LeishMANIAdb
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ATP pyrophosphate-lyase

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
ATP pyrophosphate-lyase
Gene product:
receptor-type adenylate cyclase, putative
Species:
Leishmania braziliensis
UniProt:
A4H8V5_LEIBR
TriTrypDb:
LbrM.17.0100 , LBRM2903_170006300 *
Length:
1080

Annotations

LeishMANIAdb annotations

Carries an ATP pyrophosphate-lyase domain on its cytoplasmic segment. Likely acts as a receptor for some unknown extracellular stimulus. Extremely expanded kinetoplastid protein family.. Expressed in the insect stage (promastigote) but not in the mammalian host stage of the parasite life cycle.. Localization: Cell surface (by feature)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 2
Forrest at al. (procyclic) no yes: 2
Silverman et al. no yes: 0
Pissara et al. yes yes: 57
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 5
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 46, no: 29
NetGPI no yes: 0, no: 75
Cellular components
TermNameLevelCount
GO:0016020 membrane 2 70
GO:0110165 cellular anatomical entity 1 76
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Expansion

Sequence features

A4H8V5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H8V5

Function

Biological processes
TermNameLevelCount
GO:0006139 nucleobase-containing compound metabolic process 3 76
GO:0006163 purine nucleotide metabolic process 5 76
GO:0006164 purine nucleotide biosynthetic process 6 76
GO:0006171 cAMP biosynthetic process 8 76
GO:0006725 cellular aromatic compound metabolic process 3 76
GO:0006753 nucleoside phosphate metabolic process 4 76
GO:0006793 phosphorus metabolic process 3 76
GO:0006796 phosphate-containing compound metabolic process 4 76
GO:0006807 nitrogen compound metabolic process 2 76
GO:0007165 signal transduction 2 76
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Molecular functions
TermNameLevelCount
GO:0003824 catalytic activity 1 63
GO:0016829 lyase activity 2 63
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Putative motif mimicry

LeishmaniaFromToDomain/MotifScore
CLV_C14_Caspase3-7 1010 1014 PF00656 0.811
CLV_C14_Caspase3-7 609 613 PF00656 0.663
CLV_C14_Caspase3-7 670 674 PF00656 0.505
CLV_MEL_PAP_1 743 749 PF00089 0.296
CLV_NRD_NRD_1 1018 1020 PF00675 0.419
CLV_NRD_NRD_1 114 116 PF00675 0.535
CLV_NRD_NRD_1 78 80 PF00675 0.714
CLV_NRD_NRD_1 833 835 PF00675 0.426
CLV_PCSK_KEX2_1 1018 1020 PF00082 0.416
CLV_PCSK_KEX2_1 114 116 PF00082 0.487
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Homologs

ProteinTaxonomySequence identityCoverage
A0A0N0P457 Leptomonas seymouri 30% 81%
A0A0S4J2K5 Bodo saltans 27% 81%
A0A1X0P171 Trypanosomatidae 36% 84%
A0A3Q8IJB0 Leishmania donovani 62% 81%
A0A3R7M6J4 Trypanosoma rangeli 38% 100%
A0A3S5H6Z8 Leishmania donovani 62% 81%
A0A3S7WU91 Leishmania donovani 68% 76%
A0A3S7WU94 Leishmania donovani 57% 78%
A0A3S7WU95 Leishmania donovani 60% 77%
A0A3S7XB85 Leishmania donovani 30% 77%
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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS