ER membrane protein complex subunit 2

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H8W1_LEIBR

TriTrypDb:

LbrM.17.0160 , LBRM2903_170007000

Length:

317

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0032991	protein-containing complex	1	12
GO:0072546	EMC complex	3	12
GO:0098796	membrane protein complex	2	12
GO:0140534	endoplasmic reticulum protein-containing complex	2	12

Expansion

Sequence features

A4H8W1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H8W1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	307	311	PF00656	0.508
CLV_MEL_PAP_1	91	97	PF00089	0.465
CLV_NRD_NRD_1	297	299	PF00675	0.500
CLV_PCSK_KEX2_1	138	140	PF00082	0.264
CLV_PCSK_KEX2_1	229	231	PF00082	0.424
CLV_PCSK_KEX2_1	274	276	PF00082	0.373
CLV_PCSK_KEX2_1	297	299	PF00082	0.500
CLV_PCSK_PC1ET2_1	138	140	PF00082	0.264
CLV_PCSK_PC1ET2_1	229	231	PF00082	0.466
CLV_PCSK_PC1ET2_1	274	276	PF00082	0.455
CLV_PCSK_SKI1_1	43	47	PF00082	0.367
CLV_Separin_Metazoa	264	268	PF03568	0.420
DOC_CYCLIN_RxL_1	101	111	PF00134	0.463
DOC_CYCLIN_RxL_1	39	50	PF00134	0.496
DOC_MAPK_gen_1	94	102	PF00069	0.428
DOC_USP7_MATH_1	53	57	PF00917	0.491
DOC_WW_Pin1_4	11	16	PF00397	0.427
DOC_WW_Pin1_4	300	305	PF00397	0.299
LIG_14-3-3_CanoR_1	101	108	PF00244	0.412
LIG_APCC_ABBAyCdc20_2	159	165	PF00400	0.337
LIG_BIR_II_1	1	5	PF00653	0.624
LIG_BRCT_BRCA1_1	241	245	PF00533	0.494
LIG_eIF4E_1	204	210	PF01652	0.467
LIG_eIF4E_1	239	245	PF01652	0.486
LIG_FHA_1	283	289	PF00498	0.472
LIG_FHA_1	301	307	PF00498	0.438
LIG_FHA_1	47	53	PF00498	0.383
LIG_FHA_1	83	89	PF00498	0.473
LIG_FHA_2	12	18	PF00498	0.449
LIG_FHA_2	162	168	PF00498	0.532
LIG_FHA_2	170	176	PF00498	0.408
LIG_FHA_2	182	188	PF00498	0.341
LIG_LIR_Gen_1	172	181	PF02991	0.474
LIG_LIR_Gen_1	214	225	PF02991	0.484
LIG_LIR_Gen_1	66	76	PF02991	0.373
LIG_LIR_Gen_1	85	95	PF02991	0.452
LIG_LIR_Nem_3	172	176	PF02991	0.414
LIG_LIR_Nem_3	183	188	PF02991	0.317
LIG_LIR_Nem_3	214	220	PF02991	0.466
LIG_LIR_Nem_3	62	68	PF02991	0.383
LIG_LIR_Nem_3	85	90	PF02991	0.401
LIG_NRBOX	190	196	PF00104	0.474
LIG_PTB_Apo_2	187	194	PF02174	0.341
LIG_PTB_Phospho_1	187	193	PF10480	0.337
LIG_SH2_GRB2like	87	90	PF00017	0.479
LIG_SH2_SRC	150	153	PF00017	0.330
LIG_SH2_SRC	173	176	PF00017	0.496
LIG_SH2_STAP1	123	127	PF00017	0.457
LIG_SH2_STAP1	150	154	PF00017	0.415
LIG_SH2_STAP1	239	243	PF00017	0.357
LIG_SH2_STAP1	68	72	PF00017	0.347
LIG_SH2_STAT5	163	166	PF00017	0.400
LIG_SH2_STAT5	173	176	PF00017	0.501
LIG_SH2_STAT5	193	196	PF00017	0.369
LIG_SH2_STAT5	216	219	PF00017	0.375
