RING-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Zinc finger, C3HC4 type (RING finger), putative

Species:

Leishmania braziliensis

UniProt:

A4H8X2_LEIBR

TriTrypDb:

LbrM.17.0270 , LBRM2903_170008500

Length:

712

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H8X2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H8X2

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	6
GO:0043167	ion binding	2	6
GO:0043169	cation binding	3	6
GO:0046872	metal ion binding	4	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	479	483	PF00656	0.724
CLV_NRD_NRD_1	244	246	PF00675	0.574
CLV_NRD_NRD_1	341	343	PF00675	0.648
CLV_NRD_NRD_1	581	583	PF00675	0.516
CLV_NRD_NRD_1	710	712	PF00675	0.522
CLV_NRD_NRD_1	89	91	PF00675	0.507
CLV_PCSK_FUR_1	708	712	PF00082	0.507
CLV_PCSK_KEX2_1	110	112	PF00082	0.600
CLV_PCSK_KEX2_1	244	246	PF00082	0.671
CLV_PCSK_KEX2_1	341	343	PF00082	0.648
CLV_PCSK_KEX2_1	581	583	PF00082	0.543
CLV_PCSK_KEX2_1	710	712	PF00082	0.522
CLV_PCSK_KEX2_1	89	91	PF00082	0.507
CLV_PCSK_PC1ET2_1	110	112	PF00082	0.600
CLV_PCSK_SKI1_1	145	149	PF00082	0.649
CLV_PCSK_SKI1_1	626	630	PF00082	0.481
DEG_APCC_DBOX_1	415	423	PF00400	0.466
DEG_SCF_FBW7_1	283	290	PF00400	0.638
DEG_SPOP_SBC_1	257	261	PF00917	0.604
DEG_SPOP_SBC_1	376	380	PF00917	0.584
DOC_CKS1_1	265	270	PF01111	0.656
DOC_CKS1_1	594	599	PF01111	0.561
DOC_CKS1_1	606	611	PF01111	0.569
DOC_CYCLIN_yClb5_NLxxxL_5	175	183	PF00134	0.549
DOC_CYCLIN_yCln2_LP_2	551	557	PF00134	0.604
DOC_MAPK_DCC_7	62	72	PF00069	0.427
DOC_MAPK_FxFP_2	645	648	PF00069	0.322
DOC_MAPK_gen_1	688	696	PF00069	0.520
DOC_MAPK_MEF2A_6	688	696	PF00069	0.520
DOC_PP1_RVXF_1	624	631	PF00149	0.487
DOC_PP2B_LxvP_1	150	153	PF13499	0.602
DOC_PP2B_LxvP_1	351	354	PF13499	0.488
DOC_PP4_FxxP_1	24	27	PF00568	0.312
DOC_PP4_FxxP_1	265	268	PF00568	0.660
DOC_PP4_FxxP_1	645	648	PF00568	0.340
DOC_USP7_MATH_1	134	138	PF00917	0.718
DOC_USP7_MATH_1	153	157	PF00917	0.666
DOC_USP7_MATH_1	216	220	PF00917	0.716
DOC_USP7_MATH_1	253	257	PF00917	0.615
DOC_USP7_MATH_1	294	298	PF00917	0.669
DOC_USP7_MATH_1	376	380	PF00917	0.710
DOC_USP7_MATH_1	403	407	PF00917	0.350
DOC_USP7_MATH_1	622	626	PF00917	0.535
DOC_USP7_MATH_1	653	657	PF00917	0.478
DOC_USP7_MATH_1	672	676	PF00917	0.574
DOC_USP7_MATH_2	324	330	PF00917	0.515
DOC_WW_Pin1_4	127	132	PF00397	0.747
DOC_WW_Pin1_4	136	141	PF00397	0.737
DOC_WW_Pin1_4	194	199	PF00397	0.656
DOC_WW_Pin1_4	2	7	PF00397	0.422
DOC_WW_Pin1_4	249	254	PF00397	0.815
DOC_WW_Pin1_4	258	263	PF00397	0.653
DOC_WW_Pin1_4	264	269	PF00397	0.602
DOC_WW_Pin1_4	283	288	PF00397	0.630
DOC_WW_Pin1_4	349	354	PF00397	0.652
DOC_WW_Pin1_4	422	427	PF00397	0.525
DOC_WW_Pin1_4	593	598	PF00397	0.761
DOC_WW_Pin1_4	605	610	PF00397	0.514
LIG_14-3-3_CanoR_1	145	151	PF00244	0.637
LIG_14-3-3_CanoR_1	288	293	PF00244	0.532
