Guanine nucleotide-binding protein subunit beta-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

WD domain, G-beta repeat, putative

Species:

Leishmania braziliensis

UniProt:

A4H8W6_LEIBR

TriTrypDb:

LbrM.17.0210 , LBRM2903_170007900

Length:

702

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	13
GO:0032991	protein-containing complex	1	13
GO:0043226	organelle	2	13
GO:0043228	non-membrane-bounded organelle	3	13
GO:0043229	intracellular organelle	3	13
GO:0043232	intracellular non-membrane-bounded organelle	4	13
GO:0110165	cellular anatomical entity	1	13
GO:1990904	ribonucleoprotein complex	2	13

Expansion

Sequence features

A4H8W6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H8W6

Function

Biological processes
Term	Name	Level	Count
GO:0007165	signal transduction	2	1
GO:0009987	cellular process	1	3
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0065007	biological regulation	1	1
GO:0006793	phosphorus metabolic process	3	2
GO:0006796	phosphate-containing compound metabolic process	4	2
GO:0008152	metabolic process	1	2
GO:0016310	phosphorylation	5	2
GO:0044237	cellular metabolic process	2	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0016301	kinase activity	4	2
GO:0016740	transferase activity	2	2
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	159	161	PF00675	0.574
CLV_NRD_NRD_1	263	265	PF00675	0.483
CLV_NRD_NRD_1	297	299	PF00675	0.607
CLV_NRD_NRD_1	84	86	PF00675	0.606
CLV_PCSK_KEX2_1	159	161	PF00082	0.574
CLV_PCSK_KEX2_1	263	265	PF00082	0.427
CLV_PCSK_KEX2_1	360	362	PF00082	0.712
CLV_PCSK_KEX2_1	484	486	PF00082	0.356
CLV_PCSK_KEX2_1	522	524	PF00082	0.484
CLV_PCSK_KEX2_1	83	85	PF00082	0.701
CLV_PCSK_PC1ET2_1	360	362	PF00082	0.508
CLV_PCSK_PC1ET2_1	484	486	PF00082	0.289
CLV_PCSK_PC1ET2_1	522	524	PF00082	0.484
CLV_PCSK_SKI1_1	299	303	PF00082	0.500
CLV_PCSK_SKI1_1	318	322	PF00082	0.685
CLV_PCSK_SKI1_1	360	364	PF00082	0.687
CLV_PCSK_SKI1_1	484	488	PF00082	0.477
CLV_PCSK_SKI1_1	645	649	PF00082	0.361
DEG_APCC_DBOX_1	198	206	PF00400	0.505
DEG_SPOP_SBC_1	13	17	PF00917	0.495
DOC_CKS1_1	117	122	PF01111	0.501
DOC_CKS1_1	265	270	PF01111	0.423
DOC_CKS1_1	355	360	PF01111	0.597
DOC_CYCLIN_RxL_1	481	488	PF00134	0.472
DOC_MAPK_DCC_7	90	98	PF00069	0.517
DOC_MAPK_gen_1	263	271	PF00069	0.413
DOC_MAPK_gen_1	360	369	PF00069	0.737
DOC_MAPK_MEF2A_6	104	111	PF00069	0.515
DOC_MAPK_MEF2A_6	360	369	PF00069	0.492
DOC_MAPK_MEF2A_6	534	542	PF00069	0.392
DOC_MAPK_MEF2A_6	90	98	PF00069	0.517
DOC_PP1_RVXF_1	483	490	PF00149	0.272
DOC_PP1_RVXF_1	628	634	PF00149	0.425
DOC_PP4_FxxP_1	489	492	PF00568	0.526
