Putative NADH-ubiquinone oxidoreductase,mitochondrial

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

NADH-ubiquinone oxidoreductase, mitochondrial, putative

Species:

Leishmania braziliensis

UniProt:

A4H8X0_LEIBR

TriTrypDb:

LbrM.17.0250 , LBRM2903_170008300

Length:

274

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005747	mitochondrial respiratory chain complex I	4	1
GO:0030964	NADH dehydrogenase complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0045271	respiratory chain complex I	4	1
GO:0098796	membrane protein complex	2	1
GO:0098798	mitochondrial protein-containing complex	2	1
GO:0098800	inner mitochondrial membrane protein complex	3	1
GO:0098803	respiratory chain complex	3	1
GO:1902494	catalytic complex	2	1
GO:1902495	transmembrane transporter complex	3	1
GO:1990204	oxidoreductase complex	3	1
GO:1990351	transporter complex	2	1

Expansion

Sequence features

A4H8X0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H8X0

Function

Biological processes
Term	Name	Level	Count
GO:0006091	generation of precursor metabolites and energy	3	1
GO:0006120	mitochondrial electron transport, NADH to ubiquinone	7	1
GO:0008152	metabolic process	1	1
GO:0009060	aerobic respiration	6	1
GO:0009987	cellular process	1	1
GO:0015980	energy derivation by oxidation of organic compounds	4	1
GO:0019646	aerobic electron transport chain	6	1
GO:0022900	electron transport chain	4	1
GO:0022904	respiratory electron transport chain	5	1
GO:0044237	cellular metabolic process	2	1
GO:0045333	cellular respiration	5	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0005488	binding	1	11
GO:0016491	oxidoreductase activity	2	11
GO:0043167	ion binding	2	11
GO:0043169	cation binding	3	11
GO:0046872	metal ion binding	4	11
GO:0051536	iron-sulfur cluster binding	3	11
GO:0051537	2 iron, 2 sulfur cluster binding	4	11
GO:0051540	metal cluster binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	164	168	PF00656	0.300
CLV_NRD_NRD_1	2	4	PF00675	0.532
CLV_NRD_NRD_1	233	235	PF00675	0.525
CLV_NRD_NRD_1	74	76	PF00675	0.321
CLV_PCSK_FUR_1	72	76	PF00082	0.300
CLV_PCSK_KEX2_1	2	4	PF00082	0.540
CLV_PCSK_KEX2_1	233	235	PF00082	0.525
CLV_PCSK_KEX2_1	74	76	PF00082	0.300
CLV_PCSK_SKI1_1	101	105	PF00082	0.373
CLV_PCSK_SKI1_1	2	6	PF00082	0.468
CLV_PCSK_SKI1_1	222	226	PF00082	0.485
DEG_Nend_UBRbox_1	1	4	PF02207	0.657
DOC_MAPK_DCC_7	75	85	PF00069	0.300
DOC_MAPK_gen_1	72	82	PF00069	0.294
DOC_MAPK_HePTP_8	149	161	PF00069	0.300
DOC_MAPK_MEF2A_6	152	161	PF00069	0.300
DOC_PP4_FxxP_1	247	250	PF00568	0.536
DOC_USP7_MATH_1	18	22	PF00917	0.557
DOC_USP7_MATH_1	7	11	PF00917	0.648
DOC_USP7_UBL2_3	261	265	PF12436	0.584
DOC_WW_Pin1_4	136	141	PF00397	0.300
LIG_14-3-3_CanoR_1	242	246	PF00244	0.511
LIG_14-3-3_CanoR_1	74	83	PF00244	0.311
LIG_BIR_III_2	259	263	PF00653	0.553
LIG_BIR_III_2	268	272	PF00653	0.617
LIG_BRCT_BRCA1_1	243	247	PF00533	0.564
LIG_FHA_1	241	247	PF00498	0.600
LIG_FHA_1	29	35	PF00498	0.601
LIG_FHA_1	77	83	PF00498	0.412
LIG_FHA_2	162	168	PF00498	0.295
LIG_FHA_2	169	175	PF00498	0.300
LIG_FHA_2	211	217	PF00498	0.445
LIG_FHA_2	41	47	PF00498	0.521
LIG_LIR_Apic_2	190	195	PF02991	0.300
LIG_LIR_Apic_2	244	250	PF02991	0.531
LIG_LIR_Gen_1	118	128	PF02991	0.295
LIG_LIR_Gen_1	153	161	PF02991	0.300
LIG_LIR_Gen_1	199	206	PF02991	0.317
LIG_LIR_Gen_1	207	215	PF02991	0.261
LIG_LIR_Gen_1	56	67	PF02991	0.411
