LeishMANIAdb
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RING-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
RING-type domain-containing protein
Gene product:
Ring finger domain containing protein, putative
Species:
Leishmania braziliensis
UniProt:
A4H8U9_LEIBR
TriTrypDb:
LbrM.17.0040 , LBRM2903_170005700 *
Length:
193

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 7
NetGPI no yes: 0, no: 7
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H8U9
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H8U9

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 122 124 PF00675 0.528
CLV_PCSK_FUR_1 120 124 PF00082 0.566
CLV_PCSK_KEX2_1 120 122 PF00082 0.519
DEG_Nend_UBRbox_3 1 3 PF02207 0.529
DOC_CKS1_1 142 147 PF01111 0.735
DOC_CYCLIN_yCln2_LP_2 71 77 PF00134 0.376
DOC_MAPK_gen_1 120 127 PF00069 0.599
DOC_MAPK_MEF2A_6 8 15 PF00069 0.539
DOC_USP7_MATH_1 17 21 PF00917 0.618
DOC_USP7_MATH_1 25 29 PF00917 0.549
DOC_USP7_MATH_1 31 35 PF00917 0.622
DOC_WW_Pin1_4 141 146 PF00397 0.735
LIG_14-3-3_CanoR_1 112 119 PF00244 0.579
LIG_14-3-3_CanoR_1 139 143 PF00244 0.594
LIG_14-3-3_CanoR_1 93 99 PF00244 0.430
LIG_FHA_1 168 174 PF00498 0.553
LIG_FHA_1 49 55 PF00498 0.578
LIG_FHA_1 59 65 PF00498 0.376
LIG_Rb_LxCxE_1 81 97 PF01857 0.430
LIG_SH2_GRB2like 39 42 PF00017 0.733
LIG_SH2_STAT5 39 42 PF00017 0.733
LIG_SH3_3 10 16 PF00018 0.600
MOD_CK1_1 141 147 PF00069 0.631
MOD_CK1_1 20 26 PF00069 0.649
MOD_CK1_1 34 40 PF00069 0.703
MOD_GlcNHglycan 22 25 PF01048 0.678
MOD_GSK3_1 137 144 PF00069 0.654
MOD_GSK3_1 25 32 PF00069 0.652
MOD_N-GLC_1 29 34 PF02516 0.660
MOD_NEK2_1 137 142 PF00069 0.515
MOD_PIKK_1 25 31 PF00454 0.734
MOD_PKA_2 138 144 PF00069 0.562
MOD_PKA_2 94 100 PF00069 0.376
MOD_Plk_1 137 143 PF00069 0.526
MOD_Plk_1 41 47 PF00069 0.632
MOD_Plk_2-3 159 165 PF00069 0.770
MOD_Plk_2-3 167 173 PF00069 0.635
MOD_Plk_2-3 48 54 PF00069 0.714
MOD_Plk_2-3 67 73 PF00069 0.187
MOD_Plk_4 138 144 PF00069 0.500
MOD_ProDKin_1 141 147 PF00069 0.734
MOD_SUMO_for_1 78 81 PF00179 0.430
TRG_DiLeu_BaEn_1 138 143 PF01217 0.682
TRG_ER_diArg_1 119 122 PF00400 0.524
TRG_ER_diArg_1 125 128 PF00400 0.542
TRG_ER_diArg_1 173 176 PF00400 0.483
TRG_ER_diArg_1 92 95 PF00400 0.376

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P2S1 Leptomonas seymouri 56% 100%
A0A3S7WU93 Leishmania donovani 75% 91%
A4HX68 Leishmania infantum 75% 91%
E9ARC5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 76% 100%
Q4QEJ5 Leishmania major 74% 100%
V5ASR6 Trypanosoma cruzi 38% 98%

Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS