J domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DnaJ domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4H8V0_LEIBR

TriTrypDb:

LbrM.17.0050 , LBRM2903_170005800

Length:

262

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A4H8V0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H8V0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	159	161	PF00675	0.399
CLV_NRD_NRD_1	2	4	PF00675	0.488
CLV_NRD_NRD_1	219	221	PF00675	0.599
CLV_NRD_NRD_1	241	243	PF00675	0.671
CLV_NRD_NRD_1	260	262	PF00675	0.768
CLV_NRD_NRD_1	56	58	PF00675	0.397
CLV_PCSK_KEX2_1	2	4	PF00082	0.487
CLV_PCSK_KEX2_1	221	223	PF00082	0.602
CLV_PCSK_KEX2_1	233	235	PF00082	0.581
CLV_PCSK_KEX2_1	241	243	PF00082	0.482
CLV_PCSK_KEX2_1	56	58	PF00082	0.392
CLV_PCSK_PC1ET2_1	221	223	PF00082	0.632
CLV_PCSK_PC1ET2_1	233	235	PF00082	0.551
CLV_PCSK_SKI1_1	153	157	PF00082	0.432
CLV_PCSK_SKI1_1	23	27	PF00082	0.480
CLV_PCSK_SKI1_1	241	245	PF00082	0.587
CLV_PCSK_SKI1_1	43	47	PF00082	0.235
DEG_APCC_DBOX_1	159	167	PF00400	0.503
DEG_Nend_UBRbox_1	1	4	PF02207	0.727
DOC_AGCK_PIF_1	172	177	PF00069	0.322
DOC_CYCLIN_RxL_1	101	111	PF00134	0.536
DOC_CYCLIN_RxL_1	150	159	PF00134	0.630
DOC_CYCLIN_RxL_1	40	50	PF00134	0.627
DOC_MAPK_DCC_7	133	141	PF00069	0.440
DOC_MAPK_gen_1	101	109	PF00069	0.442
DOC_MAPK_gen_1	160	171	PF00069	0.656
DOC_PP1_RVXF_1	239	246	PF00149	0.388
DOC_PP1_RVXF_1	72	79	PF00149	0.578
DOC_PP4_FxxP_1	202	205	PF00568	0.375
DOC_USP7_MATH_1	29	33	PF00917	0.653
DOC_WW_Pin1_4	145	150	PF00397	0.618
DOC_WW_Pin1_4	47	52	PF00397	0.557
DOC_WW_Pin1_4	81	86	PF00397	0.525
LIG_14-3-3_CanoR_1	103	108	PF00244	0.536
LIG_EH1_1	176	184	PF00400	0.215
LIG_eIF4E_1	177	183	PF01652	0.239
LIG_FHA_1	187	193	PF00498	0.401
LIG_FHA_1	67	73	PF00498	0.627
LIG_FHA_2	109	115	PF00498	0.455
LIG_FHA_2	117	123	PF00498	0.455
LIG_FHA_2	62	68	PF00498	0.596
LIG_LIR_Gen_1	122	132	PF02991	0.457
LIG_LIR_Gen_1	176	185	PF02991	0.295
LIG_LIR_Gen_1	206	212	PF02991	0.350
LIG_LIR_Nem_3	122	128	PF02991	0.457
LIG_LIR_Nem_3	204	210	PF02991	0.336
LIG_Pex14_2	203	207	PF04695	0.357
LIG_Pex14_2	245	249	PF04695	0.389
LIG_SH2_CRK	104	108	PF00017	0.536
LIG_SH2_CRK	125	129	PF00017	0.455
LIG_SH2_STAT5	177	180	PF00017	0.215
LIG_SUMO_SIM_par_1	188	193	PF11976	0.410
MOD_CK1_1	195	201	PF00069	0.327
MOD_CK2_1	116	122	PF00069	0.355
MOD_CK2_1	61	67	PF00069	0.503
MOD_Cter_Amidation	259	262	PF01082	0.499
MOD_GSK3_1	108	115	PF00069	0.314
MOD_GSK3_1	186	193	PF00069	0.356
MOD_NEK2_1	155	160	PF00069	0.458
MOD_NEK2_1	186	191	PF00069	0.414
MOD_NEK2_2	18	23	PF00069	0.475
MOD_PKB_1	101	109	PF00069	0.410
MOD_Plk_4	137	143	PF00069	0.364
MOD_Plk_4	186	192	PF00069	0.355
MOD_Plk_4	195	201	PF00069	0.391
MOD_ProDKin_1	145	151	PF00069	0.518
MOD_ProDKin_1	47	53	PF00069	0.440
MOD_ProDKin_1	81	87	PF00069	0.402
MOD_SUMO_rev_2	215	223	PF00179	0.536
MOD_SUMO_rev_2	226	235	PF00179	0.436
TRG_DiLeu_BaEn_2	205	211	PF01217	0.432
TRG_DiLeu_BaLyEn_6	239	244	PF01217	0.481
TRG_ENDOCYTIC_2	104	107	PF00928	0.279
TRG_ENDOCYTIC_2	125	128	PF00928	0.279
TRG_ENDOCYTIC_2	177	180	PF00928	0.279
TRG_ENDOCYTIC_2	208	211	PF00928	0.409
TRG_ER_diArg_1	1	3	PF00400	0.617
TRG_ER_diArg_1	100	103	PF00400	0.279
TRG_ER_diArg_1	168	171	PF00400	0.515
TRG_ER_diArg_1	240	242	PF00400	0.531
TRG_ER_diArg_1	56	58	PF00400	0.468
TRG_Pf-PMV_PEXEL_1	105	110	PF00026	0.297
TRG_Pf-PMV_PEXEL_1	153	157	PF00026	0.405

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P361	Leptomonas seymouri	69%	100%
A0A0S4J092	Bodo saltans	47%	80%
A0A1X0NT05	Trypanosomatidae	62%	96%
A0A3Q8IJ96	Leishmania donovani	85%	100%
A0A3R7LVM9	Trypanosoma rangeli	55%	98%
A4HX69	Leishmania infantum	85%	100%
C9ZTU1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	58%	92%
E9ARC6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q4QEJ4	Leishmania major	83%	100%