LIG_SH2_STAT5	312	315	PF00017	0.520
LIG_SH2_STAT5	87	90	PF00017	0.374
LIG_UBA3_1	194	200	PF00899	0.261
MOD_CK1_1	57	63	PF00069	0.518
MOD_CK1_1	9	15	PF00069	0.447
MOD_CK2_1	169	175	PF00069	0.409
MOD_CK2_1	181	187	PF00069	0.350
MOD_CK2_1	57	63	PF00069	0.465
MOD_Cter_Amidation	95	98	PF01082	0.523
MOD_GlcNHglycan	140	143	PF01048	0.371
MOD_GlcNHglycan	270	273	PF01048	0.504
MOD_GlcNHglycan	306	309	PF01048	0.372
MOD_GlcNHglycan	35	38	PF01048	0.534
MOD_GlcNHglycan	56	59	PF01048	0.491
MOD_GSK3_1	300	307	PF00069	0.405
MOD_GSK3_1	53	60	PF00069	0.447
MOD_GSK3_1	96	103	PF00069	0.495
MOD_N-GLC_1	249	254	PF02516	0.456
MOD_N-GLC_1	82	87	PF02516	0.469
MOD_NEK2_1	244	249	PF00069	0.534
MOD_NEK2_1	90	95	PF00069	0.507
MOD_NEK2_2	292	297	PF00069	0.481
MOD_NEK2_2	96	101	PF00069	0.391
MOD_PIKK_1	237	243	PF00454	0.472
MOD_PIKK_1	244	250	PF00454	0.519
MOD_PIKK_1	280	286	PF00454	0.532
MOD_PKA_1	138	144	PF00069	0.256
MOD_PKA_2	100	106	PF00069	0.471
MOD_PKA_2	138	144	PF00069	0.342
MOD_PKA_2	33	39	PF00069	0.476
MOD_Plk_1	82	88	PF00069	0.464
MOD_Plk_4	169	175	PF00069	0.418
MOD_Plk_4	212	218	PF00069	0.449
MOD_Plk_4	239	245	PF00069	0.458
MOD_Plk_4	82	88	PF00069	0.383
MOD_ProDKin_1	11	17	PF00069	0.422
MOD_ProDKin_1	300	306	PF00069	0.295
MOD_SUMO_rev_2	12	21	PF00179	0.449
TRG_DiLeu_BaEn_1	206	211	PF01217	0.424
TRG_DiLeu_BaEn_4	206	212	PF01217	0.297
TRG_DiLeu_BaEn_4	277	283	PF01217	0.491
TRG_ENDOCYTIC_2	123	126	PF00928	0.375
TRG_ENDOCYTIC_2	173	176	PF00928	0.460
TRG_ENDOCYTIC_2	185	188	PF00928	0.276
TRG_ENDOCYTIC_2	68	71	PF00928	0.351
TRG_ENDOCYTIC_2	87	90	PF00928	0.374
TRG_ER_diArg_1	296	298	PF00400	0.501
TRG_NES_CRM1_1	63	77	PF08389	0.428
TRG_Pf-PMV_PEXEL_1	106	111	PF00026	0.462
TRG_Pf-PMV_PEXEL_1	120	124	PF00026	0.442
TRG_Pf-PMV_PEXEL_1	155	160	PF00026	0.473

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYX7	Leptomonas seymouri	82%	100%
A0A0S4J0N8	Bodo saltans	42%	100%
A0A1X0NTH4	Trypanosomatidae	56%	100%
A0A3R7KD80	Trypanosoma rangeli	52%	100%
A0A3S7WUH2	Leishmania donovani	92%	100%
A4HXA8	Leishmania infantum	92%	100%
B0BNG0	Rattus norvegicus	29%	100%
C9ZTV4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	54%	98%
E9AQY7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q15006	Homo sapiens	26%	100%
Q4QEH6	Leishmania major	92%	100%
Q5E993	Bos taurus	29%	100%
Q5M7J9	Xenopus tropicalis	31%	100%
Q5R882	Pongo abelii	26%	100%
Q6INS3	Xenopus laevis	28%	100%
Q6TGY8	Danio rerio	30%	100%
Q8AVU9	Xenopus laevis	30%	100%
Q9CRD2	Mus musculus	29%	100%
V5B876	Trypanosoma cruzi	51%	100%