RRM domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H8V1_LEIBR

TriTrypDb:

LbrM.17.0060 , LBRM2903_170005900

Length:

232

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H8V1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H8V1

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	2
GO:0005488	binding	1	2
GO:0097159	organic cyclic compound binding	2	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	179	183	PF00656	0.671
CLV_C14_Caspase3-7	30	34	PF00656	0.463
CLV_NRD_NRD_1	16	18	PF00675	0.682
CLV_NRD_NRD_1	222	224	PF00675	0.567
CLV_NRD_NRD_1	84	86	PF00675	0.473
CLV_NRD_NRD_1	93	95	PF00675	0.462
CLV_PCSK_FUR_1	80	84	PF00082	0.537
CLV_PCSK_KEX2_1	16	18	PF00082	0.597
CLV_PCSK_KEX2_1	222	224	PF00082	0.567
CLV_PCSK_KEX2_1	79	81	PF00082	0.436
CLV_PCSK_KEX2_1	82	84	PF00082	0.461
CLV_PCSK_KEX2_1	93	95	PF00082	0.419
CLV_PCSK_PC1ET2_1	79	81	PF00082	0.497
CLV_PCSK_PC1ET2_1	82	84	PF00082	0.504
CLV_PCSK_PC1ET2_1	93	95	PF00082	0.399
CLV_PCSK_PC7_1	218	224	PF00082	0.589
CLV_PCSK_PC7_1	80	86	PF00082	0.562
CLV_PCSK_SKI1_1	206	210	PF00082	0.495
CLV_PCSK_SKI1_1	222	226	PF00082	0.385
CLV_PCSK_SKI1_1	5	9	PF00082	0.550
CLV_PCSK_SKI1_1	54	58	PF00082	0.426
CLV_PCSK_SKI1_1	95	99	PF00082	0.477
DOC_CYCLIN_RxL_1	13	24	PF00134	0.561
DOC_CYCLIN_RxL_1	92	101	PF00134	0.505
DOC_MAPK_MEF2A_6	194	201	PF00069	0.553
DOC_PP1_RVXF_1	14	21	PF00149	0.547
DOC_PP2B_LxvP_1	25	28	PF13499	0.469
DOC_USP7_MATH_1	107	111	PF00917	0.540
DOC_USP7_MATH_1	181	185	PF00917	0.529
DOC_WW_Pin1_4	103	108	PF00397	0.470
DOC_WW_Pin1_4	173	178	PF00397	0.542
LIG_14-3-3_CanoR_1	148	153	PF00244	0.334
LIG_14-3-3_CanoR_1	17	23	PF00244	0.562
LIG_BRCT_BRCA1_1	48	52	PF00533	0.536
LIG_CtBP_PxDLS_1	28	32	PF00389	0.345
LIG_deltaCOP1_diTrp_1	41	51	PF00928	0.429
LIG_FHA_1	133	139	PF00498	0.561
LIG_FHA_2	174	180	PF00498	0.757
LIG_LIR_Gen_1	114	122	PF02991	0.345
LIG_LIR_Gen_1	49	56	PF02991	0.471
LIG_LIR_Nem_3	114	119	PF02991	0.322
LIG_LIR_Nem_3	151	155	PF02991	0.517
LIG_LIR_Nem_3	41	47	PF02991	0.455
LIG_LIR_Nem_3	49	55	PF02991	0.473
LIG_PTB_Apo_2	31	38	PF02174	0.496
LIG_SH2_STAP1	40	44	PF00017	0.508
LIG_SH2_STAT3	40	43	PF00017	0.518
LIG_TRAF2_1	176	179	PF00917	0.538
LIG_WRC_WIRS_1	47	52	PF05994	0.529
MOD_CK1_1	103	109	PF00069	0.417
MOD_CK2_1	173	179	PF00069	0.714
MOD_CK2_1	180	186	PF00069	0.765
MOD_CK2_1	199	205	PF00069	0.515
MOD_Cter_Amidation	14	17	PF01082	0.602
MOD_Cter_Amidation	220	223	PF01082	0.352
MOD_GlcNHglycan	100	103	PF01048	0.627
MOD_GlcNHglycan	119	122	PF01048	0.568
MOD_GlcNHglycan	123	126	PF01048	0.370
MOD_GlcNHglycan	182	186	PF01048	0.778
MOD_GSK3_1	103	110	PF00069	0.448
MOD_GSK3_1	111	118	PF00069	0.342
MOD_GSK3_1	169	176	PF00069	0.765
MOD_GSK3_1	181	188	PF00069	0.633
MOD_NEK2_1	18	23	PF00069	0.502
MOD_NEK2_1	199	204	PF00069	0.473
MOD_NEK2_1	214	219	PF00069	0.367
MOD_NEK2_1	56	61	PF00069	0.543
MOD_NEK2_1	98	103	PF00069	0.641
MOD_Plk_1	57	63	PF00069	0.382
MOD_Plk_1	86	92	PF00069	0.516
MOD_Plk_2-3	186	192	PF00069	0.534
MOD_Plk_4	107	113	PF00069	0.468
MOD_Plk_4	46	52	PF00069	0.536
MOD_Plk_4	86	92	PF00069	0.536
MOD_ProDKin_1	103	109	PF00069	0.467
MOD_ProDKin_1	173	179	PF00069	0.543
TRG_DiLeu_BaEn_1	129	134	PF01217	0.537
TRG_DiLeu_BaLyEn_6	93	98	PF01217	0.466
TRG_ER_diArg_1	16	18	PF00400	0.682
TRG_ER_diArg_1	222	224	PF00400	0.567
TRG_ER_diArg_1	83	85	PF00400	0.484
TRG_ER_diArg_1	94	97	PF00400	0.436
TRG_NLS_Bipartite_1	79	98	PF00514	0.462
TRG_NLS_MonoCore_2	91	96	PF00514	0.498
TRG_NLS_MonoExtC_3	78	83	PF00514	0.481
TRG_NLS_MonoExtC_3	91	96	PF00514	0.459
TRG_NLS_MonoExtN_4	92	98	PF00514	0.490
TRG_Pf-PMV_PEXEL_1	153	157	PF00026	0.613
TRG_Pf-PMV_PEXEL_1	223	227	PF00026	0.312
TRG_Pf-PMV_PEXEL_1	54	58	PF00026	0.450

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I083	Leptomonas seymouri	58%	95%
A0A1X0NT13	Trypanosomatidae	45%	94%
A0A3R7KLV2	Trypanosoma rangeli	44%	90%
A0A3S5H6Z6	Leishmania donovani	75%	98%
A4HX70	Leishmania infantum	75%	98%
C9ZTU2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9ARC7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	73%	100%
Q4QEJ3	Leishmania major	77%	100%