Kinesin motor domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

kinesin motor domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4H8W5_LEIBR

TriTrypDb:

LbrM.17.0200 , LBRM2903_170007800

Length:

685

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 1
NetGPI	no	yes: 0, no: 1

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H8W5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H8W5

Function

Biological processes
Term	Name	Level	Count
GO:0007017	microtubule-based process	2	2
GO:0007018	microtubule-based movement	3	2
GO:0009987	cellular process	1	2

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	2
GO:0003774	cytoskeletal motor activity	1	2
GO:0003777	microtubule motor activity	2	2
GO:0005488	binding	1	2
GO:0005515	protein binding	2	2
GO:0005524	ATP binding	5	2
GO:0008017	microtubule binding	5	2
GO:0008092	cytoskeletal protein binding	3	2
GO:0015631	tubulin binding	4	2
GO:0017076	purine nucleotide binding	4	2
GO:0030554	adenyl nucleotide binding	5	2
GO:0032553	ribonucleotide binding	3	2
GO:0032555	purine ribonucleotide binding	4	2
GO:0032559	adenyl ribonucleotide binding	5	2
GO:0035639	purine ribonucleoside triphosphate binding	4	2
GO:0036094	small molecule binding	2	2
GO:0043167	ion binding	2	2
GO:0043168	anion binding	3	2
GO:0097159	organic cyclic compound binding	2	2
GO:0097367	carbohydrate derivative binding	2	2
GO:0140657	ATP-dependent activity	1	2
GO:1901265	nucleoside phosphate binding	3	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	269	273	PF00656	0.846
CLV_C14_Caspase3-7	364	368	PF00656	0.842
CLV_MEL_PAP_1	176	182	PF00089	0.693
CLV_NRD_NRD_1	236	238	PF00675	0.813
CLV_NRD_NRD_1	262	264	PF00675	0.807
CLV_NRD_NRD_1	37	39	PF00675	0.674
CLV_NRD_NRD_1	554	556	PF00675	0.658
CLV_NRD_NRD_1	603	605	PF00675	0.826
CLV_PCSK_FUR_1	601	605	PF00082	0.806
CLV_PCSK_KEX2_1	109	111	PF00082	0.851
CLV_PCSK_KEX2_1	236	238	PF00082	0.813
CLV_PCSK_KEX2_1	26	28	PF00082	0.685
CLV_PCSK_KEX2_1	261	263	PF00082	0.808
CLV_PCSK_KEX2_1	37	39	PF00082	0.481
CLV_PCSK_KEX2_1	553	555	PF00082	0.672
CLV_PCSK_KEX2_1	603	605	PF00082	0.826
CLV_PCSK_PC1ET2_1	109	111	PF00082	0.851
CLV_PCSK_PC1ET2_1	26	28	PF00082	0.685
CLV_PCSK_PC7_1	599	605	PF00082	0.794
CLV_PCSK_SKI1_1	262	266	PF00082	0.815
CLV_PCSK_SKI1_1	37	41	PF00082	0.690
CLV_PCSK_SKI1_1	515	519	PF00082	0.662
CLV_PCSK_SKI1_1	555	559	PF00082	0.645
