Monocyte to macrophage differentiation factor 2

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF3522), putative

Species:

Leishmania braziliensis

UniProt:

A4H8U8_LEIBR

TriTrypDb:

LbrM.17.0030 , LBRM2903_170005600

Length:

221

Annotations

LeishMANIAdb annotations

Very distantly similar to animal TMEM8 and MMD2 proteins. Its function is obscure, although gene fusions with lipid hydrolases suggest a related function

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 20
NetGPI	no	yes: 0, no: 21

Cellular components
Term	Name	Level	Count
GO:0005886	plasma membrane	3	22
GO:0016020	membrane	2	22
GO:0110165	cellular anatomical entity	1	22

Expansion

Sequence features

A4H8U8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H8U8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	30	32	PF00675	0.280
CLV_PCSK_KEX2_1	30	32	PF00082	0.264
DEG_Nend_UBRbox_1	1	4	PF02207	0.418
DOC_CKS1_1	22	27	PF01111	0.172
DOC_CYCLIN_yCln2_LP_2	22	28	PF00134	0.325
DOC_MAPK_DCC_7	118	126	PF00069	0.343
DOC_MAPK_HePTP_8	109	121	PF00069	0.188
DOC_MAPK_MEF2A_6	112	121	PF00069	0.309
DOC_MAPK_MEF2A_6	2	11	PF00069	0.460
DOC_PP4_FxxP_1	89	92	PF00568	0.491
DOC_WW_Pin1_4	119	124	PF00397	0.395
DOC_WW_Pin1_4	21	26	PF00397	0.172
DOC_WW_Pin1_4	3	8	PF00397	0.329
LIG_14-3-3_CanoR_1	118	122	PF00244	0.318
LIG_14-3-3_CanoR_1	176	185	PF00244	0.270
LIG_BRCT_BRCA1_1	188	192	PF00533	0.351
LIG_EH_1	90	94	PF12763	0.364
LIG_FHA_1	104	110	PF00498	0.310
LIG_FHA_1	22	28	PF00498	0.330
LIG_FHA_2	61	67	PF00498	0.323
LIG_LIR_Gen_1	180	190	PF02991	0.221
LIG_LIR_Gen_1	64	75	PF02991	0.238
LIG_LIR_LC3C_4	106	109	PF02991	0.272
LIG_LIR_Nem_3	128	133	PF02991	0.389
LIG_LIR_Nem_3	173	178	PF02991	0.288
LIG_LIR_Nem_3	180	185	PF02991	0.347
LIG_LIR_Nem_3	189	195	PF02991	0.360
LIG_LIR_Nem_3	24	29	PF02991	0.305
LIG_LIR_Nem_3	64	70	PF02991	0.233
LIG_MLH1_MIPbox_1	188	192	PF16413	0.351
LIG_PCNA_yPIPBox_3	69	79	PF02747	0.194
LIG_Pex14_2	101	105	PF04695	0.314
LIG_Pex14_2	89	93	PF04695	0.410
LIG_SH2_CRK	152	156	PF00017	0.172
LIG_SH2_PTP2	83	86	PF00017	0.271
LIG_SH2_STAT5	26	29	PF00017	0.438
LIG_SH2_STAT5	33	36	PF00017	0.458
LIG_SH2_STAT5	83	86	PF00017	0.352
LIG_SH3_3	194	200	PF00018	0.504
LIG_SUMO_SIM_par_1	122	128	PF11976	0.268
LIG_TRFH_1	127	131	PF08558	0.272
LIG_TYR_ITIM	150	155	PF00017	0.330
LIG_TYR_ITIM	81	86	PF00017	0.450
LIG_UBA3_1	125	134	PF00899	0.406
LIG_WRC_WIRS_1	45	50	PF05994	0.326
MOD_CK1_1	17	23	PF00069	0.218
MOD_CK1_1	55	61	PF00069	0.282
MOD_CK2_1	60	66	PF00069	0.323
MOD_GlcNHglycan	145	148	PF01048	0.224
MOD_GlcNHglycan	179	182	PF01048	0.367
MOD_GlcNHglycan	188	191	PF01048	0.395
MOD_GSK3_1	17	24	PF00069	0.289
MOD_NEK2_1	11	16	PF00069	0.344
MOD_NEK2_1	125	130	PF00069	0.481
MOD_NEK2_1	154	159	PF00069	0.294
MOD_NEK2_1	177	182	PF00069	0.220
MOD_NEK2_1	44	49	PF00069	0.291
MOD_PK_1	141	147	PF00069	0.470
MOD_PKA_2	117	123	PF00069	0.364
MOD_Plk_4	11	17	PF00069	0.279
MOD_Plk_4	44	50	PF00069	0.305
MOD_ProDKin_1	119	125	PF00069	0.395
MOD_ProDKin_1	21	27	PF00069	0.172
MOD_ProDKin_1	3	9	PF00069	0.328
TRG_ENDOCYTIC_2	152	155	PF00928	0.240
TRG_ENDOCYTIC_2	83	86	PF00928	0.410
TRG_ER_diArg_1	29	31	PF00400	0.481

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1L8	Leptomonas seymouri	37%	98%
A0A0N1IHQ2	Leptomonas seymouri	54%	100%
A0A0S4J3W8	Bodo saltans	40%	98%
A0A0S4J4A1	Bodo saltans	40%	100%
A0A1X0NUH8	Trypanosomatidae	36%	100%
A0A1X0NUR6	Trypanosomatidae	49%	100%
A0A3Q8ICP7	Leishmania donovani	74%	100%
A0A3R7NKX5	Trypanosoma rangeli	44%	100%
A0A3S5H6Z5	Leishmania donovani	35%	98%
A4HX66	Leishmania infantum	74%	100%
A4HX67	Leishmania infantum	35%	98%
C9ZTT2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
C9ZTT4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
C9ZTT6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9ARC3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	68%	100%
E9ARC4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	37%	98%
Q4QEJ6	Leishmania major	34%	100%
Q4QEJ7	Leishmania major	71%	100%
V5ASR1	Trypanosoma cruzi	42%	100%
V5BCQ2	Trypanosoma cruzi	37%	100%