	PF08389	0.542
TRG_Pf-PMV_PEXEL_1	53	57	PF00026	0.632

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5H8	Leptomonas seymouri	37%	100%
A0A3Q8IAL8	Leishmania donovani	73%	100%
A4HXB3	Leishmania infantum	73%	100%
E9AR09	Leishmania mexicana (strain MHOM/GT/2001/U1103)	73%	100%
Q4QEF4	Leishmania major	74%	100%