Dus domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

dihydrouridine synthase (Dus), putative

Species:

Leishmania braziliensis

UniProt:

A4H8X8_LEIBR

TriTrypDb:

LbrM.17.0330 , LBRM2903_170009100

Length:

590

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

A4H8X8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H8X8

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0003824	catalytic activity	1	11
GO:0005488	binding	1	11
GO:0016491	oxidoreductase activity	2	11
GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	3	11
GO:0017150	tRNA dihydrouridine synthase activity	5	11
GO:0036094	small molecule binding	2	11
GO:0043167	ion binding	2	11
GO:0043168	anion binding	3	11
GO:0050660	flavin adenine dinucleotide binding	4	11
GO:0097159	organic cyclic compound binding	2	11
GO:0106413	dihydrouridine synthase activity	4	11
GO:0140098	catalytic activity, acting on RNA	3	11
GO:0140101	catalytic activity, acting on a tRNA	4	11
GO:0140640	catalytic activity, acting on a nucleic acid	2	11
GO:1901265	nucleoside phosphate binding	3	11
GO:1901363	heterocyclic compound binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	246	248	PF00675	0.207
CLV_NRD_NRD_1	279	281	PF00675	0.207
CLV_NRD_NRD_1	394	396	PF00675	0.207
CLV_NRD_NRD_1	436	438	PF00675	0.182
CLV_NRD_NRD_1	499	501	PF00675	0.294
CLV_PCSK_KEX2_1	174	176	PF00082	0.695
CLV_PCSK_KEX2_1	246	248	PF00082	0.207
CLV_PCSK_KEX2_1	279	281	PF00082	0.207
CLV_PCSK_KEX2_1	435	437	PF00082	0.182
CLV_PCSK_KEX2_1	499	501	PF00082	0.311
CLV_PCSK_PC1ET2_1	174	176	PF00082	0.695
CLV_PCSK_SKI1_1	120	124	PF00082	0.535
CLV_PCSK_SKI1_1	225	229	PF00082	0.334
CLV_PCSK_SKI1_1	231	235	PF00082	0.280
CLV_PCSK_SKI1_1	326	330	PF00082	0.220
CLV_PCSK_SKI1_1	356	360	PF00082	0.161
CLV_PCSK_SKI1_1	448	452	PF00082	0.207
CLV_PCSK_SKI1_1	499	503	PF00082	0.301
DEG_APCC_DBOX_1	534	542	PF00400	0.334
DEG_MDM2_SWIB_1	501	509	PF02201	0.262
DEG_ODPH_VHL_1	234	245	PF01847	0.420
DEG_SCF_FBW7_1	36	43	PF00400	0.492
DEG_SPOP_SBC_1	146	150	PF00917	0.649
DEG_SPOP_SBC_1	40	44	PF00917	0.491
DOC_AGCK_PIF_2	402	407	PF00069	0.495
DOC_CDC14_PxL_1	186	194	PF14671	0.469
DOC_CKS1_1	37	42	PF01111	0.493
DOC_CYCLIN_yCln2_LP_2	451	457	PF00134	0.407
DOC_MAPK_RevD_3	232	247	PF00069	0.244
DOC_PP1_RVXF_1	361	367	PF00149	0.349
DOC_PP2B_LxvP_1	35	38	PF13499	0.488
DOC_USP7_MATH_1	14	18	PF00917	0.702
DOC_USP7_MATH_1	205	209	PF00917	0.534
DOC_USP7_MATH_1	219	223	PF00917	0.525
DOC_USP7_MATH_1	25	29	PF00917	0.654
DOC_USP7_MATH_1	67	71	PF00917	0.594
DOC_USP7_MATH_2	145	151	PF00917	0.491
DOC_WW_Pin1_4	175	180	PF00397	0.509
DOC_WW_Pin1_4	36	41	PF00397	0.547
DOC_WW_Pin1_4	565	570	PF00397	0.369
LIG_14-3-3_CanoR_1	206	214	PF00244	0.524
LIG_14-3-3_CanoR_1	220	228	PF00244	0.327
LIG_14-3-3_CanoR_1	247	253	PF00244	0.463
LIG_14-3-3_CanoR_1	269	278	PF00244	0.438
LIG_14-3-3_CanoR_1	45	54	PF00244	0.544
LIG_14-3-3_CanoR_1	552	560	PF00244	0.331
LIG_14-3-3_CanoR_1	68	72	PF00244	0.542
LIG_APCC_ABBAyCdc20_2	453	459	PF00400	0.407
LIG_BIR_II_1	1	5	PF00653	0.624
LIG_BIR_III_4	72	76	PF00653	0.596
LIG_BRCT_BRCA1_1	311	315	PF00533	0.420
LIG_deltaCOP1_diTrp_1	504	508	PF00928	0.260
LIG_eIF4E_1	512	518	PF01652	0.278
LIG_FHA_1	146	152	PF00498	0.596
LIG_FHA_1	338	344	PF00498	0.501
LIG_FHA_1	546	552	PF00498	0.251
LIG_FHA_2	116	122	PF00498	0.372
LIG_FHA_2	147	153	PF00498	0.631
LIG_FHA_2	255	261	PF00498	0.408
LIG_LIR_Apic_2	60	64	PF02991	0.441
LIG_LIR_Gen_1	273	282	PF02991	0.421
LIG_LIR_Gen_1	301	308	PF02991	0.422
LIG_LIR_Gen_1	312	323	PF02991	0.399
LIG_LIR_Gen_1	504	513	PF02991	0.262
LIG_LIR_Gen_1	548	558	PF02991	0.303