CLV_Separin_Metazoa	196	200	PF03568	0.649
DEG_APCC_DBOX_1	26	34	PF00400	0.664
DEG_APCC_DBOX_1	521	529	PF00400	0.694
DEG_APCC_DBOX_1	591	599	PF00400	0.765
DEG_Nend_Nbox_1	1	3	PF02207	0.721
DEG_SCF_FBW7_2	274	281	PF00400	0.847
DEG_SPOP_SBC_1	401	405	PF00917	0.838
DOC_CKS1_1	139	144	PF01111	0.841
DOC_CYCLIN_RxL_1	34	44	PF00134	0.682
DOC_CYCLIN_yCln2_LP_2	602	608	PF00134	0.828
DOC_MAPK_gen_1	283	292	PF00069	0.839
DOC_MAPK_HePTP_8	46	58	PF00069	0.735
DOC_MAPK_MEF2A_6	283	292	PF00069	0.839
DOC_MAPK_MEF2A_6	49	58	PF00069	0.732
DOC_MAPK_MEF2A_6	67	76	PF00069	0.368
DOC_PP2B_LxvP_1	290	293	PF13499	0.827
DOC_PP2B_LxvP_1	355	358	PF13499	0.828
DOC_PP2B_LxvP_1	40	43	PF13499	0.708
DOC_PP2B_LxvP_1	668	671	PF13499	0.846
DOC_PP4_FxxP_1	350	353	PF00568	0.839
DOC_USP7_MATH_1	157	161	PF00917	0.812
DOC_USP7_MATH_1	313	317	PF00917	0.841
DOC_USP7_MATH_1	402	406	PF00917	0.838
DOC_USP7_MATH_1	461	465	PF00917	0.851
DOC_USP7_MATH_1	488	492	PF00917	0.746
DOC_USP7_MATH_1	517	521	PF00917	0.650
DOC_USP7_MATH_1	587	591	PF00917	0.818
DOC_USP7_MATH_1	649	653	PF00917	0.833
DOC_USP7_MATH_2	671	677	PF00917	0.829
DOC_WW_Pin1_4	138	143	PF00397	0.839
DOC_WW_Pin1_4	159	164	PF00397	0.793
DOC_WW_Pin1_4	274	279	PF00397	0.846
DOC_WW_Pin1_4	311	316	PF00397	0.844
DOC_WW_Pin1_4	384	389	PF00397	0.827
DOC_WW_Pin1_4	472	477	PF00397	0.873
DOC_WW_Pin1_4	484	489	PF00397	0.572
DOC_WW_Pin1_4	651	656	PF00397	0.835
LIG_14-3-3_CanoR_1	130	138	PF00244	0.852
LIG_14-3-3_CanoR_1	179	183	PF00244	0.689
LIG_14-3-3_CanoR_1	236	240	PF00244	0.818
LIG_14-3-3_CanoR_1	262	268	PF00244	0.822
LIG_14-3-3_CanoR_1	410	416	PF00244	0.840
LIG_14-3-3_CanoR_1	419	429	PF00244	0.690
LIG_14-3-3_CanoR_1	434	442	PF00244	0.609
LIG_14-3-3_CanoR_1	470	479	PF00244	0.872
LIG_14-3-3_CanoR_1	592	596	PF00244	0.779
LIG_AP2alpha_2	53	55	PF02296	0.722
LIG_APCC_Cbox_2	251	257	PF00515	0.805
LIG_BRCT_BRCA1_1	490	494	PF00533	0.705
LIG_BRCT_MDC1_1	681	685	PF00533	0.824
LIG_CaM_IQ_9	65	81	PF13499	0.687
LIG_EVH1_2	671	675	PF00568	0.826
LIG_FHA_1	11	17	PF00498	0.679
LIG_FHA_1	126	132	PF00498	0.847
LIG_FHA_1	134	140	PF00498	0.712
LIG_FHA_1	167	173	PF00498	0.668
LIG_FHA_1	184	190	PF00498	0.382
LIG_FHA_1	292	298	PF00498	0.829
LIG_FHA_1	30	36	PF00498	0.321
LIG_FHA_1	305	311	PF00498	0.621
LIG_FHA_1	463	469	PF00498	0.860
LIG_FHA_1	473	479	PF00498	0.700
LIG_FHA_1	626	632	PF00498	0.856
