LeishMANIAdb
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Putative mitogen-activated protein kinase kinase 3

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative mitogen-activated protein kinase kinase 3
Gene product:
mitogen-activated protein kinase kinase 3, putative
Species:
Leishmania braziliensis
UniProt:
A4H8V2_LEIBR
TriTrypDb:
LbrM.17.0070 , LBRM2903_170006000 *
Length:
499

Annotations

LeishMANIAdb annotations

A large and apprently artificial collection of diverse kinetoplastid protein kinases. A subfamily has 2TM regions, but the majority is cytoplasmic.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 18
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 21
NetGPI no yes: 0, no: 21
Cellular components
Term Name Level Count
GO:0005929 cilium 4 11
GO:0042995 cell projection 2 11
GO:0043226 organelle 2 11
GO:0043227 membrane-bounded organelle 3 11
GO:0110165 cellular anatomical entity 1 13
GO:0120025 plasma membrane bounded cell projection 3 11
GO:0005737 cytoplasm 2 2
GO:0005952 cAMP-dependent protein kinase complex 3 1
GO:0032991 protein-containing complex 1 1
GO:0051286 cell tip 3 1
GO:0060187 cell pole 2 1
GO:0061695 transferase complex, transferring phosphorus-containing groups 4 1
GO:0140535 intracellular protein-containing complex 2 1
GO:1902494 catalytic complex 2 1
GO:1902554 serine/threonine protein kinase complex 6 1
GO:1902911 protein kinase complex 5 1
GO:1990234 transferase complex 3 1
GO:0032838 plasma membrane bounded cell projection cytoplasm 4 1
GO:0097014 ciliary plasm 5 1
GO:0099568 cytoplasmic region 3 1

Expansion

Sequence features

A4H8V2
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H8V2

Function

Biological processes
Term Name Level Count
GO:0006468 protein phosphorylation 5 22
GO:0006793 phosphorus metabolic process 3 22
GO:0006796 phosphate-containing compound metabolic process 4 22
GO:0006807 nitrogen compound metabolic process 2 22
GO:0008152 metabolic process 1 22
GO:0009987 cellular process 1 22
GO:0016310 phosphorylation 5 22
GO:0019538 protein metabolic process 3 22
GO:0036211 protein modification process 4 22
GO:0043170 macromolecule metabolic process 3 22
GO:0043412 macromolecule modification 4 22
GO:0044237 cellular metabolic process 2 22
GO:0044238 primary metabolic process 2 22
GO:0071704 organic substance metabolic process 2 22
GO:1901564 organonitrogen compound metabolic process 3 22
GO:0007165 signal transduction 2 2
GO:0018105 peptidyl-serine phosphorylation 6 2
GO:0018193 peptidyl-amino acid modification 5 2
GO:0018209 peptidyl-serine modification 6 2
GO:0050789 regulation of biological process 2 2
GO:0050794 regulation of cellular process 3 2
GO:0065007 biological regulation 1 2
GO:0035556 intracellular signal transduction 3 1
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 22
GO:0003824 catalytic activity 1 22
GO:0004672 protein kinase activity 3 22
GO:0005488 binding 1 22
GO:0005524 ATP binding 5 22
GO:0016301 kinase activity 4 22
GO:0016740 transferase activity 2 22
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 22
GO:0016773 phosphotransferase activity, alcohol group as acceptor 4 22
GO:0017076 purine nucleotide binding 4 22
GO:0030554 adenyl nucleotide binding 5 22
GO:0032553 ribonucleotide binding 3 22
GO:0032555 purine ribonucleotide binding 4 22
GO:0032559 adenyl ribonucleotide binding 5 22
GO:0035639 purine ribonucleoside triphosphate binding 4 22
GO:0036094 small molecule binding 2 22
GO:0043167 ion binding 2 22
GO:0043168 anion binding 3 22
GO:0097159 organic cyclic compound binding 2 22
GO:0097367 carbohydrate derivative binding 2 22
GO:0140096 catalytic activity, acting on a protein 2 22
GO:1901265 nucleoside phosphate binding 3 22
GO:1901363 heterocyclic compound binding 2 22
GO:0004674 protein serine/threonine kinase activity 4 10
GO:0043169 cation binding 3 5
GO:0046872 metal ion binding 4 5
GO:0004690 cyclic nucleotide-dependent protein kinase activity 5 1
GO:0004691 cAMP-dependent protein kinase activity 6 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 221 225 PF00656 0.373
CLV_C14_Caspase3-7 233 237 PF00656 0.354
CLV_NRD_NRD_1 218 220 PF00675 0.282
CLV_NRD_NRD_1 239 241 PF00675 0.449
CLV_NRD_NRD_1 493 495 PF00675 0.676
CLV_NRD_NRD_1 75 77 PF00675 0.286
CLV_PCSK_KEX2_1 218 220 PF00082 0.311
CLV_PCSK_KEX2_1 239 241 PF00082 0.488
CLV_PCSK_KEX2_1 280 282 PF00082 0.355
CLV_PCSK_KEX2_1 475 477 PF00082 0.612
CLV_PCSK_KEX2_1 493 495 PF00082 0.619
CLV_PCSK_KEX2_1 5 7 PF00082 0.338
CLV_PCSK_KEX2_1 75 77 PF00082 0.269
CLV_PCSK_KEX2_1 9 11 PF00082 0.394
CLV_PCSK_PC1ET2_1 280 282 PF00082 0.422
CLV_PCSK_PC1ET2_1 475 477 PF00082 0.664
CLV_PCSK_PC1ET2_1 5 7 PF00082 0.343
CLV_PCSK_PC1ET2_1 9 11 PF00082 0.343
CLV_PCSK_SKI1_1 223 227 PF00082 0.276
CLV_PCSK_SKI1_1 229 233 PF00082 0.299
CLV_PCSK_SKI1_1 358 362 PF00082 0.444
CLV_PCSK_SKI1_1 76 80 PF00082 0.264
CLV_PCSK_SKI1_1 96 100 PF00082 0.315
DEG_Kelch_Keap1_1 429 434 PF01344 0.449
DEG_Nend_Nbox_1 1 3 PF02207 0.162
DEG_SPOP_SBC_1 306 310 PF00917 0.357
DOC_MAPK_gen_1 259 267 PF00069 0.560
DOC_MAPK_gen_1 278 285 PF00069 0.346
DOC_MAPK_gen_1 475 483 PF00069 0.546
DOC_PP4_FxxP_1 138 141 PF00568 0.267
DOC_USP7_MATH_1 307 311 PF00917 0.481
DOC_USP7_MATH_1 380 384 PF00917 0.454
DOC_USP7_MATH_1 56 60 PF00917 0.383
DOC_USP7_UBL2_3 147 151 PF12436 0.428
DOC_USP7_UBL2_3 223 227 PF12436 0.291
DOC_USP7_UBL2_3 471 475 PF12436 0.580
DOC_USP7_UBL2_3 5 9 PF12436 0.326
LIG_14-3-3_CanoR_1 218 226 PF00244 0.237
LIG_14-3-3_CanoR_1 239 244 PF00244 0.590
LIG_14-3-3_CanoR_1 389 398 PF00244 0.438
LIG_14-3-3_CanoR_1 66 70 PF00244 0.253
LIG_14-3-3_CanoR_1 75 85 PF00244 0.221
LIG_Actin_WH2_2 323 340 PF00022 0.429
LIG_Actin_WH2_2 343 360 PF00022 0.187
LIG_APCC_ABBAyCdc20_2 91 97 PF00400 0.306
LIG_BRCT_BRCA1_1 313 317 PF00533 0.322
LIG_Clathr_ClatBox_1 82 86 PF01394 0.249
LIG_DLG_GKlike_1 239 247 PF00625 0.476
LIG_FHA_1 12 18 PF00498 0.342
LIG_FHA_1 179 185 PF00498 0.314
LIG_FHA_1 24 30 PF00498 0.271
LIG_FHA_1 331 337 PF00498 0.350
LIG_FHA_1 72 78 PF00498 0.233
LIG_FHA_2 307 313 PF00498 0.474
LIG_FHA_2 39 45 PF00498 0.282
LIG_LIR_Apic_2 135 141 PF02991 0.326
LIG_LIR_Apic_2 146 152 PF02991 0.326
LIG_LIR_Gen_1 341 352 PF02991 0.367
LIG_LIR_LC3C_4 109 112 PF02991 0.387
LIG_LIR_Nem_3 288 293 PF02991 0.420
LIG_LIR_Nem_3 295 299 PF02991 0.397
LIG_LIR_Nem_3 341 347 PF02991 0.359
LIG_SH2_CRK 149 153 PF00017 0.249
LIG_SH2_CRK 296 300 PF00017 0.458
LIG_SH2_SRC 214 217 PF00017 0.214
LIG_SH2_SRC 304 307 PF00017 0.394
LIG_SH2_SRC 444 447 PF00017 0.484
LIG_SH2_SRC 54 57 PF00017 0.383
LIG_SH2_STAP1 244 248 PF00017 0.400
LIG_SH2_STAT3 170 173 PF00017 0.252
LIG_SH2_STAT3 244 247 PF00017 0.483
LIG_SH2_STAT5 275 278 PF00017 0.327
LIG_SH2_STAT5 298 301 PF00017 0.438
LIG_SH2_STAT5 304 307 PF00017 0.489
LIG_SH2_STAT5 54 57 PF00017 0.423
LIG_SH2_STAT5 87 90 PF00017 0.439
LIG_SH3_3 195 201 PF00018 0.290
LIG_SH3_3 250 256 PF00018 0.505
LIG_SH3_3 478 484 PF00018 0.513
LIG_SUMO_SIM_anti_2 349 355 PF11976 0.431
LIG_SUMO_SIM_par_1 323 329 PF11976 0.314
LIG_TRAF2_2 201 206 PF00917 0.168
LIG_UBA3_1 273 280 PF00899 0.468
LIG_UBA3_1 352 358 PF00899 0.307
LIG_WRC_WIRS_1 413 418 PF05994 0.350
MOD_CK1_1 28 34 PF00069 0.317
MOD_CK1_1 365 371 PF00069 0.350
MOD_CK1_1 393 399 PF00069 0.355
MOD_CK1_1 406 412 PF00069 0.354
MOD_CK1_1 429 435 PF00069 0.576
MOD_CK1_1 451 457 PF00069 0.605
MOD_CK1_1 467 473 PF00069 0.658
MOD_CK2_1 306 312 PF00069 0.350
MOD_CK2_1 428 434 PF00069 0.449
MOD_CK2_1 65 71 PF00069 0.265
MOD_GlcNHglycan 220 223 PF01048 0.322
MOD_GlcNHglycan 249 252 PF01048 0.573
MOD_GlcNHglycan 256 259 PF01048 0.468
MOD_GlcNHglycan 405 408 PF01048 0.373
MOD_GlcNHglycan 466 469 PF01048 0.730
MOD_GSK3_1 128 135 PF00069 0.316
MOD_GSK3_1 239 246 PF00069 0.594
MOD_GSK3_1 307 314 PF00069 0.372
MOD_GSK3_1 326 333 PF00069 0.229
MOD_GSK3_1 348 355 PF00069 0.368
MOD_GSK3_1 358 365 PF00069 0.306
MOD_GSK3_1 447 454 PF00069 0.590
MOD_GSK3_1 67 74 PF00069 0.272
MOD_N-GLC_2 464 466 PF02516 0.490
MOD_NEK2_1 117 122 PF00069 0.297
MOD_NEK2_1 243 248 PF00069 0.492
MOD_NEK2_1 311 316 PF00069 0.267
MOD_NEK2_1 330 335 PF00069 0.497
MOD_NEK2_1 38 43 PF00069 0.315
MOD_NEK2_1 449 454 PF00069 0.612
MOD_NEK2_2 132 137 PF00069 0.280
MOD_PIKK_1 103 109 PF00454 0.373
MOD_PIKK_1 206 212 PF00454 0.252
MOD_PIKK_1 243 249 PF00454 0.485
MOD_PIKK_1 76 82 PF00454 0.274
MOD_PKA_1 218 224 PF00069 0.249
MOD_PKA_1 239 245 PF00069 0.461
MOD_PKA_1 475 481 PF00069 0.671
MOD_PKA_2 218 224 PF00069 0.236
MOD_PKA_2 238 244 PF00069 0.683
MOD_PKA_2 475 481 PF00069 0.514
MOD_PKA_2 65 71 PF00069 0.305
MOD_Plk_1 311 317 PF00069 0.544
MOD_Plk_1 340 346 PF00069 0.352
MOD_Plk_1 38 44 PF00069 0.240
MOD_Plk_2-3 326 332 PF00069 0.276
MOD_Plk_2-3 65 71 PF00069 0.340
MOD_Plk_4 117 123 PF00069 0.383
MOD_Plk_4 239 245 PF00069 0.665
MOD_Plk_4 25 31 PF00069 0.277
MOD_Plk_4 263 269 PF00069 0.325
MOD_Plk_4 348 354 PF00069 0.311
MOD_Plk_4 412 418 PF00069 0.454
MOD_Plk_4 46 52 PF00069 0.317
MOD_SUMO_for_1 36 39 PF00179 0.383
TRG_DiLeu_BaEn_1 25 30 PF01217 0.302
TRG_DiLeu_BaLyEn_6 269 274 PF01217 0.446
TRG_DiLeu_BaLyEn_6 332 337 PF01217 0.308
TRG_DiLeu_BaLyEn_6 383 388 PF01217 0.491
TRG_ENDOCYTIC_2 287 290 PF00928 0.373
TRG_ENDOCYTIC_2 296 299 PF00928 0.438
TRG_ER_diArg_1 218 220 PF00400 0.248
TRG_ER_diArg_1 75 77 PF00400 0.259
TRG_Pf-PMV_PEXEL_1 229 233 PF00026 0.330
TRG_Pf-PMV_PEXEL_1 272 277 PF00026 0.357
TRG_Pf-PMV_PEXEL_1 76 80 PF00026 0.428

