ATP pyrophosphate-lyase

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

receptor-type adenylate cyclase b

Species:

Leishmania braziliensis

UniProt:

A4H8V7_LEIBR

TriTrypDb:

LbrM.17.0120 , LBRM2903_350042800

Length:

1144

Annotations

LeishMANIAdb annotations

Carries an ATP pyrophosphate-lyase domain on its cytoplasmic segment. Likely acts as a receptor for some unknown extracellular stimulus. Extremely expanded kinetoplastid protein family.. Expressed in the insect stage (promastigote) but not in the mammalian host stage of the parasite life cycle.. Localization: Cell surface (by feature)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 60

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 5

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 47, no: 29
NetGPI	no	yes: 0, no: 76

Show entries

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	71
GO:0110165	cellular anatomical entity	1	77

Previous1Next

Expansion

Sequence features

A4H8V7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H8V7

Function

Show entries

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	75
GO:0006163	purine nucleotide metabolic process	5	75
GO:0006164	purine nucleotide biosynthetic process	6	75
GO:0006171	cAMP biosynthetic process	8	75
GO:0006725	cellular aromatic compound metabolic process	3	75
GO:0006753	nucleoside phosphate metabolic process	4	75
GO:0006793	phosphorus metabolic process	3	75
GO:0006796	phosphate-containing compound metabolic process	4	75
GO:0006807	nitrogen compound metabolic process	2	75
GO:0007165	signal transduction	2	75

Previous1 2 3 4 5 6Next

Show entries

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	64
GO:0004016	adenylate cyclase activity	3	1
GO:0009975	cyclase activity	2	1
GO:0016829	lyase activity	2	64
GO:0016849	phosphorus-oxygen lyase activity	3	1

Previous1Next

Putative motif mimicry

Show entries


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	218	222	PF00656	0.332
CLV_C14_Caspase3-7	661	665	PF00656	0.664
CLV_C14_Caspase3-7	722	726	PF00656	0.505
CLV_MEL_PAP_1	795	801	PF00089	0.298
CLV_NRD_NRD_1	1053	1055	PF00675	0.613
CLV_NRD_NRD_1	1093	1095	PF00675	0.499
CLV_NRD_NRD_1	1102	1104	PF00675	0.647
CLV_NRD_NRD_1	131	133	PF00675	0.705
CLV_NRD_NRD_1	371	373	PF00675	0.675
CLV_NRD_NRD_1	428	430	PF00675	0.673

Previous1 2 3 4 5…37Next

Homologs

Show entries


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P457	Leptomonas seymouri	30%	86%
A0A1X0P171	Trypanosomatidae	34%	89%
A0A3Q8IJB0	Leishmania donovani	68%	86%
A0A3R7M6J4	Trypanosoma rangeli	38%	100%
A0A3R7R8G4	Trypanosoma rangeli	32%	100%
A0A3S5H6Z8	Leishmania donovani	68%	86%
A0A3S7WU91	Leishmania donovani	60%	81%
A0A3S7WU94	Leishmania donovani	52%	83%
A0A3S7WU95	Leishmania donovani	67%	82%
A0A3S7XB85	Leishmania donovani	31%	81%

Previous1 2 3 4 5…8Next