Cystathionine beta-synthase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cystathionine beta-synthase (fragment)

Species:

Leishmania braziliensis

UniProt:

A4H8W8_LEIBR

TriTrypDb:

LbrM.17.0230 , LBRM2903_170008100

Length:

120

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 1
NetGPI	no	yes: 0, no: 1

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H8W8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H8W8

Function

Biological processes
Term	Name	Level	Count
GO:0000096	sulfur amino acid metabolic process	4	2
GO:0000097	sulfur amino acid biosynthetic process	5	2
GO:0006082	organic acid metabolic process	3	2
GO:0006520	amino acid metabolic process	3	2
GO:0006534	cysteine metabolic process	5	2
GO:0006535	cysteine biosynthetic process from serine	7	2
GO:0006563	L-serine metabolic process	6	2
GO:0006790	sulfur compound metabolic process	3	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0008652	amino acid biosynthetic process	4	2
GO:0009058	biosynthetic process	2	2
GO:0009069	serine family amino acid metabolic process	5	2
GO:0009070	serine family amino acid biosynthetic process	6	2
GO:0009987	cellular process	1	2
GO:0016053	organic acid biosynthetic process	4	2
GO:0019344	cysteine biosynthetic process	6	2
GO:0019752	carboxylic acid metabolic process	5	2
GO:0043436	oxoacid metabolic process	4	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044249	cellular biosynthetic process	3	2
GO:0044272	sulfur compound biosynthetic process	4	2
GO:0044281	small molecule metabolic process	2	2
GO:0044283	small molecule biosynthetic process	3	2
GO:0046394	carboxylic acid biosynthetic process	5	2
GO:0071704	organic substance metabolic process	2	2
GO:1901564	organonitrogen compound metabolic process	3	2
GO:1901566	organonitrogen compound biosynthetic process	4	2
GO:1901576	organic substance biosynthetic process	3	2
GO:1901605	alpha-amino acid metabolic process	4	2
GO:1901607	alpha-amino acid biosynthetic process	5	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0004122	cystathionine beta-synthase activity	5	2
GO:0016829	lyase activity	2	2
GO:0016835	carbon-oxygen lyase activity	3	2
GO:0016836	hydro-lyase activity	4	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
DOC_MAPK_MEF2A_6	95	103	PF00069	0.554
DOC_PP4_FxxP_1	45	48	PF00568	0.554
DOC_USP7_MATH_1	48	52	PF00917	0.554
DOC_WW_Pin1_4	18	23	PF00397	0.554
LIG_14-3-3_CanoR_1	98	104	PF00244	0.554
LIG_FHA_1	19	25	PF00498	0.554
LIG_LIR_Apic_2	44	48	PF02991	0.554
LIG_PDZ_Class_2	115	120	PF00595	0.554
LIG_SH2_CRK	97	101	PF00017	0.554
MOD_CDK_SPxxK_3	18	25	PF00069	0.554
MOD_CK1_1	81	87	PF00069	0.554
MOD_GlcNHglycan	2	5	PF01048	0.802
MOD_GlcNHglycan	80	83	PF01048	0.554
MOD_GSK3_1	110	117	PF00069	0.554
MOD_GSK3_1	77	84	PF00069	0.554
MOD_LATS_1	109	115	PF00433	0.554
MOD_N-GLC_1	66	71	PF02516	0.554
MOD_NEK2_2	48	53	PF00069	0.554
MOD_PK_1	71	77	PF00069	0.554
MOD_PKA_1	105	111	PF00069	0.554
MOD_Plk_1	111	117	PF00069	0.554
MOD_Plk_4	71	77	PF00069	0.554
MOD_ProDKin_1	18	24	PF00069	0.554
MOD_SUMO_for_1	41	44	PF00179	0.554
TRG_ENDOCYTIC_2	97	100	PF00928	0.554

Homologs


Protein	Taxonomy	Sequence identity	Coverage
P48028	Pseudomonas syringae pv. syringae	46%	71%