DOC_USP7_MATH_1	124	128	PF00917	0.603
DOC_USP7_MATH_1	13	17	PF00917	0.664
DOC_USP7_MATH_1	152	156	PF00917	0.747
DOC_USP7_MATH_1	198	202	PF00917	0.668
DOC_USP7_MATH_1	22	26	PF00917	0.527
DOC_USP7_MATH_1	395	399	PF00917	0.570
DOC_USP7_MATH_1	424	428	PF00917	0.399
DOC_USP7_MATH_1	467	471	PF00917	0.474
DOC_USP7_MATH_1	554	558	PF00917	0.545
DOC_USP7_MATH_1	64	68	PF00917	0.542
DOC_WW_Pin1_4	103	108	PF00397	0.531
DOC_WW_Pin1_4	116	121	PF00397	0.475
DOC_WW_Pin1_4	136	141	PF00397	0.719
DOC_WW_Pin1_4	144	149	PF00397	0.776
DOC_WW_Pin1_4	18	23	PF00397	0.527
DOC_WW_Pin1_4	238	243	PF00397	0.618
DOC_WW_Pin1_4	264	269	PF00397	0.470
DOC_WW_Pin1_4	354	359	PF00397	0.568
DOC_WW_Pin1_4	414	419	PF00397	0.389
DOC_WW_Pin1_4	457	462	PF00397	0.478
DOC_WW_Pin1_4	498	503	PF00397	0.390
DOC_WW_Pin1_4	540	545	PF00397	0.443
DOC_WW_Pin1_4	56	61	PF00397	0.565
DOC_WW_Pin1_4	611	616	PF00397	0.490
DOC_WW_Pin1_4	89	94	PF00397	0.549
DOC_WW_Pin1_4	96	101	PF00397	0.578
LIG_14-3-3_CanoR_1	12	22	PF00244	0.571
LIG_14-3-3_CanoR_1	172	178	PF00244	0.633
LIG_14-3-3_CanoR_1	361	366	PF00244	0.586
LIG_14-3-3_CanoR_1	394	400	PF00244	0.567
LIG_14-3-3_CanoR_1	485	490	PF00244	0.338
LIG_14-3-3_CanoR_1	630	636	PF00244	0.405
LIG_APCC_ABBA_1	275	280	PF00400	0.484
LIG_BRCT_BRCA1_1	651	655	PF00533	0.247
LIG_EH_1	115	119	PF12763	0.550
LIG_EH_1	250	254	PF12763	0.475
LIG_FHA_1	104	110	PF00498	0.675
LIG_FHA_1	117	123	PF00498	0.622
LIG_FHA_1	156	162	PF00498	0.775
LIG_FHA_1	364	370	PF00498	0.623
LIG_FHA_1	481	487	PF00498	0.408
LIG_FHA_1	90	96	PF00498	0.618
LIG_FHA_2	417	423	PF00498	0.272
LIG_FHA_2	661	667	PF00498	0.407
LIG_FXI_DFP_1	323	327	PF00024	0.646
LIG_IRF3_LxIS_1	93	99	PF10401	0.510
LIG_LIR_Apic_2	488	492	PF02991	0.526
LIG_LIR_Gen_1	322	330	PF02991	0.644
LIG_LIR_Gen_1	568	578	PF02991	0.337
LIG_LIR_Gen_1	652	661	PF02991	0.345
LIG_LIR_Nem_3	322	326	PF02991	0.645
LIG_LIR_Nem_3	526	530	PF02991	0.456
LIG_LIR_Nem_3	568	573	PF02991	0.384
LIG_LIR_Nem_3	652	658	PF02991	0.368
LIG_LIR_Nem_3	691	696	PF02991	0.318
LIG_MYND_1	191	195	PF01753	0.517
LIG_PCNA_PIPBox_1	512	521	PF02747	0.459
LIG_PCNA_yPIPBox_3	505	519	PF02747	0.443
LIG_PTB_Apo_2	248	255	PF02174	0.479
LIG_PTB_Apo_2	453	460	PF02174	0.440
LIG_REV1ctd_RIR_1	251	259	PF16727	0.456
LIG_SH2_SRC	278	281	PF00017	0.460
LIG_SH2_SRC	530	533	PF00017	0.257
LIG_SH2_STAP1	278	282	PF00017	0.473
LIG_SH2_STAP1	684	688	PF00017	0.322
LIG_SH2_STAT5	210	213	PF00017	0.471
LIG_SH2_STAT5	465	468	PF00017	0.459
LIG_SH2_STAT5	506	509	PF00017	0.497
LIG_SH2_STAT5	548	551	PF00017	0.483
LIG_SH2_STAT5	584	587	PF00017	0.357
LIG_SH2_STAT5	657	660	PF00017	0.377
