Histone H2A

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Histone H2A

Gene product:

histone H2A variant Z

Species:

Leishmania braziliensis

UniProt:

A4H8X1_LEIBR

TriTrypDb:

LbrM.17.0260 , LBRM2903_170008400

Length:

182

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0000786	nucleosome	3	11
GO:0005634	nucleus	5	10
GO:0032991	protein-containing complex	1	11
GO:0032993	protein-DNA complex	2	11
GO:0043226	organelle	2	10
GO:0043227	membrane-bounded organelle	3	10
GO:0043229	intracellular organelle	3	10
GO:0043231	intracellular membrane-bounded organelle	4	10
GO:0044815	DNA packaging complex	2	11
GO:0110165	cellular anatomical entity	1	11
GO:0005654	nucleoplasm	2	1

Expansion

Sequence features

A4H8X1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H8X1

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006352	DNA-templated transcription initiation	6	1
GO:0006367	transcription initiation at RNA polymerase II promoter	7	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0006996	organelle organization	4	1
GO:0008152	metabolic process	1	1
GO:0009058	biosynthetic process	2	1
GO:0009059	macromolecule biosynthetic process	4	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0016070	RNA metabolic process	5	1
GO:0018130	heterocycle biosynthetic process	4	1
GO:0019438	aromatic compound biosynthetic process	4	1
GO:0032774	RNA biosynthetic process	5	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034654	nucleobase-containing compound biosynthetic process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044249	cellular biosynthetic process	3	1
GO:0044271	cellular nitrogen compound biosynthetic process	4	1
GO:0046483	heterocycle metabolic process	3	1
GO:0051276	chromosome organization	5	1
GO:0071704	organic substance metabolic process	2	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1901362	organic cyclic compound biosynthetic process	4	1
GO:1901576	organic substance biosynthetic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	11
GO:0003677	DNA binding	4	11
GO:0005198	structural molecule activity	1	11
GO:0005488	binding	1	11
GO:0005515	protein binding	2	11
GO:0030527	structural constituent of chromatin	2	11
GO:0046982	protein heterodimerization activity	4	11
GO:0046983	protein dimerization activity	3	11
GO:0097159	organic cyclic compound binding	2	11
GO:1901363	heterocyclic compound binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	65	67	PF00675	0.272
CLV_NRD_NRD_1	93	95	PF00675	0.242
CLV_PCSK_KEX2_1	179	181	PF00082	0.590
CLV_PCSK_KEX2_1	54	56	PF00082	0.252
CLV_PCSK_KEX2_1	65	67	PF00082	0.255
CLV_PCSK_PC1ET2_1	179	181	PF00082	0.590
CLV_PCSK_PC1ET2_1	54	56	PF00082	0.252
CLV_PCSK_SKI1_1	136	140	PF00082	0.245
CLV_PCSK_SKI1_1	176	180	PF00082	0.260
DEG_APCC_DBOX_1	135	143	PF00400	0.442
DOC_MAPK_gen_1	132	140	PF00069	0.442
DOC_MAPK_gen_1	71	79	PF00069	0.442
DOC_MAPK_JIP1_4	134	140	PF00069	0.442
DOC_MAPK_MEF2A_6	134	142	PF00069	0.442
DOC_USP7_UBL2_3	167	171	PF12436	0.444
DOC_USP7_UBL2_3	172	176	PF12436	0.438
DOC_USP7_UBL2_3	38	42	PF12436	0.613
DOC_USP7_UBL2_3	44	48	PF12436	0.283
DOC_USP7_UBL2_3	50	54	PF12436	0.475
DOC_USP7_UBL2_3	58	62	PF12436	0.466
LIG_14-3-3_CanoR_1	97	105	PF00244	0.455
LIG_BIR_II_1	1	5	PF00653	0.608
LIG_FHA_1	112	118	PF00498	0.442
LIG_FHA_1	128	134	PF00498	0.442
LIG_FHA_1	29	35	PF00498	0.630
LIG_FHA_2	2	8	PF00498	0.624
LIG_Integrin_RGD_1	143	145	PF01839	0.242
LIG_SH2_STAT3	93	96	PF00017	0.521
LIG_SH2_STAT5	105	108	PF00017	0.437
LIG_SH2_STAT5	112	115	PF00017	0.414
LIG_SH2_STAT5	3	6	PF00017	0.662
LIG_SH3_3	9	15	PF00018	0.580
LIG_SUMO_SIM_par_1	114	121	PF11976	0.501
LIG_TRAF2_1	4	7	PF00917	0.689
MOD_CK1_1	32	38	PF00069	0.594
MOD_CK2_1	1	7	PF00069	0.659
MOD_Cter_Amidation	52	55	PF01082	0.252
MOD_Cter_Amidation	63	66	PF01082	0.255
MOD_GlcNHglycan	100	103	PF01048	0.242
MOD_GlcNHglycan	119	123	PF01048	0.321
MOD_GlcNHglycan	176	179	PF01048	0.306
MOD_GlcNHglycan	24	27	PF01048	0.585
MOD_GlcNHglycan	34	37	PF01048	0.516
MOD_GlcNHglycan	5	11	PF01048	0.533
MOD_GSK3_1	170	177	PF00069	0.528
MOD_GSK3_1	24	31	PF00069	0.609
MOD_PKA_1	174	180	PF00069	0.521
MOD_PKA_2	152	158	PF00069	0.364
MOD_PKA_2	67	73	PF00069	0.497
MOD_Plk_1	28	34	PF00069	0.605
MOD_Plk_4	29	35	PF00069	0.630
TRG_NLS_MonoExtN_4	171	178	PF00514	0.443

