Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H8X7_LEIBR

TriTrypDb:

LbrM.17.0320 , LBRM2903_170009000

Length:

144

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 4, no: 5
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

A4H8X7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H8X7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	132	134	PF00082	0.437
CLV_PCSK_PC1ET2_1	132	134	PF00082	0.434
CLV_PCSK_SKI1_1	110	114	PF00082	0.432
CLV_PCSK_SKI1_1	3	7	PF00082	0.330
DEG_Nend_Nbox_1	1	3	PF02207	0.593
DEG_SPOP_SBC_1	54	58	PF00917	0.239
DOC_MAPK_MEF2A_6	116	124	PF00069	0.277
DOC_MAPK_RevD_3	117	133	PF00069	0.340
DOC_PP1_RVXF_1	108	114	PF00149	0.228
DOC_PP4_FxxP_1	112	115	PF00568	0.224
DOC_USP7_MATH_1	54	58	PF00917	0.294
DOC_USP7_UBL2_3	128	132	PF12436	0.344
LIG_14-3-3_CanoR_1	53	63	PF00244	0.248
LIG_APCC_ABBA_1	109	114	PF00400	0.224
LIG_BRCT_BRCA1_1	55	59	PF00533	0.289
LIG_FHA_1	106	112	PF00498	0.291
LIG_FHA_1	119	125	PF00498	0.298
LIG_FHA_1	17	23	PF00498	0.412
LIG_LIR_Gen_1	56	66	PF02991	0.253
LIG_LIR_Nem_3	56	62	PF02991	0.289
LIG_PDZ_Class_1	139	144	PF00595	0.344
LIG_PTB_Apo_2	31	38	PF02174	0.341
LIG_PTB_Phospho_1	31	37	PF10480	0.341
LIG_SH2_SRC	7	10	PF00017	0.203
LIG_SH2_STAT5	139	142	PF00017	0.474
LIG_SH2_STAT5	37	40	PF00017	0.292
LIG_SH2_STAT5	7	10	PF00017	0.284
LIG_Sin3_3	18	25	PF02671	0.211
LIG_SUMO_SIM_par_1	118	123	PF11976	0.311
LIG_Vh1_VBS_1	1	19	PF01044	0.389
MOD_CK1_1	100	106	PF00069	0.264
MOD_CK2_1	24	30	PF00069	0.661
MOD_GlcNHglycan	141	144	PF01048	0.619
MOD_GSK3_1	135	142	PF00069	0.414
MOD_GSK3_1	33	40	PF00069	0.238
MOD_GSK3_1	80	87	PF00069	0.360
MOD_N-GLC_1	105	110	PF02516	0.531
MOD_N-GLC_1	33	38	PF02516	0.421
MOD_N-GLC_1	48	53	PF02516	0.614
MOD_N-GLC_2	95	97	PF02516	0.469
MOD_NEK2_1	1	6	PF00069	0.651
MOD_NEK2_2	48	53	PF00069	0.297
MOD_Plk_1	105	111	PF00069	0.339
MOD_Plk_1	48	54	PF00069	0.381
MOD_Plk_1	84	90	PF00069	0.238
MOD_Plk_2-3	118	124	PF00069	0.322
MOD_Plk_4	135	141	PF00069	0.439
MOD_Plk_4	84	90	PF00069	0.376
MOD_Plk_4	97	103	PF00069	0.315
MOD_SUMO_for_1	127	130	PF00179	0.234
MOD_SUMO_rev_2	75	83	PF00179	0.348

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0NT01	Trypanosomatidae	40%	100%
A0A3S5IS80	Trypanosoma rangeli	38%	100%
A0A3S7WUB5	Leishmania donovani	57%	100%
A4HXA1	Leishmania infantum	57%	100%
C9ZTX4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
E9AR03	Leishmania mexicana (strain MHOM/GT/2001/U1103)	53%	100%
Q4QEG0	Leishmania major	53%	100%
V5B7F7	Trypanosoma cruzi	37%	100%