LIG_SH2_STAT5	677	680	PF00017	0.377
LIG_SH3_2	355	360	PF14604	0.478
LIG_SH3_3	114	120	PF00018	0.616
LIG_SH3_3	131	137	PF00018	0.590
LIG_SH3_3	16	22	PF00018	0.759
LIG_SH3_3	188	194	PF00018	0.611
LIG_SH3_3	352	358	PF00018	0.722
LIG_SH3_3	45	51	PF00018	0.558
LIG_SH3_3	7	13	PF00018	0.699
LIG_SUMO_SIM_anti_2	331	337	PF11976	0.461
LIG_SUMO_SIM_anti_2	644	650	PF11976	0.242
LIG_SUMO_SIM_par_1	364	370	PF11976	0.489
LIG_SxIP_EBH_1	11	23	PF03271	0.499
LIG_TRAF2_1	78	81	PF00917	0.537
LIG_WRC_WIRS_1	320	325	PF05994	0.647
LIG_WRC_WIRS_1	396	401	PF05994	0.539
LIG_WRC_WIRS_1	486	491	PF05994	0.391
LIG_WW_1	194	197	PF00397	0.513
LIG_WW_2	191	194	PF00397	0.519
MOD_CDK_SPK_2	18	23	PF00069	0.527
MOD_CDK_SPK_2	56	61	PF00069	0.520
MOD_CDK_SPxK_1	354	360	PF00069	0.499
MOD_CDK_SPxxK_3	354	361	PF00069	0.486
MOD_CDK_SPxxK_3	457	464	PF00069	0.297
MOD_CDK_SPxxK_3	498	505	PF00069	0.199
MOD_CK1_1	132	138	PF00069	0.734
MOD_CK1_1	155	161	PF00069	0.703
MOD_CK1_1	17	23	PF00069	0.774
MOD_CK1_1	170	176	PF00069	0.662
MOD_CK1_1	214	220	PF00069	0.556
MOD_CK1_1	224	230	PF00069	0.580
MOD_CK1_1	238	244	PF00069	0.501
MOD_CK1_1	311	317	PF00069	0.597
MOD_CK1_1	398	404	PF00069	0.352
MOD_CK1_1	501	507	PF00069	0.248
MOD_CK1_1	562	568	PF00069	0.409
MOD_CK1_1	583	589	PF00069	0.363
MOD_CK1_1	59	65	PF00069	0.749
MOD_CK1_1	590	596	PF00069	0.332
MOD_CK2_1	175	181	PF00069	0.637
MOD_CK2_1	238	244	PF00069	0.492
MOD_CK2_1	281	287	PF00069	0.542
MOD_CK2_1	414	420	PF00069	0.387
MOD_CK2_1	590	596	PF00069	0.356
MOD_CK2_1	660	666	PF00069	0.367
MOD_CK2_1	74	80	PF00069	0.728
MOD_Cter_Amidation	296	299	PF01082	0.591
MOD_Cter_Amidation	81	84	PF01082	0.518
MOD_GlcNHglycan	154	157	PF01048	0.698
MOD_GlcNHglycan	177	180	PF01048	0.707
MOD_GlcNHglycan	231	234	PF01048	0.769
MOD_GlcNHglycan	310	313	PF01048	0.794
MOD_GlcNHglycan	341	344	PF01048	0.599
MOD_GlcNHglycan	401	404	PF01048	0.398
MOD_GlcNHglycan	508	511	PF01048	0.324
MOD_GlcNHglycan	550	553	PF01048	0.306
MOD_GlcNHglycan	561	564	PF01048	0.398
MOD_GlcNHglycan	602	605	PF01048	0.378
MOD_GlcNHglycan	636	639	PF01048	0.373
MOD_GSK3_1	124	131	PF00069	0.733
MOD_GSK3_1	13	20	PF00069	0.744
MOD_GSK3_1	132	139	PF00069	0.629
MOD_GSK3_1	167	174	PF00069	0.736
MOD_GSK3_1	217	224	PF00069	0.568
MOD_GSK3_1	22	29	PF00069	0.780
MOD_GSK3_1	225	232	PF00069	0.587
MOD_GSK3_1	234	241	PF00069	0.505
MOD_GSK3_1	363	370	PF00069	0.632
MOD_GSK3_1	395	402	PF00069	0.529
MOD_GSK3_1	550	557	PF00069	0.274
MOD_GSK3_1	561	568	PF00069	0.389
MOD_GSK3_1	578	585	PF00069	0.402
MOD_GSK3_1	605	612	PF00069	0.315
MOD_GSK3_1	618	625	PF00069	0.700
MOD_N-GLC_1	235	240	PF02516	0.656