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCA7	Leptomonas seymouri	92%	100%
A0A0S4KEA6	Bodo saltans	60%	100%
A0A1X0NTG5	Trypanosomatidae	75%	100%
A0A381MJI1	Leishmania infantum	42%	100%
A0A3Q8IHC3	Leishmania donovani	43%	100%
A0A3Q8IL41	Leishmania donovani	42%	100%
A0A3S5H701	Leishmania donovani	91%	100%
A0A3S5IQH1	Trypanosoma rangeli	80%	100%
A1A4R1	Bos taurus	52%	100%
A2YMC6	Oryza sativa subsp. indica	48%	100%
A3LXE7	Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545)	50%	100%
A3LZZ0	Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545)	52%	100%
A4HBV1	Leishmania braziliensis	49%	100%
A4HBV2	Leishmania braziliensis	48%	100%
A4HBV3	Leishmania braziliensis	48%	100%
A4HHI4	Leishmania braziliensis	45%	100%
A4HK98	Leishmania braziliensis	48%	100%
A4HX95	Leishmania infantum	91%	100%
A5DBG4	Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324)	53%	100%
A5DWF1	Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239)	50%	100%
C9ZTW8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	79%	100%
E9AE33	Leishmania major	44%	100%
E9AE34	Leishmania major	44%	100%
E9AE35	Leishmania major	44%	100%
E9AGW1	Leishmania infantum	42%	100%
E9ALP9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	42%	100%
E9AQZ7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
E9AV77	Leishmania mexicana (strain MHOM/GT/2001/U1103)	42%	100%
O04848	Arabidopsis thaliana	48%	100%
O62695	Oryctolagus cuniculus	54%	100%
P02264	Oncorhynchus mykiss	52%	100%
P02269	Asterias rubens	51%	100%
P02272	Gallus gallus	55%	100%
P02275	Triticum aestivum	48%	100%
P04735	Psammechinus miliaris	48%	100%
P04909	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	52%	100%
P04910	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	54%	100%
P06897	Xenopus laevis	52%	100%
P06898	Xenopus laevis	41%	100%
P16865	Volvox carteri	53%	100%
P16866	Volvox carteri	52%	100%
P16886	Strongylocentrotus purpuratus	47%	100%
P35061	Acropora formosa	48%	100%
P35062	Gallus gallus	51%	100%
P40282	Plasmodium falciparum	51%	100%
P50567	Chlamydomonas reinhardtii	52%	100%
P70082	Gallus gallus	52%	100%
P70094	Xenopus laevis	53%	100%
Q12692	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	54%	100%
Q16777	Homo sapiens	52%	100%
Q27511	Caenorhabditis elegans	57%	100%
Q32LA7	Bos taurus	55%	100%
Q3THW5	Mus musculus	55%	100%
Q43213	Triticum aestivum	48%	100%
Q43214	Triticum aestivum	47%	100%
Q4JHM8	Leishmania donovani	42%	100%
Q4PHE4	Ustilago maydis (strain 521 / FGSC 9021)	53%	100%
Q4QCA4	Leishmania major	43%	100%
Q4QEG6	Leishmania major	89%	100%
Q4R3X5	Macaca fascicularis	52%	100%
Q54LA5	Dictyostelium discoideum	43%	100%
Q59SU5	Candida albicans (strain SC5314 / ATCC MYA-2876)	49%	100%
Q5BJ65	Xenopus tropicalis	55%	100%
Q64523	Mus musculus	52%	100%
Q6BKW8	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	52%	100%
Q6BRG3	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	50%	100%
Q6C4I6	Yarrowia lipolytica (strain CLIB 122 / E 150)	52%	100%
Q6CK59	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	49%	100%
Q6CUC8	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	54%	100%
Q6DER6	Xenopus tropicalis	53%	100%
Q6GM74	Xenopus laevis	55%	100%
Q6Y237	Pagrus major	55%	100%
Q6ZL42	Oryza sativa subsp. japonica	48%	100%
Q71PD7	Danio rerio	55%	100%
Q71UI9	Homo sapiens	55%	100%
Q74ZL4	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	49%	100%
Q757L4	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	49%	100%
Q75CC6	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	57%	100%
Q94F49	Arabidopsis thaliana	48%	100%
Q9FJE8	Arabidopsis thaliana	49%	100%
Q9S9K7	Arabidopsis thaliana	48%	100%