Thioredoxin domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4H8W2_LEIBR

TriTrypDb:

LbrM.17.0170 , LBRM2903_170007500

Length:

866

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 6, no: 0
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H8W2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H8W2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	569	573	PF00656	0.515
CLV_C14_Caspase3-7	615	619	PF00656	0.588
CLV_NRD_NRD_1	150	152	PF00675	0.493
CLV_NRD_NRD_1	398	400	PF00675	0.411
CLV_NRD_NRD_1	444	446	PF00675	0.481
CLV_NRD_NRD_1	632	634	PF00675	0.531
CLV_NRD_NRD_1	639	641	PF00675	0.578
CLV_NRD_NRD_1	709	711	PF00675	0.555
CLV_NRD_NRD_1	720	722	PF00675	0.529
CLV_NRD_NRD_1	741	743	PF00675	0.585
CLV_NRD_NRD_1	789	791	PF00675	0.604
CLV_NRD_NRD_1	803	805	PF00675	0.629
CLV_NRD_NRD_1	808	810	PF00675	0.630
CLV_NRD_NRD_1	811	813	PF00675	0.618
CLV_NRD_NRD_1	831	833	PF00675	0.496
CLV_PCSK_FUR_1	739	743	PF00082	0.579
CLV_PCSK_FUR_1	809	813	PF00082	0.678
CLV_PCSK_FUR_1	826	830	PF00082	0.506
CLV_PCSK_KEX2_1	150	152	PF00082	0.493
CLV_PCSK_KEX2_1	444	446	PF00082	0.481
CLV_PCSK_KEX2_1	632	634	PF00082	0.560
CLV_PCSK_KEX2_1	639	641	PF00082	0.630
CLV_PCSK_KEX2_1	708	710	PF00082	0.583
CLV_PCSK_KEX2_1	720	722	PF00082	0.516
CLV_PCSK_KEX2_1	731	733	PF00082	0.478
CLV_PCSK_KEX2_1	741	743	PF00082	0.589
CLV_PCSK_KEX2_1	789	791	PF00082	0.604
CLV_PCSK_KEX2_1	803	805	PF00082	0.629
CLV_PCSK_KEX2_1	808	810	PF00082	0.630
CLV_PCSK_KEX2_1	811	813	PF00082	0.747
CLV_PCSK_KEX2_1	828	830	PF00082	0.508
CLV_PCSK_KEX2_1	831	833	PF00082	0.496
CLV_PCSK_PC1ET2_1	720	722	PF00082	0.563
CLV_PCSK_PC1ET2_1	731	733	PF00082	0.438
CLV_PCSK_PC7_1	804	810	PF00082	0.550
CLV_PCSK_PC7_1	826	832	PF00082	0.445
CLV_PCSK_SKI1_1	172	176	PF00082	0.509
CLV_PCSK_SKI1_1	198	202	PF00082	0.432
CLV_PCSK_SKI1_1	258	262	PF00082	0.474
CLV_PCSK_SKI1_1	416	420	PF00082	0.438
CLV_PCSK_SKI1_1	571	575	PF00082	0.538
CLV_PCSK_SKI1_1	60	64	PF00082	0.454
CLV_PCSK_SKI1_1	658	662	PF00082	0.556
CLV_PCSK_SKI1_1	755	759	PF00082	0.409
CLV_PCSK_SKI1_1	763	767	PF00082	0.411
CLV_PCSK_SKI1_1	849	853	PF00082	0.640
DEG_APCC_DBOX_1	241	249	PF00400	0.461
DEG_SPOP_SBC_1	283	287	PF00917	0.408
DEG_SPOP_SBC_1	321	325	PF00917	0.487
DOC_MAPK_gen_1	150	158	PF00069	0.492
DOC_MAPK_gen_1	536	544	PF00069	0.499
DOC_MAPK_gen_1	780	788	PF00069	0.531
DOC_MAPK_MEF2A_6	150	157	PF00069	0.553
DOC_MAPK_MEF2A_6	536	544	PF00069	0.499
DOC_MAPK_NFAT4_5	150	158	PF00069	0.557
DOC_PP1_RVXF_1	417	423	PF00149	0.362
DOC_PP2B_LxvP_1	345	348	PF13499	0.600
DOC_PP2B_LxvP_1	95	98	PF13499	0.504
DOC_PP4_FxxP_1	189	192	PF00568	0.601
DOC_PP4_FxxP_1	62	65	PF00568	0.503
DOC_USP7_MATH_1	252	256	PF00917	0.566
DOC_USP7_MATH_1	263	267	PF00917	0.368
DOC_USP7_MATH_1	283	287	PF00917	0.385
DOC_USP7_MATH_1	321	325	PF00917	0.445
DOC_USP7_MATH_1	458	462	PF00917	0.714
DOC_USP7_MATH_1	507	511	PF00917	0.475
DOC_USP7_MATH_1	51	55	PF00917	0.718
DOC_USP7_MATH_1	578	582	PF00917	0.505
DOC_USP7_MATH_1	589	593	PF00917	0.396
DOC_USP7_MATH_1	614	618	PF00917	0.635
DOC_USP7_MATH_1	620	624	PF00917	0.602
DOC_USP7_MATH_1	712	716	PF00917	0.422
DOC_USP7_MATH_1	75	79	PF00917	0.495
DOC_USP7_MATH_1	820	824	PF00917	0.642
DOC_USP7_UBL2_3	718	722	PF12436	0.414
DOC_USP7_UBL2_3	763	767	PF12436	0.429
DOC_WW_Pin1_4	11	16	PF00397	0.574
DOC_WW_Pin1_4	111	116	PF00397	0.600
DOC_WW_Pin1_4	184	189	PF00397	0.548
DOC_WW_Pin1_4	234	239	PF00397	0.504
DOC_WW_Pin1_4	34	39	PF00397	0.487
DOC_WW_Pin1_4	343	348	PF00397	0.544
DOC_WW_Pin1_4	469	474	PF00397	0.523
DOC_WW_Pin1_4	662	667	PF00397	0.574
DOC_WW_Pin1_4	687	692	PF00397	0.606
DOC_WW_Pin1_4	696	701	PF00397	0.629
LIG_14-3-3_CanoR_1	445	453	PF00244	0.514
LIG_14-3-3_CanoR_1	60	65	PF00244	0.451
LIG_14-3-3_CanoR_1	693	700	PF00244	0.662
LIG_14-3-3_CanoR_1	803	810	PF00244	0.551
LIG_14-3-3_CanoR_1	849	854	PF00244	0.639
LIG_Actin_WH2_2	20	37	PF00022	0.433
LIG_Actin_WH2_2	411	427	PF00022	0.368
LIG_Actin_WH2_2	540	556	PF00022	0.531
LIG_APCC_ABBA_1	103	108	PF00400	0.431
LIG_BIR_III_2	572	576	PF00653	0.503
LIG_BRCT_BRCA1_1	230	234	PF00533	0.472
LIG_BRCT_BRCA1_1	334	338	PF00533	0.586
LIG_BRCT_BRCA1_1	589	593	PF00533	0.450
LIG_BRCT_BRCA1_1	796	800	PF00533	0.518
LIG_CaM_IQ_9	411	427	PF13499	0.406
LIG_CSL_BTD_1	470	473	PF09270	0.438
LIG_FHA_1	163	169	PF00498	0.503
LIG_FHA_1	223	229	PF00498	0.633
LIG_FHA_1	242	248	PF00498	0.454
LIG_FHA_1	393	399	PF00498	0.606
LIG_FHA_1	59	65	PF00498	0.461
LIG_FHA_1	80	86	PF00498	0.577
LIG_FHA_1	97	103	PF00498	0.491
LIG_FHA_2	339	345	PF00498	0.524
LIG_FHA_2	351	357	PF00498	0.656
LIG_FHA_2	516	522	PF00498	0.500
LIG_FHA_2	675	681	PF00498	0.546
LIG_FHA_2	747	753	PF00498	0.413
LIG_FHA_2	811	817	PF00498	0.630
LIG_FHA_2	850	856	PF00498	0.637
LIG_GBD_Chelix_1	438	446	PF00786	0.378
LIG_LIR_Apic_2	140	144	PF02991	0.486
LIG_LIR_Apic_2	187	192	PF02991	0.590
LIG_LIR_Apic_2	59	65	PF02991	0.603
LIG_LIR_Gen_1	202	213	PF02991	0.451
LIG_LIR_Gen_1	225	234	PF02991	0.492
LIG_LIR_Gen_1	23	32	PF02991	0.441
LIG_LIR_Gen_1	607	614	PF02991	0.458
LIG_LIR_Gen_1	857	866	PF02991	0.503
LIG_LIR_Nem_3	202	208	PF02991	0.499
LIG_LIR_Nem_3	23	27	PF02991	0.449
LIG_LIR_Nem_3	266	272	PF02991	0.399
