Cilia- and flagella-associated protein 206

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H8W4_LEIBR

TriTrypDb:

LbrM.17.0190 , LBRM2903_170007700

Length:

836

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	9
GO:0005856	cytoskeleton	5	8
GO:0005929	cilium	4	8
GO:0042995	cell projection	2	8
GO:0043226	organelle	2	8
GO:0043227	membrane-bounded organelle	3	8
GO:0043228	non-membrane-bounded organelle	3	8
GO:0043229	intracellular organelle	3	8
GO:0043232	intracellular non-membrane-bounded organelle	4	8
GO:0110165	cellular anatomical entity	1	9
GO:0120025	plasma membrane bounded cell projection	3	8
GO:0005815	microtubule organizing center	2	1
GO:0005930	axoneme	2	1
GO:0036064	ciliary basal body	3	1

Expansion

Sequence features

A4H8W4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H8W4

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	9
GO:0016043	cellular component organization	3	9
GO:0030030	cell projection organization	4	9
GO:0071840	cellular component organization or biogenesis	2	9
GO:0003352	regulation of cilium movement	6	1
GO:0003356	regulation of cilium beat frequency	7	1
GO:0032886	regulation of microtubule-based process	4	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0060632	regulation of microtubule-based movement	5	1
GO:0065007	biological regulation	1	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	172	176	PF00656	0.364
CLV_C14_Caspase3-7	493	497	PF00656	0.455
CLV_NRD_NRD_1	222	224	PF00675	0.441
CLV_NRD_NRD_1	327	329	PF00675	0.384
CLV_NRD_NRD_1	759	761	PF00675	0.409
CLV_NRD_NRD_1	784	786	PF00675	0.581
CLV_NRD_NRD_1	830	832	PF00675	0.615
CLV_NRD_NRD_1	87	89	PF00675	0.477
CLV_PCSK_KEX2_1	327	329	PF00082	0.396
CLV_PCSK_KEX2_1	759	761	PF00082	0.415
CLV_PCSK_KEX2_1	784	786	PF00082	0.599
CLV_PCSK_KEX2_1	87	89	PF00082	0.477
CLV_PCSK_SKI1_1	327	331	PF00082	0.265
CLV_PCSK_SKI1_1	381	385	PF00082	0.472
CLV_PCSK_SKI1_1	443	447	PF00082	0.336
CLV_PCSK_SKI1_1	485	489	PF00082	0.520
CLV_PCSK_SKI1_1	516	520	PF00082	0.490
CLV_PCSK_SKI1_1	760	764	PF00082	0.425
DEG_APCC_DBOX_1	200	208	PF00400	0.501
DEG_APCC_DBOX_1	637	645	PF00400	0.609
DEG_Nend_UBRbox_2	1	3	PF02207	0.460
DEG_SCF_FBW7_2	355	361	PF00400	0.532
DEG_SCF_TRCP1_1	284	290	PF00400	0.454
DEG_SPOP_SBC_1	456	460	PF00917	0.492
DOC_ANK_TNKS_1	87	94	PF00023	0.474
DOC_CKS1_1	116	121	PF01111	0.435
DOC_CKS1_1	355	360	PF01111	0.527
DOC_CYCLIN_RxL_1	376	388	PF00134	0.505
DOC_CYCLIN_RxL_1	654	665	PF00134	0.500
DOC_CYCLIN_RxL_1	700	713	PF00134	0.540
DOC_CYCLIN_yClb5_NLxxxL_5	376	383	PF00134	0.301
DOC_CYCLIN_yCln2_LP_2	108	111	PF00134	0.432
DOC_MAPK_FxFP_2	70	73	PF00069	0.440
DOC_MAPK_gen_1	233	241	PF00069	0.464
DOC_MAPK_gen_1	327	335	PF00069	0.386
DOC_MAPK_gen_1	579	586	PF00069	0.576
DOC_MAPK_gen_1	759	765	PF00069	0.425
DOC_MAPK_MEF2A_6	233	241	PF00069	0.451
DOC_PP1_RVXF_1	325	332	PF00149	0.351
DOC_PP1_RVXF_1	482	489	PF00149	0.533
DOC_PP1_RVXF_1	655	662	PF00149	0.488
DOC_PP2B_LxvP_1	108	111	PF13499	0.432
DOC_PP2B_LxvP_1	445	448	PF13499	0.474
DOC_PP2B_LxvP_1	621	624	PF13499	0.533
DOC_PP4_FxxP_1	112	115	PF00568	0.415
DOC_PP4_FxxP_1	70	73	PF00568	0.440
DOC_USP7_MATH_1	149	153	PF00917	0.484
DOC_USP7_MATH_1	244	248	PF00917	0.547
DOC_USP7_MATH_1	275	279	PF00917	0.457
DOC_USP7_MATH_1	298	302	PF00917	0.377
DOC_USP7_MATH_1	455	459	PF00917	0.662
DOC_USP7_MATH_1	461	465	PF00917	0.672
DOC_USP7_MATH_1	518	522	PF00917	0.464
DOC_USP7_MATH_1	548	552	PF00917	0.623
DOC_USP7_MATH_1	628	632	PF00917	0.669
DOC_USP7_MATH_2	11	17	PF00917	0.431
DOC_USP7_UBL2_3	229	233	PF12436	0.531
DOC_WW_Pin1_4	115	120	PF00397	0.566
DOC_WW_Pin1_4	354	359	PF00397	0.518
DOC_WW_Pin1_4	466	471	PF00397	0.690
DOC_WW_Pin1_4	54	59	PF00397	0.460
DOC_WW_Pin1_4	62	67	PF00397	0.423
DOC_WW_Pin1_4	632	637	PF00397	0.709
DOC_WW_Pin1_4	648	653	PF00397	0.401
LIG_14-3-3_CanoR_1	148	158	PF00244	0.391
LIG_14-3-3_CanoR_1	201	205	PF00244	0.507
LIG_14-3-3_CanoR_1	327	332	PF00244	0.265
LIG_14-3-3_CanoR_1	516	525	PF00244	0.531
LIG_14-3-3_CanoR_1	638	642	PF00244	0.399
LIG_Actin_WH2_2	409	426	PF00022	0.306
LIG_AP2alpha_2	675	677	PF02296	0.426
LIG_BRCT_BRCA1_1	95	99	PF00533	0.450
LIG_CaM_NSCaTE_8	511	518	PF13499	0.278
LIG_Clathr_ClatBox_1	245	249	PF01394	0.527
LIG_CtBP_PxDLS_1	50	54	PF00389	0.454
LIG_deltaCOP1_diTrp_1	256	266	PF00928	0.498
LIG_eIF4E_1	403	409	PF01652	0.481
LIG_FHA_1	119	125	PF00498	0.527
LIG_FHA_1	153	159	PF00498	0.390
LIG_FHA_1	207	213	PF00498	0.339
LIG_FHA_1	318	324	PF00498	0.409
LIG_FHA_1	328	334	PF00498	0.473
LIG_FHA_1	378	384	PF00498	0.447
LIG_FHA_1	386	392	PF00498	0.477
LIG_FHA_1	447	453	PF00498	0.495
LIG_FHA_1	558	564	PF00498	0.467
LIG_FHA_1	616	622	PF00498	0.601
LIG_FHA_1	718	724	PF00498	0.684
LIG_FHA_1	738	744	PF00498	0.558
LIG_FHA_1	797	803	PF00498	0.646
LIG_FHA_1	822	828	PF00498	0.503
LIG_FHA_2	351	357	PF00498	0.500
LIG_FHA_2	719	725	PF00498	0.504
LIG_FHA_2	799	805	PF00498	0.574
LIG_HCF-1_HBM_1	748	751	PF13415	0.519
LIG_KLC1_Yacidic_2	707	711	PF13176	0.482
LIG_LIR_Apic_2	45	49	PF02991	0.456
LIG_LIR_Apic_2	5	11	PF02991	0.445
LIG_LIR_Apic_2	67	73	PF02991	0.441
LIG_LIR_Gen_1	401	409	PF02991	0.449
LIG_LIR_Nem_3	256	262	PF02991	0.383
LIG_LIR_Nem_3	401	406	PF02991	0.418
LIG_LIR_Nem_3	675	680	PF02991	0.416
LIG_LIR_Nem_3	69	75	PF02991	0.440
LIG_MYND_1	111	115	PF01753	0.420
LIG_NRBOX	157	163	PF00104	0.452
LIG_NRBOX	17	23	PF00104	0.437
LIG_NRBOX	194	200	PF00104	0.493
LIG_NRBOX	441	447	PF00104	0.438
LIG_Pex14_2	20	24	PF04695	0.440
LIG_Pex14_2	72	76	PF04695	0.439
LIG_Pex14_2	752	756	PF04695	0.538
LIG_SH2_CRK	117	121	PF00017	0.439
LIG_SH2_CRK	435	439	PF00017	0.509
LIG_SH2_CRK	46	50	PF00017	0.449
LIG_SH2_CRK	607	611	PF00017	0.489
LIG_SH2_CRK	8	12	PF00017	0.436
LIG_SH2_NCK_1	117	121	PF00017	0.439
LIG_SH2_NCK_1	46	50	PF00017	0.449
LIG_SH2_SRC	679	682	PF00017	0.485
LIG_SH2_SRC	709	712	PF00017	0.510
LIG_SH2_SRC	746	749	PF00017	0.571
LIG_SH2_STAP1	435	439	PF00017	0.413
LIG_SH2_STAP1	525	529	PF00017	0.538
LIG_SH2_STAT3	141	144	PF00017	0.561
LIG_SH2_STAT5	117	120	PF00017	0.435
LIG_SH2_STAT5	197	200	PF00017	0.402
LIG_SH2_STAT5	46	49	PF00017	0.458
LIG_SH2_STAT5	607	610	PF00017	0.485
LIG_SH2_STAT5	660	663	PF00017	0.524
LIG_SH2_STAT5	679	682	PF00017	0.218
LIG_SH2_STAT5	709	712	PF00017	0.442
LIG_SH2_STAT5	746	749	PF00017	0.531
LIG_SH2_STAT5	751	754	PF00017	0.495
LIG_SH2_STAT5	815	818	PF00017	0.470
LIG_SH3_1	117	123	PF00018	0.437
LIG_SH3_3	116	122	PF00018	0.434
LIG_SH3_3	352	358	PF00018	0.518
LIG_SH3_3	428	434	PF00018	0.522
LIG_SH3_3	483	489	PF00018	0.460
LIG_SH3_3	53	59	PF00018	0.461
LIG_SH3_3	542	548	PF00018	0.636
LIG_SH3_3	72	78	PF00018	0.361
LIG_SH3_CIN85_PxpxPR_1	652	657	PF14604	0.408
LIG_SUMO_SIM_par_1	49	54	PF11976	0.453
LIG_TRAF2_2	609	614	PF00917	0.314
LIG_UBA3_1	161	169	PF00899	0.493
LIG_WRC_WIRS_1	669	674	PF05994	0.437
MOD_CDC14_SPxK_1	635	638	PF00782	0.584
MOD_CDK_SPxK_1	632	638	PF00069	0.592
MOD_CK1_1	152	158	PF00069	0.400
MOD_CK1_1	203	209	PF00069	0.463
MOD_CK1_1	285	291	PF00069	0.626
MOD_CK1_1	297	303	PF00069	0.440
MOD_CK1_1	35	41	PF00069	0.436
MOD_CK1_1	350	356	PF00069	0.457
MOD_CK1_1	468	474	PF00069	0.627
MOD_CK1_1	54	60	PF00069	0.386
MOD_CK1_1	565	571	PF00069	0.497
MOD_CK1_1	629	635	PF00069	0.719
MOD_CK1_1	637	643	PF00069	0.541
MOD_CK1_1	647	653	PF00069	0.547
MOD_CK1_1	775	781	PF00069	0.516
MOD_CK2_1	718	724	PF00069	0.624
MOD_CK2_1	822	828	PF00069	0.503
MOD_CMANNOS	753	756	PF00535	0.430
MOD_GlcNHglycan	151	154	PF01048	0.486
MOD_GlcNHglycan	175	178	PF01048	0.516
MOD_GlcNHglycan	253	256	PF01048	0.536
MOD_GlcNHglycan	277	280	PF01048	0.627
MOD_GlcNHglycan	284	287	PF01048	0.574
MOD_GlcNHglycan	296	299	PF01048	0.362
MOD_GlcNHglycan	342	345	PF01048	0.464
MOD_GlcNHglycan	365	368	PF01048	0.429
MOD_GlcNHglycan	453	456	PF01048	0.658
MOD_GlcNHglycan	459	462	PF01048	0.696
MOD_GlcNHglycan	463	466	PF01048	0.707
MOD_GlcNHglycan	520	523	PF01048	0.536
MOD_GlcNHglycan	550	553	PF01048	0.607
MOD_GlcNHglycan	573	576	PF01048	0.431
MOD_GlcNHglycan	618	621	PF01048	0.464
MOD_GlcNHglycan	645	649	PF01048	0.574
MOD_GlcNHglycan	796	799	PF01048	0.746
MOD_GlcNHglycan	823	827	PF01048	0.510
MOD_GSK3_1	148	155	PF00069	0.345
MOD_GSK3_1	2	9	PF00069	0.454
MOD_GSK3_1	215	222	PF00069	0.534
MOD_GSK3_1	294	301	PF00069	0.496
MOD_GSK3_1	32	39	PF00069	0.436
MOD_GSK3_1	347	354	PF00069	0.496
MOD_GSK3_1	447	454	PF00069	0.542
MOD_GSK3_1	457	464	PF00069	0.617
MOD_GSK3_1	516	523	PF00069	0.361
MOD_GSK3_1	585	592	PF00069	0.645
MOD_GSK3_1	62	69	PF00069	0.452
MOD_GSK3_1	626	633	PF00069	0.670
MOD_GSK3_1	644	651	PF00069	0.357
MOD_GSK3_1	77	84	PF00069	0.385
MOD_GSK3_1	794	801	PF00069	0.705
MOD_N-GLC_1	292	297	PF02516	0.344
MOD_N-GLC_1	377	382	PF02516	0.519
MOD_N-GLC_1	461	466	PF02516	0.697
MOD_NEK2_1	219	224	PF00069	0.368
MOD_NEK2_1	340	345	PF00069	0.522
MOD_NEK2_1	349	354	PF00069	0.471
MOD_NEK2_1	383	388	PF00069	0.556
MOD_NEK2_1	423	428	PF00069	0.453
MOD_NEK2_1	51	56	PF00069	0.466
MOD_NEK2_1	710	715	PF00069	0.382
MOD_NEK2_1	99	104	PF00069	0.439
MOD_NEK2_2	277	282	PF00069	0.481
MOD_NEK2_2	66	71	PF00069	0.445
MOD_NEK2_2	798	803	PF00069	0.522
MOD_NEK2_2	82	87	PF00069	0.393
MOD_PIKK_1	626	632	PF00454	0.475
MOD_PIKK_1	735	741	PF00454	0.584
MOD_PIKK_1	773	779	PF00454	0.515
MOD_PIKK_1	796	802	PF00454	0.618
MOD_PIKK_1	804	810	PF00454	0.622
MOD_PKA_1	327	333	PF00069	0.267
MOD_PKA_2	200	206	PF00069	0.512
MOD_PKA_2	327	333	PF00069	0.460
MOD_PKA_2	423	429	PF00069	0.464
MOD_PKA_2	615	621	PF00069	0.589
MOD_PKA_2	637	643	PF00069	0.627
MOD_PKA_2	717	723	PF00069	0.673
MOD_PKA_2	819	825	PF00069	0.513
MOD_PKB_1	171	179	PF00069	0.358
MOD_PKB_1	569	577	PF00069	0.367
MOD_PKB_1	770	778	PF00069	0.434
MOD_Plk_1	100	106	PF00069	0.439
MOD_Plk_1	292	298	PF00069	0.336
MOD_Plk_1	461	467	PF00069	0.497
MOD_Plk_1	557	563	PF00069	0.335
MOD_Plk_1	747	753	PF00069	0.368
MOD_Plk_1	822	828	PF00069	0.546
MOD_Plk_4	13	19	PF00069	0.433
MOD_Plk_4	298	304	PF00069	0.419
MOD_Plk_4	692	698	PF00069	0.456
MOD_Plk_4	747	753	PF00069	0.562
MOD_ProDKin_1	115	121	PF00069	0.571
MOD_ProDKin_1	354	360	PF00069	0.521
MOD_ProDKin_1	466	472	PF00069	0.693
MOD_ProDKin_1	54	60	PF00069	0.463
MOD_ProDKin_1	62	68	PF00069	0.422
MOD_ProDKin_1	632	638	PF00069	0.705
MOD_ProDKin_1	648	654	PF00069	0.404
MOD_SUMO_for_1	232	235	PF00179	0.476
MOD_SUMO_for_1	399	402	PF00179	0.490
MOD_SUMO_rev_2	361	367	PF00179	0.540
TRG_DiLeu_BaEn_1	13	18	PF01217	0.434
TRG_DiLeu_BaEn_1	441	446	PF01217	0.418
TRG_DiLeu_BaEn_1	558	563	PF01217	0.545
TRG_DiLeu_BaEn_3	401	407	PF01217	0.267
TRG_DiLeu_BaLyEn_6	56	61	PF01217	0.461
TRG_ENDOCYTIC_2	270	273	PF00928	0.462
TRG_ENDOCYTIC_2	403	406	PF00928	0.414
TRG_ENDOCYTIC_2	435	438	PF00928	0.490
TRG_ENDOCYTIC_2	607	610	PF00928	0.485
TRG_ENDOCYTIC_2	660	663	PF00928	0.507
TRG_ER_diArg_1	326	328	PF00400	0.397
TRG_ER_diArg_1	569	572	PF00400	0.558
TRG_ER_diArg_1	758	760	PF00400	0.406
TRG_ER_diArg_1	769	772	PF00400	0.471
TRG_ER_diArg_1	783	785	PF00400	0.564
TRG_NES_CRM1_1	157	170	PF08389	0.469
TRG_NES_CRM1_1	325	339	PF08389	0.468
TRG_Pf-PMV_PEXEL_1	706	711	PF00026	0.488

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HWJ8	Leptomonas seymouri	58%	100%
A0A0S4J344	Bodo saltans	29%	100%
A0A1X0NSZ8	Trypanosomatidae	34%	100%
A0A3Q8IAK5	Leishmania donovani	81%	100%
C9ZTV6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
Q23H79	Tetrahymena thermophila (strain SB210)	22%	100%
Q4QEH3	Leishmania major	80%	99%
Q6PE87	Mus musculus	25%	100%
Q8IYR0	Homo sapiens	25%	100%
Q95JU3	Macaca fascicularis	26%	100%
V5BH83	Trypanosoma cruzi	33%	100%