Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H8W9_LEIBR

TriTrypDb:

LbrM.17.0240 , LBRM2903_170008200

Length:

819

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H8W9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H8W9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	157	161	PF00656	0.556
CLV_C14_Caspase3-7	176	180	PF00656	0.512
CLV_C14_Caspase3-7	425	429	PF00656	0.531
CLV_C14_Caspase3-7	576	580	PF00656	0.536
CLV_NRD_NRD_1	256	258	PF00675	0.687
CLV_NRD_NRD_1	273	275	PF00675	0.406
CLV_NRD_NRD_1	315	317	PF00675	0.648
CLV_NRD_NRD_1	362	364	PF00675	0.662
CLV_NRD_NRD_1	480	482	PF00675	0.600
CLV_NRD_NRD_1	561	563	PF00675	0.525
CLV_NRD_NRD_1	644	646	PF00675	0.488
CLV_NRD_NRD_1	710	712	PF00675	0.630
CLV_PCSK_KEX2_1	256	258	PF00082	0.620
CLV_PCSK_KEX2_1	273	275	PF00082	0.504
CLV_PCSK_KEX2_1	315	317	PF00082	0.648
CLV_PCSK_KEX2_1	362	364	PF00082	0.662
CLV_PCSK_KEX2_1	480	482	PF00082	0.600
CLV_PCSK_KEX2_1	561	563	PF00082	0.525
CLV_PCSK_KEX2_1	644	646	PF00082	0.488
CLV_PCSK_SKI1_1	142	146	PF00082	0.690
CLV_PCSK_SKI1_1	257	261	PF00082	0.605
CLV_PCSK_SKI1_1	46	50	PF00082	0.564
CLV_PCSK_SKI1_1	518	522	PF00082	0.651
CLV_PCSK_SKI1_1	586	590	PF00082	0.804
CLV_PCSK_SKI1_1	630	634	PF00082	0.477
CLV_PCSK_SKI1_1	777	781	PF00082	0.453
CLV_PCSK_SKI1_1	798	802	PF00082	0.447
DEG_APCC_DBOX_1	625	633	PF00400	0.409
DEG_SCF_FBW7_1	102	109	PF00400	0.569
DEG_SCF_FBW7_1	407	414	PF00400	0.584
DEG_SPOP_SBC_1	620	624	PF00917	0.476
DEG_SPOP_SBC_1	686	690	PF00917	0.529
DEG_SPOP_SBC_1	93	97	PF00917	0.573
DOC_ANK_TNKS_1	719	726	PF00023	0.588
DOC_CKS1_1	1	6	PF01111	0.577
DOC_CKS1_1	103	108	PF01111	0.651
DOC_CYCLIN_RxL_1	136	150	PF00134	0.546
DOC_MAPK_DCC_7	367	377	PF00069	0.546
DOC_MAPK_gen_1	362	368	PF00069	0.661
DOC_MAPK_gen_1	480	490	PF00069	0.707
DOC_PP1_RVXF_1	140	147	PF00149	0.542
DOC_PP1_RVXF_1	801	808	PF00149	0.525
DOC_PP2B_LxvP_1	368	371	PF13499	0.708
DOC_PP2B_LxvP_1	404	407	PF13499	0.514
DOC_PP2B_LxvP_1	49	52	PF13499	0.578
DOC_PP2B_LxvP_1	681	684	PF13499	0.532
DOC_PP4_FxxP_1	744	747	PF00568	0.462
DOC_USP7_MATH_1	11	15	PF00917	0.606
DOC_USP7_MATH_1	175	179	PF00917	0.593
DOC_USP7_MATH_1	282	286	PF00917	0.555
DOC_USP7_MATH_1	303	307	PF00917	0.563
DOC_USP7_MATH_1	335	339	PF00917	0.669
DOC_USP7_MATH_1	373	377	PF00917	0.577
DOC_USP7_MATH_1	442	446	PF00917	0.532
DOC_USP7_MATH_1	461	465	PF00917	0.650
DOC_USP7_MATH_1	582	586	PF00917	0.576
DOC_USP7_MATH_1	616	620	PF00917	0.632
DOC_USP7_MATH_1	625	629	PF00917	0.602
DOC_USP7_MATH_2	535	541	PF00917	0.549
DOC_WW_Pin1_4	102	107	PF00397	0.833
DOC_WW_Pin1_4	122	127	PF00397	0.550
DOC_WW_Pin1_4	128	133	PF00397	0.580
DOC_WW_Pin1_4	136	141	PF00397	0.548
DOC_WW_Pin1_4	208	213	PF00397	0.566
DOC_WW_Pin1_4	317	322	PF00397	0.677
DOC_WW_Pin1_4	348	353	PF00397	0.652
DOC_WW_Pin1_4	366	371	PF00397	0.643
DOC_WW_Pin1_4	407	412	PF00397	0.599
DOC_WW_Pin1_4	604	609	PF00397	0.597
DOC_WW_Pin1_4	612	617	PF00397	0.710
DOC_WW_Pin1_4	664	669	PF00397	0.586
DOC_WW_Pin1_4	673	678	PF00397	0.580
DOC_WW_Pin1_4	715	720	PF00397	0.708
LIG_14-3-3_CanoR_1	309	314	PF00244	0.574
LIG_14-3-3_CanoR_1	571	581	PF00244	0.607
LIG_14-3-3_CanoR_1	626	630	PF00244	0.429
LIG_14-3-3_CanoR_1	661	671	PF00244	0.564
LIG_14-3-3_CanoR_1	687	692	PF00244	0.742
LIG_14-3-3_CanoR_1	762	770	PF00244	0.480
LIG_BIR_II_1	1	5	PF00653	0.541
LIG_BIR_III_4	179	183	PF00653	0.716
LIG_BRCT_BRCA1_1	378	382	PF00533	0.556
LIG_CtBP_PxDLS_1	497	501	PF00389	0.530
LIG_FHA_1	231	237	PF00498	0.496
LIG_FHA_1	419	425	PF00498	0.594
LIG_FHA_1	52	58	PF00498	0.524
LIG_FHA_1	531	537	PF00498	0.660
LIG_FHA_1	588	594	PF00498	0.685
LIG_FHA_1	596	602	PF00498	0.508
LIG_FHA_1	63	69	PF00498	0.509
LIG_FHA_1	765	771	PF00498	0.541
LIG_FHA_1	77	83	PF00498	0.711
LIG_FHA_1	93	99	PF00498	0.753
LIG_FHA_2	174	180	PF00498	0.583
LIG_FHA_2	218	224	PF00498	0.528
LIG_FHA_2	253	259	PF00498	0.451
LIG_FHA_2	318	324	PF00498	0.560
LIG_FHA_2	506	512	PF00498	0.540
LIG_FHA_2	574	580	PF00498	0.533
LIG_FHA_2	58	64	PF00498	0.596
LIG_FHA_2	587	593	PF00498	0.513
LIG_FHA_2	701	707	PF00498	0.681
LIG_FHA_2	786	792	PF00498	0.482
LIG_LIR_Gen_1	410	419	PF02991	0.577
LIG_LIR_Nem_3	410	416	PF02991	0.578
LIG_LIR_Nem_3	774	779	PF02991	0.646
LIG_LIR_Nem_3	794	800	PF02991	0.324
LIG_LIR_Nem_3	806	810	PF02991	0.463
LIG_PTB_Apo_2	140	147	PF02174	0.530
LIG_SH2_CRK	776	780	PF00017	0.537
LIG_SH2_STAT3	574	577	PF00017	0.533
LIG_SH2_STAT3	810	813	PF00017	0.395
LIG_SH2_STAT5	574	577	PF00017	0.612
LIG_SH3_1	367	373	PF00018	0.546
LIG_SH3_2	295	300	PF14604	0.618
LIG_SH3_2	357	362	PF14604	0.724
LIG_SH3_3	108	114	PF00018	0.645
LIG_SH3_3	150	156	PF00018	0.572
LIG_SH3_3	206	212	PF00018	0.623
LIG_SH3_3	292	298	PF00018	0.611
LIG_SH3_3	346	352	PF00018	0.659
LIG_SH3_3	354	360	PF00018	0.622
LIG_SH3_3	367	373	PF00018	0.585
LIG_SH3_3	381	387	PF00018	0.555
LIG_SH3_3	498	504	PF00018	0.615
LIG_SH3_3	603	609	PF00018	0.599
LIG_SH3_3	713	719	PF00018	0.672
LIG_SH3_3	728	734	PF00018	0.739
LIG_SH3_3	78	84	PF00018	0.720
LIG_SUMO_SIM_anti_2	487	494	PF11976	0.637
LIG_TRAF2_1	509	512	PF00917	0.621
LIG_TRAF2_1	646	649	PF00917	0.558
LIG_UBA3_1	412	418	PF00899	0.492
LIG_WRC_WIRS_1	260	265	PF05994	0.445
LIG_WW_2	111	114	PF00397	0.778
LIG_WW_3	119	123	PF00397	0.662
LIG_WW_3	607	611	PF00397	0.544
MOD_CDC14_SPxK_1	131	134	PF00782	0.580
MOD_CDC14_SPxK_1	139	142	PF00782	0.520
MOD_CDC14_SPxK_1	607	610	PF00782	0.647
MOD_CDK_SPK_2	715	720	PF00069	0.562
MOD_CDK_SPxK_1	128	134	PF00069	0.589
MOD_CDK_SPxK_1	136	142	PF00069	0.532
MOD_CDK_SPxK_1	322	328	PF00069	0.543
MOD_CDK_SPxK_1	604	610	PF00069	0.594
MOD_CDK_SPxxK_3	317	324	PF00069	0.559
MOD_CK1_1	14	20	PF00069	0.564
MOD_CK1_1	147	153	PF00069	0.584
MOD_CK1_1	161	167	PF00069	0.682
MOD_CK1_1	178	184	PF00069	0.619
MOD_CK1_1	285	291	PF00069	0.546
MOD_CK1_1	337	343	PF00069	0.718
MOD_CK1_1	350	356	PF00069	0.590
MOD_CK1_1	376	382	PF00069	0.636
MOD_CK1_1	394	400	PF00069	0.795
MOD_CK1_1	464	470	PF00069	0.784
MOD_CK1_1	541	547	PF00069	0.590
MOD_CK1_1	553	559	PF00069	0.583
MOD_CK1_1	570	576	PF00069	0.594
MOD_CK1_1	584	590	PF00069	0.629
MOD_CK1_1	6	12	PF00069	0.599
MOD_CK1_1	602	608	PF00069	0.755
MOD_CK1_1	615	621	PF00069	0.559
MOD_CK1_1	729	735	PF00069	0.768
MOD_CK1_1	76	82	PF00069	0.635
MOD_CK1_1	764	770	PF00069	0.432
MOD_CK2_1	252	258	PF00069	0.553
MOD_CK2_1	317	323	PF00069	0.679
MOD_CK2_1	350	356	PF00069	0.731
MOD_CK2_1	505	511	PF00069	0.545
MOD_CK2_1	586	592	PF00069	0.548
MOD_CK2_1	785	791	PF00069	0.491
MOD_CK2_1	793	799	PF00069	0.508
MOD_DYRK1A_RPxSP_1	122	126	PF00069	0.734
MOD_DYRK1A_RPxSP_1	208	212	PF00069	0.552
MOD_GlcNHglycan	13	16	PF01048	0.677
MOD_GlcNHglycan	17	20	PF01048	0.592
MOD_GlcNHglycan	179	183	PF01048	0.811
MOD_GlcNHglycan	24	29	PF01048	0.460
MOD_GlcNHglycan	266	269	PF01048	0.454
MOD_GlcNHglycan	329	333	PF01048	0.655
MOD_GlcNHglycan	337	340	PF01048	0.728
MOD_GlcNHglycan	378	381	PF01048	0.674
MOD_GlcNHglycan	437	440	PF01048	0.572
MOD_GlcNHglycan	543	546	PF01048	0.504
MOD_GlcNHglycan	601	604	PF01048	0.576
MOD_GlcNHglycan	618	621	PF01048	0.637
MOD_GlcNHglycan	623	626	PF01048	0.598
MOD_GlcNHglycan	677	680	PF01048	0.787
MOD_GlcNHglycan	728	731	PF01048	0.597
MOD_GlcNHglycan	76	79	PF01048	0.566
MOD_GlcNHglycan	764	767	PF01048	0.490
MOD_GlcNHglycan	8	11	PF01048	0.569
MOD_GSK3_1	101	108	PF00069	0.602
MOD_GSK3_1	11	18	PF00069	0.590
MOD_GSK3_1	161	168	PF00069	0.703
MOD_GSK3_1	204	211	PF00069	0.593
MOD_GSK3_1	226	233	PF00069	0.615
MOD_GSK3_1	301	308	PF00069	0.810
MOD_GSK3_1	337	344	PF00069	0.683
MOD_GSK3_1	390	397	PF00069	0.765
MOD_GSK3_1	407	414	PF00069	0.526
MOD_GSK3_1	448	455	PF00069	0.644
MOD_GSK3_1	480	487	PF00069	0.699
MOD_GSK3_1	537	544	PF00069	0.550
MOD_GSK3_1	58	65	PF00069	0.712
MOD_GSK3_1	582	589	PF00069	0.622
MOD_GSK3_1	595	602	PF00069	0.602
MOD_GSK3_1	604	611	PF00069	0.640
MOD_GSK3_1	612	619	PF00069	0.656
MOD_GSK3_1	621	628	PF00069	0.566
MOD_GSK3_1	671	678	PF00069	0.573
MOD_GSK3_1	715	722	PF00069	0.633
MOD_GSK3_1	760	767	PF00069	0.472
MOD_LATS_1	482	488	PF00433	0.555
MOD_N-GLC_1	173	178	PF02516	0.597
MOD_N-GLC_1	474	479	PF02516	0.754
MOD_N-GLC_1	567	572	PF02516	0.588
MOD_N-GLC_1	726	731	PF02516	0.674
MOD_N-GLC_2	456	458	PF02516	0.553
MOD_N-GLC_2	735	737	PF02516	0.495
MOD_NEK2_1	144	149	PF00069	0.733
MOD_NEK2_1	158	163	PF00069	0.639
MOD_NEK2_1	165	170	PF00069	0.647
MOD_NEK2_1	204	209	PF00069	0.570
MOD_NEK2_1	398	403	PF00069	0.585
MOD_NEK2_1	433	438	PF00069	0.638
MOD_NEK2_1	505	510	PF00069	0.546
MOD_NEK2_1	521	526	PF00069	0.704
MOD_NEK2_1	536	541	PF00069	0.542
MOD_NEK2_1	572	577	PF00069	0.681
MOD_NEK2_1	654	659	PF00069	0.537
MOD_NEK2_1	670	675	PF00069	0.636
MOD_NEK2_1	685	690	PF00069	0.551
MOD_NEK2_1	760	765	PF00069	0.471
MOD_NEK2_2	625	630	PF00069	0.427
MOD_PIKK_1	202	208	PF00454	0.600
MOD_PIKK_1	3	9	PF00454	0.580
MOD_PIKK_1	309	315	PF00454	0.719
MOD_PIKK_1	461	467	PF00454	0.563
MOD_PIKK_1	521	527	PF00454	0.707
MOD_PIKK_1	530	536	PF00454	0.623
MOD_PIKK_1	561	567	PF00454	0.460
MOD_PIKK_1	573	579	PF00454	0.686
MOD_PIKK_1	764	770	PF00454	0.547
MOD_PIKK_1	791	797	PF00454	0.500
MOD_PK_1	484	490	PF00069	0.714
MOD_PK_1	516	522	PF00069	0.634
MOD_PKA_1	315	321	PF00069	0.570
MOD_PKA_1	480	486	PF00069	0.558
MOD_PKA_1	561	567	PF00069	0.440
MOD_PKA_2	308	314	PF00069	0.560
MOD_PKA_2	315	321	PF00069	0.553
MOD_PKA_2	480	486	PF00069	0.571
MOD_PKA_2	561	567	PF00069	0.440
MOD_PKA_2	570	576	PF00069	0.594
MOD_PKA_2	625	631	PF00069	0.417
MOD_PKA_2	686	692	PF00069	0.743
MOD_PKA_2	761	767	PF00069	0.483
MOD_Plk_1	390	396	PF00069	0.696
MOD_Plk_1	567	573	PF00069	0.617
MOD_Plk_1	62	68	PF00069	0.614
MOD_Plk_1	705	711	PF00069	0.566
MOD_Plk_4	259	265	PF00069	0.487
MOD_Plk_4	394	400	PF00069	0.583
MOD_Plk_4	486	492	PF00069	0.637
MOD_Plk_4	496	502	PF00069	0.614
MOD_Plk_4	94	100	PF00069	0.697
MOD_ProDKin_1	102	108	PF00069	0.835
MOD_ProDKin_1	122	128	PF00069	0.551
MOD_ProDKin_1	136	142	PF00069	0.548
MOD_ProDKin_1	208	214	PF00069	0.565
MOD_ProDKin_1	317	323	PF00069	0.675
MOD_ProDKin_1	348	354	PF00069	0.651
MOD_ProDKin_1	366	372	PF00069	0.639
MOD_ProDKin_1	407	413	PF00069	0.600
MOD_ProDKin_1	604	610	PF00069	0.599
MOD_ProDKin_1	612	618	PF00069	0.706
MOD_ProDKin_1	664	670	PF00069	0.587
MOD_ProDKin_1	673	679	PF00069	0.579
MOD_ProDKin_1	715	721	PF00069	0.710
MOD_SUMO_rev_2	786	794	PF00179	0.535
TRG_DiLeu_BaEn_1	649	654	PF01217	0.536
TRG_DiLeu_BaLyEn_6	419	424	PF01217	0.639
TRG_DiLeu_BaLyEn_6	501	506	PF01217	0.707
TRG_ENDOCYTIC_2	776	779	PF00928	0.462
TRG_ENDOCYTIC_2	797	800	PF00928	0.454
TRG_ER_diArg_1	121	124	PF00400	0.679
TRG_ER_diArg_1	273	276	PF00400	0.524
TRG_ER_diArg_1	314	316	PF00400	0.646
TRG_Pf-PMV_PEXEL_1	257	261	PF00026	0.448
TRG_Pf-PMV_PEXEL_1	46	50	PF00026	0.597

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I4I6	Leptomonas seymouri	35%	89%
A0A3S7WUB6	Leishmania donovani	60%	100%
A4HX93	Leishmania infantum	60%	100%
E9AQZ5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	59%	100%
Q4QEG8	Leishmania major	62%	99%