LeishMANIAdb
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Putative receptor-type adenylate cyclase

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative receptor-type adenylate cyclase
Gene product:
receptor-type adenylate cyclase, putative (fragment)
Species:
Leishmania braziliensis
UniProt:
A4H8V6_LEIBR
TriTrypDb:
LbrM.17.0110
Length:
688

Annotations

LeishMANIAdb annotations

Carries an ATP pyrophosphate-lyase domain on its cytoplasmic segment. Likely acts as a receptor for some unknown extracellular stimulus. Extremely expanded kinetoplastid protein family.. Expressed in the insect stage (promastigote) but not in the mammalian host stage of the parasite life cycle.. Localization: Cell surface (by feature)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 10
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 yes yes: 8, no: 8
NetGPI no yes: 0, no: 16
Cellular components
Term Name Level Count
GO:0016020 membrane 2 8
GO:0110165 cellular anatomical entity 1 8

Expansion

Sequence features

A4H8V6
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H8V6

Function

Biological processes
Term Name Level Count
GO:0006139 nucleobase-containing compound metabolic process 3 2
GO:0006163 purine nucleotide metabolic process 5 2
GO:0006164 purine nucleotide biosynthetic process 6 2
GO:0006171 cAMP biosynthetic process 8 2
GO:0006725 cellular aromatic compound metabolic process 3 2
GO:0006753 nucleoside phosphate metabolic process 4 2
GO:0006793 phosphorus metabolic process 3 2
GO:0006796 phosphate-containing compound metabolic process 4 2
GO:0006807 nitrogen compound metabolic process 2 2
GO:0007165 signal transduction 2 2
GO:0008152 metabolic process 1 2
GO:0009058 biosynthetic process 2 2
GO:0009117 nucleotide metabolic process 5 2
GO:0009150 purine ribonucleotide metabolic process 6 2
GO:0009152 purine ribonucleotide biosynthetic process 7 2
GO:0009165 nucleotide biosynthetic process 6 2
GO:0009187 cyclic nucleotide metabolic process 6 2
GO:0009190 cyclic nucleotide biosynthetic process 7 2
GO:0009259 ribonucleotide metabolic process 5 2
GO:0009260 ribonucleotide biosynthetic process 6 2
GO:0009987 cellular process 1 2
GO:0018130 heterocycle biosynthetic process 4 2
GO:0019438 aromatic compound biosynthetic process 4 2
GO:0019637 organophosphate metabolic process 3 2
GO:0019693 ribose phosphate metabolic process 4 2
GO:0034641 cellular nitrogen compound metabolic process 3 2
GO:0034654 nucleobase-containing compound biosynthetic process 4 2
GO:0035556 intracellular signal transduction 3 2
GO:0044237 cellular metabolic process 2 2
GO:0044238 primary metabolic process 2 2
GO:0044249 cellular biosynthetic process 3 2
GO:0044271 cellular nitrogen compound biosynthetic process 4 2
GO:0044281 small molecule metabolic process 2 2
GO:0046058 cAMP metabolic process 7 2
GO:0046390 ribose phosphate biosynthetic process 5 2
GO:0046483 heterocycle metabolic process 3 2
GO:0050789 regulation of biological process 2 2
GO:0050794 regulation of cellular process 3 2
GO:0052652 cyclic purine nucleotide metabolic process 6 2
GO:0055086 nucleobase-containing small molecule metabolic process 3 2
GO:0065007 biological regulation 1 2
GO:0071704 organic substance metabolic process 2 2
GO:0072521 purine-containing compound metabolic process 4 2
GO:0072522 purine-containing compound biosynthetic process 5 2
GO:0090407 organophosphate biosynthetic process 4 2
GO:1901135 carbohydrate derivative metabolic process 3 2
GO:1901137 carbohydrate derivative biosynthetic process 4 2
GO:1901293 nucleoside phosphate biosynthetic process 5 2
GO:1901360 organic cyclic compound metabolic process 3 2
GO:1901362 organic cyclic compound biosynthetic process 4 2
GO:1901564 organonitrogen compound metabolic process 3 2
GO:1901566 organonitrogen compound biosynthetic process 4 2
GO:1901576 organic substance biosynthetic process 3 2
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 8
GO:0004016 adenylate cyclase activity 3 7
GO:0009975 cyclase activity 2 7
GO:0016829 lyase activity 2 8
GO:0016849 phosphorus-oxygen lyase activity 3 7

