Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H8W0_LEIBR

TriTrypDb:

LbrM.17.0150 , LBRM2903_170006900

Length:

484

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005813	centrosome	3	1
GO:0005814	centriole	5	1
GO:0005815	microtubule organizing center	2	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H8W0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H8W0

Function

Biological processes
Term	Name	Level	Count
GO:0007017	microtubule-based process	2	1
GO:0007098	centrosome cycle	3	1
GO:0009987	cellular process	1	1
GO:0010564	regulation of cell cycle process	5	1
GO:0010638	positive regulation of organelle organization	6	1
GO:0010824	regulation of centrosome duplication	6	1
GO:0016043	cellular component organization	3	1
GO:0022402	cell cycle process	2	1
GO:0031023	microtubule organizing center organization	3	1
GO:0032886	regulation of microtubule-based process	4	1
GO:0033043	regulation of organelle organization	5	1
GO:0044087	regulation of cellular component biogenesis	4	1
GO:0044089	positive regulation of cellular component biogenesis	5	1
GO:0045787	positive regulation of cell cycle	5	1
GO:0046599	regulation of centriole replication	6	1
GO:0046601	positive regulation of centriole replication	7	1
GO:0046605	regulation of centrosome cycle	5	1
GO:0048518	positive regulation of biological process	3	1
GO:0048522	positive regulation of cellular process	4	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0051128	regulation of cellular component organization	4	1
GO:0051130	positive regulation of cellular component organization	5	1
GO:0051493	regulation of cytoskeleton organization	6	1
GO:0051495	positive regulation of cytoskeleton organization	7	1
GO:0051726	regulation of cell cycle	4	1
GO:0065007	biological regulation	1	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0090068	positive regulation of cell cycle process	6	1
GO:1902115	regulation of organelle assembly	5	1
GO:1902117	positive regulation of organelle assembly	6	1
GO:1903722	regulation of centriole elongation	6	1
GO:1903724	positive regulation of centriole elongation	7	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	66	70	PF00656	0.524
CLV_NRD_NRD_1	11	13	PF00675	0.812
CLV_NRD_NRD_1	141	143	PF00675	0.479
CLV_NRD_NRD_1	162	164	PF00675	0.522
CLV_NRD_NRD_1	207	209	PF00675	0.495
CLV_NRD_NRD_1	25	27	PF00675	0.726
CLV_NRD_NRD_1	254	256	PF00675	0.522
CLV_NRD_NRD_1	348	350	PF00675	0.487
CLV_NRD_NRD_1	357	359	PF00675	0.451
CLV_NRD_NRD_1	362	364	PF00675	0.468
CLV_PCSK_KEX2_1	157	159	PF00082	0.513
CLV_PCSK_KEX2_1	161	163	PF00082	0.516
CLV_PCSK_KEX2_1	207	209	PF00082	0.495
CLV_PCSK_KEX2_1	25	27	PF00082	0.737
CLV_PCSK_KEX2_1	254	256	PF00082	0.466
CLV_PCSK_KEX2_1	348	350	PF00082	0.471
CLV_PCSK_KEX2_1	356	358	PF00082	0.476
CLV_PCSK_KEX2_1	362	364	PF00082	0.486
CLV_PCSK_PC1ET2_1	157	159	PF00082	0.534
CLV_PCSK_PC1ET2_1	161	163	PF00082	0.524
CLV_PCSK_PC7_1	158	164	PF00082	0.510
CLV_PCSK_PC7_1	358	364	PF00082	0.583
CLV_PCSK_SKI1_1	158	162	PF00082	0.435
CLV_PCSK_SKI1_1	165	169	PF00082	0.468
CLV_PCSK_SKI1_1	328	332	PF00082	0.356
CLV_PCSK_SKI1_1	348	352	PF00082	0.456
DEG_APCC_DBOX_1	473	481	PF00400	0.515
DEG_SCF_FBW7_1	417	423	PF00400	0.444
DEG_SPOP_SBC_1	402	406	PF00917	0.737
DEG_SPOP_SBC_1	479	483	PF00917	0.362
DOC_CKS1_1	417	422	PF01111	0.463
DOC_MAPK_gen_1	161	171	PF00069	0.491
DOC_MAPK_gen_1	471	479	PF00069	0.414
DOC_MAPK_MEF2A_6	457	466	PF00069	0.484
DOC_PP1_RVXF_1	309	315	PF00149	0.347
DOC_SPAK_OSR1_1	93	97	PF12202	0.497
DOC_USP7_MATH_1	105	109	PF00917	0.533
DOC_USP7_MATH_1	301	305	PF00917	0.590
DOC_USP7_MATH_1	393	397	PF00917	0.758
DOC_USP7_MATH_1	400	404	PF00917	0.708
DOC_USP7_MATH_1	78	82	PF00917	0.648
DOC_USP7_UBL2_3	143	147	PF12436	0.623
DOC_USP7_UBL2_3	157	161	PF12436	0.441
DOC_WW_Pin1_4	24	29	PF00397	0.726
DOC_WW_Pin1_4	281	286	PF00397	0.639
DOC_WW_Pin1_4	366	371	PF00397	0.706
DOC_WW_Pin1_4	416	421	PF00397	0.483
DOC_WW_Pin1_4	82	87	PF00397	0.564
DOC_WW_Pin1_4	97	102	PF00397	0.690
LIG_14-3-3_CanoR_1	149	156	PF00244	0.504
LIG_14-3-3_CanoR_1	276	285	PF00244	0.595
LIG_14-3-3_CanoR_1	324	331	PF00244	0.557
LIG_14-3-3_CanoR_1	348	355	PF00244	0.450
LIG_14-3-3_CanoR_1	42	50	PF00244	0.656
LIG_14-3-3_CanoR_1	445	449	PF00244	0.439
LIG_14-3-3_CanoR_1	62	72	PF00244	0.727
LIG_14-3-3_CanoR_1	93	103	PF00244	0.593
LIG_Actin_WH2_2	442	459	PF00022	0.366
LIG_BIR_III_2	367	371	PF00653	0.477
LIG_BRCT_BRCA1_1	149	153	PF00533	0.491
LIG_BRCT_BRCA1_1	98	102	PF00533	0.475
LIG_FHA_1	173	179	PF00498	0.487
LIG_FHA_1	277	283	PF00498	0.491
LIG_FHA_1	349	355	PF00498	0.508
LIG_FHA_1	396	402	PF00498	0.642
LIG_FHA_1	413	419	PF00498	0.650
LIG_FHA_1	441	447	PF00498	0.571
LIG_FHA_1	457	463	PF00498	0.497
LIG_FHA_1	98	104	PF00498	0.653
LIG_FHA_2	177	183	PF00498	0.329
LIG_FHA_2	432	438	PF00498	0.580
LIG_FHA_2	78	84	PF00498	0.682
LIG_LIR_Gen_1	150	160	PF02991	0.488
LIG_LIR_Gen_1	266	274	PF02991	0.432
LIG_LIR_LC3C_4	447	450	PF02991	0.335
LIG_LIR_Nem_3	131	136	PF02991	0.386
LIG_LIR_Nem_3	150	156	PF02991	0.404
LIG_LIR_Nem_3	266	270	PF02991	0.443
LIG_LIR_Nem_3	272	277	PF02991	0.440
LIG_PDZ_Class_1	479	484	PF00595	0.379
LIG_RPA_C_Plants	208	219	PF08784	0.529
LIG_SH2_STAT3	277	280	PF00017	0.559
LIG_SH2_STAT5	267	270	PF00017	0.445
LIG_SH3_3	368	374	PF00018	0.651
LIG_SH3_3	83	89	PF00018	0.767
LIG_SUMO_SIM_anti_2	442	450	PF11976	0.355
LIG_SUMO_SIM_anti_2	475	483	PF11976	0.369
LIG_TRAF2_1	263	266	PF00917	0.494
MOD_CK1_1	104	110	PF00069	0.641
MOD_CK1_1	369	375	PF00069	0.607
MOD_CK1_1	4	10	PF00069	0.694
MOD_CK1_1	403	409	PF00069	0.761
MOD_CK1_1	45	51	PF00069	0.668
MOD_CK1_1	63	69	PF00069	0.517
MOD_CK1_1	97	103	PF00069	0.666
MOD_CK2_1	176	182	PF00069	0.404
MOD_CK2_1	266	272	PF00069	0.599
MOD_CK2_1	431	437	PF00069	0.597
MOD_CK2_1	77	83	PF00069	0.805
MOD_GlcNHglycan	103	106	PF01048	0.645