LIG_LIR_Nem_3	118	123	PF02991	0.295
LIG_LIR_Nem_3	153	159	PF02991	0.300
LIG_LIR_Nem_3	199	203	PF02991	0.248
LIG_LIR_Nem_3	205	211	PF02991	0.329
LIG_LIR_Nem_3	56	62	PF02991	0.383
LIG_Pex14_2	119	123	PF04695	0.300
LIG_SH2_CRK	192	196	PF00017	0.300
LIG_SH2_GRB2like	156	159	PF00017	0.300
LIG_SH2_GRB2like	192	195	PF00017	0.373
LIG_SH2_GRB2like	45	48	PF00017	0.548
LIG_SH2_NCK_1	192	196	PF00017	0.300
LIG_SH2_PTP2	93	96	PF00017	0.300
LIG_SH2_SRC	156	159	PF00017	0.300
LIG_SH2_SRC	200	203	PF00017	0.314
LIG_SH2_SRC	93	96	PF00017	0.292
LIG_SH2_STAT3	131	134	PF00017	0.300
LIG_SH2_STAT5	156	159	PF00017	0.300
LIG_SH2_STAT5	202	205	PF00017	0.314
LIG_SH2_STAT5	254	257	PF00017	0.495
LIG_SH2_STAT5	93	96	PF00017	0.300
LIG_SH3_1	225	231	PF00018	0.415
LIG_SH3_2	228	233	PF14604	0.415
LIG_SH3_3	179	185	PF00018	0.295
LIG_SH3_3	225	231	PF00018	0.415
LIG_SH3_3	247	253	PF00018	0.481
LIG_SH3_3	65	71	PF00018	0.326
LIG_SH3_4	261	268	PF00018	0.443
LIG_SUMO_SIM_par_1	164	174	PF11976	0.326
LIG_SUMO_SIM_par_1	185	191	PF11976	0.363
MOD_CK1_1	190	196	PF00069	0.300
MOD_CK1_1	21	27	PF00069	0.711
MOD_CK1_1	210	216	PF00069	0.445
MOD_CK2_1	168	174	PF00069	0.300
MOD_CK2_1	210	216	PF00069	0.419
MOD_Cter_Amidation	72	75	PF01082	0.412
MOD_GlcNHglycan	23	26	PF01048	0.486
MOD_GlcNHglycan	7	10	PF01048	0.665
MOD_GlcNHglycan	76	79	PF01048	0.300
MOD_GSK3_1	14	21	PF00069	0.672
MOD_N-GLC_1	196	201	PF02516	0.412
MOD_N-GLC_2	30	32	PF02516	0.459
MOD_NEK2_1	135	140	PF00069	0.300
MOD_NEK2_1	161	166	PF00069	0.263
MOD_NEK2_1	28	33	PF00069	0.532
MOD_NEK2_1	76	81	PF00069	0.192
MOD_PKA_1	2	8	PF00069	0.691
MOD_PKA_1	74	80	PF00069	0.300
MOD_PKA_2	2	8	PF00069	0.601
MOD_PKA_2	241	247	PF00069	0.479
MOD_PKA_2	74	80	PF00069	0.300
MOD_PKB_1	72	80	PF00069	0.320
MOD_Plk_1	150	156	PF00069	0.445
MOD_Plk_1	196	202	PF00069	0.367
MOD_Plk_1	204	210	PF00069	0.214
MOD_Plk_1	45	51	PF00069	0.417
MOD_Plk_2-3	204	210	PF00069	0.320
MOD_Plk_4	115	121	PF00069	0.290
MOD_Plk_4	210	216	PF00069	0.445
MOD_Plk_4	241	247	PF00069	0.467
MOD_ProDKin_1	136	142	PF00069	0.300
MOD_SUMO_for_1	260	263	PF00179	0.469
MOD_SUMO_rev_2	257	267	PF00179	0.569
TRG_DiLeu_BaLyEn_6	78	83	PF01217	0.300
TRG_ENDOCYTIC_2	120	123	PF00928	0.300
TRG_ENDOCYTIC_2	156	159	PF00928	0.300
TRG_ENDOCYTIC_2	200	203	PF00928	0.306
TRG_ENDOCYTIC_2	59	62	PF00928	0.372
TRG_ENDOCYTIC_2	93	96	PF00928	0.300
TRG_ER_diArg_1	1	3	PF00400	0.553
TRG_ER_diArg_1	71	74	PF00400	0.320
TRG_Pf-PMV_PEXEL_1	212	216	PF00026	0.320

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJN3	Leptomonas seymouri	82%	98%
A0A0S4KI12	Bodo saltans	67%	100%
A0A1X0NUP5	Trypanosomatidae	76%	100%
A0A3Q8ICR5	Leishmania donovani	91%	100%
A4HX94	Leishmania infantum	91%	100%
C9ZTW6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	73%	100%
E9AQZ6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
O22769	Arabidopsis thaliana	46%	100%
P04394	Bos taurus	47%	100%
P19234	Rattus norvegicus	49%	100%
P19404	Homo sapiens	47%	100%
P29914	Paracoccus denitrificans	37%	100%
P40915	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	39%	100%
P56909	Rhizobium meliloti (strain 1021)	35%	100%
Q0MQI7	Pongo pygmaeus	47%	100%
Q0MQI8	Gorilla gorilla gorilla	47%	100%
Q0MQI9	Pan troglodytes	47%	100%
Q20719	Caenorhabditis elegans	44%	100%
Q4QEG7	Leishmania major	91%	100%
Q54F10	Dictyostelium discoideum	46%	100%
Q9D6J6	Mus musculus	47%	100%
V5D8N1	Trypanosoma cruzi	77%	100%