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 237 241 PF00656 0.576
CLV_NRD_NRD_1 117 119 PF00675 0.533
CLV_NRD_NRD_1 12 14 PF00675 0.705
CLV_NRD_NRD_1 197 199 PF00675 0.508
CLV_NRD_NRD_1 383 385 PF00675 0.409
CLV_NRD_NRD_1 419 421 PF00675 0.448
CLV_PCSK_FUR_1 195 199 PF00082 0.497
CLV_PCSK_KEX2_1 12 14 PF00082 0.705
CLV_PCSK_KEX2_1 197 199 PF00082 0.503
CLV_PCSK_KEX2_1 383 385 PF00082 0.409
CLV_PCSK_KEX2_1 419 421 PF00082 0.409
CLV_PCSK_SKI1_1 118 122 PF00082 0.501
CLV_PCSK_SKI1_1 198 202 PF00082 0.527
CLV_PCSK_SKI1_1 218 222 PF00082 0.228
CLV_PCSK_SKI1_1 274 278 PF00082 0.388
CLV_PCSK_SKI1_1 295 299 PF00082 0.513
CLV_PCSK_SKI1_1 383 387 PF00082 0.555
CLV_PCSK_SKI1_1 559 563 PF00082 0.463
CLV_PCSK_SKI1_1 645 649 PF00082 0.576
CLV_PCSK_SKI1_1 97 101 PF00082 0.560
DEG_SPOP_SBC_1 280 284 PF00917 0.568
DOC_CDC14_PxL_1 121 129 PF14671 0.568
DOC_CDC14_PxL_1 510 518 PF14671 0.582
DOC_CKS1_1 446 451 PF01111 0.389
DOC_CYCLIN_yCln2_LP_2 226 232 PF00134 0.570
DOC_CYCLIN_yCln2_LP_2 410 416 PF00134 0.538
DOC_MAPK_gen_1 195 204 PF00069 0.393
DOC_MAPK_MEF2A_6 180 187 PF00069 0.447
DOC_MAPK_MEF2A_6 501 510 PF00069 0.534
DOC_MAPK_RevD_3 183 198 PF00069 0.494
DOC_PP1_RVXF_1 293 299 PF00149 0.463
DOC_PP1_RVXF_1 680 686 PF00149 0.550
DOC_PP2B_LxvP_1 226 229 PF13499 0.567
DOC_PP4_FxxP_1 134 137 PF00568 0.494
DOC_PP4_FxxP_1 155 158 PF00568 0.524
DOC_PP4_FxxP_1 589 592 PF00568 0.455
DOC_PP4_FxxP_1 603 606 PF00568 0.573
DOC_PP4_FxxP_1 658 661 PF00568 0.554
DOC_USP7_MATH_1 280 284 PF00917 0.560
DOC_USP7_MATH_1 624 628 PF00917 0.622
DOC_USP7_MATH_1 661 665 PF00917 0.563
DOC_USP7_MATH_1 670 674 PF00917 0.591
DOC_WW_Pin1_4 308 313 PF00397 0.564
DOC_WW_Pin1_4 445 450 PF00397 0.390
DOC_WW_Pin1_4 583 588 PF00397 0.487
DOC_WW_Pin1_4 666 671 PF00397 0.603
LIG_14-3-3_CanoR_1 166 175 PF00244 0.357
LIG_14-3-3_CanoR_1 195 204 PF00244 0.459
LIG_14-3-3_CanoR_1 274 280 PF00244 0.541
LIG_14-3-3_CanoR_1 281 288 PF00244 0.529
LIG_14-3-3_CanoR_1 522 527 PF00244 0.531
LIG_Actin_WH2_2 179 194 PF00022 0.460
LIG_Actin_WH2_2 562 577 PF00022 0.477
LIG_AP2alpha_2 68 70 PF02296 0.377
LIG_APCC_ABBA_1 131 136 PF00400 0.532
LIG_APCC_ABBA_1 298 303 PF00400 0.541
LIG_BIR_II_1 1 5 PF00653 0.744
LIG_BRCT_BRCA1_1 475 479 PF00533 0.343
LIG_BRCT_BRCA1_1 585 589 PF00533 0.503
LIG_FHA_1 112 118 PF00498 0.493
LIG_FHA_1 12 18 PF00498 0.617
LIG_FHA_1 182 188 PF00498 0.459
LIG_FHA_1 321 327 PF00498 0.391
LIG_FHA_1 346 352 PF00498 0.568
LIG_FHA_1 563 569 PF00498 0.490
LIG_FHA_1 580 586 PF00498 0.390
LIG_FHA_1 655 661 PF00498 0.528
LIG_FHA_1 663 669 PF00498 0.510
LIG_FHA_2 244 250 PF00498 0.451
LIG_FHA_2 309 315 PF00498 0.584
LIG_GBD_Chelix_1 269 277 PF00786 0.486
LIG_Integrin_isoDGR_2 95 97 PF01839 0.538
LIG_IRF3_LxIS_1 579 586 PF10401 0.509
LIG_LIR_Apic_2 152 158 PF02991 0.521
LIG_LIR_Apic_2 442 446 PF02991 0.564
LIG_LIR_Apic_2 586 592 PF02991 0.483
LIG_LIR_Apic_2 657 661 PF02991 0.609
LIG_LIR_Gen_1 199 209 PF02991 0.533
LIG_LIR_Gen_1 211 222 PF02991 0.459
LIG_LIR_Gen_1 246 256 PF02991 0.378
LIG_LIR_Gen_1 271 280 PF02991 0.547
LIG_LIR_Gen_1 327 336 PF02991 0.381
LIG_LIR_Gen_1 537 546 PF02991 0.587
LIG_LIR_Gen_1 599 608 PF02991 0.527
LIG_LIR_Nem_3 122 127 PF02991 0.542
LIG_LIR_Nem_3 199 204 PF02991 0.510
LIG_LIR_Nem_3 211 217 PF02991 0.443
LIG_LIR_Nem_3 254 258 PF02991 0.428
LIG_LIR_Nem_3 271 275 PF02991 0.546
LIG_LIR_Nem_3 327 331 PF02991 0.399
LIG_LIR_Nem_3 537 541 PF02991 0.613
LIG_LIR_Nem_3 599 604 PF02991 0.554
LIG_LIR_Nem_3 611 616 PF02991 0.387
LIG_LYPXL_yS_3 124 127 PF13949 0.443
LIG_LYPXL_yS_3 255 258 PF13949 0.480
LIG_MYND_1 133 137 PF01753 0.333
LIG_MYND_3 605 609 PF01753 0.586
LIG_Pex14_1 477 481 PF04695 0.378
LIG_Pex14_2 155 159 PF04695 0.536
LIG_Pex14_2 481 485 PF04695 0.584
LIG_PTB_Apo_2 59 66 PF02174 0.479
LIG_PTB_Phospho_1 59 65 PF10480 0.477
LIG_Rb_pABgroove_1 421 429 PF01858 0.359
LIG_RPA_C_Fungi 613 625 PF08784 0.392
LIG_SH2_CRK 214 218 PF00017 0.500
LIG_SH2_CRK 232 236 PF00017 0.581
LIG_SH2_CRK 328 332 PF00017 0.433
LIG_SH2_CRK 443 447 PF00017 0.568
LIG_SH2_GRB2like 328 331 PF00017 0.404
LIG_SH2_NCK_1 328 332 PF00017 0.568
LIG_SH2_NCK_1 639 643 PF00017 0.532
LIG_SH2_SRC 328 331 PF00017 0.575
LIG_SH2_STAP1 302 306 PF00017 0.531
LIG_SH2_STAP1 487 491 PF00017 0.597
LIG_SH2_STAP1 564 568 PF00017 0.497
LIG_SH2_STAP1 616 620 PF00017 0.377
LIG_SH2_STAT3 344 347 PF00017 0.380
LIG_SH2_STAT3 459 462 PF00017 0.539
LIG_SH2_STAT5 203 206 PF00017 0.416
LIG_SH2_STAT5 286 289 PF00017 0.384
LIG_SH2_STAT5 422 425 PF00017 0.431
LIG_SH2_STAT5 459 462 PF00017 0.539
LIG_SH2_STAT5 493 496 PF00017 0.554
LIG_SH2_STAT5 564 567 PF00017 0.485