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P2S2 Leptomonas seymouri 66% 90%
A0A0S4JTJ8 Bodo saltans 30% 100%
A0A1X0NTP1 Trypanosomatidae 51% 86%
A0A3Q8IB30 Leishmania donovani 33% 100%
A0A3Q8IB74 Leishmania donovani 29% 100%
A0A3R7MKJ1 Trypanosoma rangeli 45% 92%
A0A3S5H528 Leishmania donovani 25% 100%
A0A3S7WTN9 Leishmania donovani 34% 100%
A0A3S7WUE7 Leishmania donovani 88% 90%
A0A3S7WWE7 Leishmania donovani 25% 100%
A4H3D2 Leishmania braziliensis 23% 100%
A4H3J3 Leishmania braziliensis 25% 100%
A4H8C4 Leishmania braziliensis 34% 100%
A4H9L8 Leishmania braziliensis 33% 100%
A4HBL4 Leishmania braziliensis 25% 100%
A4HRT2 Leishmania infantum 25% 100%
A4HWP5 Leishmania infantum 34% 100%
A4HX71 Leishmania infantum 88% 90%
A4HXY2 Leishmania infantum 33% 100%
A4HZA2 Leishmania infantum 25% 100%
C9ZTU6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 47% 92%
E9ACB1 Leishmania major 24% 100%
E9ACG8 Leishmania major 25% 100%
E9AGS0 Leishmania infantum 29% 100%
E9AJJ9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 23% 100%
E9AKZ7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 25% 100%
E9AQF3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 32% 100%
E9ARC8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 86% 90%
E9ARP5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 34% 100%
E9ARW9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 29% 100%
E9AUY2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 25% 100%
O80673 Arabidopsis thaliana 29% 87%
P00518 Oryctolagus cuniculus 29% 100%
P07934 Mus musculus 29% 100%
P13286 Rattus norvegicus 30% 100%
Q16816 Homo sapiens 29% 100%
Q27687 Leishmania major 32% 100%
Q4QCK0 Leishmania major 24% 100%
Q4QDK3 Leishmania major 29% 100%
Q4QEJ2 Leishmania major 87% 100%
Q4QF23 Leishmania major 34% 100%
Q4QIV8 Leishmania major 24% 100%
Q9LET1 Arabidopsis thaliana 28% 86%
V5BH88 Trypanosoma cruzi 45% 92%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS