Histone H2A

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Histone H2A

Gene product:

histone H2A variant Z

Species:

Leishmania braziliensis

UniProt:

A4H8X1_LEIBR

TriTrypDb:

LbrM.17.0260 , LBRM2903_170008400

Length:

182

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

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Cellular components
Term	Name	Level	Count
GO:0000786	nucleosome	3	11
GO:0005634	nucleus	5	10
GO:0005654	nucleoplasm	2	1
GO:0032991	protein-containing complex	1	11
GO:0032993	protein-DNA complex	2	11
GO:0043226	organelle	2	10
GO:0043227	membrane-bounded organelle	3	10
GO:0043229	intracellular organelle	3	10
GO:0043231	intracellular membrane-bounded organelle	4	10
GO:0044815	DNA packaging complex	2	11

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Expansion

Sequence features

A4H8X1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H8X1

Function

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Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006352	DNA-templated transcription initiation	6	1
GO:0006367	transcription initiation at RNA polymerase II promoter	7	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0006996	organelle organization	4	1
GO:0008152	metabolic process	1	1
GO:0009058	biosynthetic process	2	1
GO:0009059	macromolecule biosynthetic process	4	1
GO:0009987	cellular process	1	1

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Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	11
GO:0003677	DNA binding	4	11
GO:0005198	structural molecule activity	1	11
GO:0005488	binding	1	11
GO:0005515	protein binding	2	11
GO:0030527	structural constituent of chromatin	2	11
GO:0046982	protein heterodimerization activity	4	11
GO:0046983	protein dimerization activity	3	11
GO:0097159	organic cyclic compound binding	2	11
GO:1901363	heterocyclic compound binding	2	11

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	65	67	PF00675	0.272
CLV_NRD_NRD_1	93	95	PF00675	0.242
CLV_PCSK_KEX2_1	179	181	PF00082	0.590
CLV_PCSK_KEX2_1	54	56	PF00082	0.252
CLV_PCSK_KEX2_1	65	67	PF00082	0.255
CLV_PCSK_PC1ET2_1	179	181	PF00082	0.590
CLV_PCSK_PC1ET2_1	54	56	PF00082	0.252
CLV_PCSK_SKI1_1	136	140	PF00082	0.245
CLV_PCSK_SKI1_1	176	180	PF00082	0.260
DEG_APCC_DBOX_1	135	143	PF00400	0.442

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCA7	Leptomonas seymouri	92%	100%
A0A0S4KEA6	Bodo saltans	60%	100%
A0A1X0NTG5	Trypanosomatidae	75%	100%
A0A381MJI1	Leishmania infantum	42%	100%
A0A3Q8IHC3	Leishmania donovani	43%	100%
A0A3Q8IL41	Leishmania donovani	42%	100%
A0A3S5H701	Leishmania donovani	91%	100%
A0A3S5IQH1	Trypanosoma rangeli	80%	100%
A1A4R1	Bos taurus	52%	100%
A2YMC6	Oryza sativa subsp. indica	48%	100%

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