LIG_SH2_STAT5 59 62 PF00017 0.486
LIG_SH2_STAT5 601 604 PF00017 0.539
LIG_SH2_STAT5 613 616 PF00017 0.342
LIG_SH3_1 443 449 PF00018 0.372
LIG_SH3_3 127 133 PF00018 0.401
LIG_SH3_3 443 449 PF00018 0.550
LIG_SH3_3 496 502 PF00018 0.459
LIG_SH3_3 581 587 PF00018 0.493
LIG_SUMO_SIM_anti_2 181 188 PF11976 0.401
LIG_SUMO_SIM_anti_2 565 570 PF11976 0.486
LIG_SUMO_SIM_par_1 181 188 PF11976 0.343
LIG_SUMO_SIM_par_1 564 570 PF11976 0.481
LIG_SUMO_SIM_par_1 581 586 PF11976 0.434
LIG_TRFH_1 224 228 PF08558 0.524
LIG_TRFH_1 65 69 PF08558 0.511
LIG_TYR_ITIM 326 331 PF00017 0.526
LIG_UBA3_1 186 192 PF00899 0.554
LIG_UBA3_1 468 474 PF00899 0.354
LIG_WRC_WIRS_1 221 226 PF05994 0.544
MOD_CK1_1 111 117 PF00069 0.457
MOD_CK1_1 320 326 PF00069 0.557
MOD_CK1_1 375 381 PF00069 0.629
MOD_CK1_1 480 486 PF00069 0.551
MOD_CK1_1 640 646 PF00069 0.499
MOD_CK1_1 673 679 PF00069 0.592
MOD_CK2_1 138 144 PF00069 0.507
MOD_GlcNHglycan 162 165 PF01048 0.402
MOD_GlcNHglycan 232 235 PF01048 0.468
MOD_GlcNHglycan 240 243 PF01048 0.423
MOD_GlcNHglycan 283 286 PF01048 0.524
MOD_GlcNHglycan 319 322 PF01048 0.553
MOD_GlcNHglycan 377 380 PF01048 0.628
MOD_GlcNHglycan 38 41 PF01048 0.622
MOD_GlcNHglycan 482 485 PF01048 0.564
MOD_GlcNHglycan 503 506 PF01048 0.413
MOD_GlcNHglycan 532 536 PF01048 0.642
MOD_GlcNHglycan 628 631 PF01048 0.466
MOD_GlcNHglycan 640 643 PF01048 0.521
MOD_GlcNHglycan 88 91 PF01048 0.493
MOD_GSK3_1 138 145 PF00069 0.470
MOD_GSK3_1 181 188 PF00069 0.516
MOD_GSK3_1 2 9 PF00069 0.688
MOD_GSK3_1 230 237 PF00069 0.420
MOD_GSK3_1 275 282 PF00069 0.453
MOD_GSK3_1 316 323 PF00069 0.519
MOD_GSK3_1 473 480 PF00069 0.455
MOD_GSK3_1 497 504 PF00069 0.531
MOD_GSK3_1 579 586 PF00069 0.511
MOD_GSK3_1 620 627 PF00069 0.512
MOD_GSK3_1 662 669 PF00069 0.567
MOD_GSK3_1 670 677 PF00069 0.613
MOD_GSK3_1 86 93 PF00069 0.453
MOD_N-GLC_1 111 116 PF02516 0.469
MOD_N-GLC_1 508 513 PF02516 0.519
MOD_N-GLC_1 546 551 PF02516 0.530
MOD_N-GLC_1 562 567 PF02516 0.507
MOD_N-GLC_1 579 584 PF02516 0.362
MOD_NEK2_1 138 143 PF00069 0.511
MOD_NEK2_1 159 164 PF00069 0.431
MOD_NEK2_1 202 207 PF00069 0.533
MOD_NEK2_1 238 243 PF00069 0.516
MOD_NEK2_1 251 256 PF00069 0.352
MOD_NEK2_1 317 322 PF00069 0.471
MOD_NEK2_1 345 350 PF00069 0.446
MOD_NEK2_1 546 551 PF00069 0.459
MOD_NEK2_1 6 11 PF00069 0.703
