Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4H8Y0_LEIBR

TriTrypDb:

LbrM.17.0350 , LBRM2903_170009300

Length:

803

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

A4H8Y0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H8Y0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	599	603	PF00656	0.467
CLV_NRD_NRD_1	197	199	PF00675	0.730
CLV_NRD_NRD_1	210	212	PF00675	0.681
CLV_NRD_NRD_1	232	234	PF00675	0.633
CLV_NRD_NRD_1	324	326	PF00675	0.622
CLV_NRD_NRD_1	333	335	PF00675	0.607
CLV_PCSK_FUR_1	322	326	PF00082	0.614
CLV_PCSK_KEX2_1	197	199	PF00082	0.722
CLV_PCSK_KEX2_1	210	212	PF00082	0.684
CLV_PCSK_KEX2_1	232	234	PF00082	0.633
CLV_PCSK_KEX2_1	324	326	PF00082	0.622
CLV_PCSK_KEX2_1	333	335	PF00082	0.607
CLV_PCSK_PC7_1	193	199	PF00082	0.643
CLV_PCSK_SKI1_1	100	104	PF00082	0.596
CLV_PCSK_SKI1_1	14	18	PF00082	0.640
CLV_PCSK_SKI1_1	149	153	PF00082	0.608
CLV_PCSK_SKI1_1	183	187	PF00082	0.551
CLV_PCSK_SKI1_1	247	251	PF00082	0.690
CLV_PCSK_SKI1_1	328	332	PF00082	0.594
DEG_APCC_DBOX_1	115	123	PF00400	0.355
DEG_APCC_DBOX_1	99	107	PF00400	0.397
DEG_SPOP_SBC_1	212	216	PF00917	0.434
DEG_SPOP_SBC_1	475	479	PF00917	0.452
DEG_SPOP_SBC_1	629	633	PF00917	0.428
DOC_CDC14_PxL_1	434	442	PF14671	0.425
DOC_CKS1_1	251	256	PF01111	0.408
DOC_CYCLIN_RxL_1	11	21	PF00134	0.484
DOC_CYCLIN_yCln2_LP_2	106	112	PF00134	0.439
DOC_CYCLIN_yCln2_LP_2	487	493	PF00134	0.551
DOC_MAPK_DCC_7	104	112	PF00069	0.336
DOC_MAPK_MEF2A_6	424	431	PF00069	0.436
DOC_MAPK_MEF2A_6	482	491	PF00069	0.445
DOC_MAPK_NFAT4_5	482	490	PF00069	0.444
DOC_PP2B_LxvP_1	487	490	PF13499	0.549
DOC_PP2B_LxvP_1	708	711	PF13499	0.438
DOC_PP2B_LxvP_1	76	79	PF13499	0.577
DOC_PP4_FxxP_1	286	289	PF00568	0.475
DOC_PP4_FxxP_1	446	449	PF00568	0.439
DOC_USP7_MATH_1	202	206	PF00917	0.488
DOC_USP7_MATH_1	212	216	PF00917	0.425
DOC_USP7_MATH_1	234	238	PF00917	0.417
DOC_USP7_MATH_1	279	283	PF00917	0.488
DOC_USP7_MATH_1	359	363	PF00917	0.431
DOC_USP7_MATH_1	417	421	PF00917	0.432
DOC_USP7_MATH_1	433	437	PF00917	0.407
DOC_USP7_MATH_1	475	479	PF00917	0.492
DOC_USP7_MATH_1	52	56	PF00917	0.543
DOC_USP7_MATH_1	521	525	PF00917	0.510
DOC_USP7_MATH_1	552	556	PF00917	0.492
DOC_USP7_MATH_1	583	587	PF00917	0.519
DOC_USP7_MATH_1	610	614	PF00917	0.418
DOC_USP7_MATH_1	62	66	PF00917	0.433