MOD_N-GLC_1	246	251	PF02516	0.632
MOD_N-GLC_1	308	313	PF02516	0.505
MOD_N-GLC_1	455	460	PF02516	0.270
MOD_NEK2_1	142	147	PF00069	0.763
MOD_NEK2_1	168	173	PF00069	0.685
MOD_NEK2_1	26	31	PF00069	0.605
MOD_NEK2_1	382	387	PF00069	0.719
MOD_NEK2_1	399	404	PF00069	0.394
MOD_NEK2_1	518	523	PF00069	0.361
MOD_NEK2_1	578	583	PF00069	0.321
MOD_NEK2_2	22	27	PF00069	0.506
MOD_NEK2_2	554	559	PF00069	0.297
MOD_NMyristoyl	1	7	PF02799	0.643
MOD_PKA_2	11	17	PF00069	0.661
MOD_PKA_2	171	177	PF00069	0.643
MOD_PKA_2	198	204	PF00069	0.559
MOD_PKA_2	211	217	PF00069	0.721
MOD_PKA_2	622	628	PF00069	0.588
MOD_Plk_1	429	435	PF00069	0.371
MOD_Plk_1	455	461	PF00069	0.320
MOD_Plk_1	554	560	PF00069	0.274
MOD_Plk_4	211	217	PF00069	0.651
MOD_Plk_4	26	32	PF00069	0.584
MOD_Plk_4	363	369	PF00069	0.616
MOD_Plk_4	450	456	PF00069	0.348
MOD_Plk_4	5	11	PF00069	0.563
MOD_Plk_4	666	672	PF00069	0.322
MOD_ProDKin_1	103	109	PF00069	0.533
MOD_ProDKin_1	116	122	PF00069	0.476
MOD_ProDKin_1	136	142	PF00069	0.721
MOD_ProDKin_1	144	150	PF00069	0.779
MOD_ProDKin_1	18	24	PF00069	0.528
MOD_ProDKin_1	238	244	PF00069	0.616
MOD_ProDKin_1	264	270	PF00069	0.476
MOD_ProDKin_1	354	360	PF00069	0.571
MOD_ProDKin_1	414	420	PF00069	0.387
MOD_ProDKin_1	457	463	PF00069	0.322
MOD_ProDKin_1	498	504	PF00069	0.199
MOD_ProDKin_1	540	546	PF00069	0.274
MOD_ProDKin_1	56	62	PF00069	0.566
MOD_ProDKin_1	611	617	PF00069	0.500
MOD_ProDKin_1	89	95	PF00069	0.550
MOD_ProDKin_1	96	102	PF00069	0.577
MOD_SUMO_rev_2	385	392	PF00179	0.517
MOD_SUMO_rev_2	460	466	PF00179	0.266
MOD_SUMO_rev_2	501	507	PF00179	0.200
MOD_SUMO_rev_2	526	536	PF00179	0.488
TRG_DiLeu_BaEn_2	271	277	PF01217	0.532
TRG_DiLeu_BaLyEn_6	297	302	PF01217	0.502
TRG_DiLeu_BaLyEn_6	48	53	PF01217	0.512
TRG_DiLeu_BaLyEn_6	482	487	PF01217	0.280
TRG_DiLeu_BaLyEn_6	91	96	PF01217	0.509
TRG_ENDOCYTIC_2	278	281	PF00928	0.449
TRG_ENDOCYTIC_2	684	687	PF00928	0.263
TRG_ER_diArg_1	159	162	PF00400	0.576
TRG_ER_diArg_1	83	85	PF00400	0.628
TRG_NLS_MonoExtN_4	358	364	PF00514	0.503
TRG_Pf-PMV_PEXEL_1	159	163	PF00026	0.527

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I384	Leptomonas seymouri	68%	99%
A0A1X0NT03	Trypanosomatidae	51%	100%
A0A3Q8IDW5	Leishmania donovani	65%	100%
A0A3Q8IGX5	Leishmania donovani	25%	100%
A0A3R7NBP1	Trypanosoma rangeli	49%	100%
A4HX90	Leishmania infantum	69%	100%
A4ICS7	Leishmania infantum	25%	100%
C9ZTV9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
E9AQZ2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	64%	100%
E9ASH7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	100%
Q4QEH1	Leishmania major	69%	100%