MOD_NEK2_1 86 91 PF00069 0.438
MOD_NEK2_2 168 173 PF00069 0.542
MOD_NEK2_2 286 291 PF00069 0.475
MOD_NEK2_2 7 12 PF00069 0.747
MOD_PIKK_1 390 396 PF00454 0.508
MOD_PIKK_1 546 552 PF00454 0.558
MOD_PKA_2 11 17 PF00069 0.690
MOD_PKA_2 196 202 PF00069 0.547
MOD_PKA_2 280 286 PF00069 0.528
MOD_PKA_2 590 596 PF00069 0.386
MOD_Plk_1 111 117 PF00069 0.464
MOD_Plk_1 181 187 PF00069 0.478
MOD_Plk_1 243 249 PF00069 0.499
MOD_Plk_1 351 357 PF00069 0.580
MOD_Plk_1 562 568 PF00069 0.553
MOD_Plk_1 645 651 PF00069 0.583
MOD_Plk_4 123 129 PF00069 0.530
MOD_Plk_4 168 174 PF00069 0.473
MOD_Plk_4 243 249 PF00069 0.532
MOD_Plk_4 351 357 PF00069 0.550
MOD_Plk_4 579 585 PF00069 0.429
MOD_Plk_4 590 596 PF00069 0.422
MOD_ProDKin_1 308 314 PF00069 0.567
MOD_ProDKin_1 445 451 PF00069 0.387
MOD_ProDKin_1 583 589 PF00069 0.487
MOD_ProDKin_1 666 672 PF00069 0.603
MOD_SUMO_rev_2 103 108 PF00179 0.536
MOD_SUMO_rev_2 354 363 PF00179 0.582
MOD_SUMO_rev_2 68 78 PF00179 0.489
TRG_DiLeu_BaLyEn_6 569 574 PF01217 0.521
TRG_ENDOCYTIC_2 124 127 PF00928 0.546
TRG_ENDOCYTIC_2 214 217 PF00928 0.461
TRG_ENDOCYTIC_2 255 258 PF00928 0.536
TRG_ENDOCYTIC_2 301 304 PF00928 0.514
TRG_ENDOCYTIC_2 328 331 PF00928 0.390
TRG_ENDOCYTIC_2 601 604 PF00928 0.573
TRG_ENDOCYTIC_2 616 619 PF00928 0.553
TRG_ER_diArg_1 194 197 PF00400 0.483
TRG_ER_diArg_1 382 384 PF00400 0.419
TRG_NES_CRM1_1 215 227 PF08389 0.372

Homologs

Protein Taxonomy Sequence identity Coverage
A0A1X0NPQ6 Trypanosomatidae 26% 76%
A0A1X0NPY2 Trypanosomatidae 28% 95%
A0A3R7KBB6 Trypanosoma rangeli 26% 78%
A0A3R7R8G4 Trypanosoma rangeli 26% 67%
A0A422MVE8 Trypanosoma rangeli 27% 100%
A0A422NJL1 Trypanosoma rangeli 26% 89%
A4HX88 Leishmania infantum 52% 76%
C9ZM85 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 26% 100%
C9ZN42 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 26% 100%
C9ZN86 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 26% 91%
C9ZQ91 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 24% 74%
C9ZTS3 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 28% 100%
C9ZUG1 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 27% 100%
E8NHJ6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 62% 80%
V5AW53 Trypanosoma cruzi 28% 85%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS