Sm domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H8X3_LEIBR

TriTrypDb:

LbrM.17.0280 , LBRM2903_170008600

Length:

195

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H8X3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H8X3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	178	180	PF00675	0.550
CLV_NRD_NRD_1	62	64	PF00675	0.255
CLV_PCSK_FUR_1	178	182	PF00082	0.539
CLV_PCSK_KEX2_1	178	180	PF00082	0.601
CLV_PCSK_KEX2_1	62	64	PF00082	0.256
CLV_PCSK_PC1ET2_1	180	182	PF00082	0.635
CLV_PCSK_SKI1_1	185	189	PF00082	0.573
CLV_PCSK_SKI1_1	71	75	PF00082	0.248
CLV_Separin_Metazoa	98	102	PF03568	0.380
DEG_Nend_UBRbox_1	1	4	PF02207	0.582
LIG_14-3-3_CanoR_1	134	143	PF00244	0.480
LIG_14-3-3_CanoR_1	151	159	PF00244	0.382
LIG_14-3-3_CanoR_1	62	68	PF00244	0.556
LIG_Clathr_ClatBox_1	45	49	PF01394	0.446
LIG_FHA_1	24	30	PF00498	0.620
LIG_FHA_1	40	46	PF00498	0.521
LIG_LIR_Gen_1	154	163	PF02991	0.616
LIG_LIR_Gen_1	49	60	PF02991	0.530
LIG_LIR_Nem_3	49	55	PF02991	0.407
LIG_Pex14_2	124	128	PF04695	0.530
LIG_REV1ctd_RIR_1	122	131	PF16727	0.488
LIG_SH2_CRK	52	56	PF00017	0.443
LIG_SH2_PTP2	112	115	PF00017	0.380
LIG_SH2_STAT5	112	115	PF00017	0.435
LIG_SH2_STAT5	117	120	PF00017	0.435
LIG_SH2_STAT5	39	42	PF00017	0.435
MOD_CK1_1	11	17	PF00069	0.617
MOD_CK1_1	138	144	PF00069	0.629
MOD_CK2_1	24	30	PF00069	0.600
MOD_CK2_1	75	81	PF00069	0.459
MOD_CK2_1	99	105	PF00069	0.546
MOD_GlcNHglycan	137	140	PF01048	0.594
MOD_GlcNHglycan	146	149	PF01048	0.526
MOD_GlcNHglycan	190	193	PF01048	0.578
MOD_GlcNHglycan	21	24	PF01048	0.748
MOD_GSK3_1	113	120	PF00069	0.494
MOD_GSK3_1	134	141	PF00069	0.693
MOD_GSK3_1	19	26	PF00069	0.612
MOD_N-GLC_1	19	24	PF02516	0.595
MOD_NEK2_1	24	29	PF00069	0.563
MOD_NEK2_1	84	89	PF00069	0.595
MOD_PIKK_1	75	81	PF00454	0.459
MOD_PKA_1	185	191	PF00069	0.463
MOD_PKA_2	100	106	PF00069	0.516
MOD_Plk_1	19	25	PF00069	0.526
MOD_Plk_4	113	119	PF00069	0.451
TRG_ENDOCYTIC_2	112	115	PF00928	0.380
TRG_ENDOCYTIC_2	52	55	PF00928	0.530
TRG_ER_diArg_1	108	111	PF00400	0.450
TRG_ER_diArg_1	172	175	PF00400	0.581
TRG_ER_diArg_1	178	181	PF00400	0.572
TRG_ER_diArg_1	61	63	PF00400	0.521

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HUV2	Leptomonas seymouri	47%	75%
A0A1X0NSZ2	Trypanosomatidae	34%	88%
A0A3S7WUC9	Leishmania donovani	74%	96%
A0A422N3W3	Trypanosoma rangeli	36%	73%
A4HX97	Leishmania infantum	75%	96%
C9ZTX0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	95%
E9AQZ9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	97%
Q4QEG4	Leishmania major	73%	100%
V5BH99	Trypanosoma cruzi	37%	90%