DOC_USP7_MATH_1	8	12	PF00917	0.425
DOC_USP7_MATH_1	85	89	PF00917	0.417
DOC_USP7_MATH_2	373	379	PF00917	0.527
DOC_USP7_UBL2_3	468	472	PF12436	0.450
DOC_USP7_UBL2_3	597	601	PF12436	0.432
DOC_WW_Pin1_4	250	255	PF00397	0.403
DOC_WW_Pin1_4	275	280	PF00397	0.488
DOC_WW_Pin1_4	285	290	PF00397	0.492
DOC_WW_Pin1_4	423	428	PF00397	0.465
DOC_WW_Pin1_4	460	465	PF00397	0.460
DOC_WW_Pin1_4	497	502	PF00397	0.470
DOC_WW_Pin1_4	503	508	PF00397	0.528
DOC_WW_Pin1_4	523	528	PF00397	0.421
DOC_WW_Pin1_4	541	546	PF00397	0.511
DOC_WW_Pin1_4	630	635	PF00397	0.434
DOC_WW_Pin1_4	68	73	PF00397	0.633
DOC_WW_Pin1_4	87	92	PF00397	0.501
LIG_14-3-3_CanoR_1	116	120	PF00244	0.359
LIG_14-3-3_CanoR_1	130	140	PF00244	0.361
LIG_14-3-3_CanoR_1	183	192	PF00244	0.377
LIG_14-3-3_CanoR_1	210	219	PF00244	0.445
LIG_14-3-3_CanoR_1	233	239	PF00244	0.414
LIG_14-3-3_CanoR_1	290	296	PF00244	0.411
LIG_14-3-3_CanoR_1	336	346	PF00244	0.471
LIG_14-3-3_CanoR_1	364	373	PF00244	0.452
LIG_14-3-3_CanoR_1	38	42	PF00244	0.440
LIG_14-3-3_CanoR_1	400	405	PF00244	0.460
LIG_14-3-3_CanoR_1	456	464	PF00244	0.540
LIG_14-3-3_CanoR_1	551	559	PF00244	0.488
LIG_BRCT_BRCA1_1	282	286	PF00533	0.443
LIG_BRCT_BRCA1_1	367	371	PF00533	0.428
LIG_BRCT_BRCA1_1	442	446	PF00533	0.549
LIG_CaM_IQ_9	314	330	PF13499	0.409
LIG_DLG_GKlike_1	400	408	PF00625	0.426
LIG_EH1_1	644	652	PF00400	0.483
LIG_EVH1_1	76	80	PF00568	0.525
LIG_EVH1_2	79	83	PF00568	0.423
LIG_FHA_1	296	302	PF00498	0.429
LIG_FHA_1	339	345	PF00498	0.450
LIG_FHA_1	347	353	PF00498	0.511
LIG_FHA_1	367	373	PF00498	0.381
LIG_FHA_1	400	406	PF00498	0.427
LIG_FHA_1	424	430	PF00498	0.434
LIG_FHA_1	541	547	PF00498	0.586
LIG_FHA_1	778	784	PF00498	0.216
LIG_FHA_2	338	344	PF00498	0.486
LIG_FHA_2	93	99	PF00498	0.414
LIG_HP1_1	85	89	PF01393	0.514
LIG_KLC1_Yacidic_2	673	678	PF13176	0.506
LIG_LIR_Apic_2	283	289	PF02991	0.475
LIG_LIR_Apic_2	443	449	PF02991	0.441
LIG_LIR_Apic_2	682	688	PF02991	0.400
LIG_LIR_Gen_1	108	119	PF02991	0.403
LIG_LIR_Gen_1	239	249	PF02991	0.442
LIG_LIR_Gen_1	612	622	PF02991	0.459
LIG_LIR_Gen_1	655	663	PF02991	0.406
LIG_LIR_Gen_1	664	672	PF02991	0.393
LIG_LIR_Gen_1	673	681	PF02991	0.382
LIG_LIR_Gen_1	691	699	PF02991	0.387
LIG_LIR_Gen_1	777	787	PF02991	0.302
LIG_LIR_LC3C_4	386	390	PF02991	0.516
LIG_LIR_Nem_3	108	114	PF02991	0.458
LIG_LIR_Nem_3	162	166	PF02991	0.378
LIG_LIR_Nem_3	239	244	PF02991	0.449
LIG_LIR_Nem_3	612	617	PF02991	0.470
LIG_LIR_Nem_3	655	661	PF02991	0.401
LIG_LIR_Nem_3	664	669	PF02991	0.404
LIG_LIR_Nem_3	673	679	PF02991	0.386
LIG_LIR_Nem_3	691	695	PF02991	0.380
LIG_LIR_Nem_3	777	782	PF02991	0.302
LIG_LIR_Nem_3	81	86	PF02991	0.499
LIG_LIR_Nem_3	90	96	PF02991	0.403
LIG_PCNA_yPIPBox_3	229	242	PF02747	0.424
LIG_Pex14_1	111	115	PF04695	0.383
LIG_Pex14_2	138	142	PF04695	0.361
LIG_Pex14_2	246	250	PF04695	0.487
LIG_Pex14_2	784	788	PF04695	0.302
LIG_REV1ctd_RIR_1	328	338	PF16727	0.362
LIG_SH2_CRK	163	167	PF00017	0.373
LIG_SH2_CRK	685	689	PF00017	0.388
LIG_SH2_CRK	779	783	PF00017	0.302
LIG_SH2_NCK_1	303	307	PF00017	0.336
LIG_SH2_NCK_1	36	40	PF00017	0.379
LIG_SH2_PTP2	658	661	PF00017	0.332
LIG_SH2_SRC	7	10	PF00017	0.432
LIG_SH2_STAP1	779	783	PF00017	0.363
LIG_SH2_STAT3	357	360	PF00017	0.524
LIG_SH2_STAT5	105	108	PF00017	0.357
LIG_SH2_STAT5	357	360	PF00017	0.524
LIG_SH2_STAT5	658	661	PF00017	0.340
LIG_SH2_STAT5	676	679	PF00017	0.502
LIG_SH2_STAT5	685	688	PF00017	0.394
LIG_SH2_STAT5	755	758	PF00017	0.400
LIG_SH2_STAT5	779	782	PF00017	0.302
LIG_SH2_STAT5	94	97	PF00017	0.414
LIG_SH3_3	435	441	PF00018	0.496
LIG_SH3_3	504	510	PF00018	0.461
LIG_SH3_3	543	549	PF00018	0.490
LIG_SH3_3	576	582	PF00018	0.466
LIG_SH3_3	71	77	PF00018	0.631
LIG_Sin3_3	715	722	PF02671	0.419
LIG_SUMO_SIM_anti_2	648	653	PF11976	0.477
LIG_SUMO_SIM_par_1	386	393	PF11976	0.517
LIG_SUMO_SIM_par_1	85	90	PF11976	0.558
LIG_TRAF2_1	671	674	PF00917	0.377
LIG_TRAF2_1	680	683	PF00917	0.392
LIG_TRAF2_1	724	727	PF00917	0.417
LIG_UBA3_1	16	20	PF00899	0.442
LIG_WRC_WIRS_1	238	243	PF05994	0.453
LIG_WRC_WIRS_1	689	694	PF05994	0.425
MOD_CDC14_SPxK_1	526	529	PF00782	0.451
MOD_CDK_SPK_2	285	290	PF00069	0.432
MOD_CDK_SPK_2	503	508	PF00069	0.494
MOD_CDK_SPxK_1	523	529	PF00069	0.454
MOD_CK1_1	205	211	PF00069	0.451
MOD_CK1_1	214	220	PF00069	0.480
MOD_CK1_1	237	243	PF00069	0.596
MOD_CK1_1	280	286	PF00069	0.474
MOD_CK1_1	288	294	PF00069	0.469
MOD_CK1_1	37	43	PF00069	0.477
MOD_CK1_1	393	399	PF00069	0.448
MOD_CK1_1	403	409	PF00069	0.456
MOD_CK1_1	460	466	PF00069	0.546
MOD_CK1_1	478	484	PF00069	0.428
MOD_CK1_1	48	54	PF00069	0.556
MOD_CK1_1	506	512	PF00069	0.471
MOD_CK1_1	563	569	PF00069	0.466
MOD_CK1_1	61	67	PF00069	0.439
MOD_CK1_1	612	618	PF00069	0.528
MOD_CK1_1	777	783	PF00069	0.302
MOD_CK2_1	3	9	PF00069	0.445
MOD_CK2_1	337	343	PF00069	0.375
MOD_CK2_1	393	399	PF00069	0.420
MOD_CK2_1	697	703	PF00069	0.383
MOD_CK2_1	92	98	PF00069	0.374
MOD_GlcNHglycan	198	201	PF01048	0.666
MOD_GlcNHglycan	216	219	PF01048	0.751
MOD_GlcNHglycan	282	285	PF01048	0.670
MOD_GlcNHglycan	290	293	PF01048	0.737
MOD_GlcNHglycan	377	380	PF01048	0.675
MOD_GlcNHglycan	405	408	PF01048	0.678
MOD_GlcNHglycan	411	414	PF01048	0.671
MOD_GlcNHglycan	435	438	PF01048	0.630
MOD_GlcNHglycan	452	455	PF01048	0.649
MOD_GlcNHglycan	47	50	PF01048	0.692
MOD_GlcNHglycan	482	485	PF01048	0.651
MOD_GlcNHglycan	497	500	PF01048	0.670
MOD_GlcNHglycan	523	526	PF01048	0.694
MOD_GlcNHglycan	554	557	PF01048	0.749
MOD_GlcNHglycan	565	568	PF01048	0.667
MOD_GlcNHglycan	571	574	PF01048	0.692
MOD_GlcNHglycan	585	588	PF01048	0.695
MOD_GlcNHglycan	594	597	PF01048	0.791
MOD_GlcNHglycan	60	63	PF01048	0.622
MOD_GlcNHglycan	618	621	PF01048	0.663
MOD_GlcNHglycan	635	638	PF01048	0.675
MOD_GlcNHglycan	699	702	PF01048	0.600
MOD_GlcNHglycan	720	723	PF01048	0.621
MOD_GlcNHglycan	748	751	PF01048	0.662
MOD_GlcNHglycan	761	764	PF01048	0.562
MOD_GSK3_1	130	137	PF00069	0.361
MOD_GSK3_1	201	208	PF00069	0.452
MOD_GSK3_1	275	282	PF00069	0.456
MOD_GSK3_1	291	298	PF00069	0.469
MOD_GSK3_1	3	10	PF00069	0.440
MOD_GSK3_1	388	395	PF00069	0.465
MOD_GSK3_1	399	406	PF00069	0.464
MOD_GSK3_1	470	477	PF00069	0.494
MOD_GSK3_1	48	55	PF00069	0.497
MOD_GSK3_1	497	504	PF00069	0.507
MOD_GSK3_1	506	513	PF00069	0.492
MOD_GSK3_1	58	65	PF00069	0.461
MOD_GSK3_1	609	616	PF00069	0.472
MOD_GSK3_1	629	636	PF00069	0.429
MOD_GSK3_1	661	668	PF00069	0.347
MOD_GSK3_1	755	762	PF00069	0.445
MOD_LATS_1	209	215	PF00433	0.436
MOD_N-GLC_1	131	136	PF02516	0.567
MOD_N-GLC_1	234	239	PF02516	0.638
MOD_N-GLC_1	275	280	PF02516	0.632
MOD_N-GLC_1	347	352	PF02516	0.618
MOD_N-GLC_1	409	414	PF02516	0.649
MOD_N-GLC_1	45	50	PF02516	0.672
MOD_N-GLC_2	609	611	PF02516	0.659
MOD_NEK2_1	110	115	PF00069	0.388
MOD_NEK2_1	346	351	PF00069	0.493
MOD_NEK2_1	367	372	PF00069	0.511
MOD_NEK2_1	388	393	PF00069	0.518
MOD_NEK2_1	409	414	PF00069	0.456
MOD_NEK2_1	470	475	PF00069	0.441
MOD_NEK2_1	661	666	PF00069	0.346
MOD_NEK2_1	795	800	PF00069	0.559
MOD_NEK2_2	202	207	PF00069	0.446
MOD_NEK2_2	359	364	PF00069	0.519
MOD_NEK2_2	755	760	PF00069	0.392
MOD_NMyristoyl	1	7	PF02799	0.453
MOD_PIKK_1	277	283	PF00454	0.541
MOD_PIKK_1	390	396	PF00454	0.427
MOD_PIKK_1	558	564	PF00454	0.463
MOD_PKA_2	115	121	PF00069	0.361
MOD_PKA_2	196	202	PF00069	0.451
MOD_PKA_2	365	371	PF00069	0.498
MOD_PKA_2	37	43	PF00069	0.444
MOD_PKA_2	399	405	PF00069	0.458
MOD_PKA_2	530	536	PF00069	0.571
MOD_PKA_2	552	558	PF00069	0.465
MOD_PKB_1	351	359	PF00069	0.524
MOD_PKB_1	364	372	PF00069	0.419
MOD_Plk_1	134	140	PF00069	0.372
MOD_Plk_1	234	240	PF00069	0.408
MOD_Plk_1	347	353	PF00069	0.419
MOD_Plk_1	681	687	PF00069	0.395
MOD_Plk_1	777	783	PF00069	0.302
MOD_Plk_1	8	14	PF00069	0.460
MOD_Plk_2-3	92	98	PF00069	0.374
MOD_Plk_4	110	116	PF00069	0.401
MOD_Plk_4	237	243	PF00069	0.456
MOD_Plk_4	353	359	PF00069	0.525
MOD_Plk_4	367	373	PF00069	0.422
MOD_Plk_4	400	406	PF00069	0.427
MOD_Plk_4	645	651	PF00069	0.443
MOD_Plk_4	777	783	PF00069	0.302
MOD_ProDKin_1	250	256	PF00069	0.405
MOD_ProDKin_1	275	281	PF00069	0.490
MOD_ProDKin_1	285	291	PF00069	0.490
MOD_ProDKin_1	423	429	PF00069	0.467
MOD_ProDKin_1	460	466	PF00069	0.460
MOD_ProDKin_1	497	503	PF00069	0.483
MOD_ProDKin_1	506	512	PF00069	0.512
MOD_ProDKin_1	523	529	PF00069	0.456
MOD_ProDKin_1	541	547	PF00069	0.511
MOD_ProDKin_1	630	636	PF00069	0.432
MOD_ProDKin_1	68	74	PF00069	0.633
MOD_ProDKin_1	87	93	PF00069	0.492
MOD_SUMO_for_1	19	22	PF00179	0.435
TRG_DiLeu_BaEn_1	384	389	PF01217	0.427
TRG_DiLeu_BaLyEn_6	691	696	PF01217	0.381
TRG_ENDOCYTIC_2	163	166	PF00928	0.375
TRG_ENDOCYTIC_2	658	661	PF00928	0.392
TRG_ENDOCYTIC_2	676	679	PF00928	0.388
TRG_ENDOCYTIC_2	779	782	PF00928	0.302
TRG_ENDOCYTIC_2	792	795	PF00928	0.447
TRG_ENDOCYTIC_2	93	96	PF00928	0.365
TRG_ER_diArg_1	210	212	PF00400	0.494
TRG_ER_diArg_1	232	234	PF00400	0.433
TRG_ER_diArg_1	333	336	PF00400	0.412
TRG_ER_diArg_1	363	366	PF00400	0.467
TRG_Pf-PMV_PEXEL_1	104	108	PF00026	0.558
TRG_Pf-PMV_PEXEL_1	694	698	PF00026	0.535

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HRJ8	Leptomonas seymouri	47%	100%
A0A3Q8IAP9	Leishmania donovani	67%	100%
A4HXA4	Leishmania infantum	68%	100%
E9AR06	Leishmania mexicana (strain MHOM/GT/2001/U1103)	65%	100%
Q4QEF7	Leishmania major	66%	99%