MOD_GlcNHglycan	150	153	PF01048	0.471
MOD_GlcNHglycan	288	291	PF01048	0.747
MOD_GlcNHglycan	36	39	PF01048	0.551
MOD_GlcNHglycan	393	396	PF01048	0.644
MOD_GlcNHglycan	4	7	PF01048	0.668
MOD_GlcNHglycan	44	47	PF01048	0.519
MOD_GlcNHglycan	452	455	PF01048	0.452
MOD_GlcNHglycan	80	83	PF01048	0.684
MOD_GSK3_1	172	179	PF00069	0.325
MOD_GSK3_1	272	279	PF00069	0.496
MOD_GSK3_1	286	293	PF00069	0.656
MOD_GSK3_1	297	304	PF00069	0.605
MOD_GSK3_1	369	376	PF00069	0.663
MOD_GSK3_1	391	398	PF00069	0.713
MOD_GSK3_1	400	407	PF00069	0.749
MOD_GSK3_1	41	48	PF00069	0.683
MOD_GSK3_1	412	419	PF00069	0.697
MOD_GSK3_1	440	447	PF00069	0.487
MOD_GSK3_1	53	60	PF00069	0.560
MOD_GSK3_1	7	14	PF00069	0.656
MOD_GSK3_1	78	85	PF00069	0.688
MOD_GSK3_1	97	104	PF00069	0.646
MOD_LATS_1	40	46	PF00433	0.504
MOD_N-GLC_1	231	236	PF02516	0.517
MOD_NEK2_1	1	6	PF00069	0.726
MOD_NEK2_2	176	181	PF00069	0.324
MOD_NMyristoyl	1	7	PF02799	0.509
MOD_PIKK_1	276	282	PF00454	0.561
MOD_PIKK_1	323	329	PF00454	0.376
MOD_PIKK_1	375	381	PF00454	0.715
MOD_PIKK_1	64	70	PF00454	0.601
MOD_PK_1	53	59	PF00069	0.520
MOD_PKA_1	348	354	PF00069	0.460
MOD_PKA_2	11	17	PF00069	0.754
MOD_PKA_2	118	124	PF00069	0.435
MOD_PKA_2	148	154	PF00069	0.324
MOD_PKA_2	323	329	PF00069	0.569
MOD_PKA_2	348	354	PF00069	0.455
MOD_PKA_2	41	47	PF00069	0.651
MOD_PKA_2	444	450	PF00069	0.440
MOD_PKA_2	456	462	PF00069	0.530
MOD_PKA_2	52	58	PF00069	0.679
MOD_PKA_2	61	67	PF00069	0.730
MOD_PKB_1	51	59	PF00069	0.681
MOD_Plk_1	105	111	PF00069	0.555
MOD_Plk_1	187	193	PF00069	0.435
MOD_Plk_1	231	237	PF00069	0.518
MOD_Plk_1	53	59	PF00069	0.597
MOD_Plk_2-3	266	272	PF00069	0.488
MOD_Plk_4	266	272	PF00069	0.488
MOD_Plk_4	444	450	PF00069	0.492
MOD_ProDKin_1	24	30	PF00069	0.728
MOD_ProDKin_1	281	287	PF00069	0.646
MOD_ProDKin_1	366	372	PF00069	0.709
MOD_ProDKin_1	416	422	PF00069	0.479
MOD_ProDKin_1	82	88	PF00069	0.562
MOD_ProDKin_1	97	103	PF00069	0.690
MOD_SUMO_rev_2	150	159	PF00179	0.324
TRG_DiLeu_BaEn_1	164	169	PF01217	0.460
TRG_DiLeu_BaEn_1	444	449	PF01217	0.487
TRG_DiLeu_BaLyEn_6	237	242	PF01217	0.536
TRG_ENDOCYTIC_2	267	270	PF00928	0.408
TRG_ENDOCYTIC_2	271	274	PF00928	0.404
TRG_ER_diArg_1	206	208	PF00400	0.485
TRG_ER_diArg_1	238	241	PF00400	0.466
TRG_ER_diArg_1	348	350	PF00400	0.497
TRG_ER_diArg_1	355	358	PF00400	0.474
TRG_ER_diArg_1	361	363	PF00400	0.455
TRG_ER_diArg_1	50	53	PF00400	0.668
TRG_Pf-PMV_PEXEL_1	240	244	PF00026	0.485
TRG_Pf-PMV_PEXEL_1	341	345	PF00026	0.442
TRG_Pf-PMV_PEXEL_1	380	384	PF00026	0.669
TRG_Pf-PMV_PEXEL_1	471	475	PF00026	0.503

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1P9K9	Leptomonas seymouri	56%	95%
A0A1X0NUG8	Trypanosomatidae	40%	100%
A0A3S7WUA9	Leishmania donovani	75%	92%
A0A422NFB5	Trypanosoma rangeli	38%	100%
A4HXA7	Leishmania infantum	75%	92%
C9ZTV1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
E9AQY6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	92%
Q4QEH7	Leishmania major	75%	100%