LIG_FHA_2	185	191	PF00498	0.671
LIG_FHA_2	655	661	PF00498	0.829
LIG_Integrin_isoDGR_2	382	384	PF01839	0.850
LIG_LIR_Gen_1	193	203	PF02991	0.643
LIG_LIR_Gen_1	52	61	PF02991	0.705
LIG_LIR_Gen_1	639	647	PF02991	0.819
LIG_LIR_Nem_3	147	152	PF02991	0.824
LIG_LIR_Nem_3	193	198	PF02991	0.636
LIG_LIR_Nem_3	491	497	PF02991	0.697
LIG_LIR_Nem_3	52	58	PF02991	0.716
LIG_LIR_Nem_3	639	643	PF02991	0.826
LIG_LIR_Nem_3	652	656	PF02991	0.609
LIG_SH2_STAT3	497	500	PF00017	0.676
LIG_SH2_STAT5	497	500	PF00017	0.676
LIG_SH3_3	294	300	PF00018	0.830
LIG_SH3_3	465	471	PF00018	0.862
LIG_SH3_3	482	488	PF00018	0.502
LIG_SH3_3	576	582	PF00018	0.815
LIG_SH3_CIN85_PxpxPR_1	484	489	PF14604	0.782
LIG_SUMO_SIM_par_1	524	530	PF11976	0.718
LIG_WRC_WIRS_1	559	564	PF05994	0.645
MOD_CDK_SPK_2	484	489	PF00069	0.782
MOD_CDK_SPxxK_3	651	658	PF00069	0.836
MOD_CK1_1	123	129	PF00069	0.847
MOD_CK1_1	159	165	PF00069	0.782
MOD_CK1_1	244	250	PF00069	0.816
MOD_CK1_1	266	272	PF00069	0.841
MOD_CK1_1	301	307	PF00069	0.838
MOD_CK1_1	331	337	PF00069	0.840
MOD_CK1_1	428	434	PF00069	0.860
MOD_CK1_1	533	539	PF00069	0.732
MOD_CK1_1	549	555	PF00069	0.381
MOD_CK1_1	561	567	PF00069	0.443
MOD_CK1_1	654	660	PF00069	0.835
MOD_CK1_1	99	105	PF00069	0.853
MOD_CK2_1	184	190	PF00069	0.679
MOD_CK2_1	235	241	PF00069	0.813
MOD_CK2_1	484	490	PF00069	0.768
MOD_CK2_1	654	660	PF00069	0.835
MOD_Cter_Amidation	259	262	PF01082	0.805
MOD_GlcNHglycan	114	117	PF01048	0.851
MOD_GlcNHglycan	159	162	PF01048	0.803
MOD_GlcNHglycan	164	167	PF01048	0.639
MOD_GlcNHglycan	209	212	PF01048	0.664
MOD_GlcNHglycan	232	235	PF01048	0.766
MOD_GlcNHglycan	243	246	PF01048	0.631
MOD_GlcNHglycan	269	272	PF01048	0.846
MOD_GlcNHglycan	315	318	PF01048	0.847
MOD_GlcNHglycan	330	333	PF01048	0.571
MOD_GlcNHglycan	363	366	PF01048	0.845
MOD_GlcNHglycan	395	398	PF01048	0.848
MOD_GlcNHglycan	413	416	PF01048	0.522
MOD_GlcNHglycan	423	426	PF01048	0.663
MOD_GlcNHglycan	472	475	PF01048	0.871
MOD_GlcNHglycan	490	494	PF01048	0.390
MOD_GlcNHglycan	632	636	PF01048	0.847
MOD_GlcNHglycan	640	643	PF01048	0.687
MOD_GlcNHglycan	647	650	PF01048	0.559
MOD_GlcNHglycan	675	678	PF01048	0.842
MOD_GSK3_1	108	115	PF00069	0.851
MOD_GSK3_1	116	123	PF00069	0.715
MOD_GSK3_1	125	132	PF00069	0.549
MOD_GSK3_1	153	160	PF00069	0.820
MOD_GSK3_1	162	169	PF00069	0.568
MOD_GSK3_1	237	244	PF00069	0.823
MOD_GSK3_1	263	270	PF00069	0.828
