Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

protein kinase, putative

Species:

Leishmania braziliensis

UniProt:

A4H8Y2_LEIBR

TriTrypDb:

LbrM.17.0370 , LBRM2903_170009500 , LBRM2903_170009600

Length:

1167

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

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Expansion

Sequence features

A4H8Y2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H8Y2

Function

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Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	7
GO:0006793	phosphorus metabolic process	3	7
GO:0006796	phosphate-containing compound metabolic process	4	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0008152	metabolic process	1	7
GO:0009987	cellular process	1	7
GO:0016310	phosphorylation	5	7
GO:0019538	protein metabolic process	3	7
GO:0036211	protein modification process	4	7
GO:0043170	macromolecule metabolic process	3	7

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Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	7
GO:0003824	catalytic activity	1	7
GO:0004672	protein kinase activity	3	7
GO:0004674	protein serine/threonine kinase activity	4	1
GO:0005488	binding	1	7
GO:0005524	ATP binding	5	7
GO:0016301	kinase activity	4	7
GO:0016740	transferase activity	2	7
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	7
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	7

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	103	107	PF00656	0.750
CLV_C14_Caspase3-7	164	168	PF00656	0.754
CLV_C14_Caspase3-7	601	605	PF00656	0.544
CLV_C14_Caspase3-7	66	70	PF00656	0.502
CLV_NRD_NRD_1	1148	1150	PF00675	0.411
CLV_NRD_NRD_1	149	151	PF00675	0.506
CLV_NRD_NRD_1	466	468	PF00675	0.455
CLV_NRD_NRD_1	675	677	PF00675	0.493
CLV_NRD_NRD_1	741	743	PF00675	0.561
CLV_NRD_NRD_1	963	965	PF00675	0.380

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1P903	Leptomonas seymouri	51%	100%
A0A3S7WUB7	Leishmania donovani	64%	98%
A4HXB2	Leishmania infantum	64%	100%
E9AR08	Leishmania mexicana (strain MHOM/GT/2001/U1103)	63%	98%
Q4QEF5	Leishmania major	61%	100%

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