Putative Qa-SNARE protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Qa-SNARE protein, putative

Species:

Leishmania braziliensis

UniProt:

A4H8Y1_LEIBR

TriTrypDb:

LbrM.17.0360 , LBRM2903_170009400

Length:

365

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 1, no: 5
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6
GO:0005789	endoplasmic reticulum membrane	4	1
GO:0005794	Golgi apparatus	5	1
GO:0010008	endosome membrane	5	1
GO:0012506	vesicle membrane	4	1
GO:0012507	ER to Golgi transport vesicle membrane	6	1
GO:0030658	transport vesicle membrane	5	1
GO:0030659	cytoplasmic vesicle membrane	5	1
GO:0030662	coated vesicle membrane	5	1
GO:0031090	organelle membrane	3	1
GO:0031201	SNARE complex	3	2
GO:0031902	late endosome membrane	6	1
GO:0032991	protein-containing complex	1	2
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0098588	bounding membrane of organelle	4	1
GO:0098796	membrane protein complex	2	2

Expansion

Sequence features

A4H8Y1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H8Y1

Function

Biological processes
Term	Name	Level	Count
GO:0006906	vesicle fusion	6	1
GO:0006996	organelle organization	4	1
GO:0009987	cellular process	1	2
GO:0016043	cellular component organization	3	1
GO:0016050	vesicle organization	5	1
GO:0048284	organelle fusion	5	1
GO:0061024	membrane organization	4	1
GO:0061025	membrane fusion	5	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0090174	organelle membrane fusion	6	1
GO:0006810	transport	3	2
GO:0006890	retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	6	2
GO:0016192	vesicle-mediated transport	4	2
GO:0048193	Golgi vesicle transport	5	2
GO:0051179	localization	1	2
GO:0051234	establishment of localization	2	2
GO:0008104	protein localization	4	1
GO:0015031	protein transport	4	1
GO:0033036	macromolecule localization	2	1
GO:0045184	establishment of protein localization	3	1
GO:0051641	cellular localization	2	1
GO:0070727	cellular macromolecule localization	3	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1