LIG_14-3-3_CanoR_1	384	392	PF00244	0.584
LIG_14-3-3_CanoR_1	460	470	PF00244	0.632
LIG_14-3-3_CanoR_1	626	631	PF00244	0.514
LIG_14-3-3_CanoR_1	89	94	PF00244	0.649
LIG_Actin_WH2_2	68	85	PF00022	0.531
LIG_APCC_ABBA_1	21	26	PF00400	0.225
LIG_BIR_III_2	3	7	PF00653	0.463
LIG_BRCT_BRCA1_1	626	630	PF00533	0.626
LIG_FHA_1	188	194	PF00498	0.629
LIG_FHA_1	223	229	PF00498	0.717
LIG_FHA_1	284	290	PF00498	0.615
LIG_FHA_1	3	9	PF00498	0.455
LIG_FHA_1	334	340	PF00498	0.479
LIG_FHA_1	387	393	PF00498	0.502
LIG_FHA_1	476	482	PF00498	0.717
LIG_FHA_1	499	505	PF00498	0.418
LIG_FHA_1	540	546	PF00498	0.595
LIG_FHA_1	616	622	PF00498	0.490
LIG_FHA_2	122	128	PF00498	0.653
LIG_FHA_2	296	302	PF00498	0.504
LIG_FHA_2	477	483	PF00498	0.672
LIG_FHA_2	520	526	PF00498	0.565
LIG_GSK3_LRP6_1	249	254	PF00069	0.547
LIG_LIR_Apic_2	22	27	PF02991	0.312
LIG_LIR_Gen_1	71	80	PF02991	0.384
LIG_LIR_Nem_3	319	323	PF02991	0.525
LIG_LIR_Nem_3	71	76	PF02991	0.381
LIG_NRBOX	418	424	PF00104	0.471
LIG_NRBOX	442	448	PF00104	0.446
LIG_SH2_STAT5	593	596	PF00017	0.553
LIG_SH3_3	128	134	PF00018	0.679
LIG_SH3_3	247	253	PF00018	0.649
LIG_SH3_3	25	31	PF00018	0.420
LIG_SH3_3	46	52	PF00018	0.313
LIG_SH3_3	55	61	PF00018	0.428
LIG_SH3_3	591	597	PF00018	0.556
LIG_SH3_3	62	68	PF00018	0.489
LIG_SUMO_SIM_anti_2	406	411	PF11976	0.353
LIG_SUMO_SIM_anti_2	552	560	PF11976	0.609
LIG_SUMO_SIM_par_1	297	304	PF11976	0.512
LIG_TRAF2_1	120	123	PF00917	0.615
LIG_TRAF2_1	472	475	PF00917	0.543
LIG_WRC_WIRS_1	392	397	PF05994	0.467
LIG_WW_1	590	593	PF00397	0.549
MOD_CDK_SPK_2	127	132	PF00069	0.564
MOD_CDK_SPK_2	283	288	PF00069	0.592
MOD_CK1_1	197	203	PF00069	0.593
MOD_CK1_1	227	233	PF00069	0.706
MOD_CK1_1	256	262	PF00069	0.610
MOD_CK1_1	333	339	PF00069	0.689
MOD_CK1_1	388	394	PF00069	0.577
MOD_CK1_1	461	467	PF00069	0.573
MOD_CK1_1	560	566	PF00069	0.536
MOD_CK2_1	295	301	PF00069	0.511
MOD_CK2_1	307	313	PF00069	0.486
MOD_CK2_1	469	475	PF00069	0.669
MOD_CK2_1	519	525	PF00069	0.552
MOD_CK2_1	679	685	PF00069	0.514
MOD_CK2_1	697	703	PF00069	0.299
MOD_CMANNOS	337	340	PF00535	0.544
MOD_Cter_Amidation	242	245	PF01082	0.558
MOD_GlcNHglycan	102	105	PF01048	0.588
MOD_GlcNHglycan	157	160	PF01048	0.662
MOD_GlcNHglycan	229	232	PF01048	0.688
MOD_GlcNHglycan	255	258	PF01048	0.601
MOD_GlcNHglycan	278	282	PF01048	0.579
MOD_GlcNHglycan	303	306	PF01048	0.650
MOD_GlcNHglycan	309	312	PF01048	0.637
MOD_GlcNHglycan	313	317	PF01048	0.734
MOD_GlcNHglycan	398	401	PF01048	0.426
MOD_GlcNHglycan	463	466	PF01048	0.569
MOD_GlcNHglycan	471	474	PF01048	0.612
MOD_GlcNHglycan	525	530	PF01048	0.597
MOD_GlcNHglycan	562	565	PF01048	0.561
MOD_GlcNHglycan	655	658	PF01048	0.471
MOD_GlcNHglycan	672	675	PF01048	0.605
MOD_GlcNHglycan	680	684	PF01048	0.663
MOD_GlcNHglycan	84	87	PF01048	0.607
MOD_GSK3_1	100	107	PF00069	0.709
MOD_GSK3_1	130	137	PF00069	0.643
