Cytidine deaminase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cytidine deaminase-like protein

Species:

Leishmania braziliensis

UniProt:

A4H8X9_LEIBR

TriTrypDb:

LbrM.17.0340 , LBRM2903_170009200

Length:

182

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005829	cytosol	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H8X9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H8X9

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006213	pyrimidine nucleoside metabolic process	5	1
GO:0006216	cytidine catabolic process	8	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009116	nucleoside metabolic process	4	1
GO:0009119	ribonucleoside metabolic process	5	1
GO:0009164	nucleoside catabolic process	5	1
GO:0009972	cytidine deamination	9	1
GO:0009987	cellular process	1	1
GO:0019439	aromatic compound catabolic process	4	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034655	nucleobase-containing compound catabolic process	4	1
GO:0034656	nucleobase-containing small molecule catabolic process	4	1
GO:0042454	ribonucleoside catabolic process	6	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044248	cellular catabolic process	3	1
GO:0044270	cellular nitrogen compound catabolic process	4	1
GO:0044281	small molecule metabolic process	2	1
GO:0044282	small molecule catabolic process	3	1
GO:0046087	cytidine metabolic process	7	1
GO:0046131	pyrimidine ribonucleoside metabolic process	6	1
GO:0046133	pyrimidine ribonucleoside catabolic process	7	1
GO:0046135	pyrimidine nucleoside catabolic process	6	1
GO:0046483	heterocycle metabolic process	3	1
GO:0046700	heterocycle catabolic process	4	1
GO:0055086	nucleobase-containing small molecule metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0072527	pyrimidine-containing compound metabolic process	4	1
GO:0072529	pyrimidine-containing compound catabolic process	5	1
GO:1901135	carbohydrate derivative metabolic process	3	1
GO:1901136	carbohydrate derivative catabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1901361	organic cyclic compound catabolic process	4	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901565	organonitrogen compound catabolic process	4	1
GO:1901575	organic substance catabolic process	3	1
GO:1901657	glycosyl compound metabolic process	4	1
GO:1901658	glycosyl compound catabolic process	5	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0004126	cytidine deaminase activity	4	2
GO:0005488	binding	1	1
GO:0008270	zinc ion binding	6	1
GO:0016787	hydrolase activity	2	2
GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	3	2
GO:0016814	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines	4	2
GO:0019239	deaminase activity	3	2
GO:0043167	ion binding	2	1
GO:0043169	cation binding	3	1
GO:0046872	metal ion binding	4	1
GO:0046914	transition metal ion binding	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	88	90	PF00675	0.286
CLV_PCSK_KEX2_1	88	90	PF00082	0.301
CLV_PCSK_SKI1_1	123	127	PF00082	0.269
CLV_PCSK_SKI1_1	149	153	PF00082	0.275
DEG_APCC_DBOX_1	122	130	PF00400	0.451
DOC_ANK_TNKS_1	81	88	PF00023	0.515
DOC_CKS1_1	115	120	PF01111	0.418
DOC_CYCLIN_RxL_1	120	128	PF00134	0.503
DOC_MAPK_gen_1	88	96	PF00069	0.481
DOC_WW_Pin1_4	114	119	PF00397	0.376
DOC_WW_Pin1_4	38	43	PF00397	0.554
DOC_WW_Pin1_4	5	10	PF00397	0.533
LIG_BIR_II_1	1	5	PF00653	0.348
LIG_BRCT_BRCA1_1	132	136	PF00533	0.463
LIG_LIR_Gen_1	138	146	PF02991	0.329
LIG_LIR_Gen_1	41	51	PF02991	0.564
LIG_LIR_LC3C_4	138	142	PF02991	0.283
LIG_LIR_Nem_3	133	139	PF02991	0.373
LIG_LIR_Nem_3	39	43	PF02991	0.499
LIG_SH2_GRB2like	43	46	PF00017	0.465
LIG_SH2_GRB2like	65	68	PF00017	0.465
LIG_SH2_GRB2like	90	93	PF00017	0.374
LIG_SH2_SRC	90	93	PF00017	0.505
LIG_SH2_STAP1	90	94	PF00017	0.482
LIG_SH3_3	103	109	PF00018	0.532
LIG_SUMO_SIM_anti_2	138	144	PF11976	0.212
LIG_SUMO_SIM_par_1	14	19	PF11976	0.428
LIG_WRC_WIRS_1	70	75	PF05994	0.360
MOD_CK1_1	41	47	PF00069	0.528
MOD_Cter_Amidation	86	89	PF01082	0.243
MOD_GlcNHglycan	1	4	PF01048	0.499
MOD_N-GLC_1	44	49	PF02516	0.354
MOD_N-GLC_1	66	71	PF02516	0.297
MOD_NEK2_1	169	174	PF00069	0.463
MOD_PIKK_1	130	136	PF00454	0.414
MOD_Plk_1	44	50	PF00069	0.544
MOD_Plk_1	66	72	PF00069	0.513
MOD_Plk_4	169	175	PF00069	0.455
MOD_ProDKin_1	114	120	PF00069	0.387
MOD_ProDKin_1	38	44	PF00069	0.554
MOD_ProDKin_1	5	11	PF00069	0.529
TRG_ENDOCYTIC_2	43	46	PF00928	0.449
TRG_ER_diArg_1	88	90	PF00400	0.485
TRG_Pf-PMV_PEXEL_1	123	128	PF00026	0.303

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1P973	Leptomonas seymouri	72%	100%
A0A0S4JP63	Bodo saltans	54%	90%
A0A1X0NSY6	Trypanosomatidae	58%	98%
A0A3Q8IAT7	Leishmania donovani	84%	100%
A0A422NXF1	Trypanosoma rangeli	58%	98%
A4HXA3	Leishmania infantum	84%	100%
C9ZXD1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	57%	70%
E9AR05	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
P19079	Bacillus subtilis (strain 168)	35%	100%
P32320	Homo sapiens	35%	100%
P47718	Mycoplasma pirum	33%	100%
P56389	Mus musculus	36%	100%
P9WPH2	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	36%	100%
P9WPH3	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	36%	100%
Q06549	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	31%	100%
Q09190	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	34%	100%
Q4QEF8	Leishmania major	83%	100%
Q54I82	Dictyostelium discoideum	34%	100%
Q9KD53	Halalkalibacterium halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125)	38%	100%
Q9S3M0	Sporosarcina psychrophila	33%	100%