LIG_LIR_LC3C_4	167	171	PF02991	0.468
LIG_LIR_Nem_3	273	278	PF02991	0.419
LIG_LIR_Nem_3	301	305	PF02991	0.441
LIG_LIR_Nem_3	312	318	PF02991	0.404
LIG_LIR_Nem_3	504	508	PF02991	0.260
LIG_LIR_Nem_3	548	553	PF02991	0.306
LIG_Pex14_2	311	315	PF04695	0.438
LIG_Pex14_2	501	505	PF04695	0.261
LIG_PTB_Apo_2	239	246	PF02174	0.431
LIG_PTB_Apo_2	401	408	PF02174	0.407
LIG_PTB_Phospho_1	401	407	PF10480	0.407
LIG_SH2_GRB2like	576	579	PF00017	0.580
LIG_SH2_NCK_1	576	580	PF00017	0.663
LIG_SH2_PTP2	512	515	PF00017	0.268
LIG_SH2_SRC	512	515	PF00017	0.268
LIG_SH2_SRC	576	579	PF00017	0.545
LIG_SH2_STAP1	399	403	PF00017	0.407
LIG_SH2_STAP1	576	580	PF00017	0.580
LIG_SH2_STAT3	407	410	PF00017	0.501
LIG_SH2_STAT5	399	402	PF00017	0.407
LIG_SH2_STAT5	407	410	PF00017	0.407
LIG_SH2_STAT5	512	515	PF00017	0.268
LIG_SH2_STAT5	61	64	PF00017	0.432
LIG_SH3_3	1	7	PF00018	0.729
LIG_SH3_3	230	236	PF00018	0.318
LIG_SH3_3	24	30	PF00018	0.499
LIG_SH3_3	290	296	PF00018	0.407
LIG_SUMO_SIM_anti_2	167	172	PF11976	0.466
LIG_TRAF2_1	162	165	PF00917	0.461
LIG_TRAF2_1	560	563	PF00917	0.287
LIG_UBA3_1	456	461	PF00899	0.420
LIG_WW_1	529	532	PF00397	0.349
MOD_CDK_SPK_2	565	570	PF00069	0.369
MOD_CDK_SPxxK_3	565	572	PF00069	0.388
MOD_CK1_1	136	142	PF00069	0.757
MOD_CK1_1	150	156	PF00069	0.505
MOD_CK1_1	273	279	PF00069	0.420
MOD_CK1_1	309	315	PF00069	0.407
MOD_CK1_1	543	549	PF00069	0.449
MOD_CK2_1	115	121	PF00069	0.480
MOD_CK2_1	146	152	PF00069	0.664
MOD_CK2_1	205	211	PF00069	0.570
MOD_CK2_1	25	31	PF00069	0.608
MOD_CK2_1	254	260	PF00069	0.408
MOD_CK2_1	466	472	PF00069	0.420
MOD_GlcNHglycan	10	13	PF01048	0.493
MOD_GlcNHglycan	16	19	PF01048	0.462
MOD_GlcNHglycan	179	182	PF01048	0.658
MOD_GlcNHglycan	307	311	PF01048	0.217
MOD_GlcNHglycan	329	332	PF01048	0.217
MOD_GlcNHglycan	461	464	PF01048	0.283
MOD_GSK3_1	146	153	PF00069	0.713
MOD_GSK3_1	193	200	PF00069	0.683
MOD_GSK3_1	201	208	PF00069	0.610
MOD_GSK3_1	352	359	PF00069	0.345
MOD_GSK3_1	36	43	PF00069	0.587
MOD_GSK3_1	537	544	PF00069	0.322
MOD_GSK3_1	92	99	PF00069	0.483
MOD_NEK2_1	108	113	PF00069	0.425
MOD_NEK2_1	192	197	PF00069	0.594
MOD_NEK2_1	291	296	PF00069	0.513
MOD_NEK2_1	306	311	PF00069	0.531
MOD_NEK2_1	327	332	PF00069	0.361
MOD_NEK2_2	386	391	PF00069	0.438
MOD_PIKK_1	92	98	PF00454	0.586
MOD_PKA_2	205	211	PF00069	0.541
MOD_PKA_2	219	225	PF00069	0.312
MOD_PKA_2	397	403	PF00069	0.349
MOD_PKA_2	551	557	PF00069	0.325
MOD_PKA_2	67	73	PF00069	0.578
MOD_PKA_2	96	102	PF00069	0.457
MOD_PKB_1	175	183	PF00069	0.693
MOD_Plk_1	146	152	PF00069	0.493
MOD_Plk_1	210	216	PF00069	0.548
MOD_Plk_1	254	260	PF00069	0.429
MOD_Plk_1	273	279	PF00069	0.496
MOD_Plk_2-3	147	153	PF00069	0.493
MOD_Plk_2-3	424	430	PF00069	0.420
MOD_Plk_4	412	418	PF00069	0.349
MOD_Plk_4	504	510	PF00069	0.262
MOD_Plk_4	537	543	PF00069	0.325
MOD_ProDKin_1	175	181	PF00069	0.509
MOD_ProDKin_1	36	42	PF00069	0.546
MOD_ProDKin_1	565	571	PF00069	0.374
MOD_SUMO_for_1	57	60	PF00179	0.367
MOD_SUMO_rev_2	458	462	PF00179	0.407
TRG_DiLeu_BaEn_1	164	169	PF01217	0.549
TRG_DiLeu_BaEn_1	31	36	PF01217	0.609
TRG_DiLeu_BaEn_1	537	542	PF01217	0.346
TRG_DiLeu_BaEn_2	503	509	PF01217	0.260
TRG_DiLeu_BaEn_2	86	92	PF01217	0.767
TRG_ENDOCYTIC_2	313	316	PF00928	0.413
TRG_ENDOCYTIC_2	399	402	PF00928	0.407
TRG_ENDOCYTIC_2	512	515	PF00928	0.269
TRG_ER_diArg_1	245	247	PF00400	0.407
TRG_ER_diArg_1	278	280	PF00400	0.407
TRG_ER_diArg_1	435	437	PF00400	0.423
TRG_ER_diArg_1	499	501	PF00400	0.311
TRG_NES_CRM1_1	504	519	PF08389	0.276
TRG_NLS_MonoExtN_4	393	399	PF00514	0.420
TRG_Pf-PMV_PEXEL_1	225	230	PF00026	0.467
TRG_Pf-PMV_PEXEL_1	500	504	PF00026	0.277

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYR2	Leptomonas seymouri	77%	98%
A0A0S4JKI3	Bodo saltans	55%	94%
A0A1X0NSY5	Trypanosomatidae	65%	100%
A0A3S5H702	Leishmania donovani	85%	99%
A0A422NXR8	Trypanosoma rangeli	64%	100%
A1CNY3	Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1 / QM 1276 / 107)	40%	81%
A1D1U0	Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181)	41%	81%
A2QAU6	Aspergillus niger (strain CBS 513.88 / FGSC A1513)	42%	79%
A4HXA2	Leishmania infantum	85%	99%
A4RLF4	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)	43%	80%
A6QYC6	Ajellomyces capsulatus (strain NAm1 / WU24)	41%	80%
A6RMI1	Botryotinia fuckeliana (strain B05.10)	43%	79%
A7EKL8	Sclerotinia sclerotiorum (strain ATCC 18683 / 1980 / Ss-1)	43%	79%
A8NZY7	Coprinopsis cinerea (strain Okayama-7 / 130 / ATCC MYA-4618 / FGSC 9003)	41%	87%
C9ZTX9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	61%	100%
E9AR04	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	89%
Q0CZL3	Aspergillus terreus (strain NIH 2624 / FGSC A1156)	42%	82%
Q0U9D6	Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173)	41%	80%
Q1E2F4	Coccidioides immitis (strain RS)	41%	81%
Q2HDP2	Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)	42%	83%
Q2UL89	Aspergillus oryzae (strain ATCC 42149 / RIB 40)	42%	81%
Q4P1U2	Ustilago maydis (strain 521 / FGSC 9021)	46%	68%
Q4QEF9	Leishmania major	82%	100%
Q4WRX4	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	41%	81%
Q5BF62	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	41%	83%
Q6CWM0	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	39%	89%
Q757E3	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	41%	91%
Q7SG01	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	43%	80%
Q96G46	Homo sapiens	52%	91%
Q9UTH9	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	35%	96%