Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H8X5_LEIBR

TriTrypDb:

LbrM.17.0300 , LBRM2903_170008800

Length:

298

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H8X5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H8X5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	124	128	PF00656	0.542
CLV_NRD_NRD_1	187	189	PF00675	0.701
CLV_NRD_NRD_1	280	282	PF00675	0.506
CLV_NRD_NRD_1	41	43	PF00675	0.443
CLV_PCSK_FUR_1	277	281	PF00082	0.545
CLV_PCSK_FUR_1	45	49	PF00082	0.509
CLV_PCSK_KEX2_1	211	213	PF00082	0.640
CLV_PCSK_KEX2_1	277	279	PF00082	0.559
CLV_PCSK_KEX2_1	280	282	PF00082	0.501
CLV_PCSK_KEX2_1	47	49	PF00082	0.433
CLV_PCSK_PC1ET2_1	211	213	PF00082	0.545
CLV_PCSK_PC1ET2_1	47	49	PF00082	0.506
CLV_PCSK_PC7_1	274	280	PF00082	0.627
CLV_PCSK_SKI1_1	281	285	PF00082	0.417
CLV_PCSK_SKI1_1	82	86	PF00082	0.397
DEG_Nend_Nbox_1	1	3	PF02207	0.489
DEG_SCF_FBW7_1	19	26	PF00400	0.387
DOC_CKS1_1	20	25	PF01111	0.376
DOC_MAPK_gen_1	45	54	PF00069	0.390
DOC_PP2B_LxvP_1	251	254	PF13499	0.540
DOC_PP4_FxxP_1	162	165	PF00568	0.495
DOC_SPAK_OSR1_1	30	34	PF12202	0.364
DOC_USP7_MATH_1	154	158	PF00917	0.575
DOC_USP7_MATH_1	180	184	PF00917	0.530
DOC_USP7_UBL2_3	43	47	PF12436	0.378
DOC_WW_Pin1_4	19	24	PF00397	0.604
DOC_WW_Pin1_4	195	200	PF00397	0.643
DOC_WW_Pin1_4	206	211	PF00397	0.584
DOC_WW_Pin1_4	242	247	PF00397	0.558
LIG_14-3-3_CanoR_1	147	151	PF00244	0.526
LIG_14-3-3_CanoR_1	181	185	PF00244	0.565
LIG_14-3-3_CanoR_1	278	286	PF00244	0.519
LIG_APCC_ABBA_1	119	124	PF00400	0.411
LIG_BIR_III_4	127	131	PF00653	0.494
LIG_FHA_1	20	26	PF00498	0.378
LIG_LIR_Apic_2	161	165	PF02991	0.495
LIG_LIR_Apic_2	175	180	PF02991	0.492
LIG_LIR_Gen_1	29	35	PF02991	0.361
LIG_LIR_Nem_3	29	34	PF02991	0.361
LIG_LIR_Nem_3	291	297	PF02991	0.436
LIG_MYND_1	250	254	PF01753	0.511
LIG_Pex14_2	31	35	PF04695	0.361
LIG_PTAP_UEV_1	150	155	PF05743	0.489
LIG_SH2_CRK	177	181	PF00017	0.500
LIG_SH2_SRC	60	63	PF00017	0.260
LIG_SH2_STAP1	122	126	PF00017	0.511
LIG_SH2_STAP1	56	60	PF00017	0.281
LIG_SH2_STAT5	60	63	PF00017	0.393
LIG_SH3_2	207	212	PF14604	0.526
LIG_SH3_3	148	154	PF00018	0.483
LIG_SH3_3	196	202	PF00018	0.590
LIG_SH3_3	204	210	PF00018	0.660
LIG_TRAF2_1	121	124	PF00917	0.584
LIG_WRC_WIRS_1	159	164	PF05994	0.496
MOD_CDC14_SPxK_1	209	212	PF00782	0.537
MOD_CDK_SPK_2	206	211	PF00069	0.525
MOD_CDK_SPxK_1	206	212	PF00069	0.581
MOD_CK1_1	149	155	PF00069	0.617
MOD_CK1_1	158	164	PF00069	0.723
MOD_CK1_1	263	269	PF00069	0.501
MOD_CK1_1	282	288	PF00069	0.557
MOD_CK1_1	36	42	PF00069	0.515
MOD_GlcNHglycan	11	14	PF01048	0.491
MOD_GlcNHglycan	148	151	PF01048	0.667
MOD_GlcNHglycan	162	165	PF01048	0.558
MOD_GlcNHglycan	281	284	PF01048	0.479
MOD_GlcNHglycan	38	41	PF01048	0.447
MOD_GSK3_1	141	148	PF00069	0.604
MOD_GSK3_1	15	22	PF00069	0.557
MOD_GSK3_1	154	161	PF00069	0.581
MOD_GSK3_1	191	198	PF00069	0.667
MOD_GSK3_1	233	240	PF00069	0.595
MOD_GSK3_1	242	249	PF00069	0.569
MOD_GSK3_1	263	270	PF00069	0.491
MOD_NEK2_1	145	150	PF00069	0.472
MOD_NEK2_1	155	160	PF00069	0.496
MOD_NEK2_1	191	196	PF00069	0.638
MOD_NEK2_1	237	242	PF00069	0.559
MOD_PK_1	231	237	PF00069	0.607
MOD_PKA_1	279	285	PF00069	0.590
MOD_PKA_2	146	152	PF00069	0.579
MOD_PKA_2	15	21	PF00069	0.463
MOD_PKA_2	180	186	PF00069	0.592
MOD_PKA_2	279	285	PF00069	0.544
MOD_PKA_2	36	42	PF00069	0.458
MOD_PKB_1	277	285	PF00069	0.599
MOD_Plk_1	100	106	PF00069	0.296
MOD_Plk_1	56	62	PF00069	0.360
MOD_Plk_4	15	21	PF00069	0.562
MOD_Plk_4	180	186	PF00069	0.495
MOD_Plk_4	217	223	PF00069	0.548
MOD_Plk_4	267	273	PF00069	0.469
MOD_Plk_4	56	62	PF00069	0.349
MOD_ProDKin_1	19	25	PF00069	0.594
MOD_ProDKin_1	195	201	PF00069	0.644
MOD_ProDKin_1	206	212	PF00069	0.587
MOD_ProDKin_1	242	248	PF00069	0.562
MOD_SUMO_for_1	46	49	PF00179	0.506
TRG_DiLeu_BaEn_4	112	118	PF01217	0.405
TRG_DiLeu_BaLyEn_6	247	252	PF01217	0.517
TRG_ER_diArg_1	185	188	PF00400	0.734
TRG_ER_diArg_1	277	280	PF00400	0.549
TRG_NES_CRM1_1	108	123	PF08389	0.340

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I9Y1	Leptomonas seymouri	38%	93%
A0A3S7WUB2	Leishmania donovani	62%	90%
A4HX99	Leishmania infantum	64%	91%
E9AR01	Leishmania mexicana (strain MHOM/GT/2001/U1103)	65%	100%
Q4QEG2	Leishmania major	64%	100%