LIG_LIR_Nem_3	468	474	PF02991	0.677
LIG_LIR_Nem_3	607	613	PF02991	0.453
LIG_LIR_Nem_3	638	644	PF02991	0.596
LIG_LIR_Nem_3	857	862	PF02991	0.499
LIG_NRBOX	151	157	PF00104	0.546
LIG_Pex14_2	264	268	PF04695	0.321
LIG_PTB_Apo_2	628	635	PF02174	0.536
LIG_PTB_Phospho_1	628	634	PF10480	0.539
LIG_SH2_CRK	141	145	PF00017	0.415
LIG_SH2_CRK	269	273	PF00017	0.446
LIG_SH2_CRK	448	452	PF00017	0.399
LIG_SH2_CRK	550	554	PF00017	0.539
LIG_SH2_GRB2like	329	332	PF00017	0.507
LIG_SH2_NCK_1	448	452	PF00017	0.399
LIG_SH2_PTP2	220	223	PF00017	0.488
LIG_SH2_SRC	220	223	PF00017	0.488
LIG_SH2_STAP1	448	452	PF00017	0.399
LIG_SH2_STAT5	205	208	PF00017	0.606
LIG_SH2_STAT5	220	223	PF00017	0.408
LIG_SH2_STAT5	329	332	PF00017	0.442
LIG_SH2_STAT5	448	451	PF00017	0.393
LIG_SH2_STAT5	57	60	PF00017	0.518
LIG_SH2_STAT5	634	637	PF00017	0.744
LIG_SH2_STAT5	656	659	PF00017	0.551
LIG_SH2_STAT5	79	82	PF00017	0.486
LIG_SH3_3	10	16	PF00018	0.587
LIG_SH3_3	232	238	PF00018	0.511
LIG_SH3_3	44	50	PF00018	0.659
LIG_SH3_3	572	578	PF00018	0.483
LIG_SH3_3	785	791	PF00018	0.607
LIG_SH3_3	95	101	PF00018	0.589
LIG_SUMO_SIM_anti_2	154	159	PF11976	0.556
LIG_SUMO_SIM_anti_2	23	29	PF11976	0.422
LIG_SUMO_SIM_anti_2	501	507	PF11976	0.387
LIG_SUMO_SIM_anti_2	69	76	PF11976	0.475
LIG_SUMO_SIM_par_1	101	110	PF11976	0.450
LIG_SUMO_SIM_par_1	294	303	PF11976	0.429
LIG_TRAF2_1	530	533	PF00917	0.629
LIG_TRAF2_1	646	649	PF00917	0.584
LIG_TRAF2_1	744	747	PF00917	0.416
LIG_TRAF2_1	781	784	PF00917	0.528
LIG_TRFH_1	226	230	PF08558	0.511
LIG_TYR_ITIM	446	451	PF00017	0.374
LIG_WRC_WIRS_1	606	611	PF05994	0.406
MOD_CDK_SPxK_1	687	693	PF00069	0.542
MOD_CDK_SPxxK_3	469	476	PF00069	0.504
MOD_CK1_1	162	168	PF00069	0.370
MOD_CK1_1	196	202	PF00069	0.480
MOD_CK1_1	286	292	PF00069	0.466
MOD_CK1_1	343	349	PF00069	0.541
MOD_CK1_1	350	356	PF00069	0.556
MOD_CK1_1	52	58	PF00069	0.675
MOD_CK1_1	623	629	PF00069	0.571
MOD_CK1_1	857	863	PF00069	0.608
MOD_CK2_1	201	207	PF00069	0.498
MOD_CK2_1	234	240	PF00069	0.502
MOD_CK2_1	350	356	PF00069	0.670
MOD_CK2_1	43	49	PF00069	0.537
MOD_CK2_1	462	468	PF00069	0.788
MOD_CK2_1	609	615	PF00069	0.418
MOD_CK2_1	674	680	PF00069	0.638
MOD_CK2_1	696	702	PF00069	0.786
MOD_CK2_1	746	752	PF00069	0.414
MOD_CK2_1	778	784	PF00069	0.742
MOD_CK2_1	811	817	PF00069	0.690
MOD_CK2_1	849	855	PF00069	0.574
MOD_CK2_1	860	866	PF00069	0.583
MOD_Cter_Amidation	801	804	PF01082	0.652
MOD_DYRK1A_RPxSP_1	469	473	PF00069	0.527
MOD_GlcNHglycan	108	112	PF01048	0.411
MOD_GlcNHglycan	133	136	PF01048	0.483
MOD_GlcNHglycan	201	204	PF01048	0.435
MOD_GlcNHglycan	250	253	PF01048	0.457
MOD_GlcNHglycan	3	6	PF01048	0.500
MOD_GlcNHglycan	334	337	PF01048	0.581
MOD_GlcNHglycan	363	366	PF01048	0.563
MOD_GlcNHglycan	402	405	PF01048	0.469
MOD_GlcNHglycan	51	54	PF01048	0.641
MOD_GlcNHglycan	568	571	PF01048	0.630
MOD_GlcNHglycan	589	592	PF01048	0.526
MOD_GlcNHglycan	625	628	PF01048	0.671
MOD_GlcNHglycan	687	690	PF01048	0.753
MOD_GlcNHglycan	696	699	PF01048	0.698
MOD_GlcNHglycan	714	717	PF01048	0.395
MOD_GlcNHglycan	75	78	PF01048	0.625
MOD_GlcNHglycan	771	775	PF01048	0.585
MOD_GlcNHglycan	813	816	PF01048	0.557
MOD_GlcNHglycan	821	825	PF01048	0.461
MOD_GlcNHglycan	855	859	PF01048	0.494
MOD_GlcNHglycan	92	95	PF01048	0.589
MOD_GSK3_1	107	114	PF00069	0.462
MOD_GSK3_1	11	18	PF00069	0.488
MOD_GSK3_1	126	133	PF00069	0.500
MOD_GSK3_1	158	165	PF00069	0.682
MOD_GSK3_1	180	187	PF00069	0.463
MOD_GSK3_1	194	201	PF00069	0.604
MOD_GSK3_1	207	214	PF00069	0.411
MOD_GSK3_1	248	255	PF00069	0.519
MOD_GSK3_1	270	277	PF00069	0.401
MOD_GSK3_1	282	289	PF00069	0.478
MOD_GSK3_1	343	350	PF00069	0.541
MOD_GSK3_1	458	465	PF00069	0.653
MOD_GSK3_1	494	501	PF00069	0.496
MOD_GSK3_1	51	58	PF00069	0.633
MOD_GSK3_1	576	583	PF00069	0.411
MOD_GSK3_1	597	604	PF00069	0.633
MOD_GSK3_1	605	612	PF00069	0.500
MOD_GSK3_1	692	699	PF00069	0.658
MOD_GSK3_1	75	82	PF00069	0.574
MOD_GSK3_1	86	93	PF00069	0.560
MOD_N-GLC_1	330	335	PF02516	0.506
MOD_N-GLC_1	392	397	PF02516	0.474
MOD_N-GLC_1	453	458	PF02516	0.503
MOD_N-GLC_1	661	666	PF02516	0.581
MOD_N-GLC_2	848	850	PF02516	0.610
MOD_NEK2_1	1	6	PF00069	0.535
MOD_NEK2_1	106	111	PF00069	0.516
MOD_NEK2_1	20	25	PF00069	0.424
MOD_NEK2_1	256	261	PF00069	0.467
MOD_NEK2_1	270	275	PF00069	0.450
MOD_NEK2_1	284	289	PF00069	0.380
MOD_NEK2_1	330	335	PF00069	0.558
MOD_NEK2_1	338	343	PF00069	0.501
MOD_NEK2_1	392	397	PF00069	0.500
MOD_NEK2_1	446	451	PF00069	0.478
MOD_NEK2_1	452	457	PF00069	0.477
MOD_NEK2_1	494	499	PF00069	0.547
MOD_NEK2_1	553	558	PF00069	0.425
MOD_NEK2_1	587	592	PF00069	0.504
MOD_NEK2_1	601	606	PF00069	0.443
MOD_NEK2_1	609	614	PF00069	0.432
MOD_NEK2_1	661	666	PF00069	0.617
MOD_NEK2_1	692	697	PF00069	0.524
MOD_NEK2_1	770	775	PF00069	0.503
MOD_NEK2_2	263	268	PF00069	0.333
MOD_PIKK_1	286	292	PF00454	0.462
MOD_PIKK_1	494	500	PF00454	0.502
MOD_PIKK_1	561	567	PF00454	0.496
MOD_PIKK_1	601	607	PF00454	0.502
MOD_PKA_1	789	795	PF00069	0.659
MOD_PKA_1	803	809	PF00069	0.564
MOD_PKA_1	811	817	PF00069	0.522
MOD_PKA_2	241	247	PF00069	0.369
MOD_PKA_2	248	254	PF00069	0.387
MOD_PKA_2	270	276	PF00069	0.478
MOD_PKA_2	424	430	PF00069	0.497
MOD_PKA_2	692	698	PF00069	0.665
MOD_PKA_2	712	718	PF00069	0.418
MOD_PKA_2	789	795	PF00069	0.673
MOD_PKA_2	803	809	PF00069	0.564
MOD_PKA_2	810	816	PF00069	0.546
MOD_PKB_1	809	817	PF00069	0.541
MOD_Plk_1	252	258	PF00069	0.434
MOD_Plk_1	300	306	PF00069	0.455
MOD_Plk_1	313	319	PF00069	0.435
MOD_Plk_1	409	415	PF00069	0.360
MOD_Plk_1	453	459	PF00069	0.514
MOD_Plk_1	462	468	PF00069	0.576
MOD_Plk_1	58	64	PF00069	0.484
MOD_Plk_2-3	43	49	PF00069	0.537
MOD_Plk_2-3	746	752	PF00069	0.414
MOD_Plk_4	15	21	PF00069	0.631
MOD_Plk_4	201	207	PF00069	0.498
MOD_Plk_4	263	269	PF00069	0.385
MOD_Plk_4	294	300	PF00069	0.490
MOD_Plk_4	447	453	PF00069	0.535
MOD_Plk_4	498	504	PF00069	0.446
MOD_Plk_4	580	586	PF00069	0.540
MOD_Plk_4	589	595	PF00069	0.467
MOD_Plk_4	605	611	PF00069	0.422
MOD_Plk_4	66	72	PF00069	0.464
MOD_Plk_4	75	81	PF00069	0.523
MOD_Plk_4	789	795	PF00069	0.517
MOD_ProDKin_1	11	17	PF00069	0.573
MOD_ProDKin_1	111	117	PF00069	0.594
MOD_ProDKin_1	184	190	PF00069	0.557
MOD_ProDKin_1	234	240	PF00069	0.502
MOD_ProDKin_1	34	40	PF00069	0.494
MOD_ProDKin_1	343	349	PF00069	0.541
MOD_ProDKin_1	469	475	PF00069	0.508
MOD_ProDKin_1	662	668	PF00069	0.576
MOD_ProDKin_1	687	693	PF00069	0.606
MOD_ProDKin_1	696	702	PF00069	0.628
MOD_SUMO_for_1	735	738	PF00179	0.410
MOD_SUMO_for_1	766	769	PF00179	0.588
MOD_SUMO_rev_2	699	707	PF00179	0.482
MOD_SUMO_rev_2	756	765	PF00179	0.413
TRG_DiLeu_BaLyEn_6	148	153	PF01217	0.556
TRG_ENDOCYTIC_2	205	208	PF00928	0.489
TRG_ENDOCYTIC_2	269	272	PF00928	0.425
TRG_ENDOCYTIC_2	448	451	PF00928	0.393
TRG_ENDOCYTIC_2	550	553	PF00928	0.497
TRG_ENDOCYTIC_2	634	637	PF00928	0.559
TRG_ENDOCYTIC_2	641	644	PF00928	0.579
TRG_ER_diArg_1	150	152	PF00400	0.493
TRG_ER_diArg_1	444	446	PF00400	0.481
TRG_ER_diArg_1	464	467	PF00400	0.646
TRG_ER_diArg_1	535	538	PF00400	0.552
TRG_ER_diArg_1	632	634	PF00400	0.531
TRG_ER_diArg_1	639	641	PF00400	0.578
TRG_ER_diArg_1	708	710	PF00400	0.591
TRG_ER_diArg_1	739	742	PF00400	0.588
TRG_ER_diArg_1	788	790	PF00400	0.611
TRG_ER_diArg_1	808	811	PF00400	0.510
TRG_ER_diArg_1	826	829	PF00400	0.509
TRG_ER_diArg_1	830	832	PF00400	0.527
TRG_ER_diArg_1	843	846	PF00400	0.549
TRG_NES_CRM1_1	485	498	PF08389	0.447
TRG_NLS_Bipartite_1	708	724	PF00514	0.501
TRG_NLS_MonoExtN_4	718	724	PF00514	0.407
TRG_Pf-PMV_PEXEL_1	150	154	PF00026	0.493
TRG_Pf-PMV_PEXEL_1	633	638	PF00026	0.484
TRG_Pf-PMV_PEXEL_1	709	714	PF00026	0.441

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2L9	Leptomonas seymouri	47%	100%
A0A3Q8IAS7	Leishmania donovani	74%	100%
A4HXA9	Leishmania infantum	74%	100%
E9AQY8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	73%	100%
Q4QEH5	Leishmania major	73%	100%