Molecular functions
Term	Name	Level	Count
GO:0000149	SNARE binding	3	1
GO:0005484	SNAP receptor activity	3	3
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0030674	protein-macromolecule adaptor activity	2	3
GO:0060090	molecular adaptor activity	1	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	152	154	PF00675	0.620
CLV_NRD_NRD_1	185	187	PF00675	0.676
CLV_NRD_NRD_1	196	198	PF00675	0.541
CLV_NRD_NRD_1	332	334	PF00675	0.651
CLV_PCSK_KEX2_1	152	154	PF00082	0.620
CLV_PCSK_KEX2_1	185	187	PF00082	0.604
CLV_PCSK_KEX2_1	203	205	PF00082	0.510
CLV_PCSK_KEX2_1	307	309	PF00082	0.612
CLV_PCSK_KEX2_1	332	334	PF00082	0.651
CLV_PCSK_PC1ET2_1	203	205	PF00082	0.550
CLV_PCSK_PC1ET2_1	307	309	PF00082	0.553
CLV_PCSK_SKI1_1	83	87	PF00082	0.554
DEG_APCC_DBOX_1	316	324	PF00400	0.349
DEG_APCC_KENBOX_2	197	201	PF00400	0.322
DEG_SPOP_SBC_1	121	125	PF00917	0.550
DEG_SPOP_SBC_1	134	138	PF00917	0.368
DOC_MAPK_gen_1	152	163	PF00069	0.423
DOC_MAPK_gen_1	203	211	PF00069	0.360
DOC_MAPK_gen_1	332	343	PF00069	0.414
DOC_MAPK_MEF2A_6	156	165	PF00069	0.425
DOC_MAPK_MEF2A_6	336	343	PF00069	0.272
DOC_PP1_RVXF_1	336	343	PF00149	0.248
DOC_PP2B_LxvP_1	33	36	PF13499	0.404
DOC_PP2B_LxvP_1	8	11	PF13499	0.416
DOC_USP7_MATH_1	178	182	PF00917	0.508
DOC_USP7_MATH_1	207	211	PF00917	0.438
DOC_WW_Pin1_4	234	239	PF00397	0.421
DOC_WW_Pin1_4	36	41	PF00397	0.458
DOC_WW_Pin1_4	42	47	PF00397	0.484
LIG_14-3-3_CanoR_1	185	191	PF00244	0.434
LIG_14-3-3_CanoR_1	266	274	PF00244	0.344
LIG_14-3-3_CanoR_1	83	88	PF00244	0.363
LIG_Clathr_ClatBox_1	107	111	PF01394	0.326
LIG_Clathr_ClatBox_1	322	326	PF01394	0.347
LIG_Clathr_ClatBox_1	96	100	PF01394	0.485
LIG_CSL_BTD_1	235	238	PF09270	0.448
LIG_EH1_1	341	349	PF00400	0.342
LIG_EVH1_1	8	12	PF00568	0.412
LIG_FHA_1	286	292	PF00498	0.464
LIG_FHA_1	295	301	PF00498	0.417
LIG_FHA_1	344	350	PF00498	0.405
LIG_FHA_2	307	313	PF00498	0.479
LIG_FHA_2	43	49	PF00498	0.442
LIG_GSK3_LRP6_1	36	41	PF00069	0.422
LIG_Integrin_RGD_1	131	133	PF01839	0.615
LIG_Integrin_RGD_1	248	250	PF01839	0.646
LIG_LIR_Gen_1	19	28	PF02991	0.375
LIG_LIR_Nem_3	19	24	PF02991	0.368
LIG_NRBOX	153	159	PF00104	0.491
LIG_NRP_CendR_1	363	365	PF00754	0.499
LIG_SH2_STAP1	176	180	PF00017	0.529
LIG_SH3_1	34	40	PF00018	0.415
LIG_SH3_3	32	38	PF00018	0.405
LIG_SH3_3	6	12	PF00018	0.463
LIG_SUMO_SIM_anti_2	318	324	PF11976	0.349
LIG_SUMO_SIM_par_1	297	304	PF11976	0.395
LIG_SUMO_SIM_par_1	321	326	PF11976	0.374
LIG_SUMO_SIM_par_1	94	100	PF11976	0.489
LIG_UBA3_1	274	283	PF00899	0.409
LIG_WRC_WIRS_1	327	332	PF05994	0.422
MOD_CDK_SPxxK_3	42	49	PF00069	0.544
MOD_CK1_1	135	141	PF00069	0.486
MOD_CK1_1	189	195	PF00069	0.382
MOD_CK1_1	217	223	PF00069	0.635
MOD_CK1_1	252	258	PF00069	0.548
MOD_CK1_1	27	33	PF00069	0.528
MOD_CK2_1	234	240	PF00069	0.557
MOD_CK2_1	306	312	PF00069	0.535
MOD_CK2_1	315	321	PF00069	0.522
MOD_GlcNHglycan	124	127	PF01048	0.695
MOD_GlcNHglycan	137	140	PF01048	0.487
MOD_GlcNHglycan	220	223	PF01048	0.628
MOD_GlcNHglycan	250	254	PF01048	0.661
MOD_GSK3_1	214	221	PF00069	0.675
MOD_GSK3_1	251	258	PF00069	0.692
MOD_GSK3_1	274	281	PF00069	0.558
MOD_GSK3_1	60	67	PF00069	0.520
MOD_LATS_1	81	87	PF00433	0.411
MOD_N-GLC_1	255	260	PF02516	0.478
MOD_N-GLC_1	285	290	PF02516	0.594
MOD_NEK2_1	26	31	PF00069	0.416
MOD_NEK2_1	343	348	PF00069	0.244
MOD_NEK2_2	16	21	PF00069	0.368
MOD_PKA_1	152	158	PF00069	0.388
MOD_PKA_2	152	158	PF00069	0.388
MOD_PKA_2	265	271	PF00069	0.410
MOD_Plk_2-3	315	321	PF00069	0.418
MOD_Plk_4	16	22	PF00069	0.413
MOD_Plk_4	295	301	PF00069	0.406
MOD_Plk_4	326	332	PF00069	0.425
MOD_Plk_4	64	70	PF00069	0.447
MOD_ProDKin_1	234	240	PF00069	0.519
MOD_ProDKin_1	36	42	PF00069	0.571
MOD_SUMO_rev_2	321	330	PF00179	0.575
TRG_DiLeu_BaEn_2	325	331	PF01217	0.565
TRG_DiLeu_BaEn_4	94	100	PF01217	0.485
TRG_DiLeu_BaLyEn_6	153	158	PF01217	0.615
TRG_DiLeu_BaLyEn_6	163	168	PF01217	0.471
TRG_DiLeu_BaLyEn_6	335	340	PF01217	0.528
TRG_ENDOCYTIC_2	84	87	PF00928	0.440
TRG_ER_diArg_1	151	153	PF00400	0.514
TRG_ER_diArg_1	185	187	PF00400	0.410
TRG_ER_diArg_1	331	333	PF00400	0.561
TRG_ER_diLys_1	361	365	PF00400	0.607
TRG_NES_CRM1_1	312	326	PF08389	0.417
TRG_NES_CRM1_1	98	111	PF08389	0.627
TRG_Pf-PMV_PEXEL_1	166	170	PF00026	0.544
TRG_Pf-PMV_PEXEL_1	283	287	PF00026	0.532

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2H7	Leptomonas seymouri	55%	100%
A0A3S7WUJ1	Leishmania donovani	67%	100%
A4HXA5	Leishmania infantum	67%	100%
E9AR07	Leishmania mexicana (strain MHOM/GT/2001/U1103)	66%	100%
Q4QEF6	Leishmania major	65%	96%