MOD_GSK3_1	336	343	PF00069	0.841
MOD_GSK3_1	402	409	PF00069	0.843
MOD_GSK3_1	411	418	PF00069	0.681
MOD_GSK3_1	421	428	PF00069	0.512
MOD_GSK3_1	430	437	PF00069	0.537
MOD_GSK3_1	484	491	PF00069	0.765
MOD_GSK3_1	527	534	PF00069	0.746
MOD_GSK3_1	587	594	PF00069	0.808
MOD_GSK3_1	645	652	PF00069	0.820
MOD_N-GLC_1	574	579	PF02516	0.793
MOD_N-GLC_1	588	593	PF02516	0.570
MOD_NEK2_1	124	129	PF00069	0.847
MOD_NEK2_1	153	158	PF00069	0.820
MOD_NEK2_1	361	366	PF00069	0.843
MOD_NEK2_1	393	398	PF00069	0.847
MOD_NEK2_1	406	411	PF00069	0.620
MOD_NEK2_1	89	94	PF00069	0.848
MOD_NEK2_2	402	407	PF00069	0.842
MOD_NEK2_2	517	522	PF00069	0.653
MOD_PIKK_1	116	122	PF00454	0.855
MOD_PIKK_1	129	135	PF00454	0.623
MOD_PIKK_1	336	342	PF00454	0.842
MOD_PIKK_1	441	447	PF00454	0.863
MOD_PIKK_1	496	502	PF00454	0.677
MOD_PIKK_1	546	552	PF00454	0.665
MOD_PKA_1	108	114	PF00069	0.851
MOD_PKA_1	26	32	PF00069	0.665
MOD_PKA_2	129	135	PF00069	0.851
MOD_PKA_2	153	159	PF00069	0.821
MOD_PKA_2	178	184	PF00069	0.694
MOD_PKA_2	235	241	PF00069	0.813
MOD_PKA_2	26	32	PF00069	0.665
MOD_PKA_2	267	273	PF00069	0.844
MOD_PKA_2	284	290	PF00069	0.541
MOD_PKA_2	406	412	PF00069	0.847
MOD_PKA_2	421	427	PF00069	0.582
MOD_PKA_2	488	494	PF00069	0.728
MOD_PKA_2	591	597	PF00069	0.776
MOD_PKB_1	261	269	PF00069	0.821
MOD_Plk_1	366	372	PF00069	0.842
MOD_Plk_1	489	495	PF00069	0.720
MOD_Plk_1	574	580	PF00069	0.795
MOD_Plk_1	588	594	PF00069	0.557
MOD_Plk_4	178	184	PF00069	0.694
MOD_ProDKin_1	138	144	PF00069	0.841
MOD_ProDKin_1	159	165	PF00069	0.782
MOD_ProDKin_1	274	280	PF00069	0.845
MOD_ProDKin_1	311	317	PF00069	0.845
MOD_ProDKin_1	384	390	PF00069	0.827
MOD_ProDKin_1	472	478	PF00069	0.873
MOD_ProDKin_1	484	490	PF00069	0.558
MOD_ProDKin_1	651	657	PF00069	0.835
MOD_SUMO_rev_2	316	325	PF00179	0.847
MOD_SUMO_rev_2	71	80	PF00179	0.691
TRG_DiLeu_BaLyEn_6	148	153	PF01217	0.818
TRG_DiLeu_BaLyEn_6	35	40	PF01217	0.670
TRG_ER_diArg_1	261	263	PF00400	0.808
TRG_ER_diArg_1	37	39	PF00400	0.674
TRG_ER_diArg_1	521	524	PF00400	0.676
TRG_ER_diArg_1	553	555	PF00400	0.672
TRG_ER_diArg_1	56	59	PF00400	0.365
TRG_ER_diArg_1	598	601	PF00400	0.761
TRG_ER_diArg_1	602	604	PF00400	0.725
TRG_Pf-PMV_PEXEL_1	308	312	PF00026	0.852
TRG_Pf-PMV_PEXEL_1	448	452	PF00026	0.855
TRG_Pf-PMV_PEXEL_1	59	64	PF00026	0.678

Homologs


Protein	Taxonomy	Sequence identity	Coverage
P46870	CHLRE	35%	88%