MOD_GSK3_1	153	160	PF00069	0.660
MOD_GSK3_1	163	170	PF00069	0.846
MOD_GSK3_1	194	201	PF00069	0.622
MOD_GSK3_1	223	230	PF00069	0.700
MOD_GSK3_1	249	256	PF00069	0.596
MOD_GSK3_1	283	290	PF00069	0.638
MOD_GSK3_1	303	310	PF00069	0.514
MOD_GSK3_1	312	319	PF00069	0.767
MOD_GSK3_1	326	333	PF00069	0.597
MOD_GSK3_1	376	383	PF00069	0.659
MOD_GSK3_1	494	501	PF00069	0.468
MOD_GSK3_1	541	548	PF00069	0.660
MOD_GSK3_1	616	623	PF00069	0.565
MOD_GSK3_1	633	640	PF00069	0.448
MOD_LATS_1	702	708	PF00433	0.353
MOD_LATS_1	87	93	PF00433	0.501
MOD_N-GLC_1	461	466	PF02516	0.648
MOD_NEK2_1	100	105	PF00069	0.495
MOD_NEK2_1	271	276	PF00069	0.489
MOD_NEK2_1	331	336	PF00069	0.560
MOD_NEK2_1	374	379	PF00069	0.545
MOD_NEK2_1	396	401	PF00069	0.406
MOD_NEK2_1	519	524	PF00069	0.626
MOD_NEK2_1	545	550	PF00069	0.598
MOD_NEK2_1	572	577	PF00069	0.660
MOD_NEK2_1	620	625	PF00069	0.534
MOD_NEK2_1	670	675	PF00069	0.602
MOD_NEK2_1	8	13	PF00069	0.406
MOD_NEK2_1	82	87	PF00069	0.599
MOD_NEK2_2	146	151	PF00069	0.723
MOD_NEK2_2	68	73	PF00069	0.386
MOD_NEK2_2	697	702	PF00069	0.328
MOD_PIKK_1	121	127	PF00454	0.643
MOD_PIKK_1	187	193	PF00454	0.644
MOD_PK_1	690	696	PF00069	0.414
MOD_PK_1	89	95	PF00069	0.503
MOD_PKA_1	89	95	PF00069	0.503
MOD_PKA_2	134	140	PF00069	0.712
MOD_PKA_2	287	293	PF00069	0.585
MOD_PKA_2	82	88	PF00069	0.607
MOD_PKA_2	89	95	PF00069	0.588
MOD_PKB_1	688	696	PF00069	0.587
MOD_Plk_1	439	445	PF00069	0.546
MOD_Plk_1	616	622	PF00069	0.438
MOD_Plk_4	295	301	PF00069	0.514
MOD_Plk_4	303	309	PF00069	0.537
MOD_Plk_4	391	397	PF00069	0.695
MOD_Plk_4	572	578	PF00069	0.466
MOD_Plk_4	616	622	PF00069	0.438
MOD_Plk_4	68	74	PF00069	0.511
MOD_ProDKin_1	127	133	PF00069	0.748
MOD_ProDKin_1	136	142	PF00069	0.734
MOD_ProDKin_1	194	200	PF00069	0.658
MOD_ProDKin_1	2	8	PF00069	0.412
MOD_ProDKin_1	249	255	PF00069	0.814
MOD_ProDKin_1	258	264	PF00069	0.645
MOD_ProDKin_1	283	289	PF00069	0.631
MOD_ProDKin_1	349	355	PF00069	0.655
MOD_ProDKin_1	422	428	PF00069	0.523
MOD_ProDKin_1	593	599	PF00069	0.761
MOD_ProDKin_1	605	611	PF00069	0.497
MOD_SUMO_rev_2	326	334	PF00179	0.511
MOD_SUMO_rev_2	583	591	PF00179	0.539
TRG_DiLeu_BaEn_1	207	212	PF01217	0.558
TRG_DiLeu_BaLyEn_6	3	8	PF01217	0.481
TRG_DiLeu_BaLyEn_6	354	359	PF01217	0.705
TRG_DiLeu_BaLyEn_6	418	423	PF01217	0.479
TRG_DiLeu_BaLyEn_6	442	447	PF01217	0.368
TRG_ER_diArg_1	340	342	PF00400	0.699
TRG_ER_diArg_1	415	418	PF00400	0.467
TRG_ER_diArg_1	466	469	PF00400	0.576
TRG_ER_diArg_1	708	711	PF00400	0.471
TRG_Pf-PMV_PEXEL_1	321	326	PF00026	0.609
TRG_Pf-PMV_PEXEL_1	357	362	PF00026	0.718

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJ27	Leptomonas seymouri	42%	100%
A0A3S7WUA7	Leishmania donovani	65%	98%
A4HX96	Leishmania infantum	65%	98%
E9AQZ8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	66%	99%
Q4QEG5	Leishmania major	66%	100%